This paper makes a systematical study on the translating strategies of humorous language,with linguistic and cultural factors taken into consideration in the discussion.It should be pointed out that whatever strategy ...This paper makes a systematical study on the translating strategies of humorous language,with linguistic and cultural factors taken into consideration in the discussion.It should be pointed out that whatever strategy is chosen in translation,it is workable so long as it can reach the best humorous effect.展开更多
Humorous utterances,especially those in the form of conversation in life,have distinctive pragmatic features.There is a close relationship between humor and pragmatics,which can be found in various books on pragmatics...Humorous utterances,especially those in the form of conversation in life,have distinctive pragmatic features.There is a close relationship between humor and pragmatics,which can be found in various books on pragmatics.In those books,humorous utterances function as examples for pragmatic analysis.Effective humorous languages often reflect one or several pragmatic features.This paper specifically introduces one of the important theories of pragmatics:cooperative principle,by which the paper analyzes the humorous utterance and explores the relationship between pragmatic rules and humorous utterance.The purpose is to make people know humorous utterance is a matter of pragmatics. The reality of the humor especially depends on implication of the language and the context.展开更多
This paper probes into the dialogues in If You Are the One based on the theoretical framework of Grice's Cooperative Principle, with a view to discovering humorous effects and conversational implicature in a certa...This paper probes into the dialogues in If You Are the One based on the theoretical framework of Grice's Cooperative Principle, with a view to discovering humorous effects and conversational implicature in a certain context. Through the analysis of representative dialogues which obey and violate the maxims respectively, this paper concludes that speakers, by appropriately violating the maxims and unconsciously observing the maxims of the CP, manage to achieve humorous effects and conversational implicature. Meanwhile, this paper aims to help people express themselves appropriately to avoid pragmatic failures and achieve the goal of communication.展开更多
Mark Twain, a mastermind of humor and realism, is seen as a giant in world literature. His humorous satire had great impact on the following men of letters; critics also attached significant importance to it and put f...Mark Twain, a mastermind of humor and realism, is seen as a giant in world literature. His humorous satire had great impact on the following men of letters; critics also attached significant importance to it and put forward various interpretations. Noticeably, his humor ous satire finds full expression in his famous short story, Running for Governor. In it, with humor and satire, he exposed the true features and hypocrisy of American democracy. The paper tries to analyze the basic elements which affected Mark Twain's humorous satire, aiming at offering rational analysis of this humorous satire in Running for Governor as well as making Twain's works readily understood.展开更多
Mammography is widely performed as a standardized procedure for breast cancer screening;however, women often feel some degree of pain during this procedure. Currently, there are limited options available for alleviati...Mammography is widely performed as a standardized procedure for breast cancer screening;however, women often feel some degree of pain during this procedure. Currently, there are limited options available for alleviating pain related to mammography. A non-medicinal approach to the alleviation of pain involves the effects of laughter on physical and psychological wellbeing. We therefore examined the possibility that humorous stimuli would alleviate the physical burden on women undergoing mammography. We assessed 29 women, 15 women received only conventional mammography (neutral group), while 14 women (humor group) watched a funny video during the same examination. The intensity of pain experienced during mammography was assessed by visual analogue scale (VAS) and the VAS results showed a statistically significant difference (P = 0.007) between the two groups, with the humor group experiencing less pain. In an additional experiment, 14 women in the humor group also underwent conventional mammography without exposure to the funny video and pain was assessed by VAS. We found that the pain experienced during conventional mammography without the funny video was significantly greater than the pain experienced during the same mammography but with the funny video (P = 0.047). These findings suggested the possibility of alleviating pain during mammography by humorous stimuli.展开更多
The paper is divided into Five Chapters,aiming to explain the humorous effect in our daily discourse in the perspective of linguistic analysis.It is another new discovery.Two languages have their own distinct features...The paper is divided into Five Chapters,aiming to explain the humorous effect in our daily discourse in the perspective of linguistic analysis.It is another new discovery.Two languages have their own distinct features.When translating,we will find a lot of humorous effect created by these language differences.The analysis of the topic is undergoing through term definition and case study.The paper might be of some help to further the humorous research in literature,art,academic circles or daily conversations.More methods of analysis,at the same time,are appreciated.展开更多
As we all know,Mark Twain is an expert in handling humor.The formation of his language style has close connection with three aspects.Local literature influences Mark Twain very much.Western humor is another influentia...As we all know,Mark Twain is an expert in handling humor.The formation of his language style has close connection with three aspects.Local literature influences Mark Twain very much.Western humor is another influential element.And his personal experience is also contributed to his humorous language style.展开更多
Denkon was a famous woman dancer.She was very beau-tiful and successful in dancing,but she wasn’t bright.Bernard Shaw was a world-famous writer and humorist,but he was an ordinary-looking man.
By exploring cooperative principle and conversation,especially from the semantic and pragmatic way,this article tries to explore how the cooperative principle makes effect in humorous conversations.It turns out that t...By exploring cooperative principle and conversation,especially from the semantic and pragmatic way,this article tries to explore how the cooperative principle makes effect in humorous conversations.It turns out that the humor comes out more from the semantic as pect.Hence it is proposed that it should focus more on the semantic meaning to achieve humor.At last,the significance of applying humor ous conversation in teaching spoken English is also discussed.展开更多
This paper takes an integrative approach to the communication and comprehension of humor from the perspectives of the humorist’s manipulation and the recipient’s vigilance informed by relevance theory.It is proposed...This paper takes an integrative approach to the communication and comprehension of humor from the perspectives of the humorist’s manipulation and the recipient’s vigilance informed by relevance theory.It is proposed that,in order to communicate humor,the humorist manipulates the recipient’s expectation of relevance in the setup and in the punchline in two different but related ways:misleading and guiding.It is also proposed that,in order to comprehend and appreciate humor,the recipient exercises vigilance against his/her own shallow processing in the setup and exercises vigilance for special cognitive effects in the punchline.On this approach,humorous communication and comprehension is viewed as an interaction between manipulation and epistemic vigilance.Strategies of manipulation and vigilance are described,and some essential issues arising from the relevance-theoretic approach to humor are reconsidered with some implications drawn.This paper contributes to enhancing the explanatory power of relevance theory for the communication and comprehension of humor.展开更多
Humor is a kind of literature that can be found everywhere in our daily life. It is also a kind of language art that can be created by various reasons. This essay will analyze humor from a knowledge of pragmatics—coo...Humor is a kind of literature that can be found everywhere in our daily life. It is also a kind of language art that can be created by various reasons. This essay will analyze humor from a knowledge of pragmatics—cooperative principle (CP) and show how the humorous effect achieved ascribed to the breaking the four maxims of the cooperative principle. It also provides a lot of examples to show how to achieve humorous effect by applying Grice’s cooperative principle. The creation of humor and violation of CP have close relationship. Violating CP in the surface may create humor. A better understanding about humor will be achieved under an analysis of CP. As a linguistic phenomenon, humor has its own charm. It’s good medicine,that can improve interpersonal relationships and make others feel comfortable.展开更多
Chinese audience love British comedy for its unique humorous effect, and the interlingual communication of humorous effects has become a major problem affecting the audience's viewing experience. Taking the subtit...Chinese audience love British comedy for its unique humorous effect, and the interlingual communication of humorous effects has become a major problem affecting the audience's viewing experience. Taking the subtitle translation project of Black Books as an example, this paper analyzes the subtitle translation of humorous elements in the sitcom Black Books from the per?spective of functional equivalence theory, combining the characteristics of British comedies, explains how humor in sitcoms tran?scends regional, cultural and linguistic barriers to make the target audience feel the effect of humor in sitcoms, and provides cor?responding subtitle translation strategies. Through this research, the author hopes to achieve the transmission effect of humor, op?timize the viewing experience of the target language audience to a certain extent, and promote cultural exchanges.展开更多
Though with different times and backgrounds,these three masterpieces-"The Egg","The Secret Life of Walter Mitty"and"Shiloh"all humorously characterize the same type protagonist-the"l...Though with different times and backgrounds,these three masterpieces-"The Egg","The Secret Life of Walter Mitty"and"Shiloh"all humorously characterize the same type protagonist-the"little man".Penetrating the humorous characterization,the three works on the one hand present the rational question of the mainstream society and the serious critique of the dominant forces,on the other hand,they also offer the humanistic affirm and concern of the marginalized little man.Thus,bundle these three master pieces together,this paper makes an effort to analyze the humorous characterization of the little man;the comic gender relationships so as to figure out the coherent thematic significance as well as the philosophical seriousness of humor in these three masterpieces.展开更多
AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator ...AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after injection.METHODS:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,respectively.The DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study period.The aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined group.RESULTS:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P<0.01).After 1mo of surgery,the concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly lower in the combined group than those of the aflibercept group(all P<0.01).The BCVA and CMT values of the two groups were statistically different after 1 and 2mo of treatment(P<0.01).However,the difference was not statistically significant after 3mo of treatment(P>0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly increased.Aflibercept and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high safety.Aflibercept combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema rapidly.However,the long-term efficacy is comparable to that of aflibercept alone.展开更多
Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific immunoglobulins.Exercise alters B cell counts and immunoglobulin l...Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific immunoglobulins.Exercise alters B cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are lacking.This systematic review assessed current literatures on the impact of acute exercise and exercise training on B cells,immunoglobulins,and markers of secretory immunity in human biofluids.Methods:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,2023.Non-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on B cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were included.Quality and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in Exercise.Study characteristics,outcome measures,and statistically significant changes were summarized tabularly.Results:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise training.All included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control conditions.Secretory and plasma immunoglobulin A levels were most consistently increased in response to exercise training.Conclusion:B cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise modalities.Well-designed trials with large sample sizes are needed to clarify how exercise shapes B cell-related immunity.展开更多
Aqueous humor provides the necessary nutrition for the lens and transports the metabolites in the eye.It was a liquid that can directly reflect the microenvironment in the eye'and it can be easily obtained during ...Aqueous humor provides the necessary nutrition for the lens and transports the metabolites in the eye.It was a liquid that can directly reflect the microenvironment in the eye'and it can be easily obtained during the operation.This review intended to analyze the components of aqueous humor in patients with different types of cataracts'so as to reflect the pathogenesis and development of the disease'evaluate the incidence of postoperative complications and provide reference value for the surgical design of sequential cataract surgery.The aqueous humor components of different types of cataracts showed different degrees of inflammation'oxidative stress and extracellular matrix remodeling.The biomarker of early neuropathy in diabetic cataract was neural cell adhesion molecule-1(NCAM1).Transforming growth factor-β(TGF-β)was the evaluation factor of disease development in patients with pseudoexfoliation syndrome.The relationships between postoperative complications of different types of cataracts and aqueous humor components were as follows:Macular edema after diabetic cataract surgery was associated with tumor necrosis factor-alpha;capsular contraction after high myopic cataract surgery was related to monocyte chemoattractant protein-1(MCP-1)and TGF-β2;Klotho and glutathione S-transferase P 1(GSTP1)were associated with high intraocular pressure after primary open-angle glaucoma complicated by cataract surgery;capsular contraction after retinitis pigmentosa complicated by cataract surgery was associated with matrix metalloproteinases;pro-inflammatory cytokines and fibroblast growth factor 4 in the aqueous humor of congenital cataracts were associated with posterior capsular opacification after surgery.Granulocyte colony stimulating factor 3 and MCP-1 were the main cytokines mediating the pain of the second eye in the binocular sequential cataract surgery short interval(1 wk)'while MCP-1 mediated pain in the long interval(6 wk).The second eye after binocular sequential cataract surgery had a higher level of proinflammatory factors.The components of aqueous humor in patients with different types of cataracts were related to the pathogenesis and postoperative complications of the disease.Monitoring the components of the aqueous humor could help better understand the intraocular microenvironment of different types of cataracts and provide a reference for predicting the development of the disease and implementing relevant targeted therapy.展开更多
Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to...Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to assess the immunological response to vaccination in Senegalese hemodialysis patients. Patients and Methods: We conducted a prospective study, in two dialysis centers in Dakar from March 30<sup>th</sup> to August 30<sup>th</sup>, 2021 including patients on hemodialysis for >6 months, vaccinated against SARS-CoV-2 according to the vaccination schedule recommended by WHO. A vaccine response was considered positive when seroconversion was observed after one dose of vaccine. The clinical efficacy of immunization was defined as the absence of new COVID-19 infection in patients who received a complete vaccination. Results: Among the 81 patients included in the study, 7.4% had anti-Spike IgM antibodies before their first vaccination. Seroprevalence of IgM antibodies was 38.3% one month after the first vaccine dose (at M1) and 8.6% one month after the second dose (at M4). Anti-Spike IgG antibodies were present in 40.3% of patients before vaccination, in 90.1% at M1, and in 59.7% at M4. Among patients previously infected with SARS-CoV-2, 10.2% had IgM antibodies at M0, 31.6% at M1, and 10.5% at M4 post-vaccination. Similarly, seroprevalences of IgG antibodies in this subgroup were 31.5%, 61.3%, and 50.0% respectively at M0, M1, and M4 post-vaccination. A comparison of seroconversion rates between M0 and M4 showed significant differences only for IgG in COVID-19 naive patients. Mean duration in dialysis and the existence of previous COVID-19 infection were associated with patients’ vaccinal response after the two doses. Age, gender and the use of immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination against COVID-19 in Senegalese hemodialysis patients induced a low seroconversion rate but it was well tolerated. Moreover, the induced protection was neither strong nor durable, particularly in patients with longer duration in dialysis.展开更多
这是希瑟做任课老师的最后一个学期,学生们给她送了小礼物作为纪念。一个小男孩犹豫了,他在想办法让老师知道他有多在乎她。主题语境:日常生活篇幅:347词建议用时:7分钟。1 When it comes to gifts,we often say it's the thought t...这是希瑟做任课老师的最后一个学期,学生们给她送了小礼物作为纪念。一个小男孩犹豫了,他在想办法让老师知道他有多在乎她。主题语境:日常生活篇幅:347词建议用时:7分钟。1 When it comes to gifts,we often say it's the thought that counts.While this can be said humorously at times,Heather Benoit is here to remind us of the truth behind this sentiment.Over a decade ago,this teacher was given a crayon by one of her students.展开更多
A man went to see his doctor one daybecause he was suffering from pains in hisstomach. After the doctor had examinedhim, carefully, he said to him, "well,there’s nothing really wrong with you,
I say shake the world with my laughter, and shake everything back to the right place!I remember an article called "English is a crazy language", and I totally agreewith that! Never have I been a fan of this ...I say shake the world with my laughter, and shake everything back to the right place!I remember an article called "English is a crazy language", and I totally agreewith that! Never have I been a fan of this crazy language, yet I should say, it did,in some way, change my thinking pattern. Or probably I should say it is the展开更多
文摘This paper makes a systematical study on the translating strategies of humorous language,with linguistic and cultural factors taken into consideration in the discussion.It should be pointed out that whatever strategy is chosen in translation,it is workable so long as it can reach the best humorous effect.
文摘Humorous utterances,especially those in the form of conversation in life,have distinctive pragmatic features.There is a close relationship between humor and pragmatics,which can be found in various books on pragmatics.In those books,humorous utterances function as examples for pragmatic analysis.Effective humorous languages often reflect one or several pragmatic features.This paper specifically introduces one of the important theories of pragmatics:cooperative principle,by which the paper analyzes the humorous utterance and explores the relationship between pragmatic rules and humorous utterance.The purpose is to make people know humorous utterance is a matter of pragmatics. The reality of the humor especially depends on implication of the language and the context.
文摘This paper probes into the dialogues in If You Are the One based on the theoretical framework of Grice's Cooperative Principle, with a view to discovering humorous effects and conversational implicature in a certain context. Through the analysis of representative dialogues which obey and violate the maxims respectively, this paper concludes that speakers, by appropriately violating the maxims and unconsciously observing the maxims of the CP, manage to achieve humorous effects and conversational implicature. Meanwhile, this paper aims to help people express themselves appropriately to avoid pragmatic failures and achieve the goal of communication.
文摘Mark Twain, a mastermind of humor and realism, is seen as a giant in world literature. His humorous satire had great impact on the following men of letters; critics also attached significant importance to it and put forward various interpretations. Noticeably, his humor ous satire finds full expression in his famous short story, Running for Governor. In it, with humor and satire, he exposed the true features and hypocrisy of American democracy. The paper tries to analyze the basic elements which affected Mark Twain's humorous satire, aiming at offering rational analysis of this humorous satire in Running for Governor as well as making Twain's works readily understood.
文摘Mammography is widely performed as a standardized procedure for breast cancer screening;however, women often feel some degree of pain during this procedure. Currently, there are limited options available for alleviating pain related to mammography. A non-medicinal approach to the alleviation of pain involves the effects of laughter on physical and psychological wellbeing. We therefore examined the possibility that humorous stimuli would alleviate the physical burden on women undergoing mammography. We assessed 29 women, 15 women received only conventional mammography (neutral group), while 14 women (humor group) watched a funny video during the same examination. The intensity of pain experienced during mammography was assessed by visual analogue scale (VAS) and the VAS results showed a statistically significant difference (P = 0.007) between the two groups, with the humor group experiencing less pain. In an additional experiment, 14 women in the humor group also underwent conventional mammography without exposure to the funny video and pain was assessed by VAS. We found that the pain experienced during conventional mammography without the funny video was significantly greater than the pain experienced during the same mammography but with the funny video (P = 0.047). These findings suggested the possibility of alleviating pain during mammography by humorous stimuli.
文摘The paper is divided into Five Chapters,aiming to explain the humorous effect in our daily discourse in the perspective of linguistic analysis.It is another new discovery.Two languages have their own distinct features.When translating,we will find a lot of humorous effect created by these language differences.The analysis of the topic is undergoing through term definition and case study.The paper might be of some help to further the humorous research in literature,art,academic circles or daily conversations.More methods of analysis,at the same time,are appreciated.
文摘As we all know,Mark Twain is an expert in handling humor.The formation of his language style has close connection with three aspects.Local literature influences Mark Twain very much.Western humor is another influential element.And his personal experience is also contributed to his humorous language style.
文摘Denkon was a famous woman dancer.She was very beau-tiful and successful in dancing,but she wasn’t bright.Bernard Shaw was a world-famous writer and humorist,but he was an ordinary-looking man.
文摘By exploring cooperative principle and conversation,especially from the semantic and pragmatic way,this article tries to explore how the cooperative principle makes effect in humorous conversations.It turns out that the humor comes out more from the semantic as pect.Hence it is proposed that it should focus more on the semantic meaning to achieve humor.At last,the significance of applying humor ous conversation in teaching spoken English is also discussed.
文摘This paper takes an integrative approach to the communication and comprehension of humor from the perspectives of the humorist’s manipulation and the recipient’s vigilance informed by relevance theory.It is proposed that,in order to communicate humor,the humorist manipulates the recipient’s expectation of relevance in the setup and in the punchline in two different but related ways:misleading and guiding.It is also proposed that,in order to comprehend and appreciate humor,the recipient exercises vigilance against his/her own shallow processing in the setup and exercises vigilance for special cognitive effects in the punchline.On this approach,humorous communication and comprehension is viewed as an interaction between manipulation and epistemic vigilance.Strategies of manipulation and vigilance are described,and some essential issues arising from the relevance-theoretic approach to humor are reconsidered with some implications drawn.This paper contributes to enhancing the explanatory power of relevance theory for the communication and comprehension of humor.
文摘Humor is a kind of literature that can be found everywhere in our daily life. It is also a kind of language art that can be created by various reasons. This essay will analyze humor from a knowledge of pragmatics—cooperative principle (CP) and show how the humorous effect achieved ascribed to the breaking the four maxims of the cooperative principle. It also provides a lot of examples to show how to achieve humorous effect by applying Grice’s cooperative principle. The creation of humor and violation of CP have close relationship. Violating CP in the surface may create humor. A better understanding about humor will be achieved under an analysis of CP. As a linguistic phenomenon, humor has its own charm. It’s good medicine,that can improve interpersonal relationships and make others feel comfortable.
文摘Chinese audience love British comedy for its unique humorous effect, and the interlingual communication of humorous effects has become a major problem affecting the audience's viewing experience. Taking the subtitle translation project of Black Books as an example, this paper analyzes the subtitle translation of humorous elements in the sitcom Black Books from the per?spective of functional equivalence theory, combining the characteristics of British comedies, explains how humor in sitcoms tran?scends regional, cultural and linguistic barriers to make the target audience feel the effect of humor in sitcoms, and provides cor?responding subtitle translation strategies. Through this research, the author hopes to achieve the transmission effect of humor, op?timize the viewing experience of the target language audience to a certain extent, and promote cultural exchanges.
文摘Though with different times and backgrounds,these three masterpieces-"The Egg","The Secret Life of Walter Mitty"and"Shiloh"all humorously characterize the same type protagonist-the"little man".Penetrating the humorous characterization,the three works on the one hand present the rational question of the mainstream society and the serious critique of the dominant forces,on the other hand,they also offer the humanistic affirm and concern of the marginalized little man.Thus,bundle these three master pieces together,this paper makes an effort to analyze the humorous characterization of the little man;the comic gender relationships so as to figure out the coherent thematic significance as well as the philosophical seriousness of humor in these three masterpieces.
基金Supported by the Shenzhen Science and Technology Innovation Committee,China(No.JCYJ20220530164600002)Scientific Research Program of Xiangjiang Philanthropy FoundationScience Research Grant of Aier Eye Hospital Group(No.AF2201D06).
文摘AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after injection.METHODS:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,respectively.The DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study period.The aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined group.RESULTS:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P<0.01).After 1mo of surgery,the concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly lower in the combined group than those of the aflibercept group(all P<0.01).The BCVA and CMT values of the two groups were statistically different after 1 and 2mo of treatment(P<0.01).However,the difference was not statistically significant after 3mo of treatment(P>0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly increased.Aflibercept and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high safety.Aflibercept combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema rapidly.However,the long-term efficacy is comparable to that of aflibercept alone.
文摘Background:B cells represent a crucial component of adaptive immunity that ensures long-term protection from infection by generating pathogen-specific immunoglobulins.Exercise alters B cell counts and immunoglobulin levels,but evidence-based conclusions on potential benefits for adaptive immunity are lacking.This systematic review assessed current literatures on the impact of acute exercise and exercise training on B cells,immunoglobulins,and markers of secretory immunity in human biofluids.Methods:According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines,MEDLINE,Web of Science,and Embase were searched on March 8,2023.Non-randomized controlled trials and crossover trials investigating the impact of acute exercise or exercise training on B cell counts and proportions,immunoglobulin levels,salivary flow rate,or secretory immunoglobulin A secretion rate were included.Quality and reporting of exercise training studies were assessed using the Tool for the Assessment of Study Quality and reporting in Exercise.Study characteristics,outcome measures,and statistically significant changes were summarized tabularly.Results:Of the 67 eligible studies,22 applied acute exercise and 45 applied exercise training.All included outcomes revealed significant alterations over time in acute exercise and exercise training context,but only a few investigations showed significant differences compared to control conditions.Secretory and plasma immunoglobulin A levels were most consistently increased in response to exercise training.Conclusion:B cell-related outcomes are altered by acute exercise and exercise training,but evidence-based conclusions cannot be drawn with high confidence due to the large heterogeneity in populations and exercise modalities.Well-designed trials with large sample sizes are needed to clarify how exercise shapes B cell-related immunity.
文摘Aqueous humor provides the necessary nutrition for the lens and transports the metabolites in the eye.It was a liquid that can directly reflect the microenvironment in the eye'and it can be easily obtained during the operation.This review intended to analyze the components of aqueous humor in patients with different types of cataracts'so as to reflect the pathogenesis and development of the disease'evaluate the incidence of postoperative complications and provide reference value for the surgical design of sequential cataract surgery.The aqueous humor components of different types of cataracts showed different degrees of inflammation'oxidative stress and extracellular matrix remodeling.The biomarker of early neuropathy in diabetic cataract was neural cell adhesion molecule-1(NCAM1).Transforming growth factor-β(TGF-β)was the evaluation factor of disease development in patients with pseudoexfoliation syndrome.The relationships between postoperative complications of different types of cataracts and aqueous humor components were as follows:Macular edema after diabetic cataract surgery was associated with tumor necrosis factor-alpha;capsular contraction after high myopic cataract surgery was related to monocyte chemoattractant protein-1(MCP-1)and TGF-β2;Klotho and glutathione S-transferase P 1(GSTP1)were associated with high intraocular pressure after primary open-angle glaucoma complicated by cataract surgery;capsular contraction after retinitis pigmentosa complicated by cataract surgery was associated with matrix metalloproteinases;pro-inflammatory cytokines and fibroblast growth factor 4 in the aqueous humor of congenital cataracts were associated with posterior capsular opacification after surgery.Granulocyte colony stimulating factor 3 and MCP-1 were the main cytokines mediating the pain of the second eye in the binocular sequential cataract surgery short interval(1 wk)'while MCP-1 mediated pain in the long interval(6 wk).The second eye after binocular sequential cataract surgery had a higher level of proinflammatory factors.The components of aqueous humor in patients with different types of cataracts were related to the pathogenesis and postoperative complications of the disease.Monitoring the components of the aqueous humor could help better understand the intraocular microenvironment of different types of cataracts and provide a reference for predicting the development of the disease and implementing relevant targeted therapy.
文摘Introduction: Following the COVID-19 pandemic, vaccination has been proposed in several countries as the main preventive measure despite very limited data, particularly in dialysis patients. We conducted this study to assess the immunological response to vaccination in Senegalese hemodialysis patients. Patients and Methods: We conducted a prospective study, in two dialysis centers in Dakar from March 30<sup>th</sup> to August 30<sup>th</sup>, 2021 including patients on hemodialysis for >6 months, vaccinated against SARS-CoV-2 according to the vaccination schedule recommended by WHO. A vaccine response was considered positive when seroconversion was observed after one dose of vaccine. The clinical efficacy of immunization was defined as the absence of new COVID-19 infection in patients who received a complete vaccination. Results: Among the 81 patients included in the study, 7.4% had anti-Spike IgM antibodies before their first vaccination. Seroprevalence of IgM antibodies was 38.3% one month after the first vaccine dose (at M1) and 8.6% one month after the second dose (at M4). Anti-Spike IgG antibodies were present in 40.3% of patients before vaccination, in 90.1% at M1, and in 59.7% at M4. Among patients previously infected with SARS-CoV-2, 10.2% had IgM antibodies at M0, 31.6% at M1, and 10.5% at M4 post-vaccination. Similarly, seroprevalences of IgG antibodies in this subgroup were 31.5%, 61.3%, and 50.0% respectively at M0, M1, and M4 post-vaccination. A comparison of seroconversion rates between M0 and M4 showed significant differences only for IgG in COVID-19 naive patients. Mean duration in dialysis and the existence of previous COVID-19 infection were associated with patients’ vaccinal response after the two doses. Age, gender and the use of immunosuppressive treatment did not influence post-vaccinal antibody production. Conclusion: Vaccination against COVID-19 in Senegalese hemodialysis patients induced a low seroconversion rate but it was well tolerated. Moreover, the induced protection was neither strong nor durable, particularly in patients with longer duration in dialysis.
文摘这是希瑟做任课老师的最后一个学期,学生们给她送了小礼物作为纪念。一个小男孩犹豫了,他在想办法让老师知道他有多在乎她。主题语境:日常生活篇幅:347词建议用时:7分钟。1 When it comes to gifts,we often say it's the thought that counts.While this can be said humorously at times,Heather Benoit is here to remind us of the truth behind this sentiment.Over a decade ago,this teacher was given a crayon by one of her students.
文摘A man went to see his doctor one daybecause he was suffering from pains in hisstomach. After the doctor had examinedhim, carefully, he said to him, "well,there’s nothing really wrong with you,
文摘I say shake the world with my laughter, and shake everything back to the right place!I remember an article called "English is a crazy language", and I totally agreewith that! Never have I been a fan of this crazy language, yet I should say, it did,in some way, change my thinking pattern. Or probably I should say it is the
