Five theories shed lights on the potential mechanisms of aging:somatic mutations,telomere loss,mitochondrial defects,and accumulation of altered proteins inside proteasomes.The existence of a program of aging is not y...Five theories shed lights on the potential mechanisms of aging:somatic mutations,telomere loss,mitochondrial defects,and accumulation of altered proteins inside proteasomes.The existence of a program of aging is not yet identified,but overlaps with a program for risks of death.On the other hand,organisms are programmed for survival,which ultimately fails.This failure results in aging,notabily,focusing on alterations of specific genes.Irregular examinations,dysfunctions,insufficient use of fluoride,and removable partial dentures,are favoring the formation of caries and periodontal pathologies.Oral lesions are due to local trauma,related gingival recession,and formation of pockets.They are associated to insufficient removal of food/plaque.Epithelial thinning,and reduction of extracellular matrix components,lead to plications and foldings of the mucosal surface,and subsequently to bacterial colonization.Geriatric dentistry(or gerodontology)is an increasing field of dentistry,mostly associated with the growing percentage of patients over 80+years.展开更多
文摘Five theories shed lights on the potential mechanisms of aging:somatic mutations,telomere loss,mitochondrial defects,and accumulation of altered proteins inside proteasomes.The existence of a program of aging is not yet identified,but overlaps with a program for risks of death.On the other hand,organisms are programmed for survival,which ultimately fails.This failure results in aging,notabily,focusing on alterations of specific genes.Irregular examinations,dysfunctions,insufficient use of fluoride,and removable partial dentures,are favoring the formation of caries and periodontal pathologies.Oral lesions are due to local trauma,related gingival recession,and formation of pockets.They are associated to insufficient removal of food/plaque.Epithelial thinning,and reduction of extracellular matrix components,lead to plications and foldings of the mucosal surface,and subsequently to bacterial colonization.Geriatric dentistry(or gerodontology)is an increasing field of dentistry,mostly associated with the growing percentage of patients over 80+years.
