Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA<sub>1c</sub>).Methods:Samples were collected from 128 type ...Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA<sub>1c</sub>).Methods:Samples were collected from 128 type 2 diabetic patients（aged 19-90 years;male 72,female 56）.The sera were analyzed for HbA<sub>1c</sub>,total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C）.According to the HbA<sub>1e</sub> level,the patients were divided into three groups,group A(HbA<sub>?</sub>【7%,n=31),group B(7%【HbA<sub>1c</sub>【10%,n=48),and group C(HbA<sub>1c</sub>】10%,n=49).The correlation of HbA<sub>1c</sub>with lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA（1c）,LDL-C had a significantly increasing trend（P【0.05）;whereas TC went up with the increased HbA（1c）,without any significant differences between three groups.There was no significant correlation between HbA<sub>1c</sub> and TG or HDL-C. With the increased level of HbA<sub>1c</sub>,TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups（P【0.05）.The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.展开更多
文摘Objective:To study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin(HbA<sub>1c</sub>).Methods:Samples were collected from 128 type 2 diabetic patients（aged 19-90 years;male 72,female 56）.The sera were analyzed for HbA<sub>1c</sub>,total cholesterol（TC）,triglycerides（TG）,high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C）.According to the HbA<sub>1e</sub> level,the patients were divided into three groups,group A(HbA<sub>?</sub>【7%,n=31),group B(7%【HbA<sub>1c</sub>【10%,n=48),and group C(HbA<sub>1c</sub>】10%,n=49).The correlation of HbA<sub>1c</sub>with lipid ratios & individual lipid indexes were analyzed.Results:With the increased level of HbA（1c）,LDL-C had a significantly increasing trend（P【0.05）;whereas TC went up with the increased HbA（1c）,without any significant differences between three groups.There was no significant correlation between HbA<sub>1c</sub> and TG or HDL-C. With the increased level of HbA<sub>1c</sub>,TC/HDL-C,LDL-C/HDL-C ratios were gradually increased, with significant differences among groups（P【0.05）.The lipid ratios,especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid. Conclusions:LDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.
