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Curriculum Reform Practices in “Cosmetic Product Formulation Design and Preparation Technology” Under the Perspective of Integration of Industry, Education, and Research
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作者 Lei Shi Shengzhao Gong +1 位作者 Xiao Huang Jiesheng Chen 《Journal of Contemporary Educational Research》 2024年第6期194-201,共8页
With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Techn... With the upgrading of industries,the cosmetics industry has posed new requirements for technical talents.As a professional core course in cosmetic technology,“Cosmetic Product Formulation Design and Preparation Technology”serves as the foundation for cultivating students’abilities in cosmetic development and preparation.To foster high-quality skilled talents capable of adapting to the rapid growth of color cosmetics and to better promote the deep integration of scientific and technological industries with curriculum teaching,the teacher team embarked on active explorations and practical teaching research for curriculum teaching reform from four dimensions:strengthening top-level design,enriching teaching content,optimizing teaching design,and reforming assessment methods.These efforts have enhanced students’comprehensive vocational qualities and innovative consciousness,contributing to the teaching reform in higher vocational colleges under the integration of industry,education,and research. 展开更多
关键词 Cosmetic Product formulation design and Preparation Technology Curriculum teaching reform Integration of industry education and research Cosmetic technology
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Integrated computer-aided formulation design:A case study of andrographolide/cyclodextrin ternary formulation 被引量:3
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作者 Haoshi Gao Yan Su +6 位作者 Wei Wang Wei Xiong Xiyang Sun Yuanhui Ji Hua Yu Haifeng Li Defang Ouyang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2021年第4期494-507,共14页
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate vario... Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists,which is time-consuming,high cost and waste materials.This research aims to integrate various computational tools,including machine learning,molecular dynamic simulation and physiologically based absorption modeling(PBAM),to enhance andrographolide(AG)/cyclodextrins(CDs)formulation design.The light GBM prediction model we built before was utilized to predict AG/CDs inclusion's binding free energy.AG/γ-CD inclusion complexes showed the strongest binding affinity,which was experimentally validated by the phase solubility study.The molecular dynamic simulation was used to investigate the inclusion mechanism between AG andγ-CD,which was experimentally characterized by DSC,FTIR and NMR techniques.PBAM was applied to simulate the in vivo behavior of the formulations,which were validated by cell and animal experiments.Cell experiments revealed that the presence of D-α-Tocopherol polyethylene glycol succinate(TPGS)significantly increased the intracellular uptake of AG in MDCKMDR1 cells and the absorptive transport of AG in MDCK-MDR1 monolayers.The relative bioavailability of the AG-CD-TPGS ternary system in rats was increased to 2.6-fold and 1.59-fold compared with crude AG and commercial dropping pills,respectively.In conclusion,this is the first time to integrate various computational tools to develop a new AG-CD-TPGS ternary formulation with significant improvement of aqueous solubility,dissolution rate and bioavailability.The integrated computational tool is a novel and robust methodology to facilitate pharmaceutical formulation design. 展开更多
关键词 Integrated computer-aided formulation design Machine learning Molecular dynamic simulation Physiologically based absorption modeling ANDROGRAPHOLIDE Cyclodextrins
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Development and Application of the Professional Software for Formulation Optimization Design
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作者 李定华 张沧 +1 位作者 张亮 王建祺 《Journal of Beijing Institute of Technology》 EI CAS 1998年第4期418-424,共7页
Aim To research the computer optimization design in material formulation. Methods The professional software including experimental design, mathematical modeling and optimization of single and multiple purposes was d... Aim To research the computer optimization design in material formulation. Methods The professional software including experimental design, mathematical modeling and optimization of single and multiple purposes was developed and applied to the formulation design for the flame retardant ethylenepropylene-diene mischpolymer (EPDM) insulation composites. With the aid of equipartition design, the mathematical models were established based on the optimization of the four properties (limiting oxygen index, volume resistance, tensile strength and elongation). Results The models from limited experiments had good significance, and the modeling analysis conclusions were in good agreement with later experiments. The optimization formulation was practically excellent. Conclusion The software enables practically a comprehensive multi-purpose use of material formulation research. 展开更多
关键词 computer optimization formulation design material development
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Design of Retarded Fractional Delay Differential Systems Using the Method of Inequalities 被引量:3
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作者 Suchin Arunsawatwong Van Quang Nguyen 《International Journal of Automation and computing》 EI 2009年第1期22-28,共7页
Methods based on numerical optimization are useful and effective in the design of control systems. This paper describes the design of retarded fractional delay differential systems (RFDDSs) by the method of inequali... Methods based on numerical optimization are useful and effective in the design of control systems. This paper describes the design of retarded fractional delay differential systems (RFDDSs) by the method of inequalities, in which the design problem is formulated so that it is suitable for solution by numerical methods. Zakian's original formulation, which was first proposed in connection with rational systems, is extended to the case of RFDDSs. In making the use of this formulation possible for RFDDSs, the associated stability problems are resolved by using the stability test and the numerical algorithm for computing the abscissa of stability recently developed by the authors. During the design process, the time responses are obtained by a known method for the numerical inversion of Laplace transforms. Two numerical examples are given, where fractional controllers are designed for a time-delay and a heat-conduction plants. 展开更多
关键词 Fractional systems systems with time-delays control systems design method of inequalities design formulation parameter optimization.
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Research on Fe-based impregnated diamond drill bits strengthened by Nano-NbC and Nano-WC 被引量:1
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作者 Ekene Matthew Egwuonwu Uzodigwe Emmanuel Nnanwuba +3 位作者 CHANG Si DUAN Longchen NING Fulong LIU Baochang 《Global Geology》 2023年第1期21-30,共10页
In order to improve the matrix performance of impregnated diamond drill bit to better meet the drilling needs,the effects of the addition of nano-WC and nano-NbC particles on the matrix material together with the mech... In order to improve the matrix performance of impregnated diamond drill bit to better meet the drilling needs,the effects of the addition of nano-WC and nano-NbC particles on the matrix material together with the mechanical properties and microstructure of the diamond-matrix composite material of the Fe-based diamond drill bit were studied by using the method of uniform formula design,regression analysis and solution finding.An indoor drilling test was also carried out using the fabricated impregnated diamond drill bit.The results showed that after the addition of nano-NbC and nano-WC,the hardness and flexural strength of the matrix material got improved,as the flexural strength of the diamond composite material increased to 4.29%,the wear-resistance ratio increased to 8.75%,and the tighter the chemical bonding between the diamond and the matrix.This,indicates that the addition of nanoparticles has a positive significance in improving the performance of the diamond composite.The results of the drilling test showed that the mechanical drilling speed of the impregnated diamond drill bit after nanoparticle strengthening is 25.85%higher than that of the conventional drill bit,and the matrix wear was increased by 17.5%.It proves that nanoparticles can improve the drilling performance and efficiency of drill bit. 展开更多
关键词 Nanoparticles uniform formulation design diffusion strengthening impregnated diamond drill bits
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Integrated “Generate, Make, and Test” for Formulated Products using Knowledge Graphs 被引量:1
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作者 Sagar Sunkle Deepak Jain +4 位作者 Krati Saxena Ashwini Patil Tushita Singh Beena Rai Vinay Kulkarni 《Data Intelligence》 2021年第3期340-375,共36页
In the multi-billion dollar formulated product industry, state of the art continues to rely heavily on experts during the "generate, make and test" steps of formulation design. We propose automation aids to ... In the multi-billion dollar formulated product industry, state of the art continues to rely heavily on experts during the "generate, make and test" steps of formulation design. We propose automation aids to each step with a knowledge graph of relevant information as the central artifact. The generate step usually focuses on coming up with new recipes for intended formulation. We propose to aid the experts who generally carry out this step manually by providing a recommendation system and a templating system on top of the knowledge graph. Using the former, the expert can create a recipe from scratch using historical formulations and related data. With the latter, the expert starts with a recipe template created by our system and substitutes the requisite constituents to form a recipe. In the current state of practice, the three steps mentioned above operate in a fragmented manner wherein observations from one step do not aid other steps in a streamlined manner. Instead of manually operated labs for the make and test steps, we assume automated or robotic labs and in-silico testing, respectively. Using two formulations, namely face cream and an exterior coating, we show how the knowledge graph may help integrate and streamline the communication between the generate, the make, and the test steps. Our initial exploration shows considerable promise. 展开更多
关键词 Formulated product design formulation recommendation formulation template Robotic labs In-silico testing Integrated generate-make-test
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