目的:观察瑞格列奈对新诊断2型糖尿病患者胰腺β细胞功能的影响。方法:采用自身前后对照和组间对照的方法,将60例新诊断2型糖尿病患者随机分为两组分别给予瑞格列奈和胰岛素治疗3个月后,比较各组治疗前后临床及生化指标、△I30/△G30比...目的:观察瑞格列奈对新诊断2型糖尿病患者胰腺β细胞功能的影响。方法:采用自身前后对照和组间对照的方法,将60例新诊断2型糖尿病患者随机分为两组分别给予瑞格列奈和胰岛素治疗3个月后,比较各组治疗前后临床及生化指标、△I30/△G30比值、胰岛素分泌指数(HOMA-β)及胰岛素抵抗指数(HOMA-IR)的变化。结果:两组均有明显的降糖效果,治疗后空腹血糖及餐后血糖、糖化血红蛋白均显著下降(P<0.05);餐后0.5 h血清胰岛素明显升高(P<0.05),说明二者均能刺激胰岛素早时相分泌,但空腹及餐后2 h血清胰岛素上升不明显(P>0.05);△I30/△G30比值升高(P<0.05),HOMA-β升高(P<0.05),HOMA-IR下降(P<0.05);但两组间比较,除2 h FIns两组组间差异有统计学意义(P<0.05)以外,其余各组间均P>0.05。结论:对新诊断2型糖尿病患者早期给予瑞格列奈强化治疗同胰岛素一样可以良好控制血糖并改善胰腺β细胞功能,改善胰岛素抵抗,可作为新诊断2型糖尿病患者有效而简便的治疗方案之一。展开更多
Native Americans are predisposed to insulin resistance and associated cardiovascular risk. Therefore, we studied whether BMI (body mass index) in a population of Cherokee children and adolescents is associated with HD...Native Americans are predisposed to insulin resistance and associated cardiovascular risk. Therefore, we studied whether BMI (body mass index) in a population of Cherokee children and adolescents is associated with HDL-C (HDL cholesterol)-, and the HDL particles Lp (lipopro-tein) A-I and LpA-I:A-I. Subjects were grouped by BMI Z score quartiles within three gender-specific age brackets (5-9, 10-14, and 15-19 y) to examine for trends in lipoprotein and HOMA-IR (homeostasis index insulin resistance) values associated with adiposity and age. HDL-C decreased by BMI Z score quartiles in all three age groups for both genders. HDL-C, LpA-I, and LpA-I:A-II decreased with age in boys but not girls. Log HOMA-IR increased by BMI Z score quartiles in all three age groups for both genders. Linear regression modeling showed BMI Z score, triglyceride, and age to be associated with HDL-C, whereas HOMA-IR was associated with LpA-I:A-II but not with HDLC or LpA-I.When waist circumference was substituted for BMI Z score in the same models, it was associated with HDL-C and both lipoprotein particles. In conclusion, adiposity is more associated with HDL-C lowering than with declines in the lipoprotein particles. HOMA-IR is less associated with HDL-C but may selectively influence LpA-I:A-II. Greater decreases in HDL-C, LpA-I, and LpA-I:A-II with age in boys is attributed to gender-specific hormonal changes. The early onset of HDL lowering in these Native American children and adolescents, particularly boys, warrants intervention strategies to prevent obesity and associated cardiovascular risk.展开更多
文摘目的:观察瑞格列奈对新诊断2型糖尿病患者胰腺β细胞功能的影响。方法:采用自身前后对照和组间对照的方法,将60例新诊断2型糖尿病患者随机分为两组分别给予瑞格列奈和胰岛素治疗3个月后,比较各组治疗前后临床及生化指标、△I30/△G30比值、胰岛素分泌指数(HOMA-β)及胰岛素抵抗指数(HOMA-IR)的变化。结果:两组均有明显的降糖效果,治疗后空腹血糖及餐后血糖、糖化血红蛋白均显著下降(P<0.05);餐后0.5 h血清胰岛素明显升高(P<0.05),说明二者均能刺激胰岛素早时相分泌,但空腹及餐后2 h血清胰岛素上升不明显(P>0.05);△I30/△G30比值升高(P<0.05),HOMA-β升高(P<0.05),HOMA-IR下降(P<0.05);但两组间比较,除2 h FIns两组组间差异有统计学意义(P<0.05)以外,其余各组间均P>0.05。结论:对新诊断2型糖尿病患者早期给予瑞格列奈强化治疗同胰岛素一样可以良好控制血糖并改善胰腺β细胞功能,改善胰岛素抵抗,可作为新诊断2型糖尿病患者有效而简便的治疗方案之一。
文摘Native Americans are predisposed to insulin resistance and associated cardiovascular risk. Therefore, we studied whether BMI (body mass index) in a population of Cherokee children and adolescents is associated with HDL-C (HDL cholesterol)-, and the HDL particles Lp (lipopro-tein) A-I and LpA-I:A-I. Subjects were grouped by BMI Z score quartiles within three gender-specific age brackets (5-9, 10-14, and 15-19 y) to examine for trends in lipoprotein and HOMA-IR (homeostasis index insulin resistance) values associated with adiposity and age. HDL-C decreased by BMI Z score quartiles in all three age groups for both genders. HDL-C, LpA-I, and LpA-I:A-II decreased with age in boys but not girls. Log HOMA-IR increased by BMI Z score quartiles in all three age groups for both genders. Linear regression modeling showed BMI Z score, triglyceride, and age to be associated with HDL-C, whereas HOMA-IR was associated with LpA-I:A-II but not with HDLC or LpA-I.When waist circumference was substituted for BMI Z score in the same models, it was associated with HDL-C and both lipoprotein particles. In conclusion, adiposity is more associated with HDL-C lowering than with declines in the lipoprotein particles. HOMA-IR is less associated with HDL-C but may selectively influence LpA-I:A-II. Greater decreases in HDL-C, LpA-I, and LpA-I:A-II with age in boys is attributed to gender-specific hormonal changes. The early onset of HDL lowering in these Native American children and adolescents, particularly boys, warrants intervention strategies to prevent obesity and associated cardiovascular risk.
