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子痫前期病人长链非编码RNA H19和长链非编码RNA HAND2-AS1表达水平与胰岛素抵抗的相关性研究
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作者 蒋天从 刘志明 +3 位作者 谷孝月 郭婉茹 石冲 戚桂杰 《安徽医药》 CAS 2024年第1期49-53,共5页
目的检测子痫前期病人胎盘组织、血清长链非编码RNA H19(LncRNA H19)与长链非编码RNAHAND2-AS1(Ln⁃cRNA HAND2-AS1)表达水平,并分析其与病人胰岛素抵抗(IR)的相关性。方法将2021年1—12月在唐山市妇幼保健院建卡的子痫前期孕妇105例作... 目的检测子痫前期病人胎盘组织、血清长链非编码RNA H19(LncRNA H19)与长链非编码RNAHAND2-AS1(Ln⁃cRNA HAND2-AS1)表达水平,并分析其与病人胰岛素抵抗(IR)的相关性。方法将2021年1—12月在唐山市妇幼保健院建卡的子痫前期孕妇105例作为子痫前期组,根据子痫前期孕妇严重程度分为轻度子痫前期组与重度子痫前期组,另选取同期孕周、年龄相符的健康孕妇97例作为对照组,收集所有孕妇身体质量指数(BMI)、孕周、收缩压、舒张压、空腹胰岛素(FINS)、空腹血糖(FBG)等一般资料,并计算稳态模型的IR指数(HOMA-IR);实时荧光定量PCR(qRT-PCR)法测定孕妇血清、胎盘组织中LncRNA H19,LncRNA HAND2-AS1水平;比较对照组与子痫前期组、轻度子痫前期组与重度子痫前期组间血清、胎盘组织LncRNA H19、LncRNA HAND2-AS1水平;Pearson法分析子痫前期孕妇血清、胎盘组织LncRNA H19、LncRNA HAND2-AS1与HOMA-IR的相关性。结果子痫前期组病人收缩压、舒张压高于对照组(P<0.05),且重度子痫前期病人收缩压、舒张压高于轻度子痫前期病人,孕周低于轻度子痫前期病人(P<0.05);与对照组相比,子痫前期组孕妇24 h尿蛋白、FBG[(5.84±0.97)mmol/L比(4.22±0.70)mmol/L]、FINS[(13.37±2.23)mU/L比(7.52±1.25)mU/L]、HOMI-IR水平(3.47±0.57比1.41±0.23)升高(P<0.05),且重度子痫前期孕妇24 h尿蛋白、FBG[(6.90±1.15)mmol/L比(5.24±0.85)mmol/L]、FINS[(13.97±2.32)mU/L比(13.05±2.17)mU/L]、HOMI-IR水平(4.27±0.71比3.03±0.50)高于轻度子痫前期孕妇(P<0.05);与对照组相比,子痫前期组孕妇血清、胎盘组织Ln⁃cRNA H19(2.52±1.42比1.01±0.15,3.75±0.62比1.02±0.17)与LncRNA HAND2-AS1水平(1.98±0.33比1.01±0.15,2.87±0.47比1.02±0.17)升高(P<0.05),且重度子痫前期孕妇血清、胎盘组织LncRNA H19(2.84±0.47比2.34±0.39,4.28±0.71比3.45±0.57)与LncRNA HAND2-AS1水平(2.59±0.43比1.63±0.27,3.56±0.59比2.49±0.41)高于轻度子痫前期孕妇(P<0.05);子痫前期病人血清与胎盘组织间LncRNA H19水平呈正相关(r=0.55,P<0.05),血清与胎盘组织间LncRNA HAND2-AS1水平呈正相关性(r=0.65,P<0.05)。子痫前期孕妇血清、胎盘组织LncRNA H19水平分别与HOMI-IR呈正相关(r=0.53、0.59,P<0.05);血清、胎盘组织LncRNA HAND2-AS1水平分别与HOMI-IR呈正相关(r=0.60、0.61,P<0.05)。结论子痫前期病人血清、胎盘组织LncRNA H19、LncRNA HAND2-AS1高表达,二者与IR密切相关,可能通过影响IR参与子痫前期发生发展。 展开更多
关键词 先兆子痫 RNA 长链非编码 LncRNA H19 LncRNA hand2-AS1 胰岛素抵抗
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基于HAND的流域洪水淹没快速分析技术
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作者 王述强 吕凯 +3 位作者 刘祥林 师鹏飞 肖家清 郝晓博 《水文》 CSCD 北大核心 2024年第2期57-65,共9页
快速分析计算流域洪水淹没,对于防洪具有重要作用,而基于水动力学模型的经典淹没算法在时效性方面存在不足,制约防洪“四预”功能实现和数字孪生流域建设。针对此,本文建立了基于HAND(Height Above Nearest Drainage)的形态淹没模型,用... 快速分析计算流域洪水淹没,对于防洪具有重要作用,而基于水动力学模型的经典淹没算法在时效性方面存在不足,制约防洪“四预”功能实现和数字孪生流域建设。针对此,本文建立了基于HAND(Height Above Nearest Drainage)的形态淹没模型,用于快速分析流域洪水淹没情况,在乐安河流域上游进行了应用验证。结果表明,模型可在5秒内完成洪水淹没计算,对四场历史洪水和三场设计洪水淹没范围的总体模拟精度平均为0.95,达到水动力学模型的模拟精度;对淹没水深的模拟存在较大误差,平均误差为0.79 m。基于HAND的形态淹没模型可快速绘制全流域洪水淹没范围图,大幅提升影响预报和防洪预演的时效性水平。 展开更多
关键词 hand 形态淹没模型 洪水淹没分析 HEC-RAS模型
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基于隐喻与转喻的人体多义词hand的认知研究及其教学启示
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作者 付爽 丰玉芳 《英语教师》 2024年第4期13-16,共4页
人体是人类认知世界的起点,人体词的义项拓展严格遵循隐喻、转喻路径进行生成和演化。为帮助英语学习者更好地理解、记忆多义词,从隐喻映射和转喻映射角度出发,考察人体多义词hand的义项拓展路径及其类别。研究发现,hand的义项派生共有... 人体是人类认知世界的起点,人体词的义项拓展严格遵循隐喻、转喻路径进行生成和演化。为帮助英语学习者更好地理解、记忆多义词,从隐喻映射和转喻映射角度出发,考察人体多义词hand的义项拓展路径及其类别。研究发现,hand的义项派生共有七种映射路径,分别为基本、抽象、人物、形貌、意动、计量、修饰,并探讨如何基于人体词分析其他多义词的义项拓展,尝试为二语词汇学习和教学提供思路。 展开更多
关键词 隐喻 转喻 映射 多义词 hand
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Tenosynovitis of hand: Causes and complications
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作者 Sathish Muthu Saravanan Annamalai Velmurugan Kandasamy 《World Journal of Clinical Cases》 SCIE 2024年第4期671-676,共6页
Tenosynovitis represents a common clinical condition characterized by inflam-mation of the synovium that encases the tendon sheath.Although tenosynovities may be noted in any tendon in the body,extremities such as han... Tenosynovitis represents a common clinical condition characterized by inflam-mation of the synovium that encases the tendon sheath.Although tenosynovities may be noted in any tendon in the body,extremities such as hand,and foot remain the sites of high predilection to acquire this condition.The predominant cause of this predilection rests in the intricate tendon arrangements in these extremities that permit fine motor actions.This editorial explores the common causes and the complications associated with this condition to improve the understanding of the readers of this common condition encountered in our everyday clinical practice. 展开更多
关键词 TENOSYNOVITIS GOUT hand COMPLICATIONS INFECTION
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Japanese Sign Language Recognition by Combining Joint Skeleton-Based Handcrafted and Pixel-Based Deep Learning Features with Machine Learning Classification
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作者 Jungpil Shin Md.Al Mehedi Hasan +2 位作者 Abu Saleh Musa Miah Kota Suzuki Koki Hirooka 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第6期2605-2625,共21页
Sign language recognition is vital for enhancing communication accessibility among the Deaf and hard-of-hearing communities.In Japan,approximately 360,000 individualswith hearing and speech disabilities rely on Japane... Sign language recognition is vital for enhancing communication accessibility among the Deaf and hard-of-hearing communities.In Japan,approximately 360,000 individualswith hearing and speech disabilities rely on Japanese Sign Language(JSL)for communication.However,existing JSL recognition systems have faced significant performance limitations due to inherent complexities.In response to these challenges,we present a novel JSL recognition system that employs a strategic fusion approach,combining joint skeleton-based handcrafted features and pixel-based deep learning features.Our system incorporates two distinct streams:the first stream extracts crucial handcrafted features,emphasizing the capture of hand and body movements within JSL gestures.Simultaneously,a deep learning-based transfer learning stream captures hierarchical representations of JSL gestures in the second stream.Then,we concatenated the critical information of the first stream and the hierarchy of the second stream features to produce the multiple levels of the fusion features,aiming to create a comprehensive representation of the JSL gestures.After reducing the dimensionality of the feature,a feature selection approach and a kernel-based support vector machine(SVM)were used for the classification.To assess the effectiveness of our approach,we conducted extensive experiments on our Lab JSL dataset and a publicly available Arabic sign language(ArSL)dataset.Our results unequivocally demonstrate that our fusion approach significantly enhances JSL recognition accuracy and robustness compared to individual feature sets or traditional recognition methods. 展开更多
关键词 Japanese Sign Language(JSL) hand gesture recognition geometric feature distance feature angle feature GoogleNet
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Virtual Keyboard:A Real-Time Hand Gesture Recognition-Based Character Input System Using LSTM and Mediapipe Holistic
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作者 Bijon Mallik Md Abdur Rahim +2 位作者 Abu Saleh Musa Miah Keun Soo Yun Jungpil Shin 《Computer Systems Science & Engineering》 2024年第2期555-570,共16页
In the digital age,non-touch communication technologies are reshaping human-device interactions and raising security concerns.A major challenge in current technology is the misinterpretation of gestures by sensors and... In the digital age,non-touch communication technologies are reshaping human-device interactions and raising security concerns.A major challenge in current technology is the misinterpretation of gestures by sensors and cameras,often caused by environmental factors.This issue has spurred the need for advanced data processing methods to achieve more accurate gesture recognition and predictions.Our study presents a novel virtual keyboard allowing character input via distinct hand gestures,focusing on two key aspects:hand gesture recognition and character input mechanisms.We developed a novel model with LSTM and fully connected layers for enhanced sequential data processing and hand gesture recognition.We also integrated CNN,max-pooling,and dropout layers for improved spatial feature extraction.This model architecture processes both temporal and spatial aspects of hand gestures,using LSTM to extract complex patterns from frame sequences for a comprehensive understanding of input data.Our unique dataset,essential for training the model,includes 1,662 landmarks from dynamic hand gestures,33 postures,and 468 face landmarks,all captured in real-time using advanced pose estimation.The model demonstrated high accuracy,achieving 98.52%in hand gesture recognition and over 97%in character input across different scenarios.Its excellent performance in real-time testing underlines its practicality and effectiveness,marking a significant advancement in enhancing human-device interactions in the digital age. 展开更多
关键词 hand gesture recognition M.P.holistic open CV virtual keyboard LSTM human-computer interaction
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Application of PDCA Cycle in Hand Hygiene Management of Psychiatric Medical Staff
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作者 Li Xiang Weidong Liu +1 位作者 Guiying Chen Mei Liu 《Journal of Clinical and Nursing Research》 2024年第3期152-157,共6页
Objective:To study the application effect of the plan-do-check-act(PDCA)cycle management in the hand hygiene management of psychiatric medical staff.Methods:One hundred and twenty medical staff from a psychiatric hosp... Objective:To study the application effect of the plan-do-check-act(PDCA)cycle management in the hand hygiene management of psychiatric medical staff.Methods:One hundred and twenty medical staff from a psychiatric hospital from May 2023 to December 2023 were selected and divided into two groups.The control group(May 2023 to August 2023)applied the conventional management model,and the observation group(September 2023 to December 2023)applied the PDCA cycle management.The hand hygiene compliance,hand hygiene knowledge,and hygiene qualifications were compared,including the amount of hand sanitizer used.Results:The proportion of medical staff’s hand hygiene compliance and hand hygiene knowledge mastery scores in the observation group were higher than those in the control group(P<0.05);the hand hygiene passing rate in the observation group was higher than that of the control group(P<0.05);the daily amount of hand sanitizer per patient bed and the amount of hand sanitizer used was higher than that of the control group(P<0.05).Conclusion:The PDCA cycle management model for psychiatric medical staff promoted the improvement of hand hygiene compliance and increased their hand hygiene qualifications.It is suitable for further popularization and application in future clinical practice. 展开更多
关键词 PSYCHIATRY PDCA cycle management hand hygiene management COMPLIANCE
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lncRNA HAND2-AS1通过调节miR-21表达对子宫内膜异位症患者子宫内膜基质细胞迁移和侵袭的抑制作用
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作者 苗卉 苗聪秀 +1 位作者 李娜 韩晶 《吉林大学学报(医学版)》 CAS CSCD 北大核心 2023年第3期733-741,共9页
目的:探讨子宫内膜异位症(EMT)患者子宫内膜组织中长链非编码RNAs(lncRNAs)HAND2-AS1对异位子宫内膜(EC)组织中子宫内膜基质细胞(ESCs)增殖、迁移和侵袭能力的影响,并阐明其可能机制。方法:收集30例EMT患者(EMT组)的EC组织和30例健康育... 目的:探讨子宫内膜异位症(EMT)患者子宫内膜组织中长链非编码RNAs(lncRNAs)HAND2-AS1对异位子宫内膜(EC)组织中子宫内膜基质细胞(ESCs)增殖、迁移和侵袭能力的影响,并阐明其可能机制。方法:收集30例EMT患者(EMT组)的EC组织和30例健康育龄女性(对照组)的子宫内膜组织,分离子宫内膜组织获取ESCs。采用脂质体转染法转染EMT患者EC组织的ESCs,并将ESCs分为pcDNA组(转染pcDNA空质粒)、HAND2-AS1组(转染HAND2-AS1过表达质粒)、mimic NC组(转染mimic NC)、miR-21 mimic组(转染miR-21 mimic)、pcDNA+mimic NC组(联合转染pcDNA和mimic NC)、HAND2-AS1+mimic NC组(联合转染HAND2-AS1过表达质粒和mimic NC)、pcDNA+miR-21 mimic组(联合转染pcDNA空质粒和miR-21 mimic)和HAND2-AS1+miR-21 mimic组(联合转染HAND2-AS1过表达质粒和miR-21 mimic),另设未转染的细胞为空白对照组。采用实时荧光定量PCR(RT-qPCR)法检测2组研究对象子宫内膜组织和ESCs中HAND2-AS1 mRNA和miR-21表达水平,采用Pearson相关系数分析其相关性。采用生物信息学软件Starbase预测lncRNA HAND2-AS1与miR-21的靶向作用关系,荧光素酶基因报告实验进行验证。CCK-8法检测各组ESCs增殖活性,Transwell小室实验检测ESCs的迁移和侵袭数。结果:2组研究对象年龄、体质量指数(BMI)和血清中卵泡刺激素(FSH)、黄体生成素(LH)及催乳素(PRL)水平比较差异均无统计学意义(P<0.05)。与对照组比较,EMT组患者血清中雌二醇(E2)水平升高(P<0.05),EMT组患者EC组织中HAND2-AS1 mRNA表达水平降低(P<0.05),miR-21表达水平升高(P<0.05);与对照组比较,EMT组ESCs中HAND2-AS1 mRNA表达水平降低(P<0.05),miR-21表达水平明显升高(P<0.01)。Pearson相关系数分析,对照组研究对象HAND2-AS1与miR-21表达水平无明显相关性(r=0.34,P>0.05),EMT组患者ES组织中和ESCs中HAND2-AS1与miR-21表达水平呈负相关关系(r=-0.57,P<0.05)。RT-qPCR法检测,与空白对照组比较,HAND2-AS1组ESCs中HAND2-AS1 mRNA表达水平明显升高(P<0.01),miR-21 mimic组ESCs中miR-21表达水平明显升高(P<0.01),HAND2-AS1+mimic NC组ESCs中miR-21表达水平降低(P<0.05),pcDNA+miR-21 mimic组ESCs中miR-21表达水平明显升高(P<0.01);与pcDNA+miR-21 mimic组比较,HAND2-AS1+miR-21 mimic组ESCs中miR-21表达水平降低(P<0.05)。lncRNA HAND2-AS1与miR-21存在潜在结合位点;双荧光素酶基因报告实验,与mimic NC组比较,miR-21 mimic组HAND2-AS1-WT中荧光素酶活性明显降低(P<0.01)。与空白对照组比较,HAND2-AS1+mimic NC组ESCs增殖活性、迁移和侵袭数均明显降低(P<0.05或P<0.01),pcDNA+miR-21 mimic组ESCs增殖活性、迁移和侵袭数升高(P<0.05);与pcDNA+miR-21 mimic组比较,HAND2-AS1+miR-21 mimic组ESCs增殖活性、迁移和侵袭数均降低(P<0.05)。结论:HAND2-AS1在EMT患者EC组织和ESCs中表达明显降低,其可通过靶向抑制miR-21表达下调EC组织中ESCs的增殖、迁移和侵袭,从而参与EMT的发生发展。 展开更多
关键词 子宫内膜异位症 异位子宫内膜 长链非编码RNA hand2-AS1 MIR-21 子宫内膜基质细胞 细胞迁移 细胞侵袭
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An Adaptive Hand Exoskeleton for Teleoperation System
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作者 Wei Wei Bangda Zhou +3 位作者 Bingfei Fan Mingyu Du Guanjun Bao Shibo Cai 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第3期123-134,共12页
Teleoperation can assist people to complete various complex tasks in inaccessible or high-risk environments,in which a wearable hand exoskeleton is one of the key devices.Adequate adaptability would be available to en... Teleoperation can assist people to complete various complex tasks in inaccessible or high-risk environments,in which a wearable hand exoskeleton is one of the key devices.Adequate adaptability would be available to enable the master hand exoskeleton to capture the motion of human fingers and reproduce the contact force between the slave hand and its object.This paper presents a novel finger exoskeleton based on the cascading four-link closed-loop kinematic chain.Each finger has an independent closed-loop kinematic chain,and the angle sensors are used to obtain the finger motion including the flexion/extension and the adduction/abduction.The cable tension is changed by the servo motor to transmit the contact force to the fingers in real time.Based on the finger exoskeleton,an adaptive hand exoskeleton is consequently developed.In addition,the hand exoskeleton is tested in a master-slave system.The experiment results show that the adaptive hand exoskeleton can be worn without any mechanical constraints,and the slave hand can follow the motions of each human finger.The accuracy and the real-time capability of the force reproduction are validated.The proposed adaptive hand exoskeleton can be employed as the master hand to remotely control the humanoid five-fingered dexterous slave hand,thus,enabling the teleoperation system to complete complex dexterous manipulation tasks. 展开更多
关键词 hand exoskeleton Humanoid dexterous hand TELEOPERATION Motion capture Force-reproduction
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Variations in the Biomechanics of 16 Palmar Hand Regions Related to Tomato Picking
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作者 Xue An Zhiguo Li +2 位作者 Jun Fu Tobi Fadiji Sheng Zhang 《Journal of Bionic Engineering》 SCIE EI CSCD 2023年第1期278-290,共13页
The aim of this study is to systematically reveal the differences in the biomechanics of 16 hand regions related to bionic picking of tomatoes.The biomechanical properties(peak loading force,elastic coefficient,maximu... The aim of this study is to systematically reveal the differences in the biomechanics of 16 hand regions related to bionic picking of tomatoes.The biomechanical properties(peak loading force,elastic coefficient,maximum percentage deformation and interaction contact mechanics between human hand and tomato fruit)of each hand region were experimentally measured and covariance analyzed.The results revealed that there were significant variations in the assessed biomechanical properties between the 16 hand regions(p<0.05).The maximum pain force threshold(peak loading force in I2 region)was 5.11 times higher than the minimum pain force threshold(in Th1 region).It was found that each hand region in its normal direction can elastically deform by at least 15.30%.The elastic coefficient of the 16 hand regions ranged from 0.22 to 2.29 N mm−1.The interaction contact force acting on the fruit surface was affected by the selected human factors and fruit features.The obtained covariance models can quantitatively predict all of the above biomechanical properties of 16 hand regions.The findings were closely related to hand grasping performance during tomato picking,such as soft contact,surface interaction,stable and dexterous grasping,provided a foundation for developing a high-performance tomato-picking bionic robotic hand. 展开更多
关键词 Human hand.Bionic grasping Elastic deformation Tomato picking Robotic hand
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Hand Hygiene by Ward Staff at Dapaong Regional Hospital in Togo
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作者 Essohanam Tabana Mouzou Sarakawabalo Assenouwe +2 位作者 Eyram Yoan Makafui Amekoudi Tchaa Hodabalo Towoezim Tchetike Pikabalo 《Open Journal of Nursing》 2023年第2期95-112,共18页
Introduction: Hand hygiene (HH) is an effective way to fight infections in healthcare settings. The general purpose of our study was to explore the knowledge, attitudes and practices of health care providers on HH at ... Introduction: Hand hygiene (HH) is an effective way to fight infections in healthcare settings. The general purpose of our study was to explore the knowledge, attitudes and practices of health care providers on HH at Dapaong regional hospital (DRH). Methodology: This was a prospective, descriptive cross-sectional study conducted from March to June 2022 in the DRH wards. Data were collected using a questionnaire and observation grid. Results: 90 care providers were surveyed. Males and non-physician personnel predominated with 57.8%, and 94.4% respectively. The survey on staff’s knowledge reported: 31.1% of practitioners did not wash their hands on arrival and departure in services. 24% did not know the difference between simple hand washing (SHW) and hygienic hand washing (HHW). 23.3% did not know the type of soap to use for HHW. The caregivers did not know the type of hand washing (HW) required after a septic and non-septic procedure in respectively 41.6%, and 37.8%. They did not know that there are two types of hand antiseptics (45.4%), nor the amount of antiseptic for HW (78.9%). The survey on staff’s attitude regarding HW found that: 70% did not remove all jewels prior HW, and 51.1% did not know that wearing gloves cannot replace the HW. For HW Staff Practice: 62.2% did not wash their hands before treatment. 91.1% did not spread the soap on their hands and forearms after wetting them. 65.55% did not rinse hands from nails to elbows. Conclusion: The HH was poorly known, the attitude of the staff was dangerous in relation to the HH and the practice of HH was very inadequate at the RHC-Dapaong. As a result, there is a need to retrain staff to increase their capacity to prevent care-related infections and enhance patient safety in the hospital. 展开更多
关键词 hand Hygiene Care Providers hand Washing ANTISEPTICS Dapaong Regional Hospital
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Cost Efficient Automated Fog Spraying Machine: A Covid-19 Hand Sanitization Solution
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作者 M.Atikur Rahman Amranur Rahman +1 位作者 Arman Hossain Arifur Rahman Bhuiyan 《Journal of New Media》 2023年第1期33-43,共11页
As a result of the introduction of new infectious illnesses,key infection prevention measures were implemented.Now,a new coronavirus(SARS-CoV-2)epidemic has expanded swiftly,causing the coronavirus illness 2019(COVID-... As a result of the introduction of new infectious illnesses,key infection prevention measures were implemented.Now,a new coronavirus(SARS-CoV-2)epidemic has expanded swiftly,causing the coronavirus illness 2019(COVID-19).Many microorganisms spread illness via hospital surfaces due to environmental pollution.This virus has been associated to close contact between persons in tight situations such as houses,hospitals,assisted living,and residential institutions.Aside from health care settings,public buildings,faith-based community centers,marketplaces,transportation,and corporate environments are prone to COVID-19 transmission.Physical contact to the sanitizer device may cause for spread Covid virus.That’s why we have pro-posed an automatic fogger mechanism-based hand sanitizer that may able to reduce covid risk.Disinfectant fog will flow when object will pass through the machine.This project will save cost,time and wastage along with Covid spreading risk.This project is about designing a good healthcare system.In recent years,sophisticated automation has influenced the health industry.Health care in poor nations is costly.So,the project is an attempt to tackle this issue. 展开更多
关键词 Covid-19 hand sanitization fogger DISINFECTANT AUTOMATION hand spray
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室间隔缺损与HAND2基因罕见变异的关联分析
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作者 李美琨 逄淑超 闫波 《中国当代儿科杂志》 CAS CSCD 北大核心 2023年第4期388-393,共6页
目的对室间隔缺损(ventricular septal defect,VSD)与HAND2基因启动子区罕见变异的关联性进行分析,并对相关分子机制进行初步探索。方法收集349例VSD组患儿和345例健康对照组儿童血液样本,通过聚合酶链反应扩增目的片段并进行测序,确定H... 目的对室间隔缺损(ventricular septal defect,VSD)与HAND2基因启动子区罕见变异的关联性进行分析,并对相关分子机制进行初步探索。方法收集349例VSD组患儿和345例健康对照组儿童血液样本,通过聚合酶链反应扩增目的片段并进行测序,确定HAND2基因启动子区的罕见变异位点。使用双荧光素酶检测进行变异位点功能分析,并通过电泳迁移率变动分析进行分子机制研究,同时使用TRANSFAC和JASPAR数据库预测转录因子。结果通过测序发现3个变异位点(g.173530852A>G、g.173531173A>G和g.173531213C>G)只出现在10例VSD患儿的HAND2基因启动子上,其中4例患儿仅有1个变异位点。双荧光素酶检测显示g.173531213C>G降低了HAND2基因启动子转录活性。电泳迁移率变动分析和转录因子预测提示g.173531213C>G产生了1个转录因子结合位点。结论HAND2基因启动子区的罕见变异g.173531213C>G可能通过影响转录因子的结合,进而参与VSD的发生发展。 展开更多
关键词 室间隔缺损 hand2基因 罕见变异 儿童
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HAND2在子宫内膜生理和疾病中的作用研究
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作者 董晓丹 李全喜 苗聪秀 《长治医学院学报》 2023年第5期392-396,共5页
碱性螺旋-环-螺旋(basie helix-loop helix,bHLH)蛋白是与各类细胞核组织的发育和功能相关的转录因子。1989年第1条bHLH被解析发现[1],至今已共有1000余条bHLH在不同物种中被鉴定[2]。2002年,LEDENT等[3]对人类基因组进行分析,共发现125... 碱性螺旋-环-螺旋(basie helix-loop helix,bHLH)蛋白是与各类细胞核组织的发育和功能相关的转录因子。1989年第1条bHLH被解析发现[1],至今已共有1000余条bHLH在不同物种中被鉴定[2]。2002年,LEDENT等[3]对人类基因组进行分析,共发现125个bHLH家族成员。这些成员在包括真核生物的生长发育调控中起着非常重要的作用. 展开更多
关键词 心脏神经脊衍生物表达转录因子 hand2 子宫内膜
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基于双目eye in hand系统的多角度树干位姿估计方法
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作者 王欢 徐秀进 +1 位作者 王红军 温志庆 《自动化与信息工程》 2023年第5期38-45,共8页
针对采摘机器人自主行走导航过程中,难以准确定位其与果树之间的相对位置,难以准确估计果树树干姿态的问题,提出基于双目eye in hand系统的多角度树干位姿估计方法。利用YOLOv5深度学习方法与半全局块匹配算法识别树干并生成局部点云;... 针对采摘机器人自主行走导航过程中,难以准确定位其与果树之间的相对位置,难以准确估计果树树干姿态的问题,提出基于双目eye in hand系统的多角度树干位姿估计方法。利用YOLOv5深度学习方法与半全局块匹配算法识别树干并生成局部点云;利用半径滤波和体素滤波减少树干点云数据;利用闭环式手眼标定方法对双目eye in hand系统进行标定,并对同一树干多角度相机位置的点云数据进行拼接;利用随机抽样一致(RANSAC)算法与无约束最小二乘法估计并优化树干的位置和姿态,获取树干的圆柱体参数。通过对30幅标定板图像进行实验,闭环式手眼标定方法的平均欧式误差为3.7177 mm;采用半径滤波和体素滤波可减少98.470%的点云数据;采用RANSAC算法、圆柱体估计算法拟合树干点云数据,得到圆柱体的半径r=41.2771 mm,R_(MAE)=2.57156 mm,R_(RMSE)=2.98936 mm;无约束最小二乘法优化后r=39.4028 mm,R_(MAE)=1.98955 mm,R_(RMSE)=2.46588 mm。该文通过对双目eye in hand系统进行标定,建立坐标系转换关系,多角度采集环境信息,准确定位机器人与果树之间的相对位置,估计果树树干的姿态。 展开更多
关键词 eye in hand手眼标定 局部立体匹配 树干圆柱体估计 多角度点云拼接
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A Novel SE-CNN Attention Architecture for sEMG-Based Hand Gesture Recognition
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作者 Zhengyuan Xu Junxiao Yu +4 位作者 Wentao Xiang Songsheng Zhu Mubashir Hussain Bin Liu Jianqing Li 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第1期157-177,共21页
In this article,to reduce the complexity and improve the generalization ability of current gesture recognition systems,we propose a novel SE-CNN attention architecture for sEMG-based hand gesture recognition.The propo... In this article,to reduce the complexity and improve the generalization ability of current gesture recognition systems,we propose a novel SE-CNN attention architecture for sEMG-based hand gesture recognition.The proposed algorithm introduces a temporal squeeze-and-excite block into a simple CNN architecture and then utilizes it to recalibrate the weights of the feature outputs from the convolutional layer.By enhancing important features while suppressing useless ones,the model realizes gesture recognition efficiently.The last procedure of the proposed algorithm is utilizing a simple attention mechanism to enhance the learned representations of sEMG signals to performmulti-channel sEMG-based gesture recognition tasks.To evaluate the effectiveness and accuracy of the proposed algorithm,we conduct experiments involving multi-gesture datasets Ninapro DB4 and Ninapro DB5 for both inter-session validation and subject-wise cross-validation.After a series of comparisons with the previous models,the proposed algorithm effectively increases the robustness with improved gesture recognition performance and generalization ability. 展开更多
关键词 hand gesture recognition SEMG CNN temporal squeeze-and-excite ATTENTION
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Hybrid Static-dynamic Sensation Electrotactile Feedback for Hand Prosthesis Tactile and Proprioception Feedback
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作者 Bin Yang Li Jiang 《Journal of Bionic Engineering》 SCIE EI CSCD 2023年第1期267-277,共11页
Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate mu... Tactile and proprioception feedback are essential to myoelectric hand prostheses control for regaining functionality of lost hands of amputees.Current studies focus on tactile feedback,while the lack of appropriate multisensory feedback,especially proprioception feedback,limits the grasping quality.Additionally,a typical non-invasive stimulation scheme for sensation feedback uses stimulation on the stationary site of the skin continuously,which can lead to fatigue and adaptation of sensation,further reduces the feedback consistency,and increases the cognitive burden for the subject.Considering the sensitivity and modality matching of sensation,this study presented a multimodal sensations feedback scheme based on hybrid static-dynamic sensation elicited by multisite Transcutaneous Electrical Nerve Stimulation(TENS)to deliver grasping force and joint position feedback.In the proposed scheme,stimulation of single electrode produced only in-loco tactile sensation under the electrode,and the sensation intensity was adjusted according to grasping force;sequential activation of multi-electrodes produced an illusion dynamic sensation of a stimulus moving,and the velocity and direction of movement were adjusted according to finger joint position.Psychometric test results demonstrated the identifiability of stimulus in the proposed scheme.Further,prosthetic hand closed-loop grasping tasks evaluate the effectiveness of the proposed feedback scheme.The results showed that the proposed feedback scheme could substantially improve the grasping accuracy and efficiency.In addition,the study outcomes also demonstrated the benefit of artificial proprioception feedback in grasping rapidity and security. 展开更多
关键词 TENS-Prosthetic hand control-Bioinspired sensation-Multimodal sensations Proprioception feedback Tactilefeedback Myoelectric control
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Computational Investigation of Hand Foot Mouth Disease Dynamics with Fuzziness
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作者 Dumitru Baleanu Fazal Dayan +3 位作者 Nauman Ahmed Muhammad Rafiq Ali Raza Muhammad Ozair Ahmad 《Computers, Materials & Continua》 SCIE EI 2023年第5期4175-4189,共15页
The first major outbreak of the severely complicated hand,foot and mouth disease(HFMD),primarily caused by enterovirus 71,was reported in Taiwan in 1998.HFMD surveillance is needed to assess the spread of HFMD.The par... The first major outbreak of the severely complicated hand,foot and mouth disease(HFMD),primarily caused by enterovirus 71,was reported in Taiwan in 1998.HFMD surveillance is needed to assess the spread of HFMD.The parameters we use in mathematical models are usually classical mathematical parameters,called crisp parameters,which are taken for granted.But any biological or physical phenomenon is best explained by uncertainty.To represent a realistic situation in any mathematical model,fuzzy parameters can be very useful.Many articles have been published on how to control and prevent HFMD from the perspective of public health and statistical modeling.However,few works use fuzzy theory in building models to simulateHFMDdynamics.In this context,we examined anHFMD model with fuzzy parameters.A Non Standard Finite Difference(NSFD)scheme is developed to solve the model.The developed technique retains essential properties such as positivity and dynamic consistency.Numerical simulations are presented to support the analytical results.The convergence and consistency of the proposed method are also discussed.The proposed method converges unconditionally while the many classical methods in the literature do not possess this property.In this regard,our proposed method can be considered as a reliable tool for studying the dynamics of HFMD. 展开更多
关键词 hand foot mouth disease fuzzy parameters NSFD scheme CONVERGENCE CONSISTENCY
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Ponseti Treatment of Bilateral Idiopathic Clubfoot: Does the Hand Dominance of the Provider Make a Difference?
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作者 Chukwuka Ozumba Udemezue Peace Ifeoma Amaraegbulam +1 位作者 Kenechi Anthony Madu Ekene Isikaku 《Journal of Biosciences and Medicines》 CAS 2023年第3期1-8,共8页
Introduction: Congenital talipes equinovarus (CTEV) is the commonest musculoskeletal deformity worldwide. The Ponseti technique is the goal standard for clubfoot treatment. During the correction phase, the provider’s... Introduction: Congenital talipes equinovarus (CTEV) is the commonest musculoskeletal deformity worldwide. The Ponseti technique is the goal standard for clubfoot treatment. During the correction phase, the provider’s right hand manipulates the right foot and the left hand, left foot. Often, one foot is ready for Achilles tenotomy before the other in bilateral clubfoot. Objective: To determine the effect of the provider’s hand dominance would have on bilateral clubfoot treated with the Ponseti technique. Method: This was a prospective cross-sectional study that analyzed idiopathic bilateral clubfoot patients aged 0 - 5 years and treated using the Ponseti technique at FMC Umuahia from October 2019 to September 2020. Informed consent and ethical clearance were obtained. The Pirani scores were obtained and compared at presentation and at each clinic visit. All trained manipulators were right-handed. Two-tailed t-test was used and a p-value less than 0.05 was deemed significant. Results: Forty-seven patients participated in the study with an M:F of 2.6:1 and mean age of 13.79 ± 13.39 months. Thirty-six patients (76.6%) had the same Pirani score on both feet at presentation, while the right and left feet were more severely affected in 8 and 3 cases respectively. The mean number of casts before readiness for tenotomy was 4.95 on the right and 5.28 on the left with p-value of 0.042. Conclusion: Though the right foot had a worse mean Pirani score on presentation, however, it required fewer casts before readiness for tenotomy than the left. 展开更多
关键词 hand Dominance BILATERAL CLUBFOOT Ponseti Technique
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Appearance Based Dynamic Hand Gesture Recognition Using 3D Separable Convolutional Neural Network
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作者 Muhammad Rizwan Sana Ul Haq +4 位作者 Noor Gul Muhammad Asif Syed Muslim Shah Tariqullah Jan Naveed Ahmad 《Computers, Materials & Continua》 SCIE EI 2023年第7期1213-1247,共35页
Appearance-based dynamic Hand Gesture Recognition(HGR)remains a prominent area of research in Human-Computer Interaction(HCI).Numerous environmental and computational constraints limit its real-time deployment.In addi... Appearance-based dynamic Hand Gesture Recognition(HGR)remains a prominent area of research in Human-Computer Interaction(HCI).Numerous environmental and computational constraints limit its real-time deployment.In addition,the performance of a model decreases as the subject’s distance from the camera increases.This study proposes a 3D separable Convolutional Neural Network(CNN),considering the model’s computa-tional complexity and recognition accuracy.The 20BN-Jester dataset was used to train the model for six gesture classes.After achieving the best offline recognition accuracy of 94.39%,the model was deployed in real-time while considering the subject’s attention,the instant of performing a gesture,and the subject’s distance from the camera.Despite being discussed in numerous research articles,the distance factor remains unresolved in real-time deployment,which leads to degraded recognition results.In the proposed approach,the distance calculation substantially improves the classification performance by reducing the impact of the subject’s distance from the camera.Additionally,the capability of feature extraction,degree of relevance,and statistical significance of the proposed model against other state-of-the-art models were validated using t-distributed Stochastic Neighbor Embedding(t-SNE),Mathew’s Correlation Coefficient(MCC),and the McNemar test,respectively.We observed that the proposed model exhibits state-of-the-art outcomes and a comparatively high significance level. 展开更多
关键词 3D separable CNN computational complexity hand gesture recognition human-computer interaction
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