Medical care has undergone remarkable improvements over the past few decades.One of the most important innovative breakthroughs in modern medicine is the advent of minimally and less invasive treatments.The trend towa...Medical care has undergone remarkable improvements over the past few decades.One of the most important innovative breakthroughs in modern medicine is the advent of minimally and less invasive treatments.The trend towards employing less invasive treatment has been vividly shown in the field of gastroenterology,particularly coloproctology.Parallel to foregut interventions,colorectal surgery has shifted towards a minimally invasive approach.Coloproctology,including both medical and surgical management of colorectal diseases,has undergone a remarkable paradigm shift.The treatment of both benign and malignant colorectal conditions has gradually transitioned towards more conservative and less inva-sive approaches.An interesting paradigm shift was the trend to avoid the need for radical resection of rectal cancer altogether in patients who showed complete response to neoadjuvant treatment.The trend of adopting less invasive appro-aches to treat various colorectal conditions does not seem to be stopping soon as further research on novel,more effective and safer methods is ongoing.展开更多
This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analy...This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analyzing various research endeavors and key technologies, encompassing ontology structure,control and decision-making, and perception and interaction, a holistic overview of the current state of humanoid robot research is presented. Furthermore, emerging challenges in the field are identified, emphasizing the necessity for a deeper understanding of biological motion mechanisms, improved structural design,enhanced material applications, advanced drive and control methods, and efficient energy utilization. The integration of bionics, brain-inspired intelligence, mechanics, and control is underscored as a promising direction for the development of advanced humanoid robotic systems. This paper serves as an invaluable resource, offering insightful guidance to researchers in the field,while contributing to the ongoing evolution and potential of humanoid robots across diverse domains.展开更多
Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical structures.The changes in moisture content in soil lead to effective stress ...Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical structures.The changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive soils.The volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such soils.Climate change is likely to amplify the ground movement potential and the associated problems are likely to worsen.The effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for Australia.The changes in TMI were then correlated to the depth of suction change(H s),an important input in ground movement calculation.Under all climate scenarios considered,reductions in TMI and increases in H s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is discussed.It is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.展开更多
Traction power systems(TPSs)play a vital role in the operation of electrified railways.The transformation of conventional railway TPSs to novel structures is not only a trend to promote the development of electrified ...Traction power systems(TPSs)play a vital role in the operation of electrified railways.The transformation of conventional railway TPSs to novel structures is not only a trend to promote the development of electrified railways toward high-efficiency and resilience but also an inevitable requirement to achieve carbon neutrality target.On the basis of sorting out the power supply structures of conventional AC and DC modes,this paper first reviews the characteristics of the existing TPSs,such as weak power supply flexibility and low-energy efficiency.Furthermore,the power supply structures of various TPSs for future electrified railways are described in detail,which satisfy longer distance,low-carbon,high-efficiency,high-reliability and high-quality power supply requirements.Meanwhile,the application prospects of different traction modes are discussed from both technical and economic aspects.Eventually,this paper introduces the research progress of mixed-system electrified railways and traction power supply technologies without catenary system,speculates on the future development trends and challenges of TPSs and predicts that TPSs will be based on the continuous power supply mode,employing power electronic equipment and intelligent information technology to construct a railway comprehensive energy system with renewable energy.展开更多
The 21st century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various tools ...The 21st century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various tools and technology which has completely changed the patient management including abdominal surgery.Surgery for abdominal diseases has moved from maximally invasive to minimally invasive(laparoscopic and robotic)surgery.Some of the newer medicines have its impact on need for surgical intervention.This article focuses on the development of these emerging molecules,tools,and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.展开更多
Together for a Shared Future Compiled by Global Young Leaders Dialogue Price:RMB 118 Paperback,250 pages Published by Foreign Languages Press Together for a Shared Future is co-authored by 35 young people from 26 coun...Together for a Shared Future Compiled by Global Young Leaders Dialogue Price:RMB 118 Paperback,250 pages Published by Foreign Languages Press Together for a Shared Future is co-authored by 35 young people from 26 countries who participated in the project China Tour of the Global Young Leaders Dialogue(GYLD),an institutional platform for idea-sharing among young people from different countries.展开更多
Background:Post-hepatectomy liver failure(PHLF)is the Achilles’heel of hepatic resection for colorectal liver metastases.The most commonly used procedure to generate hypertrophy of the functional liver remnant(FLR)is...Background:Post-hepatectomy liver failure(PHLF)is the Achilles’heel of hepatic resection for colorectal liver metastases.The most commonly used procedure to generate hypertrophy of the functional liver remnant(FLR)is portal vein embolization(PVE),which does not always lead to successful hypertrophy.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been proposed to overcome the limitations of PVE.Liver venous deprivation(LVD),a technique that includes simultaneous portal and hepatic vein embolization,has also been proposed as an alternative to ALPPS.The present study aimed to conduct a systematic review as the first network meta-analysis to compare the efficacy,effectiveness,and safety of the three regenerative techniques.Data sources:A systematic search for literature was conducted using the electronic databases Embase,PubMed(MEDLINE),Google Scholar and Cochrane.Results:The time to operation was significantly shorter in the ALPPS cohort than in the PVE and LVD cohorts by 27 and 22 days,respectively.Intraoperative parameters of blood loss and the Pringle maneuver demonstrated non-significant differences between the PVE and LVD cohorts.There was evidence of a significantly higher FLR hypertrophy rate in the ALPPS cohort when compared to the PVE cohort,but non-significant differences were observed when compared to the LVD cohort.Notably,the LVD cohort demonstrated a significantly better FLR/body weight(BW)ratio compared to both the ALPPS and PVE cohorts.Both the PVE and LVD cohorts demonstrated significantly lower major morbidity rates compared to the ALPPS cohort.The LVD cohort also demonstrated a significantly lower 90-day mortality rate compared to both the PVE and ALPPS cohorts.Conclusions:LVD in adequately selected patients may induce adequate and profound FLR hypertrophy before major hepatectomy.Present evidence demonstrated significantly lower major morbidity and mortality rates in the LVD cohort than in the ALPPS and PVE cohorts.展开更多
In weather sciences,the two specific terms“storm”and“cyclone”frequently appear in literature and usually refer to the violent nature of a number of weather systems characterized by central low pressure,strong wind...In weather sciences,the two specific terms“storm”and“cyclone”frequently appear in literature and usually refer to the violent nature of a number of weather systems characterized by central low pressure,strong winds,large precipitation amounts in the form of rain,freezing rain,or snow,as well as thunder and lightning.But what is the connection between these two specific terms?In this paper,the historic evolutions of the terms“storm”and“cyclone”are reviewed from the perspective of weather science.The earliest recorded storms in world history are also briefly introduced.Then,the origin of the term“meteorological bomb”,which is the nickname of the“explosive cyclone”is introduced.Later,the various definitions of explosive cyclones given by several researchers are discussed.Also,the climatological features of explosive cyclones,as well as the future trends of explosive cyclones under global climate change,are discussed.展开更多
Climate change caused by past,current,and future greenhouse gas emissions has become a major concern for scientists in the field in many countries and regions of the world.This study modelled future precipitation chan...Climate change caused by past,current,and future greenhouse gas emissions has become a major concern for scientists in the field in many countries and regions of the world.This study modelled future precipitation change by downscaling a set of large-scale climate predictor variables(predictors)from the second generation Canadian Earth System Model(CanESM2)under two Representative Concentration Pathway(RCP)emission scenarios(RCP4.5 and RCP8.5)in the semi-arid Borana lowland,southern Ethiopia.The Statistical DownScaling Model(SDSM)4.2.9 was employed to downscale and project future precipitation change in the middle(2036-2065;2050s)and far(2066-2095;2080s)future at the local scale.Historical precipitation observations from eight meteorological stations stretching from 1981 to 1995 and 1996 to 2005 were used for the model calibration and validation,respectively,and the time period of 1981-2018 was considered and used as the baseline period to analyze future precipitation change.The results revealed that the surface-specific humidity and the geopotential height at 500 hPa were the preferred large-scale predictors.Compared to the middle future(2050s),precipitation showed a much greater increase in the far future(2080s)under both RCP4.5 and RCP8.5 scenarios at all meteorological stations(except Teletele and Dillo stations).At Teltele station,the projected annual precipitation will decrease by 26.53%(2050s)and 39.45%(2080s)under RCP4.5 scenario,and 34.99%(2050s)and 60.62%(2080s)under RCP8.5 scenario.Seasonally,the main rainy period would shift from spring(March to May)to autumn(September to November)at Dehas,Dire,Moyale,and Teltele stations,but for Arero and Yabelo stations,spring would consistently receive more precipitation than autumn.It can be concluded that future precipitation in the semi-arid Borana lowland is predicted to differ under the two climate scenarios(RCP4.5 and RCP8.5),showing an increasing trend at most meteorological stations.This information could be helpful for policymakers to design adaptation plans in water resources management,and we suggest that the government should give more attention to improve early warning systems in drought-prone areas by providing dependable climate forecast information as early as possible.展开更多
The future changes in the relationship between the South Asian summer monsoon(SASM)and the East Asian summer monsoon(EASM)are investigated by using the high-emissions Shared Socioeconomic Pathway 5-8.5(SSP5-8.5)experi...The future changes in the relationship between the South Asian summer monsoon(SASM)and the East Asian summer monsoon(EASM)are investigated by using the high-emissions Shared Socioeconomic Pathway 5-8.5(SSP5-8.5)experiments from 26 coupled models that participated in the phase 6 of the Coupled Model Intercomparison Project(CMIP6).Six models,selected based on their best performance in simulating the upper-and lower-level pathways related to the SASM-EASM teleconnection in the historical run,can capture the positive relationship between the SASM and the rainfall over northern China.In the future scenario,the upper-level teleconnection wave pattern connecting the SASM and the EASM exhibits a significant weakening trend,due to the rainfall anomalies decrease over the northern Indian Peninsula in the future.At the lower level,the western North Pacific anticyclone is projected to strengthen in the warming climate.The positive(negative)rainfall anomalies associated with positive(negative)SASM rainfall anomalies are anticipated to extend southward from northern China to the Yangtze-Huai River valley,the Korea Peninsula,and southern Japan.The connection in the lower-level pathway may be strengthened in the future.展开更多
This study aims to examine whether life insurance futures can serve as a hedge against the COVID-19 pandemic and whether they have the characteristics of a safe haven under the impact of the health shocks of the COVID...This study aims to examine whether life insurance futures can serve as a hedge against the COVID-19 pandemic and whether they have the characteristics of a safe haven under the impact of the health shocks of the COVID-19 pandemic.We chose three life insurance stock futures in India and one in Taiwan as samples,including the market index of the two countries and the number of confirmed COVID-19 cases as sample variables.We used the growth rate of COVID-19 cases as the threshold variable,esti-mated the asymmetric threshold vector autoregression model,and found that insur-ance futures in the regime with a significant growth rate of confirmed COVID-19 cases can hedge against COVID-19 risks;therefore,insurance futures are a safe haven for the market.We further estimated the time-varying parameter vector autoregression model,and the impulse response results showed that insurance futures are a safe haven for COVID-19 pandemic risks.展开更多
This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the l...This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the lagoon, which include factors such as size, depth, water quality, and ecosystem composition. Secondly, the influence of precipitation on the water volume in the lagoon will be examined. This analysis involves assessing historical rainfall patterns in the region, as well as the amount and frequency of precipitation during the 2021 flood event. Thirdly, the hydrogeologic and geologic conditions of the lagoon will be evaluated. This involves examining factors such as the type and structure of the soil and bedrock, the presence of aquifers or other underground water sources, and the movement of water through the surrounding landscape. Finally, the study seeks to assess the risk of future flooding in Tasi-Tolu Lagoon, based on the insights gained from the previous analyses. Overall, this study’s goal is to provide a comprehensive understanding of the hydrogeological factors that contribute to flooding in Tasi-Tolu Lagoon. This knowledge could be used to inform flood mitigation strategies or to improve our ability to predict and respond to future flooding events in the region.展开更多
According to the historical records of prehistoric civilisation in China and the existing theories of prehistoric history within the academic community,it can be inferred that all human civilisations on Earth have the...According to the historical records of prehistoric civilisation in China and the existing theories of prehistoric history within the academic community,it can be inferred that all human civilisations on Earth have their origins in the period following the Great Flood,during which human civilisation was rebuilt.Furthermore,there are notable parallels between the figure of“Nuwa”in Chinese prehistoric civilisation and that of“Noah”in Western accounts.By treating the prehistoric flood event as a research approach in historical compilation,scholars can extract valuable insights into“building a community of a shared future for mankind”and use it as a symbol of global diplomatic relations.This approach can foster common values of mutual learning and exchange among nations,ultimately creating a more promising future for developing a new form of human civilisation.展开更多
BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)is an innovative surgical approach for the treatment of massive hepatocellular carcinoma(HCC),the key to successful planned ...BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)is an innovative surgical approach for the treatment of massive hepatocellular carcinoma(HCC),the key to successful planned stage 2 ALPPS is future liver remnant(FLR)volume growth,but the exact mechanism has not been elucidated.The correlation between regulatory T cells(Tregs)and postoperative FLR regeneration has not been reported.AIM To investigate the effect of CD4^(+)CD25^(+)Tregs on FLR regeneration after ALPPS.METHODS Clinical data and specimens were collected from 37 patients who developed massive HCC treated with ALPPS.Flow cytometry was performed to detect changes in the proportion of CD4^(+)CD25^(+)Tregs to CD4^(+)T cells in peripheral blood before and after ALPPS.To analyze the relationship between peripheral blood CD4^(+)CD25^(+)Treg proportion and clinicopathological information and liver volume.RESULTS The postoperative CD4^(+)CD25^(+)Treg proportion in stage 1 ALPPS was negatively correlated with the amount of proliferation volume,proliferation rate,and kinetic growth rate(KGR)of the FLR after stage 1 ALPPS.Patients with low Treg proportion had significantly higher KGR than those with high Treg proportion(P=0.006);patients with high Treg proportion had more severe postoperative pathological liver fibrosis than those with low Treg proportion(P=0.043).The area under the receiver operating characteristic curve between the percentage of Tregs and proliferation volume,proliferation rate,and KGR were all greater than 0.70.CONCLUSION CD4^(+)CD25^(+)Tregs in the peripheral blood of patients with massive HCC at stage 1 ALPPS were negatively correlated with indicators of FLR regeneration after stage 1 ALPPS and may influence the degree of fibrosis in patients’livers.Treg percentage was highly accurate in predicting the FLR regeneration after stage 1 ALPPS.展开更多
Pilots need to board the ship for pilotage,but there are risks or potential dangers in the transfer of pilot.The author reviewed the history of the development of pilot boats,analyzed the potential risks or dangers of...Pilots need to board the ship for pilotage,but there are risks or potential dangers in the transfer of pilot.The author reviewed the history of the development of pilot boats,analyzed the potential risks or dangers of transferring pilot,proposed that pilot boat shall have the function of ensuring the safety of pilot when embarking or disembarking the ships,some suggestions on the future design and manufacture of Chinese pilot boats are also given according to the advantages and disadvantages of domestic and foreign pilot boats.展开更多
This paper discusses the transformation of art education in anticipation of the future school,and emphasizes the key role of art education in cultivating students’creativity,aesthetic ability,thinking ability,and mee...This paper discusses the transformation of art education in anticipation of the future school,and emphasizes the key role of art education in cultivating students’creativity,aesthetic ability,thinking ability,and meeting social needs.The shortcomings and delays in the traditional art education mode have become evident,prompting the need to explore innovative educational methods.Digital art education is emerging as a means to offer a more immersive art experience through virtual and augmented reality technologies while broadening students’cultural horizons.Interdisciplinary integration combines art with science,engineering,mathematics,and other disciplines to cultivate students’comprehensive literacy and innovative thinking.The innovative spirit and the application of educational technology help students overcome difficulties and continuously improve their work.The article also emphasizes the alignment between art education and social needs,the importance of social support and resources,and the training and development of teachers.展开更多
This paper is a hypothetical exploration of the connections between teleological evolution,the Omega Singularity,and the future of cities,weaving together insights from a diverse array of disciplines.Our investigation...This paper is a hypothetical exploration of the connections between teleological evolution,the Omega Singularity,and the future of cities,weaving together insights from a diverse array of disciplines.Our investigation delves into the possibility that cities are evolving towards a Singularity,a state characterized by infinite knowledge,intelligence,and adaptability,which would bring about a radical transformation of urban environments and their underlying dynamics in the 21st century and beyond.At the heart of this exploration lies the role of language and time as crucial dimensions of the Urban Singularity.Moreover,we examine how linguistic developments and cross-cultural exchanges can foster more inclusive,adaptable,and resilient urban environments,while also highlighting the need for advanced technologies and communication modalities that can support the dynamic needs of future cities.Furthermore,the paper investigates the profound implications and transformative potential of merging human consciousness with the urban Singularity.By examining the interplay between these concepts,we seek for a deeper understanding of the potential trajectories and implications of these concepts for the transformation of human society and our relationship with the built environment.展开更多
Colorectal cancer(CRC)is the third most prevalent cancer in both men and women,and it is the second leading cause of cancer-related deaths globally.Around 60%-70%of CRC patients are diagnosed at advanced stages,with n...Colorectal cancer(CRC)is the third most prevalent cancer in both men and women,and it is the second leading cause of cancer-related deaths globally.Around 60%-70%of CRC patients are diagnosed at advanced stages,with nearly 20%having liver metastases.It is noteworthy that the 5-year survival rates decline significantly from 80%-90%for localized disease to a mere 10%-15%for patients with metastasis at the time of diagnosis.Early diagnosis,appropriate therapeutic strategy,accurate assessment of treatment response,and prognostication is essential for better outcome.There has been significant technological development in the last couple of decades to improve the outcome of rectal cancer including Artificial intelligence(AI).AI is a broad term used to describe the study of machines that mimic human intelligence,such as perceiving the environment,drawing logical conclusions from observations,and performing complex tasks.At present AI has demonstrated a promising role in early diagnosis,prognosis,and treatment outcomes for patients with rectal cancer,a limited role in surgical decision making,and had a bright future.展开更多
Similar to the method of continuum mechanics, the variation of the price of index futures is viewed to be continuous and regular. According to the characteristic of index futures, a basic equation of price of index fu...Similar to the method of continuum mechanics, the variation of the price of index futures is viewed to be continuous and regular. According to the characteristic of index futures, a basic equation of price of index futures was established. It is a differential equation, its solution shows that the relation between time and price forms a logarithmic circle. If the time is thought of as the probability of its corresponding price, then such a relation is perfectly coincided with the main assumption of the famous formula of option pricing, based on statistical theory, established by Black and Scholes winner of 1997 Nobel' prize on economy. In that formula, the probability of price of basic assets (they stand for index futures here) is assummed to be a logarithmic normal distribution. This agreement shows that the same result may be obtained by two analytic methods with different bases. However, the result, given by assumption by Black-Scholes, is derived from the solution of the differential equation.展开更多
文摘Medical care has undergone remarkable improvements over the past few decades.One of the most important innovative breakthroughs in modern medicine is the advent of minimally and less invasive treatments.The trend towards employing less invasive treatment has been vividly shown in the field of gastroenterology,particularly coloproctology.Parallel to foregut interventions,colorectal surgery has shifted towards a minimally invasive approach.Coloproctology,including both medical and surgical management of colorectal diseases,has undergone a remarkable paradigm shift.The treatment of both benign and malignant colorectal conditions has gradually transitioned towards more conservative and less inva-sive approaches.An interesting paradigm shift was the trend to avoid the need for radical resection of rectal cancer altogether in patients who showed complete response to neoadjuvant treatment.The trend of adopting less invasive appro-aches to treat various colorectal conditions does not seem to be stopping soon as further research on novel,more effective and safer methods is ongoing.
基金supported by the National Natural Science Foundation of China(62303457,U21A20482)Project funded by China Postdoctoral Science Foundation (2023M733737)the National Key R&D Program of China(2022YFB3303800)。
文摘This paper provides a comprehensive review of the current status, advancements, and future prospects of humanoid robots, highlighting their significance in driving the evolution of next-generation industries. By analyzing various research endeavors and key technologies, encompassing ontology structure,control and decision-making, and perception and interaction, a holistic overview of the current state of humanoid robot research is presented. Furthermore, emerging challenges in the field are identified, emphasizing the necessity for a deeper understanding of biological motion mechanisms, improved structural design,enhanced material applications, advanced drive and control methods, and efficient energy utilization. The integration of bionics, brain-inspired intelligence, mechanics, and control is underscored as a promising direction for the development of advanced humanoid robotic systems. This paper serves as an invaluable resource, offering insightful guidance to researchers in the field,while contributing to the ongoing evolution and potential of humanoid robots across diverse domains.
基金supported by President’s Scholarships from the University of South Australia towards his PhD study。
文摘Climate change is one of the major global challenges and it can have a significant influence on the behaviour and resilience of geotechnical structures.The changes in moisture content in soil lead to effective stress changes and can be accompanied by significant volume changes in reactive/expansive soils.The volume change leads to ground movement and can exert additional stresses on structures founded on or within a shallow depth of such soils.Climate change is likely to amplify the ground movement potential and the associated problems are likely to worsen.The effect of atmospheric boundary interaction on soil behaviour has often been correlated to Thornthwaite moisture index(TMI).In this study,the long-term weather data and anticipated future projections for various emission scenarios were used to generate a series of TMI maps for Australia.The changes in TMI were then correlated to the depth of suction change(H s),an important input in ground movement calculation.Under all climate scenarios considered,reductions in TMI and increases in H s values were observed.A hypothetical design scenario of a footing on expansive soil under current and future climate is discussed.It is observed that a design that might be considered adequate under the current climate scenario,may fail under future scenarios and accommodations should be made in the design for such events.
基金supported in part by the Scientific Foundation for Outstanding Young Scientists of Sichuan under Grant No.2021JDJQ0032in part by the National Natural Science Foundation of China under Grant No.52107128in part by the Natural Science Foundation of Sichuan Province under Grant No.2022NSFSC0436.
文摘Traction power systems(TPSs)play a vital role in the operation of electrified railways.The transformation of conventional railway TPSs to novel structures is not only a trend to promote the development of electrified railways toward high-efficiency and resilience but also an inevitable requirement to achieve carbon neutrality target.On the basis of sorting out the power supply structures of conventional AC and DC modes,this paper first reviews the characteristics of the existing TPSs,such as weak power supply flexibility and low-energy efficiency.Furthermore,the power supply structures of various TPSs for future electrified railways are described in detail,which satisfy longer distance,low-carbon,high-efficiency,high-reliability and high-quality power supply requirements.Meanwhile,the application prospects of different traction modes are discussed from both technical and economic aspects.Eventually,this paper introduces the research progress of mixed-system electrified railways and traction power supply technologies without catenary system,speculates on the future development trends and challenges of TPSs and predicts that TPSs will be based on the continuous power supply mode,employing power electronic equipment and intelligent information technology to construct a railway comprehensive energy system with renewable energy.
文摘The 21st century has started with several innovations in the medical sciences,with wide applications in health care management.This development has taken in the field of medicines(newer drugs/molecules),various tools and technology which has completely changed the patient management including abdominal surgery.Surgery for abdominal diseases has moved from maximally invasive to minimally invasive(laparoscopic and robotic)surgery.Some of the newer medicines have its impact on need for surgical intervention.This article focuses on the development of these emerging molecules,tools,and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.
文摘Together for a Shared Future Compiled by Global Young Leaders Dialogue Price:RMB 118 Paperback,250 pages Published by Foreign Languages Press Together for a Shared Future is co-authored by 35 young people from 26 countries who participated in the project China Tour of the Global Young Leaders Dialogue(GYLD),an institutional platform for idea-sharing among young people from different countries.
文摘Background:Post-hepatectomy liver failure(PHLF)is the Achilles’heel of hepatic resection for colorectal liver metastases.The most commonly used procedure to generate hypertrophy of the functional liver remnant(FLR)is portal vein embolization(PVE),which does not always lead to successful hypertrophy.Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)has been proposed to overcome the limitations of PVE.Liver venous deprivation(LVD),a technique that includes simultaneous portal and hepatic vein embolization,has also been proposed as an alternative to ALPPS.The present study aimed to conduct a systematic review as the first network meta-analysis to compare the efficacy,effectiveness,and safety of the three regenerative techniques.Data sources:A systematic search for literature was conducted using the electronic databases Embase,PubMed(MEDLINE),Google Scholar and Cochrane.Results:The time to operation was significantly shorter in the ALPPS cohort than in the PVE and LVD cohorts by 27 and 22 days,respectively.Intraoperative parameters of blood loss and the Pringle maneuver demonstrated non-significant differences between the PVE and LVD cohorts.There was evidence of a significantly higher FLR hypertrophy rate in the ALPPS cohort when compared to the PVE cohort,but non-significant differences were observed when compared to the LVD cohort.Notably,the LVD cohort demonstrated a significantly better FLR/body weight(BW)ratio compared to both the ALPPS and PVE cohorts.Both the PVE and LVD cohorts demonstrated significantly lower major morbidity rates compared to the ALPPS cohort.The LVD cohort also demonstrated a significantly lower 90-day mortality rate compared to both the PVE and ALPPS cohorts.Conclusions:LVD in adequately selected patients may induce adequate and profound FLR hypertrophy before major hepatectomy.Present evidence demonstrated significantly lower major morbidity and mortality rates in the LVD cohort than in the ALPPS and PVE cohorts.
基金supports of National Key R&D Program of China(2022YFC3004200)National Natural Science Foundation of China(Grant Nos.42275001 and 41775042)to this study.
文摘In weather sciences,the two specific terms“storm”and“cyclone”frequently appear in literature and usually refer to the violent nature of a number of weather systems characterized by central low pressure,strong winds,large precipitation amounts in the form of rain,freezing rain,or snow,as well as thunder and lightning.But what is the connection between these two specific terms?In this paper,the historic evolutions of the terms“storm”and“cyclone”are reviewed from the perspective of weather science.The earliest recorded storms in world history are also briefly introduced.Then,the origin of the term“meteorological bomb”,which is the nickname of the“explosive cyclone”is introduced.Later,the various definitions of explosive cyclones given by several researchers are discussed.Also,the climatological features of explosive cyclones,as well as the future trends of explosive cyclones under global climate change,are discussed.
文摘Climate change caused by past,current,and future greenhouse gas emissions has become a major concern for scientists in the field in many countries and regions of the world.This study modelled future precipitation change by downscaling a set of large-scale climate predictor variables(predictors)from the second generation Canadian Earth System Model(CanESM2)under two Representative Concentration Pathway(RCP)emission scenarios(RCP4.5 and RCP8.5)in the semi-arid Borana lowland,southern Ethiopia.The Statistical DownScaling Model(SDSM)4.2.9 was employed to downscale and project future precipitation change in the middle(2036-2065;2050s)and far(2066-2095;2080s)future at the local scale.Historical precipitation observations from eight meteorological stations stretching from 1981 to 1995 and 1996 to 2005 were used for the model calibration and validation,respectively,and the time period of 1981-2018 was considered and used as the baseline period to analyze future precipitation change.The results revealed that the surface-specific humidity and the geopotential height at 500 hPa were the preferred large-scale predictors.Compared to the middle future(2050s),precipitation showed a much greater increase in the far future(2080s)under both RCP4.5 and RCP8.5 scenarios at all meteorological stations(except Teletele and Dillo stations).At Teltele station,the projected annual precipitation will decrease by 26.53%(2050s)and 39.45%(2080s)under RCP4.5 scenario,and 34.99%(2050s)and 60.62%(2080s)under RCP8.5 scenario.Seasonally,the main rainy period would shift from spring(March to May)to autumn(September to November)at Dehas,Dire,Moyale,and Teltele stations,but for Arero and Yabelo stations,spring would consistently receive more precipitation than autumn.It can be concluded that future precipitation in the semi-arid Borana lowland is predicted to differ under the two climate scenarios(RCP4.5 and RCP8.5),showing an increasing trend at most meteorological stations.This information could be helpful for policymakers to design adaptation plans in water resources management,and we suggest that the government should give more attention to improve early warning systems in drought-prone areas by providing dependable climate forecast information as early as possible.
基金Guangdong Major Project of Basic and Applied Basic Research Foundation(2020B0301030004)National Natural Science Foundation of China(41975074)+2 种基金Guangdong Basic and Applied Basic Research Foundation(2023A1515010908)Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies(2020B1212060025)Innovation Group Project of Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)(311021001)。
文摘The future changes in the relationship between the South Asian summer monsoon(SASM)and the East Asian summer monsoon(EASM)are investigated by using the high-emissions Shared Socioeconomic Pathway 5-8.5(SSP5-8.5)experiments from 26 coupled models that participated in the phase 6 of the Coupled Model Intercomparison Project(CMIP6).Six models,selected based on their best performance in simulating the upper-and lower-level pathways related to the SASM-EASM teleconnection in the historical run,can capture the positive relationship between the SASM and the rainfall over northern China.In the future scenario,the upper-level teleconnection wave pattern connecting the SASM and the EASM exhibits a significant weakening trend,due to the rainfall anomalies decrease over the northern Indian Peninsula in the future.At the lower level,the western North Pacific anticyclone is projected to strengthen in the warming climate.The positive(negative)rainfall anomalies associated with positive(negative)SASM rainfall anomalies are anticipated to extend southward from northern China to the Yangtze-Huai River valley,the Korea Peninsula,and southern Japan.The connection in the lower-level pathway may be strengthened in the future.
基金supported in part by grants from the Ministry of Science and Technology,Taiwan,under Grant no.MOST 111-2410-H-240-001-.
文摘This study aims to examine whether life insurance futures can serve as a hedge against the COVID-19 pandemic and whether they have the characteristics of a safe haven under the impact of the health shocks of the COVID-19 pandemic.We chose three life insurance stock futures in India and one in Taiwan as samples,including the market index of the two countries and the number of confirmed COVID-19 cases as sample variables.We used the growth rate of COVID-19 cases as the threshold variable,esti-mated the asymmetric threshold vector autoregression model,and found that insur-ance futures in the regime with a significant growth rate of confirmed COVID-19 cases can hedge against COVID-19 risks;therefore,insurance futures are a safe haven for the market.We further estimated the time-varying parameter vector autoregression model,and the impulse response results showed that insurance futures are a safe haven for COVID-19 pandemic risks.
文摘This study aims to apply a hydrogeological approaches and analysis of the 2021 flood event of Tasi-Tolu Lagoon to achieve four specific goals. Firstly, the study seeks to determine the natural characteristics of the lagoon, which include factors such as size, depth, water quality, and ecosystem composition. Secondly, the influence of precipitation on the water volume in the lagoon will be examined. This analysis involves assessing historical rainfall patterns in the region, as well as the amount and frequency of precipitation during the 2021 flood event. Thirdly, the hydrogeologic and geologic conditions of the lagoon will be evaluated. This involves examining factors such as the type and structure of the soil and bedrock, the presence of aquifers or other underground water sources, and the movement of water through the surrounding landscape. Finally, the study seeks to assess the risk of future flooding in Tasi-Tolu Lagoon, based on the insights gained from the previous analyses. Overall, this study’s goal is to provide a comprehensive understanding of the hydrogeological factors that contribute to flooding in Tasi-Tolu Lagoon. This knowledge could be used to inform flood mitigation strategies or to improve our ability to predict and respond to future flooding events in the region.
文摘According to the historical records of prehistoric civilisation in China and the existing theories of prehistoric history within the academic community,it can be inferred that all human civilisations on Earth have their origins in the period following the Great Flood,during which human civilisation was rebuilt.Furthermore,there are notable parallels between the figure of“Nuwa”in Chinese prehistoric civilisation and that of“Noah”in Western accounts.By treating the prehistoric flood event as a research approach in historical compilation,scholars can extract valuable insights into“building a community of a shared future for mankind”and use it as a symbol of global diplomatic relations.This approach can foster common values of mutual learning and exchange among nations,ultimately creating a more promising future for developing a new form of human civilisation.
基金the National Natural Science Foundation of China,No.8190111624Guangxi Natural Science Foundation of China,No.2018JJB140382Guangxi University Young and Middle-Aged Teachers’Basic Scientific Research Ability Improvement Project,No.2019KY0123.
文摘BACKGROUND Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)is an innovative surgical approach for the treatment of massive hepatocellular carcinoma(HCC),the key to successful planned stage 2 ALPPS is future liver remnant(FLR)volume growth,but the exact mechanism has not been elucidated.The correlation between regulatory T cells(Tregs)and postoperative FLR regeneration has not been reported.AIM To investigate the effect of CD4^(+)CD25^(+)Tregs on FLR regeneration after ALPPS.METHODS Clinical data and specimens were collected from 37 patients who developed massive HCC treated with ALPPS.Flow cytometry was performed to detect changes in the proportion of CD4^(+)CD25^(+)Tregs to CD4^(+)T cells in peripheral blood before and after ALPPS.To analyze the relationship between peripheral blood CD4^(+)CD25^(+)Treg proportion and clinicopathological information and liver volume.RESULTS The postoperative CD4^(+)CD25^(+)Treg proportion in stage 1 ALPPS was negatively correlated with the amount of proliferation volume,proliferation rate,and kinetic growth rate(KGR)of the FLR after stage 1 ALPPS.Patients with low Treg proportion had significantly higher KGR than those with high Treg proportion(P=0.006);patients with high Treg proportion had more severe postoperative pathological liver fibrosis than those with low Treg proportion(P=0.043).The area under the receiver operating characteristic curve between the percentage of Tregs and proliferation volume,proliferation rate,and KGR were all greater than 0.70.CONCLUSION CD4^(+)CD25^(+)Tregs in the peripheral blood of patients with massive HCC at stage 1 ALPPS were negatively correlated with indicators of FLR regeneration after stage 1 ALPPS and may influence the degree of fibrosis in patients’livers.Treg percentage was highly accurate in predicting the FLR regeneration after stage 1 ALPPS.
文摘Pilots need to board the ship for pilotage,but there are risks or potential dangers in the transfer of pilot.The author reviewed the history of the development of pilot boats,analyzed the potential risks or dangers of transferring pilot,proposed that pilot boat shall have the function of ensuring the safety of pilot when embarking or disembarking the ships,some suggestions on the future design and manufacture of Chinese pilot boats are also given according to the advantages and disadvantages of domestic and foreign pilot boats.
基金This paper is one of the promotion achievements of the 2018 key project of the National Educational Technology Research Planning Project of the Central Audio-Visual Education Museum“Practical Research on Promoting High School Students’Art Performance Literacy by Information Technology”(Project number:184420013)One of the promotion achievements of Zhongshan Education and Scientific Research 2020 general project“Research on the Aesthetic Education Function of Famous Illustrations in Chinese Textbooks for Primary and Secondary Schools Published by People’s Education Press”(Project number:B2020175)One of the learning and training achievements of the“Guangdong Provincial Famous Principal Wan Fei Workshop.”This abstract is selected from author Yihong Li for the“National Training Program”early 2021 Middle School Art Backbone Teacher Workshop(A314)teaching topic“The Transformation of Art Education Towards the Future School.”。
文摘This paper discusses the transformation of art education in anticipation of the future school,and emphasizes the key role of art education in cultivating students’creativity,aesthetic ability,thinking ability,and meeting social needs.The shortcomings and delays in the traditional art education mode have become evident,prompting the need to explore innovative educational methods.Digital art education is emerging as a means to offer a more immersive art experience through virtual and augmented reality technologies while broadening students’cultural horizons.Interdisciplinary integration combines art with science,engineering,mathematics,and other disciplines to cultivate students’comprehensive literacy and innovative thinking.The innovative spirit and the application of educational technology help students overcome difficulties and continuously improve their work.The article also emphasizes the alignment between art education and social needs,the importance of social support and resources,and the training and development of teachers.
文摘This paper is a hypothetical exploration of the connections between teleological evolution,the Omega Singularity,and the future of cities,weaving together insights from a diverse array of disciplines.Our investigation delves into the possibility that cities are evolving towards a Singularity,a state characterized by infinite knowledge,intelligence,and adaptability,which would bring about a radical transformation of urban environments and their underlying dynamics in the 21st century and beyond.At the heart of this exploration lies the role of language and time as crucial dimensions of the Urban Singularity.Moreover,we examine how linguistic developments and cross-cultural exchanges can foster more inclusive,adaptable,and resilient urban environments,while also highlighting the need for advanced technologies and communication modalities that can support the dynamic needs of future cities.Furthermore,the paper investigates the profound implications and transformative potential of merging human consciousness with the urban Singularity.By examining the interplay between these concepts,we seek for a deeper understanding of the potential trajectories and implications of these concepts for the transformation of human society and our relationship with the built environment.
文摘Colorectal cancer(CRC)is the third most prevalent cancer in both men and women,and it is the second leading cause of cancer-related deaths globally.Around 60%-70%of CRC patients are diagnosed at advanced stages,with nearly 20%having liver metastases.It is noteworthy that the 5-year survival rates decline significantly from 80%-90%for localized disease to a mere 10%-15%for patients with metastasis at the time of diagnosis.Early diagnosis,appropriate therapeutic strategy,accurate assessment of treatment response,and prognostication is essential for better outcome.There has been significant technological development in the last couple of decades to improve the outcome of rectal cancer including Artificial intelligence(AI).AI is a broad term used to describe the study of machines that mimic human intelligence,such as perceiving the environment,drawing logical conclusions from observations,and performing complex tasks.At present AI has demonstrated a promising role in early diagnosis,prognosis,and treatment outcomes for patients with rectal cancer,a limited role in surgical decision making,and had a bright future.
文摘Similar to the method of continuum mechanics, the variation of the price of index futures is viewed to be continuous and regular. According to the characteristic of index futures, a basic equation of price of index futures was established. It is a differential equation, its solution shows that the relation between time and price forms a logarithmic circle. If the time is thought of as the probability of its corresponding price, then such a relation is perfectly coincided with the main assumption of the famous formula of option pricing, based on statistical theory, established by Black and Scholes winner of 1997 Nobel' prize on economy. In that formula, the probability of price of basic assets (they stand for index futures here) is assummed to be a logarithmic normal distribution. This agreement shows that the same result may be obtained by two analytic methods with different bases. However, the result, given by assumption by Black-Scholes, is derived from the solution of the differential equation.
