The case report presented in this edition by Mu et al.The report presents a case of atrial septal defect(ASD)associated with electrocardiographic changes,noting that the crochetage sign resolved after Selective His Bu...The case report presented in this edition by Mu et al.The report presents a case of atrial septal defect(ASD)associated with electrocardiographic changes,noting that the crochetage sign resolved after Selective His Bundle Pacing(S-HBP)without requiring surgical closure.The mechanisms behind the appearance and resolution of the crochetage sign remain unclear.The authors observed the dis-appearance of the crochetage sign post-S-HBP,suggesting a possible correlation between these specific R waves and the cardiac conduction system.This editorial aims to explore various types of ASD and their relationship with the cardiac con-duction system,highlighting the diagnostic significance of the crochetage sign in ASD.展开更多
The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP...The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP)was the only modality which could mitigate or prevent pacing induced dysfunction.Further,BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes.However,the high non-response rate of around 20%-30%remains a major limitation.This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system.To overcome this limitation,the concept of conduction system pacing(CSP)came up.Despite initial success of the first CSP via His bundle pacing(HBP),certain drawbacks including lead instability and dislodgements,steep learning curve and rapid battery depletion on many occasions prevented its widespread use for cardiac resynchronization therapy(CRT).Subsequently,CSP via left bundle branch-area pacing(LBBP)was developed in 2018,which over the last few years has shown efficacy comparable to BiVP-CRT in small observational studies.Further,its safety has also been well established and is largely free of the pitfalls of the HBP-CRT.In the recent metanalysis by Yasmin et al,comprising of 6 studies with 389 participants,LBBPCRT was superior to BiVP-CRT in terms of QRS duration,left ventricular ejection fraction,cardiac chamber dimensions,lead thresholds,and functional status amongst heart failure patients with left bundle branch block.However,there are important limitations of the study including the small overall numbers,inclusion of only a single small randomized controlled trial(RCT)and a small follow-up duration.Further,the entire study population analyzed was from China which makes generalizability a concern.Despite the concerns,the meta-analysis adds to the growing body of evidence demonstrating the efficacy of LBBP-CRT.At this stage,one must acknowledge that the fact that still our opinions on this technique are largely based on observational data and there is a dire need for larger RCTs to ascertain the position of LBBPCRT in management of heart failure patients with left bundle branch block.展开更多
The deleterious effects of long term right ventricular pacing are increasingly being recognized today.Current clinical practice favors the implantation of dual-chamber permanent pacemaker which maintains atrioventricu...The deleterious effects of long term right ventricular pacing are increasingly being recognized today.Current clinical practice favors the implantation of dual-chamber permanent pacemaker which maintains atrioventricular synchrony and is associated with better quality of life.However,despite the popular belief and common sense surrounding the superiority of dual-chamber pacing over single chamber pacing,the same has never been conclusively verified in clinical trials.Some observational evidence however,does exists which supports the improved cardiac hemodynamics,lower the rate of atrial fibrillation,heart failure and stroke in dual-chamber pacing compared to single-chamber pacing.In the index study by Haque et al,right ventricular pacing,particularly in ventricular paced,ven-tricular sensed,inhibited response and rate responsive pacemaker adversely im-pacted the left ventricular functions over 9-months compared to dual pacing,dual sensing,dual responsive and rate responsive pacemaker.Although there are key limitations of this study,these findings does support a growing body of evidence reinstating the superiority of dual chamber pacing compared to single chamber pacing.展开更多
Objective To compare the short-term clinical effect and electrical parameters of His-purkinje bundle pacing(HPBP) and right ventricular inflow tract septal pacing(RVIP) in the elderly. Methods Between April 2017 and S...Objective To compare the short-term clinical effect and electrical parameters of His-purkinje bundle pacing(HPBP) and right ventricular inflow tract septal pacing(RVIP) in the elderly. Methods Between April 2017 and September 2019, sixty patients with indications for permanent cardiac pacing and resynchronization therapy in Beijing Anzhen Hospital were divided into the HPBP and RVIP groups, and were analyzed. A ventricular pacing lead was implanted in left ventricular septal sites with left bundle potentials or His potentials in the HPBP group. The lead was placed in right ventricular inflow tract septal sites close to distal His-bundle regions without potentials from the His-purkinje conduction system in the RVIP group. Lead impedance, R wave amplitude, pacing thresholds, QRS duration, left ventricular ejection fraction(LVEF), and left ventricular end-diastolic diameter(LVEDD), mitral regurgitation area reflux, QTc, T wave directivity, Tp-e and Tp-e/QT ratio were compared between the HPBP and RVIP groups during the procedure and the short-month follow-up. Results No significant differences were found in lead impedance, R wave amplitude, QRS duration, LVEF, LVEDD, mitral regurgitation area reflux, QTc, T wave directivity, Tp-e and Tp-e/QT ratio between the HPBP and RVIP groups. However, the pacing threshold was significantly lower in the HPBP group than in the RVIP group(0.7 ± 0.2 vs. 0.9 ± 0.3 V, P = 0.02). Conclusions The efficacy and electrical parameters of HPBP is comparable with RVIP during the procedure and the short-term follow-up.展开更多
目的评估右心室起搏后,患起搏诱导性心肌病的老年病人升级至希浦系统起搏的临床疗效和安全性。方法在PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据库、维普数据库检索希浦系统起搏对起搏诱导性心肌病疗效的...目的评估右心室起搏后,患起搏诱导性心肌病的老年病人升级至希浦系统起搏的临床疗效和安全性。方法在PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据库、维普数据库检索希浦系统起搏对起搏诱导性心肌病疗效的相关文献,提取研究中有关临床获益和安全性的数据,在RevMan 5.4软件上进行Meta分析。结果共纳入8篇文献,包括185例病人,升级希浦系统起搏的成功率为95%。Meta分析结果显示:升级希浦系统起搏后,随访期间病人的左心室射血分数(MD=-11.73,95%CI:-14.74~-8.72,P<0.01)较升级术前提高,QRS波时限(MD=59.84,95%CI:55.98~63.70,P<0.01)较升级术前缩短,NYHA心功能分级(MD=1.05,95%CI:0.70~1.41,P<0.01)较升级术前明显降低,差异均有统计学意义。起搏阈值(MD=-0.11,95%CI:-0.24~0.02,P=0.08)和R波振幅(MD=-0.35,95%CI:-1.94~1.24,P=0.66)升级术前后差异无统计学意义。同时研究中观察到2例病人死亡。结论对于老年起搏诱导性心肌病病人,可考虑升级起搏方式为希浦系统起搏,不仅可以纠正长期右心室起搏引起的心脏电不同步和心室重塑,同时也能改善病人的临床心功能并减少手术相关并发症。展开更多
"PVC OPTIONS"功能是双腔起搏器对室性早搏反应的特殊功能。该功能设置有两种反应方式:"+PVARP ON PVC"和"A PACE ON PVC"。通常具有这项特殊功能的起搏器,其默认设置是两项功能同时开启。"A PACE O..."PVC OPTIONS"功能是双腔起搏器对室性早搏反应的特殊功能。该功能设置有两种反应方式:"+PVARP ON PVC"和"A PACE ON PVC"。通常具有这项特殊功能的起搏器,其默认设置是两项功能同时开启。"A PACE ON PVC"功能的特点是心房提前起搏,可能会被误诊为起搏功能异常。本文将着重阐述该功能的相关心电图改变。展开更多
Pacemaker mediated tachycardia(PMT)can occur in patients with DDD pacemaker implantation,and PMT in narrow sense is a kind of circular motor tachycardia,which is often caused by ventricular atrial retrograde conductio...Pacemaker mediated tachycardia(PMT)can occur in patients with DDD pacemaker implantation,and PMT in narrow sense is a kind of circular motor tachycardia,which is often caused by ventricular atrial retrograde conduction.This paper reports a case of patients with high atrial pacing value in the early stage of pacemaker implantation,resulting in atrial retrograde conduction and recurrent PMT,Almost non-stop.Although the pacemaker has the PMT automatic termination procedure,PMT is still a short array of repeated attacks due to the presence of poor atrial pacing,resulting in the patients with shortness of breath,lower extremity edema and other heart failure symptoms.Finally,PMT was stopped by prolonging PVARP,and its lower starting frequency was slowed down to 50bpm,and AV interval was kept unchanged for 250ms,so as to reduce the release of atrial pulse and encourage the emergence of self selling down-propagation excitation.The proportion of atrial and ventricular pacing was significantly reduced,which not only saved the electric energy of pacemaker,but also conformed to the physiology.In a narrow sense,pacemaker mediated tachycardia(PMT)is a kind of circular motor tachycardia,which is often caused by reverse ventricular conduction.Repeated attacks for a long time may affect the patient's heart function.Although most modern pacemakers have PMT automatic termination procedures,they are still relatively passive in the presence of some induced factors.Finally,it is necessary to extend PVARP to truly terminate and prevent PM.A case of recurrent PMT due to poor atrial pacing is reported.展开更多
The incidence of atrial fibrillation(Af)is on the first position in arThythmia and thetreatment is very difficuit The method of non-drug to prevent Af has been extensively paidattention to of late years.It is a relati...The incidence of atrial fibrillation(Af)is on the first position in arThythmia and thetreatment is very difficuit The method of non-drug to prevent Af has been extensively paidattention to of late years.It is a relatively new idea to treat Af by means of pacing.In thispaper,we made a research to the Af’s pacing treatment in 3 different conditions.The resultshowed that this method of pacing treatment Afis feaslble.In a long follow-up survey,we divided the patients into 3 groups:(1) group VVI:76 casesin all,in which 40 cases of male and 36 cases of female.All the pacemakers are unicameralVVI.(2) group AAI:46 cases in all,in which 30 cases of male and 16 cases of female.Allthe pacemakers are unicameral AAI.(3) group DDD:25 cases in all.in which 15 cases ofnude and 10 cases of female.All the pacemakers are double cameral DDD.We made afollow-up survey every 3 or 6 months after the pacemaker implantation and examined theclectrocardiogram(ECG).tested and carried out program control to the pacemaker.Theresults showed that the recunence rate of Af in VVI group is 41%,in AAI group is 4%,inDDD group is 5% This result is similar to the reports concemed overseas.It means that thepacing position had remarkable influence to the Af.In addition,the pacing treatment of Af also has some relationship pacing frequency.Itwas found in the follow-up study that the higher the frequency is,the lower the Af’srecurrence rate be comes,The reason may be that the atrium’s vulncrable period is shortedwith the pacing frequency increasing and finally prevent Afs taking place.The primary factors that influence Af are as follows:(1)the size of atrium,(2) theexistence of structural conduction and the existence of dispersive refractory period.(3)thepulse’s wave length.In a word,we think that different pacing position can influence Af’s happening,and thepacing with high frequency also has a definite effect to prevent At’s recurrence.展开更多
Objective:Physiologic cardiac pacing is a novel technique which has been largely popularized in recent decades.His bundle pacing (HBP) has been long considered the most physiologic pacing method;however, with the wide...Objective:Physiologic cardiac pacing is a novel technique which has been largely popularized in recent decades.His bundle pacing (HBP) has been long considered the most physiologic pacing method;however, with the widespread implementation of this method, its disadvantages have become apparent.In this context, left bundle branch pacing (LBBP)-directly engaged in the His-Purkinje system-has been foreseen as the best pacing method to mimic physiologic activation patterns.This review aimed to summarize recent approaches to physiologic cardiac pacing.Data sources:This review included fully peer reviewed publications up to July 2018, found in the PubMed database using the keywords "His bundle branch pacing," "right ventricular pacing," and "physiologic pacing." Study selection:All selected articles were in English, with no restriction on study design.Results:The HBP has been studied worldwide, and is currently considered the most physiologic pacing method.However, it has disadvantages, such as high pacing threshold, unsatisfactory sensing and long procedure times, among others.Although LBBP is theoretically superior to HBP, the clinical relevance of this difference remains under debate, as few large randomized clinical trials with LBBP have been published.Conclusions:Although HBP indeed appears to be the most physiologic pacing method, it has certain shortcomings, such as high pacing threshold, difficult implantation due to specific anatomic features, and others.Further studies are required to clarify the clinical significance of LBBP.展开更多
基金Supported by Guangzhou Municipal Science and Technology Bureau's 2024 Basic and Applied Basic Research Topic,China,No.2024A04J4491,and No.2024A04J4254the Scientific Research Project of Guangdong Provincial Bureau of Traditional Chinese Medicine,China,No.2022ZYYJ01the Soft Science Research Program of Luohu District,Shenzhen,China,No.LX202402016.
文摘The case report presented in this edition by Mu et al.The report presents a case of atrial septal defect(ASD)associated with electrocardiographic changes,noting that the crochetage sign resolved after Selective His Bundle Pacing(S-HBP)without requiring surgical closure.The mechanisms behind the appearance and resolution of the crochetage sign remain unclear.The authors observed the dis-appearance of the crochetage sign post-S-HBP,suggesting a possible correlation between these specific R waves and the cardiac conduction system.This editorial aims to explore various types of ASD and their relationship with the cardiac con-duction system,highlighting the diagnostic significance of the crochetage sign in ASD.
文摘The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacinginduced cardiomyopathy.Until recently,biventricular pacing(BiVP)was the only modality which could mitigate or prevent pacing induced dysfunction.Further,BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes.However,the high non-response rate of around 20%-30%remains a major limitation.This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system.To overcome this limitation,the concept of conduction system pacing(CSP)came up.Despite initial success of the first CSP via His bundle pacing(HBP),certain drawbacks including lead instability and dislodgements,steep learning curve and rapid battery depletion on many occasions prevented its widespread use for cardiac resynchronization therapy(CRT).Subsequently,CSP via left bundle branch-area pacing(LBBP)was developed in 2018,which over the last few years has shown efficacy comparable to BiVP-CRT in small observational studies.Further,its safety has also been well established and is largely free of the pitfalls of the HBP-CRT.In the recent metanalysis by Yasmin et al,comprising of 6 studies with 389 participants,LBBPCRT was superior to BiVP-CRT in terms of QRS duration,left ventricular ejection fraction,cardiac chamber dimensions,lead thresholds,and functional status amongst heart failure patients with left bundle branch block.However,there are important limitations of the study including the small overall numbers,inclusion of only a single small randomized controlled trial(RCT)and a small follow-up duration.Further,the entire study population analyzed was from China which makes generalizability a concern.Despite the concerns,the meta-analysis adds to the growing body of evidence demonstrating the efficacy of LBBP-CRT.At this stage,one must acknowledge that the fact that still our opinions on this technique are largely based on observational data and there is a dire need for larger RCTs to ascertain the position of LBBPCRT in management of heart failure patients with left bundle branch block.
文摘The deleterious effects of long term right ventricular pacing are increasingly being recognized today.Current clinical practice favors the implantation of dual-chamber permanent pacemaker which maintains atrioventricular synchrony and is associated with better quality of life.However,despite the popular belief and common sense surrounding the superiority of dual-chamber pacing over single chamber pacing,the same has never been conclusively verified in clinical trials.Some observational evidence however,does exists which supports the improved cardiac hemodynamics,lower the rate of atrial fibrillation,heart failure and stroke in dual-chamber pacing compared to single-chamber pacing.In the index study by Haque et al,right ventricular pacing,particularly in ventricular paced,ven-tricular sensed,inhibited response and rate responsive pacemaker adversely im-pacted the left ventricular functions over 9-months compared to dual pacing,dual sensing,dual responsive and rate responsive pacemaker.Although there are key limitations of this study,these findings does support a growing body of evidence reinstating the superiority of dual chamber pacing compared to single chamber pacing.
文摘Objective To compare the short-term clinical effect and electrical parameters of His-purkinje bundle pacing(HPBP) and right ventricular inflow tract septal pacing(RVIP) in the elderly. Methods Between April 2017 and September 2019, sixty patients with indications for permanent cardiac pacing and resynchronization therapy in Beijing Anzhen Hospital were divided into the HPBP and RVIP groups, and were analyzed. A ventricular pacing lead was implanted in left ventricular septal sites with left bundle potentials or His potentials in the HPBP group. The lead was placed in right ventricular inflow tract septal sites close to distal His-bundle regions without potentials from the His-purkinje conduction system in the RVIP group. Lead impedance, R wave amplitude, pacing thresholds, QRS duration, left ventricular ejection fraction(LVEF), and left ventricular end-diastolic diameter(LVEDD), mitral regurgitation area reflux, QTc, T wave directivity, Tp-e and Tp-e/QT ratio were compared between the HPBP and RVIP groups during the procedure and the short-month follow-up. Results No significant differences were found in lead impedance, R wave amplitude, QRS duration, LVEF, LVEDD, mitral regurgitation area reflux, QTc, T wave directivity, Tp-e and Tp-e/QT ratio between the HPBP and RVIP groups. However, the pacing threshold was significantly lower in the HPBP group than in the RVIP group(0.7 ± 0.2 vs. 0.9 ± 0.3 V, P = 0.02). Conclusions The efficacy and electrical parameters of HPBP is comparable with RVIP during the procedure and the short-term follow-up.
文摘目的评估右心室起搏后,患起搏诱导性心肌病的老年病人升级至希浦系统起搏的临床疗效和安全性。方法在PubMed、Cochrane Library、Web of Science、Embase、中国知网、万方数据库、维普数据库检索希浦系统起搏对起搏诱导性心肌病疗效的相关文献,提取研究中有关临床获益和安全性的数据,在RevMan 5.4软件上进行Meta分析。结果共纳入8篇文献,包括185例病人,升级希浦系统起搏的成功率为95%。Meta分析结果显示:升级希浦系统起搏后,随访期间病人的左心室射血分数(MD=-11.73,95%CI:-14.74~-8.72,P<0.01)较升级术前提高,QRS波时限(MD=59.84,95%CI:55.98~63.70,P<0.01)较升级术前缩短,NYHA心功能分级(MD=1.05,95%CI:0.70~1.41,P<0.01)较升级术前明显降低,差异均有统计学意义。起搏阈值(MD=-0.11,95%CI:-0.24~0.02,P=0.08)和R波振幅(MD=-0.35,95%CI:-1.94~1.24,P=0.66)升级术前后差异无统计学意义。同时研究中观察到2例病人死亡。结论对于老年起搏诱导性心肌病病人,可考虑升级起搏方式为希浦系统起搏,不仅可以纠正长期右心室起搏引起的心脏电不同步和心室重塑,同时也能改善病人的临床心功能并减少手术相关并发症。
文摘"PVC OPTIONS"功能是双腔起搏器对室性早搏反应的特殊功能。该功能设置有两种反应方式:"+PVARP ON PVC"和"A PACE ON PVC"。通常具有这项特殊功能的起搏器,其默认设置是两项功能同时开启。"A PACE ON PVC"功能的特点是心房提前起搏,可能会被误诊为起搏功能异常。本文将着重阐述该功能的相关心电图改变。
文摘Pacemaker mediated tachycardia(PMT)can occur in patients with DDD pacemaker implantation,and PMT in narrow sense is a kind of circular motor tachycardia,which is often caused by ventricular atrial retrograde conduction.This paper reports a case of patients with high atrial pacing value in the early stage of pacemaker implantation,resulting in atrial retrograde conduction and recurrent PMT,Almost non-stop.Although the pacemaker has the PMT automatic termination procedure,PMT is still a short array of repeated attacks due to the presence of poor atrial pacing,resulting in the patients with shortness of breath,lower extremity edema and other heart failure symptoms.Finally,PMT was stopped by prolonging PVARP,and its lower starting frequency was slowed down to 50bpm,and AV interval was kept unchanged for 250ms,so as to reduce the release of atrial pulse and encourage the emergence of self selling down-propagation excitation.The proportion of atrial and ventricular pacing was significantly reduced,which not only saved the electric energy of pacemaker,but also conformed to the physiology.In a narrow sense,pacemaker mediated tachycardia(PMT)is a kind of circular motor tachycardia,which is often caused by reverse ventricular conduction.Repeated attacks for a long time may affect the patient's heart function.Although most modern pacemakers have PMT automatic termination procedures,they are still relatively passive in the presence of some induced factors.Finally,it is necessary to extend PVARP to truly terminate and prevent PM.A case of recurrent PMT due to poor atrial pacing is reported.
文摘The incidence of atrial fibrillation(Af)is on the first position in arThythmia and thetreatment is very difficuit The method of non-drug to prevent Af has been extensively paidattention to of late years.It is a relatively new idea to treat Af by means of pacing.In thispaper,we made a research to the Af’s pacing treatment in 3 different conditions.The resultshowed that this method of pacing treatment Afis feaslble.In a long follow-up survey,we divided the patients into 3 groups:(1) group VVI:76 casesin all,in which 40 cases of male and 36 cases of female.All the pacemakers are unicameralVVI.(2) group AAI:46 cases in all,in which 30 cases of male and 16 cases of female.Allthe pacemakers are unicameral AAI.(3) group DDD:25 cases in all.in which 15 cases ofnude and 10 cases of female.All the pacemakers are double cameral DDD.We made afollow-up survey every 3 or 6 months after the pacemaker implantation and examined theclectrocardiogram(ECG).tested and carried out program control to the pacemaker.Theresults showed that the recunence rate of Af in VVI group is 41%,in AAI group is 4%,inDDD group is 5% This result is similar to the reports concemed overseas.It means that thepacing position had remarkable influence to the Af.In addition,the pacing treatment of Af also has some relationship pacing frequency.Itwas found in the follow-up study that the higher the frequency is,the lower the Af’srecurrence rate be comes,The reason may be that the atrium’s vulncrable period is shortedwith the pacing frequency increasing and finally prevent Afs taking place.The primary factors that influence Af are as follows:(1)the size of atrium,(2) theexistence of structural conduction and the existence of dispersive refractory period.(3)thepulse’s wave length.In a word,we think that different pacing position can influence Af’s happening,and thepacing with high frequency also has a definite effect to prevent At’s recurrence.
基金a grant from the National Natural Science Foundation of Ghina (No.81570220).
文摘Objective:Physiologic cardiac pacing is a novel technique which has been largely popularized in recent decades.His bundle pacing (HBP) has been long considered the most physiologic pacing method;however, with the widespread implementation of this method, its disadvantages have become apparent.In this context, left bundle branch pacing (LBBP)-directly engaged in the His-Purkinje system-has been foreseen as the best pacing method to mimic physiologic activation patterns.This review aimed to summarize recent approaches to physiologic cardiac pacing.Data sources:This review included fully peer reviewed publications up to July 2018, found in the PubMed database using the keywords "His bundle branch pacing," "right ventricular pacing," and "physiologic pacing." Study selection:All selected articles were in English, with no restriction on study design.Results:The HBP has been studied worldwide, and is currently considered the most physiologic pacing method.However, it has disadvantages, such as high pacing threshold, unsatisfactory sensing and long procedure times, among others.Although LBBP is theoretically superior to HBP, the clinical relevance of this difference remains under debate, as few large randomized clinical trials with LBBP have been published.Conclusions:Although HBP indeed appears to be the most physiologic pacing method, it has certain shortcomings, such as high pacing threshold, difficult implantation due to specific anatomic features, and others.Further studies are required to clarify the clinical significance of LBBP.
