The House of the Seven Gables （1981）, Hawthorne＇s second romance, is his another masterpiece after The Scarlet Letter （1956）. The achievement of its themes and narrative skills has been greatly complimented by re...The House of the Seven Gables （1981）, Hawthorne＇s second romance, is his another masterpiece after The Scarlet Letter （1956）. The achievement of its themes and narrative skills has been greatly complimented by readers, especially its descriptions and analyses of the characters＇ psychological activities and their personalities. The notorious Salem Witch Trials of Hawthorne＇s family has a great effect on Hawthorne＇s formation of his views about the good and evil, the sin and penalty, and the psychological descriptive style in his works. In The House of the Seven Gables, Hawthorne takes this family history as the original writing background. Through exploring modem people＇s spiritual essence, using history as narrative original, Hawthorne＇s theme illustrates the past＇s influence on the present. By exploring the changes of the characters＇ psychologies and values, especially those of Holgrave, the narrator proposes a conception of general love to eradicate the actual contradictions. Hawthorne actually provides an alternative way--a nonpolitical solution to the national problems, which demonstrates not only his artistic pursuit but also his culturally political view in his writing. This paper consists of five parts.展开更多
Under the instruction of the author's own confession in the preface of The House of the Seven Gables, it's easy for readers and critics to take the theme of this novel as past and present, stasis and change, a...Under the instruction of the author's own confession in the preface of The House of the Seven Gables, it's easy for readers and critics to take the theme of this novel as past and present, stasis and change, aristocracy and democracy, and then to unfavor?ably judge Pycheon siblings, the representatives of the former, by Holgrave, that of the latter. However, by using two narrative voic?es simultaneously in the novel, an intradiegeitic one and an extradeigetic one, Hawthorne actually reveals his equal disapproval of both the Pycheon siblings and Holgrave. In the intradiegetic narrative, the narrative voice as a whole takes its side with Holgrave and reveals Pycheon siblings'isolation from the united struggle of mankind. In the extradiegetic narrative where the narrator ad?dresses directly to his readers, the narrator expresses a similar disapproval of Holgrave, who is equally isolated from the chain of hu?manity for lacking sympathy for his fellow beings. With the co-existence of two narrative voices, Hawthorne's true concern lies in calling attention to the equally dangerous situations of isolation from the chain of humanity:an isolation from the chain of progress and that of human sympathy.展开更多
根据GABLS(Global Energy and Water Cycle Experiment Atmospheric Boundary Layer Study)的第2个个例在GRAPES(Global and Regional Assimilation and PrEdiction System)单柱模式中构造了一个试验,用于检验规定的下垫面温度强迫条件...根据GABLS(Global Energy and Water Cycle Experiment Atmospheric Boundary Layer Study)的第2个个例在GRAPES(Global and Regional Assimilation and PrEdiction System)单柱模式中构造了一个试验,用于检验规定的下垫面温度强迫条件下边界层过程的昼夜循环模拟能力。然后,将模拟结果与观测和大涡模拟结果进行了比较。结果表明,在规定的下垫面温度强迫下,GRAPES模拟的2m温度基本合理。然而,对于稳定条件(夜间),GRAPES模拟的向下的感热通量比观测的大,过估10m风速和摩擦速度,过估稳定边界层高度;对于不稳定条件(白天),GRAPES模拟的向上的感热通量比观测的小,低估不稳定边界层高度,低层位温偏冷。随后的敏感试验表明,减小边界层方案中的动量和热量的背景扩散值后,GRAPES模拟的稳定条件下的10m风速和摩擦速度,以及对流边界层的风和温度的廓线更接近大涡模拟。展开更多
Upon growth factor stimulation, the scaffold protein, Gabl, is tyrosine phosphorylated and subsequently the adaptor protein, Crk, transmits signals from Gabl. We have previously shown that Crk overexpression, which is...Upon growth factor stimulation, the scaffold protein, Gabl, is tyrosine phosphorylated and subsequently the adaptor protein, Crk, transmits signals from Gabl. We have previously shown that Crk overexpression, which is detectable in various human cancers, induces tyrosine phosphorylation of Gabl without extracellular stimuli. In the present study, the underlying mechanisms were further investigated. Mutational analyses of CrkII demonstrated that the SH2 domain, but not the SH3（N） or the regulatory Y221 residue of CrkII, is critical for the induction of Gabl- Y307 phosphorylation. SH2 mutation of CrkII also decreased the interaction with Gabl. In GST pull-down assay, Crk-SH2 bound to wild-type Gahl, whereas Crk-SH3（N） interacted with the Gabl mutant, which lacks the clus- tered tyrosine region （residues 242-410）. Tyrosine phosphorylation of Gabl was induced by all Crk family proteins, but not other SH2-containing signalling adaptors. Src-family kinase inhibitor, PP2, abrogates Crk-induced tyrosine phosphorylations of Gabl. Y307 phosphorylation was undetectable in fibroblasts lacking Src, Yes, and Fyn, even upon overexpression of Crk, whereas cells lacking only Yes and Fyn still contained Gabl with phosphorylated Y307. Furthermore, Crk induced the phosphorylation of Src-Y416; accordingly the interaction between Crk and Csk was increased. The Gabl-Y307F mutant failed to localize near the plasma membrane even upon HGF stimulation and decreased cell migration. Moreover, Gabl-Y307F disturbed the localization of Crk, FAK, and paxillin, which are the typical components of focal adhesions. Taken together, these results indicate that Crk facilitates tyrosine phosphory- lation of Gabl-Y307 through Src, contributing to the organization of focal adhesions and enhanced cell migration, thereby possibly promoting human cancer development.展开更多
With the development of human society,the social hub enlarges beyond one community to the extent that the world is deemed as a community as a whole.Communication,therefore,plays an increasingly important role in our d...With the development of human society,the social hub enlarges beyond one community to the extent that the world is deemed as a community as a whole.Communication,therefore,plays an increasingly important role in our daily life.As a consequence,communication model or the definition of which is not so much a definition as a guide in communication.However,some existed communication models are not as practical as it was.This paper tries to make an overall contrast among three communication models——Coded Model,Gable's Communication Model and Ostensive Inferential Model,to see how they assist people to comprehend verbal and non-verbal communication.展开更多
Peculiar color and form of Leizhou red-brick folk dwelling distinguishes it from other vernacular dwellings in Lingnan region(south of the Five Ridges, referring to the current Guangdong and Guangxi). The fi re-sealin...Peculiar color and form of Leizhou red-brick folk dwelling distinguishes it from other vernacular dwellings in Lingnan region(south of the Five Ridges, referring to the current Guangdong and Guangxi). The fi re-sealing gable wall(hereinafter referred to as fi re-sealing wall) in brilliant colors, diversifi ed forms and exaggerated shapes is a remarkable symbol of local dwellings. Originating from Fulao traditional vernacular dwelling and inheriting its advantages, fi re-sealing wall of Leizhou red-brick vernacular dwelling has shown diversity for the infl uence of immigrants, regional cultures, social background and economic status, and formed its own features in color, form and decoration. On the basis of fi eld investigation, this paper described diversifi ed features of the fi re-sealing wall of Leizhou red-brick vernacular dwelling, analyzed the causes of its diversity from the perspectives of aesthetics, function and technology, and explored the harmonious living philosophy implied by its function, form and art.展开更多
In order to clear constructional design of corner joint, it is necessary to further investi-gate mechanical property of corner joint in gabled frames. Through static test and finite element software analysis of compar...In order to clear constructional design of corner joint, it is necessary to further investi-gate mechanical property of corner joint in gabled frames. Through static test and finite element software analysis of comparing the panel zone with and without inclined stiffener. Some conclusions are given in the article. The load displacement curves show that the capacity of oblique nodes installed within stiffening rib components is enhanced i.e. 40% more than those without stiffening rib nodes. The results reveal that in the gabled frames, the corner node with the inclined stiffening rib can improve the bearing capacity of the specimens. When the extraterritorial flange is tension, the erection of the inclined stiffening rib can prevent structural failure and improve effectually the ductility of the structure.展开更多
Gable roofs with overhangs （eaves） are the common constructions of low-rise buildings on the southeastern coast of China, and they were vulnerable to typhoons from experience. The wind pressure distributions on gabl...Gable roofs with overhangs （eaves） are the common constructions of low-rise buildings on the southeastern coast of China, and they were vulnerable to typhoons from experience. The wind pressure distributions on gable roofs of low-rise buildings are investigated by a series of wind tunnel tests which consist of 99 test cases with various roof pitches, height-depth ratios and width-depth ratios. The block pressure coefficients and worst negative （block） pressure coefficients on different roof regions of low-rise buildings are proposed for the main structure and building envelope, respectively. The effects of roof pitch, height-depth ratio, and width-depth ratio on the pressure coefficients of each region are analyzed in detail. In addition, the pressure coefficients on the roofs for the main structure and building envelope are fitted according to roof pitch, height-depth ratio and width-depth ratio of the low-rise building. Meanwhile, the rationality of the fitting formulas is verified by comparing the fitting results with the codes of different countries. Lastly, the block pressure coefficients and worst negative pressure coefficients are recommended to guide the design of low-rise buildings in typhoon area and act as references for the future＇s modification of wind load codes.展开更多
文摘The House of the Seven Gables （1981）, Hawthorne＇s second romance, is his another masterpiece after The Scarlet Letter （1956）. The achievement of its themes and narrative skills has been greatly complimented by readers, especially its descriptions and analyses of the characters＇ psychological activities and their personalities. The notorious Salem Witch Trials of Hawthorne＇s family has a great effect on Hawthorne＇s formation of his views about the good and evil, the sin and penalty, and the psychological descriptive style in his works. In The House of the Seven Gables, Hawthorne takes this family history as the original writing background. Through exploring modem people＇s spiritual essence, using history as narrative original, Hawthorne＇s theme illustrates the past＇s influence on the present. By exploring the changes of the characters＇ psychologies and values, especially those of Holgrave, the narrator proposes a conception of general love to eradicate the actual contradictions. Hawthorne actually provides an alternative way--a nonpolitical solution to the national problems, which demonstrates not only his artistic pursuit but also his culturally political view in his writing. This paper consists of five parts.
文摘Under the instruction of the author's own confession in the preface of The House of the Seven Gables, it's easy for readers and critics to take the theme of this novel as past and present, stasis and change, aristocracy and democracy, and then to unfavor?ably judge Pycheon siblings, the representatives of the former, by Holgrave, that of the latter. However, by using two narrative voic?es simultaneously in the novel, an intradiegeitic one and an extradeigetic one, Hawthorne actually reveals his equal disapproval of both the Pycheon siblings and Holgrave. In the intradiegetic narrative, the narrative voice as a whole takes its side with Holgrave and reveals Pycheon siblings'isolation from the united struggle of mankind. In the extradiegetic narrative where the narrator ad?dresses directly to his readers, the narrator expresses a similar disapproval of Holgrave, who is equally isolated from the chain of hu?manity for lacking sympathy for his fellow beings. With the co-existence of two narrative voices, Hawthorne's true concern lies in calling attention to the equally dangerous situations of isolation from the chain of humanity:an isolation from the chain of progress and that of human sympathy.
文摘根据GABLS(Global Energy and Water Cycle Experiment Atmospheric Boundary Layer Study)的第2个个例在GRAPES(Global and Regional Assimilation and PrEdiction System)单柱模式中构造了一个试验,用于检验规定的下垫面温度强迫条件下边界层过程的昼夜循环模拟能力。然后,将模拟结果与观测和大涡模拟结果进行了比较。结果表明,在规定的下垫面温度强迫下,GRAPES模拟的2m温度基本合理。然而,对于稳定条件(夜间),GRAPES模拟的向下的感热通量比观测的大,过估10m风速和摩擦速度,过估稳定边界层高度;对于不稳定条件(白天),GRAPES模拟的向上的感热通量比观测的小,低估不稳定边界层高度,低层位温偏冷。随后的敏感试验表明,减小边界层方案中的动量和热量的背景扩散值后,GRAPES模拟的稳定条件下的10m风速和摩擦速度,以及对流边界层的风和温度的廓线更接近大涡模拟。
基金Acknowledgments We thank M Hamaguchi （Nagoya Univ., Japan） and T Iwahara （Osaka Bioscience Institute, Japan） forJak null MEFs, and N Gotoh （Tokyo Univ., Japan）, H Higashi （Hokkaido Univ., Japan）, N Mochizuki （National Cardiovascular Cent. Res. Inst., Japan）, H Hanafusa （Prof. emeritus, The Rockefeller Univ., USA and Direc- tor em., OBI, Japan）, SK Hanks （Vanderbilt Univ., USA）, and M Matsuda （Kyoto Univ., Japan） for plasmids. We also thank K Sasai （Hokkaido Univ., Japan） and Y Ohba （Hokkaido Univ., Japan） for valuable discussion. This work was supported in part by grants-in- aid from the Ministry of Education, Science, Culture, and Sports, and the Ministry of Health, Labor, and Welfare, Japan, as well as Suhara Memorial Foundation （Sapporo, Japan）, and the Mochida Medical Science Foundation （Tokyo, Japan）. The work of SF and TK is supported by grants from Cancer Research UK and the Brit- ish Cancer Charity ＂Heads Up＂. We dedicate this work to our great mentor Hidesaburo Hana- fusa, professor emeritus of the Rockefeller University, who passed away on March 15, 2009 at the age of 79. He devoted his life to science and in particular to creating the oncogene research field, to teaching and to providing profound affection to his students and postdocs. All of the alumni of Saburo＇s laboratory pride them- selves in having been his apprentices and we would like to hereby express our deeply felt gratitude to Saburo.
文摘Upon growth factor stimulation, the scaffold protein, Gabl, is tyrosine phosphorylated and subsequently the adaptor protein, Crk, transmits signals from Gabl. We have previously shown that Crk overexpression, which is detectable in various human cancers, induces tyrosine phosphorylation of Gabl without extracellular stimuli. In the present study, the underlying mechanisms were further investigated. Mutational analyses of CrkII demonstrated that the SH2 domain, but not the SH3（N） or the regulatory Y221 residue of CrkII, is critical for the induction of Gabl- Y307 phosphorylation. SH2 mutation of CrkII also decreased the interaction with Gabl. In GST pull-down assay, Crk-SH2 bound to wild-type Gahl, whereas Crk-SH3（N） interacted with the Gabl mutant, which lacks the clus- tered tyrosine region （residues 242-410）. Tyrosine phosphorylation of Gabl was induced by all Crk family proteins, but not other SH2-containing signalling adaptors. Src-family kinase inhibitor, PP2, abrogates Crk-induced tyrosine phosphorylations of Gabl. Y307 phosphorylation was undetectable in fibroblasts lacking Src, Yes, and Fyn, even upon overexpression of Crk, whereas cells lacking only Yes and Fyn still contained Gabl with phosphorylated Y307. Furthermore, Crk induced the phosphorylation of Src-Y416; accordingly the interaction between Crk and Csk was increased. The Gabl-Y307F mutant failed to localize near the plasma membrane even upon HGF stimulation and decreased cell migration. Moreover, Gabl-Y307F disturbed the localization of Crk, FAK, and paxillin, which are the typical components of focal adhesions. Taken together, these results indicate that Crk facilitates tyrosine phosphory- lation of Gabl-Y307 through Src, contributing to the organization of focal adhesions and enhanced cell migration, thereby possibly promoting human cancer development.
文摘With the development of human society,the social hub enlarges beyond one community to the extent that the world is deemed as a community as a whole.Communication,therefore,plays an increasingly important role in our daily life.As a consequence,communication model or the definition of which is not so much a definition as a guide in communication.However,some existed communication models are not as practical as it was.This paper tries to make an overall contrast among three communication models——Coded Model,Gable's Communication Model and Ostensive Inferential Model,to see how they assist people to comprehend verbal and non-verbal communication.
基金Sponsored by General Program of National Natural Science Foundation of China(51278194)
文摘Peculiar color and form of Leizhou red-brick folk dwelling distinguishes it from other vernacular dwellings in Lingnan region(south of the Five Ridges, referring to the current Guangdong and Guangxi). The fi re-sealing gable wall(hereinafter referred to as fi re-sealing wall) in brilliant colors, diversifi ed forms and exaggerated shapes is a remarkable symbol of local dwellings. Originating from Fulao traditional vernacular dwelling and inheriting its advantages, fi re-sealing wall of Leizhou red-brick vernacular dwelling has shown diversity for the infl uence of immigrants, regional cultures, social background and economic status, and formed its own features in color, form and decoration. On the basis of fi eld investigation, this paper described diversifi ed features of the fi re-sealing wall of Leizhou red-brick vernacular dwelling, analyzed the causes of its diversity from the perspectives of aesthetics, function and technology, and explored the harmonious living philosophy implied by its function, form and art.
文摘In order to clear constructional design of corner joint, it is necessary to further investi-gate mechanical property of corner joint in gabled frames. Through static test and finite element software analysis of comparing the panel zone with and without inclined stiffener. Some conclusions are given in the article. The load displacement curves show that the capacity of oblique nodes installed within stiffening rib components is enhanced i.e. 40% more than those without stiffening rib nodes. The results reveal that in the gabled frames, the corner node with the inclined stiffening rib can improve the bearing capacity of the specimens. When the extraterritorial flange is tension, the erection of the inclined stiffening rib can prevent structural failure and improve effectually the ductility of the structure.
文摘Gable roofs with overhangs （eaves） are the common constructions of low-rise buildings on the southeastern coast of China, and they were vulnerable to typhoons from experience. The wind pressure distributions on gable roofs of low-rise buildings are investigated by a series of wind tunnel tests which consist of 99 test cases with various roof pitches, height-depth ratios and width-depth ratios. The block pressure coefficients and worst negative （block） pressure coefficients on different roof regions of low-rise buildings are proposed for the main structure and building envelope, respectively. The effects of roof pitch, height-depth ratio, and width-depth ratio on the pressure coefficients of each region are analyzed in detail. In addition, the pressure coefficients on the roofs for the main structure and building envelope are fitted according to roof pitch, height-depth ratio and width-depth ratio of the low-rise building. Meanwhile, the rationality of the fitting formulas is verified by comparing the fitting results with the codes of different countries. Lastly, the block pressure coefficients and worst negative pressure coefficients are recommended to guide the design of low-rise buildings in typhoon area and act as references for the future＇s modification of wind load codes.
