Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocula...Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele...展开更多
Objective To investigate effect of Pentoxifylline on free flap. Methods Forty Wistar rats were chosen as experimental models and free flaps were harvested from the back of rats,which as pect ratio was 3: 1. Then they ...Objective To investigate effect of Pentoxifylline on free flap. Methods Forty Wistar rats were chosen as experimental models and free flaps were harvested from the back of rats,which as pect ratio was 3: 1. Then they were divided into two groups randomly. Group A was as the experimental group,receiving drug treatment.展开更多
Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirty-three type 2 DM patients were treated with 20 ml IS...Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirty-three type 2 DM patients were treated with 20 ml ISH per day, intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days, and their changes of platelet membrane glycoprotein Ⅱb/Ⅲa compound (GPⅡb/Ⅲa), granular membrane protein-140 (GMP-140), platelet aggregation rate (PAgR) and hemorrheology were observed. Results: After treatment with ISH, the GPⅡb/Ⅲa compound positive rate of 33 type 2 DM patients were lowered (P<0.05), GMP-140 showed lowering trend, PAgR obviously reduced, and compared with before treatment it showed significant difference; comparison between the two groups after treatment,it showed significant difference (P<0.05, P<0.01). At the same time, the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. Conclusion: ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients, which is vital for the treatment of DM and their vascular lesion.展开更多
Objective:To determine the effect of hyperbaric oxygenation(HBO) on treating acute cerebral infarction(ACI). Methods: We randomly divided 60 patients with acute cerebral infarction into the treatment group and the con...Objective:To determine the effect of hyperbaric oxygenation(HBO) on treating acute cerebral infarction(ACI). Methods: We randomly divided 60 patients with acute cerebral infarction into the treatment group and the control group. Hyperbaric oxygenation treatment was applied in the treatment group as routine drug therapy was used. The neurological function, living ability, clinical therapeutic effectiveness and hemorrheology changes of pa tients in the two groups before and after treatment were observed and evaluated. Results: The indexes of treatment were obviously improved one month after treatment (P ＜ 0.05 ). Clinical effective rate was 93.3 % in this group,which was obviously higher than that of the control group(P ＜ 0.05). Conclusion: Hyperbaric oxygenation can accelerate the recovery of neurological function of patients with acute cerebral infarction.展开更多
Objective:To investigate the effect of Propofol Intravenous Anesthesia on hemorheology, hemodynamics and immune function in patients with colorectal cancer after radical operation.Method: A total of 100 patients with ...Objective:To investigate the effect of Propofol Intravenous Anesthesia on hemorheology, hemodynamics and immune function in patients with colorectal cancer after radical operation.Method: A total of 100 patients with colorectal cancer treated in our hospital from September 2015 to August 2017 were randomly divided into observation group and control group according to random number table. The control group was inhaled sevoflurane anesthesia, observation group propofol intravenous anesthesia. The changes of hemorheology, hemodynamics and immune function were compared between the two groups.Results: There was no significant difference in hemorheology index, hemodynamic index, T lymphocyte subsets CD45RA+, CD45RO+, CD45RA+/CD45RO+ levels between the two groups before anesthesia. Anesthesia 1.5 h after, the levels of LBV, HBV, PV, EAI and EDI in the two groups were significantly decreased, but there was no significant difference between the observation group and the control group. At 1.5 h after anesthesia induction, the HR and SBP levels of the observation group did not change significantly compared with anesthesia before, while the HR and SBP levels of the 1.5 h after anesthesia induction in the control group were significantly lower than those before anesthesia and significantly lower than the corresponding level HR level (86.43±13.25) times/min, SBP level (110.84±15.41) mmHg in the observation group. At the end of surgery, the levels of CD45RA+ and CD45RO+ in the observation group were significantly decreased, but increased at 72 h after operation.Conclusion: After operation, CD45RA+ and CD45RO+ levels in the control group were significantly decreased, and preoperatively, which can significantly improve the hemorheology and reduced hemodynamic effects, and contribute to the recovery of patients with immune function, is worth clinical promotion.展开更多
Objective: Using the principle of promoting blood circulation to remove stasis to observe central retinal arterial and venous blood flow indexes, and hemorrheology of diabetic retinopathy patients with puerarin. Metho...Objective: Using the principle of promoting blood circulation to remove stasis to observe central retinal arterial and venous blood flow indexes, and hemorrheology of diabetic retinopathy patients with puerarin. Methods: Thirty patients with diabetic retinopathy were randomly divided into the treated group (n=15) and the control group (n=15). The treated group was given puerarin 400 mg per day intravenously dripping. The control group was given Mikebao 500 μg intramuscularly, once per day. Both groups were treated for 3 consecutive weeks as one treatment course. Two courses later, hemorrheologic parameters, central retinal arterial and venous blood flow indexes were observed. Results: Comparison before and after treatment showed red blood cell aggregation index, the whole blood viscosity rate, plasma viscosity rate, fibrinogen and erythrocyte sedimentation rate, have all improved obviously ( P <0.05, P <0.01). Compared with the control group, there was significant difference ( P <0.05, P <0.01). With the treated group before and after treatment, the peak systolic velocity (PSV) of central retinal artery, their end diastolic volume, the acceleration, the central retinal venous reflux velocity have improved respectively. Naked eye visions were also improved, compared with the control group, the difference was significant ( P <0.01). Conclusion: Puerarin could reduce blood viscosity, improve microcirculation, and play a positive therapeutic role in diabetic retinopathy.展开更多
基金This Study was supported by China National Ministry of Health Young Grants(1987)Dr. Y. T. Fox Fund for Young Education of China NationaI Committee of Education(1989)
文摘Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele...
文摘Objective To investigate effect of Pentoxifylline on free flap. Methods Forty Wistar rats were chosen as experimental models and free flaps were harvested from the back of rats,which as pect ratio was 3: 1. Then they were divided into two groups randomly. Group A was as the experimental group,receiving drug treatment.
文摘Objective: To observe the effects of Ixeris sonchifolia Hance (ISH) on platelet function and hemorrheology in type 2 diabetes mellitus (DM) patients. Methods: Thirty-three type 2 DM patients were treated with 20 ml ISH per day, intravenously dripping for 15 days; 31 patients in the red sage treated group were treated with composite red sage injection intravenous dripping for 15 days, and their changes of platelet membrane glycoprotein Ⅱb/Ⅲa compound (GPⅡb/Ⅲa), granular membrane protein-140 (GMP-140), platelet aggregation rate (PAgR) and hemorrheology were observed. Results: After treatment with ISH, the GPⅡb/Ⅲa compound positive rate of 33 type 2 DM patients were lowered (P<0.05), GMP-140 showed lowering trend, PAgR obviously reduced, and compared with before treatment it showed significant difference; comparison between the two groups after treatment,it showed significant difference (P<0.05, P<0.01). At the same time, the various parameters of hemorrheology displayed significant improvement. There was no adverse effect during the course of treatment. Conclusion: ISH could improve platelet function and abnormal hemorrheology of type 2 DM patients, which is vital for the treatment of DM and their vascular lesion.
文摘Objective:To determine the effect of hyperbaric oxygenation(HBO) on treating acute cerebral infarction(ACI). Methods: We randomly divided 60 patients with acute cerebral infarction into the treatment group and the control group. Hyperbaric oxygenation treatment was applied in the treatment group as routine drug therapy was used. The neurological function, living ability, clinical therapeutic effectiveness and hemorrheology changes of pa tients in the two groups before and after treatment were observed and evaluated. Results: The indexes of treatment were obviously improved one month after treatment (P ＜ 0.05 ). Clinical effective rate was 93.3 % in this group,which was obviously higher than that of the control group(P ＜ 0.05). Conclusion: Hyperbaric oxygenation can accelerate the recovery of neurological function of patients with acute cerebral infarction.
文摘Objective:To investigate the effect of Propofol Intravenous Anesthesia on hemorheology, hemodynamics and immune function in patients with colorectal cancer after radical operation.Method: A total of 100 patients with colorectal cancer treated in our hospital from September 2015 to August 2017 were randomly divided into observation group and control group according to random number table. The control group was inhaled sevoflurane anesthesia, observation group propofol intravenous anesthesia. The changes of hemorheology, hemodynamics and immune function were compared between the two groups.Results: There was no significant difference in hemorheology index, hemodynamic index, T lymphocyte subsets CD45RA+, CD45RO+, CD45RA+/CD45RO+ levels between the two groups before anesthesia. Anesthesia 1.5 h after, the levels of LBV, HBV, PV, EAI and EDI in the two groups were significantly decreased, but there was no significant difference between the observation group and the control group. At 1.5 h after anesthesia induction, the HR and SBP levels of the observation group did not change significantly compared with anesthesia before, while the HR and SBP levels of the 1.5 h after anesthesia induction in the control group were significantly lower than those before anesthesia and significantly lower than the corresponding level HR level (86.43±13.25) times/min, SBP level (110.84±15.41) mmHg in the observation group. At the end of surgery, the levels of CD45RA+ and CD45RO+ in the observation group were significantly decreased, but increased at 72 h after operation.Conclusion: After operation, CD45RA+ and CD45RO+ levels in the control group were significantly decreased, and preoperatively, which can significantly improve the hemorheology and reduced hemodynamic effects, and contribute to the recovery of patients with immune function, is worth clinical promotion.
文摘Objective: Using the principle of promoting blood circulation to remove stasis to observe central retinal arterial and venous blood flow indexes, and hemorrheology of diabetic retinopathy patients with puerarin. Methods: Thirty patients with diabetic retinopathy were randomly divided into the treated group (n=15) and the control group (n=15). The treated group was given puerarin 400 mg per day intravenously dripping. The control group was given Mikebao 500 μg intramuscularly, once per day. Both groups were treated for 3 consecutive weeks as one treatment course. Two courses later, hemorrheologic parameters, central retinal arterial and venous blood flow indexes were observed. Results: Comparison before and after treatment showed red blood cell aggregation index, the whole blood viscosity rate, plasma viscosity rate, fibrinogen and erythrocyte sedimentation rate, have all improved obviously ( P <0.05, P <0.01). Compared with the control group, there was significant difference ( P <0.05, P <0.01). With the treated group before and after treatment, the peak systolic velocity (PSV) of central retinal artery, their end diastolic volume, the acceleration, the central retinal venous reflux velocity have improved respectively. Naked eye visions were also improved, compared with the control group, the difference was significant ( P <0.01). Conclusion: Puerarin could reduce blood viscosity, improve microcirculation, and play a positive therapeutic role in diabetic retinopathy.
