Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism. Methods: Thirty-five women, 49 to 62 years old, with 5. 6 years menopause, were treated as the subj...Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism. Methods: Thirty-five women, 49 to 62 years old, with 5. 6 years menopause, were treated as the subjects and followed-up for 6 months, 12 months or 24 months. The course of treatment ranged from6 months to 25 months with an average of 14 months. Some related biochemical parameters, such as serumestradiol (E2 ), testosterone (T), the ratio of fasting urinary calcium to creatinine (Ca/Cr), the ratio of 24hurinary calcium to creatinine (24h Ca/Cr), 24h urinary E2, and 24h urinary hydroxyproline (HOP) were measured before and after treatment. Results: After 6～9 months or 1～2 years of treatment, the levels of serum E2and 24h urinary E2 were raised significantly, while the levels of serum T and urinary Ca/Cr fell evidently afterone or two year's treatment. The levels of serum E2 and 24h urinary E2 were significantly correlated with thelevels of fasting urinary Ca/Cr, 24h urinary Ca/Cr, serum T, and 24h urinary HOP respectively. Conclusions:Gusong-II can elevate the serum E2 levels of postmenopausal women, reduce the discharge of urinary calcium andHOP, and inhibit bone resorption. The rise of the serum EZ level might be correlated with the conversion of T toE2.展开更多
文摘Objective: To assess the effect of Gusong II in treating postmenopausal osteoporosis and try to reveal its mechanism. Methods: Thirty-five women, 49 to 62 years old, with 5. 6 years menopause, were treated as the subjects and followed-up for 6 months, 12 months or 24 months. The course of treatment ranged from6 months to 25 months with an average of 14 months. Some related biochemical parameters, such as serumestradiol (E2 ), testosterone (T), the ratio of fasting urinary calcium to creatinine (Ca/Cr), the ratio of 24hurinary calcium to creatinine (24h Ca/Cr), 24h urinary E2, and 24h urinary hydroxyproline (HOP) were measured before and after treatment. Results: After 6～9 months or 1～2 years of treatment, the levels of serum E2and 24h urinary E2 were raised significantly, while the levels of serum T and urinary Ca/Cr fell evidently afterone or two year's treatment. The levels of serum E2 and 24h urinary E2 were significantly correlated with thelevels of fasting urinary Ca/Cr, 24h urinary Ca/Cr, serum T, and 24h urinary HOP respectively. Conclusions:Gusong-II can elevate the serum E2 levels of postmenopausal women, reduce the discharge of urinary calcium andHOP, and inhibit bone resorption. The rise of the serum EZ level might be correlated with the conversion of T toE2.
