The author uses the cooperative principle to analyze the conversational implicatures in the Legend of Zhen Huan by examining how the maxims of the cooperative principle are violated.By writing this article, the author...The author uses the cooperative principle to analyze the conversational implicatures in the Legend of Zhen Huan by examining how the maxims of the cooperative principle are violated.By writing this article, the author hopes to let the audience have a further appreciation of this work and enjoy more about the charms of language.展开更多
A popular TV series in 2012,"Legend of Zhen Huan"reflecting the Harem struggle of Qing Dynasty was broadcasted by several TV stations time after time,obtaining high audience rating.With the improvement of th...A popular TV series in 2012,"Legend of Zhen Huan"reflecting the Harem struggle of Qing Dynasty was broadcasted by several TV stations time after time,obtaining high audience rating.With the improvement of the popularity,the"Zhen Huan’s Mania"phenomenon occurred in many aspects.This thesis will describe the structure of Zhen Huan style,and offer a linguistic account of their popularity in the cyberspace.展开更多
To investigate the pharmacokinetics of effective components of Bu Yang Huang Wu Decoction(BYHWD)with different dosages of Astragalus(Yiqi groups and Huoxue groups)applicating in rats with middle cerebral artery occlus...To investigate the pharmacokinetics of effective components of Bu Yang Huang Wu Decoction(BYHWD)with different dosages of Astragalus(Yiqi groups and Huoxue groups)applicating in rats with middle cerebral artery occlusion(MCAO).Replicating the animal model of cerebral ischemia-reperfusion in rats,establishing the liquid-mass spectrometry method for the determination of BYHWD and researching the pharmacokinetics of effective components of yiqi groups of BYHWD with different dosages of astragalus(3.09,6.17,12.34 g/Kg)and Huoxue goups(2.32 g/Kg)when applicated seperately in the rats suffering from cerebral ischemia reperfusion injury after femoral vein administration.The pharmacokinetics of formononetin and paeoniflorin in the different dosage groups of BYHWD met the one-compartment model,and the t1/2 of formononetin and paeoniflorin in the low-dose Yiqi and Huoxue groups were(88.43±3.82,69.18±0.11)min,MRT were(138.56±4.83,113.62±2.42)min,and AUC0-twere(28488.35±4800.32,140614.80±23954.05)ng/mL min;The t1/2 of formononetin and paeoniflorin in the middle-dose Yiqi group and Huoxue group were(82.16±1.78,67.08±3.69)min,and MRT were(127.95±2.70,116.58±4.13),AUC0-t were(48619.25±6745.75,159026.00±15003.33)ng/mL min;The t1/2 of formononetin and paeoniflorin in the high-dose Yiqi and Huoxue groups were(80.29±1.12,69.69±0.87)min and MRT was(128.79±1.46,118.78±4.56)min AUC0-twere(109942.90±13101.83,189417.90±22311.00)ng/mL·min.The concentration rate of formononetin t1/2 brain was decreased with increase of Astragalus dose.However,no significant difference between these two variables was found during experiments.Furthermore,the experiments showed that the increasing dose of astragalus would affect the pharmacokinetic behavior of paeoniflorin in the Huoxue groups.More specifically,the result showed that paeoniflorin can be metabolized more slowly in the body when applicated in high dose of the jaundice administration groups.In this way,the effect of paeoniflorin can be lasted for longer time in the body and brain.展开更多
Objective : To investigate the effect of Huan shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor β 2 (TGF β 2 ) in the remnant kidney of rats. Methods : Male Wistar ra...Objective : To investigate the effect of Huan shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor β 2 (TGF β 2 ) in the remnant kidney of rats. Methods : Male Wistar rats, after 4 weeks of 5/6 nephrectomy, were divided into two groups at random, and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24 hours were observed at beginning, 6th week and 12th week of the experiment, and FN and TGF β 2 were assayed by immunohistochemical technique and computer assisted image analysis as well. Results : Serum SCr and urinary protein of 24 hours were increased significantly in the animals after 5/6 nephrectomy. The increased parameters decreased in the HSR group after treatment, as compared with those in the control group, and the difference was significant ( P <0.05 ); Immunohistochemical measurement and computer assisted image analysis showed a marked suppression of FN and TGF β 2 in animals of the HSR group with significant difference from those in the control group ( P <0.05). Conclusion : HSR not only plays the role of renal function protection, but could also alleviate the glomerular pathological injury. The effect on TGF β 2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure.展开更多
文摘The author uses the cooperative principle to analyze the conversational implicatures in the Legend of Zhen Huan by examining how the maxims of the cooperative principle are violated.By writing this article, the author hopes to let the audience have a further appreciation of this work and enjoy more about the charms of language.
文摘A popular TV series in 2012,"Legend of Zhen Huan"reflecting the Harem struggle of Qing Dynasty was broadcasted by several TV stations time after time,obtaining high audience rating.With the improvement of the popularity,the"Zhen Huan’s Mania"phenomenon occurred in many aspects.This thesis will describe the structure of Zhen Huan style,and offer a linguistic account of their popularity in the cyberspace.
基金National Natural Science Foundation of China(Grant No.81373973,81573872,81873228)Science and Technology Planning Project of Guangdong Province(Grant No.2017KZDXM018).
文摘To investigate the pharmacokinetics of effective components of Bu Yang Huang Wu Decoction(BYHWD)with different dosages of Astragalus(Yiqi groups and Huoxue groups)applicating in rats with middle cerebral artery occlusion(MCAO).Replicating the animal model of cerebral ischemia-reperfusion in rats,establishing the liquid-mass spectrometry method for the determination of BYHWD and researching the pharmacokinetics of effective components of yiqi groups of BYHWD with different dosages of astragalus(3.09,6.17,12.34 g/Kg)and Huoxue goups(2.32 g/Kg)when applicated seperately in the rats suffering from cerebral ischemia reperfusion injury after femoral vein administration.The pharmacokinetics of formononetin and paeoniflorin in the different dosage groups of BYHWD met the one-compartment model,and the t1/2 of formononetin and paeoniflorin in the low-dose Yiqi and Huoxue groups were(88.43±3.82,69.18±0.11)min,MRT were(138.56±4.83,113.62±2.42)min,and AUC0-twere(28488.35±4800.32,140614.80±23954.05)ng/mL min;The t1/2 of formononetin and paeoniflorin in the middle-dose Yiqi group and Huoxue group were(82.16±1.78,67.08±3.69)min,and MRT were(127.95±2.70,116.58±4.13),AUC0-t were(48619.25±6745.75,159026.00±15003.33)ng/mL min;The t1/2 of formononetin and paeoniflorin in the high-dose Yiqi and Huoxue groups were(80.29±1.12,69.69±0.87)min and MRT was(128.79±1.46,118.78±4.56)min AUC0-twere(109942.90±13101.83,189417.90±22311.00)ng/mL·min.The concentration rate of formononetin t1/2 brain was decreased with increase of Astragalus dose.However,no significant difference between these two variables was found during experiments.Furthermore,the experiments showed that the increasing dose of astragalus would affect the pharmacokinetic behavior of paeoniflorin in the Huoxue groups.More specifically,the result showed that paeoniflorin can be metabolized more slowly in the body when applicated in high dose of the jaundice administration groups.In this way,the effect of paeoniflorin can be lasted for longer time in the body and brain.
文摘Objective : To investigate the effect of Huan shuai Recipe on the expression level of fibronectin (FN) and transforming growth factor β 2 (TGF β 2 ) in the remnant kidney of rats. Methods : Male Wistar rats, after 4 weeks of 5/6 nephrectomy, were divided into two groups at random, and treated with water and Huanshuai Recipe (HSR) respectively. Serum creatinine (SCr) and urinary protein of 24 hours were observed at beginning, 6th week and 12th week of the experiment, and FN and TGF β 2 were assayed by immunohistochemical technique and computer assisted image analysis as well. Results : Serum SCr and urinary protein of 24 hours were increased significantly in the animals after 5/6 nephrectomy. The increased parameters decreased in the HSR group after treatment, as compared with those in the control group, and the difference was significant ( P <0.05 ); Immunohistochemical measurement and computer assisted image analysis showed a marked suppression of FN and TGF β 2 in animals of the HSR group with significant difference from those in the control group ( P <0.05). Conclusion : HSR not only plays the role of renal function protection, but could also alleviate the glomerular pathological injury. The effect on TGF β 2 and FN may be the mechanism of HSR in slowing down the progression of chronic renal failure.
