Background and Aims: Androgenetic alopecia (AGA) is a common form of hair loss in both men and women. Despite its high prevalence and associated patient morbidity, the approved therapeutic options are limited to finas...Background and Aims: Androgenetic alopecia (AGA) is a common form of hair loss in both men and women. Despite its high prevalence and associated patient morbidity, the approved therapeutic options are limited to finasteride and minoxidil. The present study is aimed at assessing the efficacy of hair serum formulation, Trichosera<sup>®</sup>containing Bone marrow-derived mesenchymal stromal cells conditioned media as an active ingredient, for hair fall control and hair regrowth in healthy Indian human volunteers. Methods: The product was made using a 20% concentration of 10X Conditioned Media along with excipients. The final product was tested for physicochemical parameters, biomarkers, total protein content and microbial limits as per our in-house specifications. Results: The primary irritation patch test showed that the product is non-irritant and dermatologically safe. A clinical study on 40 subjects was conducted to evaluate the effectiveness of the bioactive formulation in hair fall control and hair regrowth in healthy volunteers. Phototrichogram measurement showed hair density and hair growth rate increased significantly by 11.54% and 18.66% at week 24. Hair tensile strength also increased significantly by 41.10% at 12 weeks follow-up. Hair pull test, to see a reduction in pulled hair and comb’s test to show a decrease in hair fall significantly improved from week 4 onwards. There were no significant adverse events in response to the product application. Conclusion: It is concluded that the hair serum product is completely safe on direct application to the scalp and showed significant improvement in the hair growth rate, hair density, scalp condition and reduction in hair fall. .展开更多
Androgenetic alopecia (AGA) is a common form of hair loss in both men and women, it affects up to 80% of men and 50% of women during their life. The current treatments approved for AGA are limited, inconstantly effect...Androgenetic alopecia (AGA) is a common form of hair loss in both men and women, it affects up to 80% of men and 50% of women during their life. The current treatments approved for AGA are limited, inconstantly effective and might be associated with adverse events. The aim of this study was to evaluate the efficacy and safety of a botanical topical serum (SERUM THICKER) applied for 6 months in 14 males and 10 females with mild to moderate androgenetic alopecia. The hair parameters were assessed using trichoscopy images obtained with high resolution camera FotoFinder Leviacam<sup>®</sup> and analyzed with optimized software from TrichoLAB<sup>TM</sup> and Vitual tattoo<sup>TM</sup> technology. Hair loss was assessed using a wash-test procedure, and self-assessments were collected via questionnaires. Both at 28 days and 168 days, a significant increase of the hair density was observed, respectively +4.8% (p = 0.038);+11.7% (p < 0.001) for 1 application per day and +5.2% (p = 0.032);+9% (p < 0.001) for 2 applications/week. Reported to the whole scalp, this represents an estimation of hair gain of 7000 hair in 6 months for subjects applying SERUM THICKER once a day and 5000 hair for subjects applying SERUM THICKER twice then once a week. Although, the analysis of hair shedding during washing did not permit to show a time effect or any effect of the application frequency, the analysis showed a marginal time effect in the group treated once a day (p = 0.0674). Regarding efficacy on hair loss and regrowth, although no statistical analysis were performed, it seems that for all questions and for both groups the positive answers were higher after 6 months of treatment than after 1 month. SERUM THICKER represents an interesting, effective, well-tolerated and safe multitarget treatment to address mild to moderate AGA in male and female. Efficacy was observed from one application per week and seems greater once applied once daily.展开更多
文摘Background and Aims: Androgenetic alopecia (AGA) is a common form of hair loss in both men and women. Despite its high prevalence and associated patient morbidity, the approved therapeutic options are limited to finasteride and minoxidil. The present study is aimed at assessing the efficacy of hair serum formulation, Trichosera<sup>®</sup>containing Bone marrow-derived mesenchymal stromal cells conditioned media as an active ingredient, for hair fall control and hair regrowth in healthy Indian human volunteers. Methods: The product was made using a 20% concentration of 10X Conditioned Media along with excipients. The final product was tested for physicochemical parameters, biomarkers, total protein content and microbial limits as per our in-house specifications. Results: The primary irritation patch test showed that the product is non-irritant and dermatologically safe. A clinical study on 40 subjects was conducted to evaluate the effectiveness of the bioactive formulation in hair fall control and hair regrowth in healthy volunteers. Phototrichogram measurement showed hair density and hair growth rate increased significantly by 11.54% and 18.66% at week 24. Hair tensile strength also increased significantly by 41.10% at 12 weeks follow-up. Hair pull test, to see a reduction in pulled hair and comb’s test to show a decrease in hair fall significantly improved from week 4 onwards. There were no significant adverse events in response to the product application. Conclusion: It is concluded that the hair serum product is completely safe on direct application to the scalp and showed significant improvement in the hair growth rate, hair density, scalp condition and reduction in hair fall. .
文摘Androgenetic alopecia (AGA) is a common form of hair loss in both men and women, it affects up to 80% of men and 50% of women during their life. The current treatments approved for AGA are limited, inconstantly effective and might be associated with adverse events. The aim of this study was to evaluate the efficacy and safety of a botanical topical serum (SERUM THICKER) applied for 6 months in 14 males and 10 females with mild to moderate androgenetic alopecia. The hair parameters were assessed using trichoscopy images obtained with high resolution camera FotoFinder Leviacam<sup>®</sup> and analyzed with optimized software from TrichoLAB<sup>TM</sup> and Vitual tattoo<sup>TM</sup> technology. Hair loss was assessed using a wash-test procedure, and self-assessments were collected via questionnaires. Both at 28 days and 168 days, a significant increase of the hair density was observed, respectively +4.8% (p = 0.038);+11.7% (p < 0.001) for 1 application per day and +5.2% (p = 0.032);+9% (p < 0.001) for 2 applications/week. Reported to the whole scalp, this represents an estimation of hair gain of 7000 hair in 6 months for subjects applying SERUM THICKER once a day and 5000 hair for subjects applying SERUM THICKER twice then once a week. Although, the analysis of hair shedding during washing did not permit to show a time effect or any effect of the application frequency, the analysis showed a marginal time effect in the group treated once a day (p = 0.0674). Regarding efficacy on hair loss and regrowth, although no statistical analysis were performed, it seems that for all questions and for both groups the positive answers were higher after 6 months of treatment than after 1 month. SERUM THICKER represents an interesting, effective, well-tolerated and safe multitarget treatment to address mild to moderate AGA in male and female. Efficacy was observed from one application per week and seems greater once applied once daily.
