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利用ARGO实验寻找GRBs的本底研究
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作者 高兰兰 闫瑞瑞 +1 位作者 赵兵 周勋秀 《四川大学学报(自然科学版)》 CAS CSCD 北大核心 2019年第3期495-499,共5页
位于西藏羊八井宇宙线观测站(海拔4300 m)的ARGO-YBJ实验具有高海拔、大视场、全覆盖特点,其阈能约几百个GeV,在探测高能GRBs方面具有独特的优势.ARGO-YBJ实验不能分辨光子和质子,要在大量的宇宙线事例中找出光子信号,就必须正确地估计... 位于西藏羊八井宇宙线观测站(海拔4300 m)的ARGO-YBJ实验具有高海拔、大视场、全覆盖特点,其阈能约几百个GeV,在探测高能GRBs方面具有独特的优势.ARGO-YBJ实验不能分辨光子和质子,要在大量的宇宙线事例中找出光子信号,就必须正确地估计背景事例率,这是寻找高能GRBs的关键.本文采用"等天顶角法"对ARGO实验中寻找GRBs的宇宙线本底进行了分析.由于地球的自转,天顶角随着时间的变化而变化.本文重点分析了长暴在其持续时间内天顶角的变化,从而更加准确地进行了本底估计. 展开更多
关键词 grbs 等天顶角法 ARGO-YBJ实验
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X-Ray Afterglows of GRBs 050318 and 060124 and their External Shock Origin
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作者 Jin Zhang Yi-Ping Qin +1 位作者 Fu-Wen Zhang Bin-Bin Zhang 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2007年第4期516-520,共5页
The observations with Swift X-ray telescope (XRT) challenge the conventional gamma-ray burst model in many aspects. The XRT light curves are generally composed of four consecutive segments, i.e., a steep decay segme... The observations with Swift X-ray telescope (XRT) challenge the conventional gamma-ray burst model in many aspects. The XRT light curves are generally composed of four consecutive segments, i.e., a steep decay segment, a shallow decay segment, a normal decay segment, a jet-like steep decay segment, and sometimes erratic flares as well. The physical origin of the X-ray emission is highly debatable. We focus here on the physical origin of the X-ray emissions of GRBs 050318 and 060124. We present the XRT light curves and spectra of the two bursts. The light curve decay slopes of the two bursts are normal, and their relations to the spectral indices are consistent with the prediction of the standard forward shock model. The multi-wavelength light curves at 0.5 keV, 1.0 keV, 2.0 keV and 4.0 keV can be reproduced by this model with an isotropic kinetic energy Ek = 2.2 × 10^52 erg, εe = 0.04, εB = 0.01 for GRB 050318 and Ek = 4.2 × 10^53 erg, εe = 0.05, εB = 0.01 for GRB 060124. These facts suggest that the normal decay phases of the X-rays for the two bursts are of the forward shock origin. 展开更多
关键词 gamma-rays- bursts-individual: GRB 050318 GRB 060124
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Shallow Decay of X-ray Afterglows in Short GRBs:Energy Injection from a Millisecond Magnetar?
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作者 Yu Yu Yong-Feng Huang 《Chinese Journal of Astronomy and Astrophysics》 CSCD 2007年第5期669-674,共6页
With the successful launch of Swift satellite, more and more data of early X-ray afterglows from short gamma-ray bursts have been collected. Some interesting features such as unusual afterglow light curves and unexpec... With the successful launch of Swift satellite, more and more data of early X-ray afterglows from short gamma-ray bursts have been collected. Some interesting features such as unusual afterglow light curves and unexpected X-ray flares are revealed. Especially, in some cases, there is a flat segment in the X-ray afterglow light curve. Here we present a simplified model in which we believe that the flattening part is due to energy injection from the central engine. We assume that this energy injection arises from the magnetic dipole radiation of a millisecond pulsar formed after the merger of two neutron stars. We check this model with the short GRB 060313. Our numerical results suggest that energy injection from a millisecond magnetar could make part of the X-ray afterglow light curve flat. 展开更多
关键词 gamma rays bursts -- X-rays individual (GRB 060313) -- ISM -- stars neutron
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GRB 210610B:The Internal and External Plateau as Evidence for the Delayed Outflow of Magnetar
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作者 Yi-Ning Wei Xiang-Gao Wang +8 位作者 Da-Bin Lin Wei-Kang Zheng Liang-Jun Chen Sheng-Yu Yan Shuang-Xi Yi Qi Wang Zi-Min Zhou Hui-Ya Liu En-Wei Liang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第7期170-180,共11页
After launching a jet,outflows of magnetar were used to account for the achromatic plateau of afterglow and the early X-ray flux plateau known as“internal plateau”.The lack of detecting magnetic dipole emission toge... After launching a jet,outflows of magnetar were used to account for the achromatic plateau of afterglow and the early X-ray flux plateau known as“internal plateau”.The lack of detecting magnetic dipole emission together with the energy injection feature in a single observation poses confusion until the long gamma-ray burst(GRB)210610B is detected.GRB 210610B is presented with an optical bump following an early X-ray plateau during the afterglow phase.The plateau followed by a steep decline flux overlays in the steadily decaying X-ray flux with indexα_(X,1)~2.06,indicating an internal origin and that can be fitted by the spin-down luminosity law with the initial plateau luminosity log_(10)L_(X)~48.29 erg s~(-1)and the characteristic spin-down timescale T~2818 s.A subsequent bump begins at~4000 s in the R band with a rising indexα_(R,1)~-0.30 and peaks at~14125 s,after which a decay indexα_(R,2)~0.87 and finally transiting to a steep decay withα_(R,3)~1.77 achieve the closure relation of the external shock for the normal decay phase as well as the magnetar spin-down energy injection phase,provided that the average value of the photon indexΓ_γ=1.80 derived from the spectral energy distributions(SEDs)between the X-ray and optical afterglow.The closure relation also works for the late X-ray flux.Akin to the traditional picture of GRB,the outflow powers the early X-ray plateau by dissipating energy internally and collides with the leading decelerating blast burst as time goes on,which could interpret the exotic feature of GRB 210610B.We carry out a Markov Chain Monte Carlo simulation and obtain a set of best parameters:■.The artificial light curve can fit the afterglow data well.After that,we estimated the average Lorentz factor and the X-ray radiation efficiency of the later ejecta are 35%and 0.13%,respectively. 展开更多
关键词 (stars)gamma-ray burst individual(GRB 210610B)-(stars)gamma-ray burst general-stars jets
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GRB 200612A:An Ultralong Gamma-Ray Burst Powered by Magnetar Spinning Down
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作者 陈良军 王祥高 +1 位作者 杨德龙 梁恩维 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第2期190-195,共6页
GRB 200612A could be classified as an ultralong gamma-ray burst due to its prompt emission lasting up to~1020 s and the true timescale of the central engine activity t_(burst)≥4×10^(4) s.The late X-ray light cur... GRB 200612A could be classified as an ultralong gamma-ray burst due to its prompt emission lasting up to~1020 s and the true timescale of the central engine activity t_(burst)≥4×10^(4) s.The late X-ray light curve with a decay index ofα=7.53 is steeper than the steepest possible decay from an external shock model.We propose that this X-ray afterglow can be driven by dipolar radiation from the magnetar spindown during its early stage,while the magnetar collapsed into the black hole before its spindown,resulting in a very steep decay of the late X-ray light curve.The optical data show that the light curve is still rising after 1.1 ks,suggesting a late onset.We show that GRB 200612A’s optical afterglow light curve is fitted with the forward shock model by Gaussian structured off-axis jet.This is a special case among GRBs,as it may be an ultralong gamma-ray burst powered by a magnetar in an off-axis observation scenario. 展开更多
关键词 (stars:)gamma-ray burst individual(GRB 200612A)-(stars:)gamma-ray burst general-stars MAGNETARS
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GRB 210323A:Signature of Long-lasting Lifetime of Supra-massive Magnetar as the Central Engine from the Merger of Binary Neutron Star
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作者 Yingze Shan Xiaoxuan Liu +2 位作者 Xing Yang Haoyu Yuan Houjun Lü 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2024年第8期32-41,共10页
Theoretically,a supra-massive neutron star or magnetar may be formed after the merger of binary neutron stars.GRB210323A is a short-duration gamma-ray burst(GRB)with a duration of lasting~1 s.The light curve of the pr... Theoretically,a supra-massive neutron star or magnetar may be formed after the merger of binary neutron stars.GRB210323A is a short-duration gamma-ray burst(GRB)with a duration of lasting~1 s.The light curve of the prompt emission of GRB 210323A shows a signal-peaked structure and a cutoff power-law model can adequately fit the spectra with E_p=1826±747.More interestingly,it has an extremely long-lasting plateau emission in the X-ray afterglow with a duration of~10^(4)s,and then follows a rapid decay with a decay slope~3.2.This temporal feature is challenging by invoking the external shock mode.In this paper,we suggest that the observed long-lasting X-ray plateau emission is caused by the energy injection of dipole radiation from supra-massive magnetar,and the abrupt decay following the longlasting X-ray plateau emission is explained by supra-massive magnetar collapsing into a black hole.It is the short GRB(SGRB)with the longest X-ray internal plateau emission powered by a supra-massive neutron star.If this is the case,one can estimate the physical parameters of a supra-massive magnetar,and compare with other SGRBs.We also discuss the possible gravitational-wave emission,which is powered by a supra-massive magnetar and its detectability,and the possible kilonova emission,which is powered by r-process and magnetar spin-down to compare with the observed data. 展开更多
关键词 (stars)gamma-ray burst general-(stars)gamma-ray burst individual(GRB 210323A)-stars MAGNETARS
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Measuring accelerating universe with high-redshift GRBs data and other cosmological probes
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作者 LU JianBo WANG YuTing WU YaBo 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2012年第9期1713-1719,共7页
A kinematical model (a parameterized deceleration parameter) and a dynamical model (a parameterized equation of state for dark energy) are constrained from the current observational data including the high-redshif... A kinematical model (a parameterized deceleration parameter) and a dynamical model (a parameterized equation of state for dark energy) are constrained from the current observational data including the high-redshift Gamma-Ray Bursts (GRBs) data with a redshift range from 1.4 to 9. We obtain the stringent constraint on the values of current deceleration parameter q0, current jerk parameter j0, current equation of state for dark energy Woae and transition redshift zT. In addition, we compare the difference of the constraint results between the kinematical and the dynamical scenarios. 展开更多
关键词 Gamma-Ray Bursts grbs kinematical approach dynamical approach
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Refinement of the Proposed Gamma-Ray Burst Time Delay Model
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作者 Godson Fortune Abbey Joseph Simfukwe +3 位作者 Prospery Christopher Simpemba Saul Paul Phiri Alok Srivastava Golden Gadzirayi Nyambuya 《International Journal of Astronomy and Astrophysics》 2024年第2期120-147,共28页
This paper is the second instalment in our study of the observed time delay in the arrival times of radio photons emanating from Gamma Ray Bursts (GRBs). The mundane assumption in contemporary physics as to the cause ... This paper is the second instalment in our study of the observed time delay in the arrival times of radio photons emanating from Gamma Ray Bursts (GRBs). The mundane assumption in contemporary physics as to the cause of these pondersome time delays is that they are a result of the photon being endowed with a non-zero mass. While we do not rule out the possibility of a non-zero mass for the photon, our working assumption is that the major cause of these time delays may very well be that these photons are travelling in a rarefied cosmic plasma in which the medium’s electrons interact with the electric component of the Photon, thus generating tiny currents that lead to dispersion, hence, a frequency-dependent speed of Light (FDSL). In the present instalment, we “improve” on the model presented in the first instalment by dropping the assumption that the resultant pairs of these radio photons leave the shock front simultaneously. The new assumption of a non-simultaneous— albeit systematic—emission of these photon pairs allows us to obtain a much more convincing and stronger correlation in the time delay. This new correlation allows us to build a unified model for the four GRBs in our sample using a relative distance correction mechanism. The new unified model allows us to obtain as our most significant result a value for the frequency equivalence of the interstellar medium (ISM)’s conductance ν* ~ 1.500 ± 0.009 Hzand also an independent distance measure to the GRBs where we obtain for our four GRB samples an average distance of: ~69.40 ± 0.10, 40.00 ± 0.00, 58.40 ± 0.40, and 86.00 ± 1.00 Mpc, for GRB 030329, 980425, 000418 and 021004 respectively. 展开更多
关键词 Gamma-Ray Bursts (GRB) Photon Mass PLASMA Time Delay Fireball Model
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宫颈癌中miRNA-409-3p、VEGF、Gab2表达与调强适形放疗同步化疗疗效及患者治疗后3年生存情况的关系 被引量:3
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作者 阿依努尔·色义提 王一娜 +1 位作者 古丽娜·库尔班 侯友翔 《临床和实验医学杂志》 2023年第19期2061-2065,共5页
目的 探讨宫颈癌中微小RNA-409-3p(miRNA-409-3p)、血管内皮生长因子(VEGF)、Grb2协同结合蛋白2(Gab2)表达与调强适形放疗同步化疗疗效及治疗后3年生存情况的关系。方法 采用回顾性研究方法,选取2019年1月至2020年2月在新疆医科大学附... 目的 探讨宫颈癌中微小RNA-409-3p(miRNA-409-3p)、血管内皮生长因子(VEGF)、Grb2协同结合蛋白2(Gab2)表达与调强适形放疗同步化疗疗效及治疗后3年生存情况的关系。方法 采用回顾性研究方法,选取2019年1月至2020年2月在新疆医科大学附属肿瘤医院治疗的宫颈癌患者138例,均给予调强适形放疗同步化疗。同时随访所有患者疗效及治疗后3年生存情况,分为化疗有效组(n=92)和治疗无效组(n=56)、死亡组(n=26)和存活组(n=112)。观察不同临床特征、疗效、预后患者宫颈癌组织miRNA-409-3p、VEGF、Gab2表达水平。结果 低分化宫颈癌组织miRNA-409-3p相对表达量明显低于中高分化宫颈癌组织,而VEGF mRNA和Gab2 mRNA相对表达量明显高于中高分化宫颈癌组织,差异均有统计学意义(P<0.05)。FIGO分期Ⅲ期宫颈癌组织miRNA-409-3p相对表达量明显低于Ⅱ期宫颈癌组织,而VEGF mRNA和Gab2 mRNA相对表达量明显高于Ⅱ期宫颈癌组织,差异均有统计学意义(P<0.05)。治疗有效组患者miRNA-409-3p相对表达量明显高于治疗无效组,而VEGF mRNA和Gab2 mRNA相对表达量明显高于治疗无效组,差异均有统计学意义(P<0.05)。死亡组患者miRNA-409-3p相对表达量明显高于存活组患者,而VEGF mRNA和Gab2 mRNA相对表达量明显高于存活组患者,差异均有统计学意义(P<0.05)。miRNA-409-3p、VEGF、Gab2表达预测疗效有效的ROC曲线下面积分别为0.647、0.779和0.616,预测价值较好(P<0.05)。miRNA-409-3p、VEGF、Gab2表达预测死亡的ROC曲线下面积分别为0.715、0.653和0.785,预测价值较好(P<0.05)。结论 宫颈癌组织miRNA-409-3p表达下调,而VEGF、Gab2表达上调,与调强适形放疗同步化疗疗效及预后有关,其中VEGF预测疗效有一定价值,而Gab2预测预后有一定价值。 展开更多
关键词 宫颈癌 血管内皮生长因子 Grb2协同结合蛋白2 调强适形放疗同步化疗 临床疗效 预后
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重楼皂苷在miR-125a-5p靶向调控GAB2诱导乳腺癌细胞增殖和凋亡中的作用及机制研究 被引量:2
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作者 吕世文 朱亚兰 王婧婧 《浙江医学》 CAS 2023年第20期2129-2135,2162,共8页
目的探讨重楼皂苷(RPS)在miR-125a-5p靶向调控Grb2相关结合蛋白2(GAB2)诱导乳腺癌细胞增殖和凋亡中的作用及机制。方法取人乳腺癌细胞系MCF-7和人正常乳腺上皮细胞系MCF-10A,采用qRT-PCR、Western blot法分别检测并比较两者miR-125a-5p... 目的探讨重楼皂苷(RPS)在miR-125a-5p靶向调控Grb2相关结合蛋白2(GAB2)诱导乳腺癌细胞增殖和凋亡中的作用及机制。方法取人乳腺癌细胞系MCF-7和人正常乳腺上皮细胞系MCF-10A,采用qRT-PCR、Western blot法分别检测并比较两者miR-125a-5p、GAB2表达水平。再将MCF-7细胞按随机数字表法分成6组:RPS 0μg/mL组、RPS 80μg/mL组、RPS 80μg/mL+阴性抗体组、RPS 80μg/mL+anti-miR-125a-5p组、RPS 80μg/mL+anti-miR-125a-5p+阴性干扰组和RPS 80μg/mL+anti-miR-125a-5p+si-GAB2组,每组设3个复孔;培养48 h后检测并比较miR-125a-5p、GAB2、B淋巴细胞瘤-2(Bcl-2)、Bcl-2相关X蛋白(Bax)表达水平以及细胞增殖率、细胞凋亡率。将GAB2与空白质粒和过表达miR-125a-5p质粒共转染到MCF-7细胞中,采用荧光素酶Promega检测法检测miR-125a-5p与GAB2的靶向作用。结果与MCF-10A细胞比较,MCF-7细胞中miR-125a-5p表达水平较低(P<0.05),GAB2表达水平较高(P<0.05)。与RPS 0μg/mL组比较,RPS 80μg/mL组和RPS 80μg/mL+阴性抗体组miR-125a-5p、Bax表达水平和细胞凋亡率均明显升高(均P<0.05),细胞增殖率和Bcl-2表达水平均明显降低(均P<0.05);RPS 80μg/mL组和RPS 80μg/mL+anti-miR-125a-5p+阴性干扰组GAB2表达水平均明显降低(均P<0.05)。与RPS 80μg/mL组、RPS 80μg/mL+阴性抗体组比较,RPS 80μg/mL+anti-miR-125a-5p组miR-125a-5p表达水平均明显降低(均P<0.05);RPS 80μg/mL+anti-miR-125a-5p组和RPS 80μg/mL+anti-miR-125a-5p+阴性干扰组细胞增殖率和Bcl-2表达水平均明显升高(均P<0.05),细胞凋亡率和Bax表达水平均明显降低(均P<0.05)。与RPS 80μg/mL组、RPS 80μg/mL+anti-miR-125a-5p+阴性干扰组比较,RPS 80μg/mL+anti-miR-125a-5p+si-GAB2组GAB2表达水平均明显降低(均P<0.05)。与RPS 80μg/mL+anti-miR-125a-5p组、RPS 80μg/mL+anti-miR-125a-5p+阴性干扰组比较,RPS 80μg/mL+anti-miR-125a-5p+si-GAB2组细胞增殖率和Bcl-2表达水平均明显降低(均P<0.05),细胞凋亡率和Bax表达水平均明显升高(均P<0.05)。GAB2与miR-125a-5p的结合位点为CAGGGA,GAB2的突变位点为AGUCCC;miR-125a-5p与GAB2野生型结合能明显降低荧光活性比(P<0.05),但与GAB2突变型结合不影响荧光活性比(P>0.05)。结论RPS能够介导miR-125a-5p/GAB2轴发挥抗肿瘤活性,具体机制可能与miR-125a-5p发挥抑癌效应来负向调控GAB2蛋白表达,进而影响乳腺癌细胞的增殖和凋亡能力有关。 展开更多
关键词 重楼皂苷 乳腺癌 miR-125a-5p Grb2相关结合蛋白2 增殖 凋亡 作用机制
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基于基因数据库分析GRB2在肾癌中的表达及其与患者预后的关系 被引量:1
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作者 解宸一 杨亚楠 +4 位作者 王硕 赵万东 吕志远 宋静宜 何宁宁 《精准医学杂志》 2023年第1期73-76,80,共5页
目的探讨生长因子受体结合蛋白2(GRB2)基因在肾癌中的表达及其对患者预后的影响。方法挖掘ONCOMINE数据库中肾癌GRB2基因相关数据进行基因表达分析,结合在TCGA数据库中挖掘的GRB2基因在肾癌组织和正常组织中的表达差异,获得GRB2基因的... 目的探讨生长因子受体结合蛋白2(GRB2)基因在肾癌中的表达及其对患者预后的影响。方法挖掘ONCOMINE数据库中肾癌GRB2基因相关数据进行基因表达分析,结合在TCGA数据库中挖掘的GRB2基因在肾癌组织和正常组织中的表达差异,获得GRB2基因的表达与患者预后的关系。并通过STRING数据库,构建GRB2基因的蛋白质-蛋白质互作网络图。采取实时荧光定量PCR的方法检测6例肾癌组织及其癌旁正常组织中GRB2基因的相对表达量。结果与正常肾组织相比,GRB2基因在肾癌组织中的表达明显升高,差异具有统计学意义(t=8.21,P<0.05),GRB2基因在肾癌组织中的表达升高与肾癌患者预后相关(z=2.71,P<0.05)。进一步对GRB2相关的14个相互作用蛋白进行分析显示,GRB2主要参与了细胞的增殖和凋亡过程。肾癌组织中GRB2基因相对表达量显著高于其癌旁正常组织(t=6.98,P<0.001)。结论GRB2基因在肾癌组织中高表达,且其基因表达水平与肾癌患者的预后明显相关。 展开更多
关键词 肾肿瘤 GRB2衔接蛋白质 预后 基因表达谱 蛋白质相互作用图 数据库 遗传学 数据挖掘
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GRB 220408B:A Three-episode Burst from a Precessing Jet
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作者 Zijian Zhang Yi-Han Iris Yin +27 位作者 Chenyu Wang Xiangyu Ivy Wang Jun Yang Yan-Zhi Meng Zi-Ke Liu Guo-Yin Chen Xiaoping Fu Huaizhong Gao Sihao Li Yihui Liu Xiangyun Long Yong-Chang Ma Xiaofan Pan Yuanze Sun Wei Wu Zirui Yang Zhizhen Ye Xiaoyu Yu Shuheng Zhao Xutao Zheng Tao Zhou Qing-Wen Tang Qiurong Yan Rong Zhou Zhonghai Wang Hua Feng Ming Zeng Bin-Bin Zhang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2023年第11期214-224,共11页
Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B ... Jet precession has previously been proposed to explain the apparently repeating features in the light curves of a few gamma-ray bursts(GRBs).In this paper,we further apply the precession model to a bright GRB 220408B by examining both its temporal and spectral consistency with the predictions of the model.As one of the recently confirmed GRBs observed by our GRID CubeSat mission,GRB 220408B is noteworthy as it exhibits three apparently similar emission episodes.Furthermore,the similarities are reinforced by their strong temporal correlations and similar features in terms of spectral evolution and spectral lags.Our analysis demonstrates that these features can be well explained by the modulated emission of a Fast-Rise-Exponential-Decay(FRED)shape light curve intrinsically produced by a precessing jet with a precession period of 18.4_(-0.2)~(+0.2)s,a nutation period of11.1_(-0.2)~(+0.2)s and viewed off-axis.This study provides a straightforward explanation for the complex yet similar multiepisode GRB light curves. 展开更多
关键词 gamma-rays:general (stars:)gamma-ray burst:individual(GRB 220408B) stars:jets
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低温韧性优异的耐热钢板A204GrB力学性能和组织研究
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作者 孟宪震 张军 张建 《特钢技术》 CAS 2023年第1期4-7,共4页
耐热容器钢板主要服役于高温高压环境下,因其高温性能稳定常被用于热电和热工等行业中。近年来随着能源结构的变化,化工衍生产品多样化的要求,急速温度变化的工况常有发生,而以此带来的设备故障率逐年增加;针对此种情况本文重点研究的... 耐热容器钢板主要服役于高温高压环境下,因其高温性能稳定常被用于热电和热工等行业中。近年来随着能源结构的变化,化工衍生产品多样化的要求,急速温度变化的工况常有发生,而以此带来的设备故障率逐年增加;针对此种情况本文重点研究的耐热容器钢板A204GrB,不仅在高温环境下具有较高的强度,在冲击温度到达-20℃时仍能保持冲击吸收能量均值≥70 J;钢板厚度1/4处和厚度1/2处性能相差较小,保证钢板厚度方向组织和性能均匀,稳定。 展开更多
关键词 耐热容器钢板 A204GrB 低温韧性
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变化磁场中相对论电子系集体的共振逆康普顿散射谱
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作者 刘当波 陈磊 +1 位作者 尤峻汉 张双南 《天文学报》 CSCD 北大核心 2005年第3期237-252,共16页
强磁场中的共振逆康普顿散射(RICS)是产生伽玛射线的有效机制.在前文工作的基础上,导出强磁场中子星中具有幂律能谱的大量相对论电子沿中子星磁轴向外运动时在变化磁场中产生的集体RICS辐射谱(RICS谱光度)的基本公式.由此得到在中子星... 强磁场中的共振逆康普顿散射(RICS)是产生伽玛射线的有效机制.在前文工作的基础上,导出强磁场中子星中具有幂律能谱的大量相对论电子沿中子星磁轴向外运动时在变化磁场中产生的集体RICS辐射谱(RICS谱光度)的基本公式.由此得到在中子星周边几种典型的低频辐射场中集体RICS辐射谱形的简单解析表示(如热轫致辐射场、黑体辐射场,以及非热低频幂律谱辐射场),以便与实际观测谱形比较.计算表明:在满足匹配条件(即近似共振条件)下,RICS辐射效率很高,其谱形都是两段式(折断的)的幂律谱形式,与周边低频场性质无关.通过计算,再一次论证RICS机制是伽玛射线脉冲星和伽玛暴(GRBs)在高能射线段(硬X-射线和伽玛射线)辐射的一个理想的高效辐射机制. 展开更多
关键词 辐射机制 非热 散射 方法 解析 Γ射线 理论 Γ射线 暴(grbs) 脉冲星 普通
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人结直肠癌组织中EGFR/Grb2/p-mTOR/VEGF的表达及意义 被引量:10
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作者 项洪刚 王强 +3 位作者 胡志前 徐健 王伟军 卫子然 《第二军医大学学报》 CAS CSCD 北大核心 2009年第7期775-779,共5页
目的:观察人结直肠癌组织磷酸化哺乳动物雷帕霉素靶蛋白(phosphorylated mammalian target of rapamycin,p-mTOR)、表皮生长因子受体(EGFR)、生长因子受体结合蛋白2(Grb2)和血管内皮生长因子(VEGF)等的表达,并探讨其可能的临床意义。方... 目的:观察人结直肠癌组织磷酸化哺乳动物雷帕霉素靶蛋白(phosphorylated mammalian target of rapamycin,p-mTOR)、表皮生长因子受体(EGFR)、生长因子受体结合蛋白2(Grb2)和血管内皮生长因子(VEGF)等的表达,并探讨其可能的临床意义。方法:构建含有185例结直肠癌标本的组织芯片,免疫组化法检测结直肠癌组织及癌旁组织中EGFR、Grb2、p-mTOR和VEGF的表达,并分析不同结直肠癌临床病理学特征下(如年龄、性别、浸润深度、淋巴转移、临床分期和分化程度)各自的表达情况,探讨可能的临床意义。结果:EGFR、Grb2、p-mTOR和VEGF在结直肠癌旁组织中呈少量表达或不表达,在结直肠癌组织中的表达率分别为21.1%、44.9%、42.2%和54.1%,明显高于癌旁组织(P<0.05)。结直肠癌患者不同性别、年龄、肿瘤分化程度下EGFR、Grb2、p-mTOR和VEGF表达率无统计学差异;不同浸润深度和临床分期下EGFR的表达率有统计学差异(P<0.05);不同浸润深度、淋巴转移和临床分期下p-mTOR、VEGF表达率均有统计学差异(P<0.05)。结直肠癌组织EGFR/Grb2/p-mTOR/VEGF蛋白两两间均有一定的相关性(r=0.245~0.567,P<0.05)。结论:EGFR、Grb2、p-mTOR和VEGF表达与结直肠癌的发生、发展相关,值得进一步研究以作为结直肠癌肿瘤靶向治疗新的作用靶点。 展开更多
关键词 EGFR GRB2 P-MTOR VEGF 组织芯片 结直肠肿瘤
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ErbB2/Grb2/mTOR通路在胃癌发生发展中的作用 被引量:10
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作者 于观贞 陈颖 +2 位作者 潘军 王喜 王杰军 《临床肿瘤学杂志》 CAS 2008年第8期686-690,共5页
目的:检测ErbB2/neu、Grb2和mTOR胃癌中的表达并探讨ErbB2/Grb2/mTOR通路在胃癌发生发展中的作用。方法:构建含有1072例胃癌的组织芯片,利用免疫组化检测ErbB2/neu、Grb2和mTOR在胃癌中的表达。结果:ErbB2/neu、Grb2和mTOR在胃癌中的表... 目的:检测ErbB2/neu、Grb2和mTOR胃癌中的表达并探讨ErbB2/Grb2/mTOR通路在胃癌发生发展中的作用。方法:构建含有1072例胃癌的组织芯片,利用免疫组化检测ErbB2/neu、Grb2和mTOR在胃癌中的表达。结果:ErbB2/neu、Grb2和mTOR在胃癌中的表达率分别为30.2%、47.5%和50.8%。ErbB2/neu和Grb2的过度表达与年龄(>60岁)、肿瘤部位、肿瘤类型和高分化相关(P<0.01);mTOR的过度表达与肿瘤部位、肿瘤类型、高分化、T分期和TNM分期相关(P<0.05)。Spearman相关性检验显示,3个蛋白两两之间存在显著相关(P<0.001)。单因素生存分析表明,Grb2和mTOR与预后有关(P=0.0067,P=0.0001);而在Cox回归多因素分析中,mTOR与预后有关(P=0.046)。结论:ErbB2/Grb2/mTOR通路在胃癌的发生发展中起到极其重要的作用,mTOR还可能作为胃癌患者预后的独立指标。3个蛋白可以作为胃癌治疗的靶点,继而为胃癌的治疗开拓新的思路。 展开更多
关键词 胃癌 ERBB2 GRB2 MTOR
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泥蚶(Tegillarca granosa)生长因子受体结合蛋白2(GRB2)基因的克隆与表达分析 被引量:8
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作者 董迎辉 项翔 +3 位作者 姚韩韩 包永波 孙长森 林志华 《海洋与湖沼》 CAS CSCD 北大核心 2013年第4期937-943,共7页
通过已构建的泥蚶(Tegillarca granosa)转录组文库,利用SMART RACE技术扩增得到泥蚶Tg-GRB2基因的全长cDNA序列,并对其生物信息学、组织表达及发育阶段表达特征进行了分析。结果表明,泥蚶Tg-GRB2 cDNA全长1283bp,开放阅读框为708bp,编码... 通过已构建的泥蚶(Tegillarca granosa)转录组文库,利用SMART RACE技术扩增得到泥蚶Tg-GRB2基因的全长cDNA序列,并对其生物信息学、组织表达及发育阶段表达特征进行了分析。结果表明,泥蚶Tg-GRB2 cDNA全长1283bp,开放阅读框为708bp,编码236个氨基酸;蛋白结构预测显示,Tg-GRB2蛋白包含SH3-SH2-SH3三个功能域,SH2结构域由两端的α-螺旋和中间反向平行的β-折叠片构成,SH3结构域主要由β-折叠片组成,具备典型的结构特征;氨基酸序列比对发现,Tg-GRB2与脊椎动物的同源性为62.1%—63.8%,而与玻璃海鞘和日本血吸虫同源性较低。qRT-PCR检测结果显示:Tg-GRB2 mRNA在泥蚶血液、斧足、鳃、外套膜、闭壳肌、内脏团6个组织中都有表达,而在血液中的表达量极显著地高于其它组织;在泥蚶的不同发育阶段中,Tg-GRB2 mRNA在2—4细胞胚胎、原肠胚、担轮幼虫、D形幼虫中均有较高的表达量,而在D形幼虫中表达量最高,表明Tg-GRB2基因在泥蚶早期发育中发挥重要调节作用。 展开更多
关键词 泥蚶 生长因子受体结合蛋白2(GRB2) 基因克隆 荧光定量PCR
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绞股蓝总皂苷调节自噬小体对动脉粥样硬化的防治作用 被引量:13
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作者 张妮 宋囡 +3 位作者 曹慧敏 贾连群 陈文娜 冷雪 《天然产物研究与开发》 CAS CSCD 北大核心 2017年第12期2112-2116,2127,共6页
为探究绞股蓝总皂苷调节自噬小体对动脉粥样硬化的防治作用。本研究分体内、体外实验。体内实验:30只健康Apo E-/-小鼠随机分为3组,模型组、绞股蓝总皂苷组和辛伐他汀组,每组10只。10只C57BL/6J小鼠为正常组。模型制备及给药干预完成后... 为探究绞股蓝总皂苷调节自噬小体对动脉粥样硬化的防治作用。本研究分体内、体外实验。体内实验:30只健康Apo E-/-小鼠随机分为3组,模型组、绞股蓝总皂苷组和辛伐他汀组,每组10只。10只C57BL/6J小鼠为正常组。模型制备及给药干预完成后,全自动生化分析仪检测各组小鼠血脂水平,Western blot技术检测各组小鼠主动脉Atg3、Atg4c、Atg5、Atg12蛋白表达情况。体外实验:培养EA.hy926细胞,随机分为正常组、模型组、绞股蓝总皂苷组、人参皂苷GRb3组和绞股蓝皂苷XILX组。Western blot技术检测各组细胞自噬小体形成信号通路相关蛋白Atg3、Atg4c、Atg5、Atg12的表达情况。结果发现,绞股蓝总皂苷能够降低Apo E-/-小鼠血清中的TG、TC、LDL-C水平(P<0.01),提高血清HDL-C水平(P<0.01)。且绞股蓝总皂苷能够提高Apo E-/-小鼠主动脉Atg3、Atg4c、Atg5、Atg12蛋白表达水平(P<0.05或P<0.01)。绞股蓝总皂苷、人参皂苷GRb3和绞股蓝皂苷XILX能够提高ox-LDL诱导的EA.hy926细胞自噬小体相关蛋白Atg3、Atg4c、Atg5、Atg12的表达水平(P<0.01)。且绞股蓝总皂苷效果最好。以上结果说明,股蓝总皂苷可能通过促进自噬小体形成,降低Apo E-/-小鼠血清血脂水平,保护EA.hy926细胞抗内皮损伤,进而发挥其防治AS的生物学作用,且在该过程中人参皂苷GRb3和绞股蓝皂苷XILX可能是绞股蓝总皂苷中发挥关键作用的有效成分。 展开更多
关键词 绞股蓝总皂苷 人参皂苷GRb3 绞股蓝皂苷XILX 动脉粥样硬化 自噬小体
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miR-125a-5p通过靶向调控GAB2抑制乳腺癌细胞的迁移能力 被引量:7
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作者 徐新伟 李佩瑞 +3 位作者 张增山 王学文 李洪利 尹崇高 《中国生物化学与分子生物学报》 CAS CSCD 北大核心 2017年第9期925-930,共6页
miR-125a-5p可负性调节GAB2表达,抑制胶质瘤细胞的侵袭和转移。本研究旨在证明miR-125a-5p抑癌作用的普遍性,即miR-125a-5p是否可通过靶向抑制GAB2抑制乳腺癌细胞的迁移。荧光素酶实验结果显示,miR-125a-5p可特异识别GAB2的3'-UTR,... miR-125a-5p可负性调节GAB2表达,抑制胶质瘤细胞的侵袭和转移。本研究旨在证明miR-125a-5p抑癌作用的普遍性,即miR-125a-5p是否可通过靶向抑制GAB2抑制乳腺癌细胞的迁移。荧光素酶实验结果显示,miR-125a-5p可特异识别GAB2的3'-UTR,抑制报告酶的表达。荧光定量PCR结果揭示,与正常乳腺上皮细胞MCF-10A比较,miR-125a-5p在乳腺癌细胞MDA231和MCF-7中的表达明显降低;与迁移能力相对较低的MCF-7细胞比较,miR-125a-5p在迁移能力较高的MDA231细胞中的表达量更低。Western印迹结果证明,与空载体(对照)和anti-miR125a-5p转染细胞比较,转染miR-125a-5p明显抑制GAB2蛋白在乳腺癌细胞中的表达。Transwell结果显示,与空载体转染的对照细胞比较,转染miR-125a-5p的乳腺癌细胞穿过基质胶的细胞数明显减少;相反,转染anti-miR125a-5p的细胞穿过基质胶的细胞数却明显增多。上述结果提示,miR-125a-5p在正常的乳腺细胞中高表达,而在乳腺癌细胞中低表达,其表达水平与癌细胞的迁移能力和GAB2表达呈反向关系。本研究结果还提示,miR-125a-5p通过靶向负调控GAB2抑制乳腺癌细胞的迁移能力。总之,本研究证明,miR-125a-5p在肿瘤中发挥抑癌作用。 展开更多
关键词 乳腺癌 miR-125a-5p GRB相关结合蛋白2 迁移
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Grb2和mTOR在胃癌中的表达 被引量:5
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作者 袁火忠 黄兴伟 +1 位作者 谢敏明 郭广秀 《广东医学》 CAS CSCD 北大核心 2011年第19期2544-2545,共2页
目的探讨胃癌组织中Grb2和mTOR的表达及其与胃癌临床病理因素和预后的关系。方法应用免疫组织化学法观察326例胃癌组织中Grb2和mTOR的表达特点,结合临床病理资料进行统计学分析。结果 Grb2和mTOR在正常胃黏膜上皮和管状腺瘤组织中未见... 目的探讨胃癌组织中Grb2和mTOR的表达及其与胃癌临床病理因素和预后的关系。方法应用免疫组织化学法观察326例胃癌组织中Grb2和mTOR的表达特点,结合临床病理资料进行统计学分析。结果 Grb2和mTOR在正常胃黏膜上皮和管状腺瘤组织中未见阳性染色或仅少量细胞呈淡黄色。167例(51.2%)胃癌组织Grb2染色阳性,其中79例Grb2高表达,Grb2表达与胃癌肿瘤大小、浸润深度及临床分期有关(P<0.05)。175例(53.7%)胃癌组织mTOR染色阳性,其中高表达92例,mTOR表达与胃癌肿瘤大小、浸润深度、分化程度、淋巴结转移及临床分期有关(P<0.05)。两者表达具有高度的一致性(P<0.01),且均与预后有关。结论 Grb2和mTOR在胃癌中出现异常表达,两者可能共同促进了胃癌的发生及发展,可作为胃癌治疗的靶点。 展开更多
关键词 胃癌 GRB2 MTOR 预后
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