In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible impli...In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration.We wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the disease.We also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.展开更多
Soil liquefaction is one of the complex research topics in geotechnical engineering and engineering geology. Especially after the 1964 Niigata earthquake (Japan) induced many soil liquefaction incidents, a variety of ...Soil liquefaction is one of the complex research topics in geotechnical engineering and engineering geology. Especially after the 1964 Niigata earthquake (Japan) induced many soil liquefaction incidents, a variety of soil liquefaction studies were conducted and reported, including the liquefaction potential assessment methods utilizing the shear wave velocity (V<sub>s</sub>) or SPT-N profiles (SPT: standard penetration test). This study used the V<sub>s</sub> and SPT methods recommended by the National Center for Earthquake Engineering Research (NCEER) to examine which is more conservative according to the assessment results on 41 liquefiable soil layers at sites in two major cities in Taiwan. Statistical hypothesis testing was used to make the analysis more quantitative and objective. Based on three sets of hypothesis tests, it shows that the hypothesis—the SPT method is more conservative than the V<sub>s</sub> method—was not rejected on a 5% level of significance.展开更多
In this research we are going to define two new concepts: a) “The Potential of Events” (EP) and b) “The Catholic Information” (CI). The term CI derives from the ancient Greek language and declares all the Catholic...In this research we are going to define two new concepts: a) “The Potential of Events” (EP) and b) “The Catholic Information” (CI). The term CI derives from the ancient Greek language and declares all the Catholic (general) Logical Propositions (<img src="Edit_5f13a4a5-abc6-4bc5-9e4c-4ff981627b2a.png" width="33" height="21" alt="" />) which will true for every element of a set A. We will study the Riemann Hypothesis in two stages: a) By using the EP we will prove that the distribution of events e (even) and o (odd) of Square Free Numbers (SFN) on the axis Ax(N) of naturals is Heads-Tails (H-T) type. b) By using the CI we will explain the way that the distribution of prime numbers can be correlated with the non-trivial zeros of the function <em>ζ</em>(<em>s</em>) of Riemann. The Introduction and the Chapter 2 are necessary for understanding the solution. In the Chapter 3 we will present a simple method of forecasting in many very useful applications (e.g. financial, technological, medical, social, etc) developing a generalization of this new, proven here, theory which we finally apply to the solution of RH. The following Introduction as well the Results with the Discussion at the end shed light about the possibility of the proof of all the above. The article consists of 9 chapters that are numbered by 1, 2, …, 9.展开更多
“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to ...“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to deny the possibility of a general principle for human cognition,and partly because some findings taken to support it have not reliably replicated.The author argued that considering this hypothesis through the lens of probabilistic inference has the potential to figure out both issues,at least with respect to certain prominent findings in the two languages—Chinese and English.After exploring on the inner relationship among language,thought and culture with the comparison between English and Chinese based on a series of examples including“numbers,Wuhan dialect and some different understandings of idioms”,the author made an inference that language can somewhat affect human thought under the different culture contexts.Besides,it also provides some reference for educators to take in-depth studies on the relationship among language,thought and culture,which is vitally significant for ESL educators and learners.展开更多
Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a ...Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a kind of interlingual and intercultural communication. It involves not only the transference from one language into another, but a whole set of extra-linguistic criteria. In translating we are always crossing a greater or lesser barrier or divide.展开更多
The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical r...The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical research on the CPH will spread out.Meanwhile,the discussion of implication and limitation of the CPH research will be concerned as well.展开更多
Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the ...Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the acquisition- learning hypothesis, the monitor hypothesis, the natural order hypothesis, the input hypothesis and the effective filter hypothesis. The thesis tries to explore the pedagogical implications of Krashen's Input Hypothesis on second language teaching in the aspects of the input quantity and input quality. The thesis tries to explore the most effective methods of second language teaching, in the hope that it will help to improve the efficiency of second language teaching.展开更多
AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS Th...AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,（13.61±2.56）h<sup>-1</sup>,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h<sup>-1</sup>mL<sup>-1</sup>],maximum drug concentration[C<sub>max</sub>,（4.82±1.23）μg·mL<sup>-1</sup>]of serum TMP inRMSDS were increased markedly（P【0.05）compared with those[Ka=（5.41±1.91）h<sup>-1</sup>,AUC=（5.20±2.57）μg·h<sup>-1</sup>·mL<sup>-1</sup>,C<sub>max</sub>=（2.33±1.77）μg·mL<sup>-1</sup>]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h<sup>-1</sup>,β=（0.06±0.03）h<sup>-1</sup>,the apparent first-orderintercompartmental transfer rate constants[K<sub>10</sub>=（0.24±0.07）h<sup>-1</sup>,K<sub>12</sub>=（0.11±0.02）h<sup>-1</sup>,K<sub>21</sub>=（0.11±0.02）h<sup>-1</sup>]of serum TMP in RMSDS weredecreased significantly（P【0.01）comparedwith those[K<sub>10</sub>=（0.88±0.20）h<sup>-1</sup>,K<sub>12</sub>=（1.45±0.47）h<sup>-1</sup>,K<sub>21</sub>=（0.72±0.22）h<sup>-1</sup>]of HR.However,no apparent differences occurredbetween HR and RMSDS treated with SJZD.Theserum FA concentration and its AUC[（5.6690±2.3541）μg·h<sup>-1</sup>·mL<sup>-1</sup>] in RMBSS were also higherthan those[AUC=（2.7566±0.8232）μg·h<sup>-1</sup>·mL<sup>-1</sup>]of healthy rabbits（P【0.05）.The Ka（11.51±2.82）h<sup>-1</sup>,AUC（0.84±0.17）μg·h<sup>-1</sup>·mL<sup>-1</sup>of LW & SM-derived TMP in serum weremuch lower（P【0.05）than those[Ka=（19.58±4.14）h<sup>-1</sup>,AUC=（1.27±0.26）μg·h<sup>-1</sup>·mL<sup>-1</sup>]ofLW-derived TMP in serum after oral decoctions.CONCLUSION The SDS and blood stasissyndrome state could affect significantly thepharmacokinetic parameters of drugs and theabnormal SDS pharmacokinetic parameters couldbe normalized by SJZD.The combination ofChinese medicine in TCR could reciprocallyaffect the pharmacokinetic parameters of othercomponents absorbed into the systemiccirculation.These results support the S-and R-PK hypothesis.展开更多
With the increment of the number of Gaussian components, the computation cost increases in the Gaussian mixture probability hypothesis density(GM-PHD) filter. Based on the theory of Chen et al, we propose an improved ...With the increment of the number of Gaussian components, the computation cost increases in the Gaussian mixture probability hypothesis density(GM-PHD) filter. Based on the theory of Chen et al, we propose an improved pruning algorithm for the GM-PHD filter, which utilizes not only the Gaussian components' means and covariance, but their weights as a new criterion to improve the estimate accuracy of the conventional pruning algorithm for tracking very closely proximity targets. Moreover, it solves the end-less while-loop problem without the need of a second merging step. Simulation results show that this improved algorithm is easier to implement and more robust than the formal ones.展开更多
Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a majorhealth problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient ...Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a majorhealth problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis(SPH), which identifies an elevated sinusoidal pressure(SP) as cause of fibrosis. SPH has been mainly derived from recent studies on liver stiffness. So far, pressure changes have been exclusively seen as a consequ-ence of cirrhosis. According to the SPH, however, an elevated SP is the major upstream event that initiates fibrosis via biomechanic signaling by stretching of perisinusoidal cells such as hepatic stellate cells or fibroblasts(SPH part?Ⅰ: initiation). Fibrosis progression is determined by the degree and time of elevated SP. The SPH predicts that the degree of extracellular matrix eventually matches SP with critical thresholds > 12 mmH g and > 4 wk. Elevated arterial flow and final arterialization of the cirrhotic liver represents the self-perpetuating key event exposing the low-pressure-organ to pathologically high pressures(SPH part?Ⅱ: perpetuation). It also defines the "point of no return" where fibrosis progression becomes irreversible. The SPH is able to explain the macroscopic changes of cirrhotic livers and the uniform fibrotic response to various etiologies. It also opens up new views on the role of fat and disease mechanisms in other organs. The novel concept will hopefully stimulate the search for new treatment strategies.展开更多
Many effective optimization algorithms require partial derivatives of objective functions, while some optimization problems' objective functions have no derivatives. According to former research studies, some sear...Many effective optimization algorithms require partial derivatives of objective functions, while some optimization problems' objective functions have no derivatives. According to former research studies, some search directions are obtained using the quadratic hypothesis of objective functions. Based on derivatives, quadratic function assumptions, and directional derivatives, the computational formulas of numerical first-order partial derivatives, second-order partial derivatives, and numerical second-order mixed partial derivatives were constructed. Based on the coordinate transformation relation, a set of orthogonal vectors in the fixed coordinate system was established according to the optimization direction. A numerical algorithm was proposed, taking the second order approximation direction as an example. A large stepsize numerical algorithm based on coordinate transformation was proposed. Several algorithms were validated by an unconstrained optimization of the two-dimensional Rosenbrock objective function. The numerical second order approximation direction with the numerical mixed partial derivatives showed good results. Its calculated amount is 0.2843% of that of without second-order mixed partial derivative. In the process of rotating the local coordinate system 360°, because the objective function is more complex than the quadratic function, if the numerical direction derivative is used instead of the analytic partial derivative, the optimization direction varies with a range of 103.05°. Because theoretical error is in the numerical negative gradient direction, the calculation with the coordinate transformation is 94.71% less than the calculation without coordinate transformation. If there is no theoretical error in the numerical negative gradient direction or in the large-stepsize numerical optimization algorithm based on the coordinate transformation, the sawtooth phenomenon occurs. When each numerical mixed partial derivative takes more than one point, the optimization results cannot be improved. The numerical direction based on the quadratic hypothesis only requires the objective function to be obtained, but does not require derivability and does not take into account truncation error and rounding error. Thus, the application scopes of many optimization methods are extended.展开更多
"The Input Hypothesis"and"The Affective Filter Hypothesis"are the most important branches of the"Monitor The ory"declared by the famous American linguist Krashen in 1980s.This thesis is b..."The Input Hypothesis"and"The Affective Filter Hypothesis"are the most important branches of the"Monitor The ory"declared by the famous American linguist Krashen in 1980s.This thesis is based on Krashen's Input Hypothesis and Affec tive Filter Hypothesis,aiming to provide an applicable guide for foreign language teachers and learners in China.展开更多
Krashen's Input Hypothesis and Pienemann's Teachability Hypothesis are two fairly important L2 acquisition theories.They catch more and more educators' attention and really contribute a lot to the teaching...Krashen's Input Hypothesis and Pienemann's Teachability Hypothesis are two fairly important L2 acquisition theories.They catch more and more educators' attention and really contribute a lot to the teaching field.By elaborating the two theories and analyzing their similarities and differences,this paper aims to better the application of them into teaching and learning practices.展开更多
Probability Hypothesis Density (PHD) filtering approach has shown its advantages in tracking time varying number of targets even when there are noise,clutter and misdetection. For linear Gaussian Mixture (GM) system,P...Probability Hypothesis Density (PHD) filtering approach has shown its advantages in tracking time varying number of targets even when there are noise,clutter and misdetection. For linear Gaussian Mixture (GM) system,PHD filter has a closed form recursion (GMPHD). But PHD filter cannot estimate the trajectories of multi-target because it only provides identity-free estimate of target states. Existing data association methods still remain a big challenge mostly because they are com-putationally expensive. In this paper,we proposed a new data association algorithm using GMPHD filter,which significantly alleviated the heavy computing load and performed multi-target trajectory tracking effectively in the meantime.展开更多
The original online version of this article (Durmagambetov, A.A. (2016) The Riemann Hypothesis-Millennium Prize Problem. Advances in Pure Mathematics, 6, 915-920. 10.4236/apm.2016.612069) unfortunately contains a mist...The original online version of this article (Durmagambetov, A.A. (2016) The Riemann Hypothesis-Millennium Prize Problem. Advances in Pure Mathematics, 6, 915-920. 10.4236/apm.2016.612069) unfortunately contains a mistake. The author wishes to correct the errors in Theorem 2 of the result part.展开更多
From the theorem 1 formulated in [1], a set of functions of measure zero within the set of all corresponding functions has to be excluded. These are the cases where the Omega functions Ω(u)?are piece-wise co...From the theorem 1 formulated in [1], a set of functions of measure zero within the set of all corresponding functions has to be excluded. These are the cases where the Omega functions Ω(u)?are piece-wise constant on intervals of equal length and non-increasing due to application of second mean-value theorem or, correspondingly, where for the Xi functions Ξ(z)?the functions Ξ(y)y are periodic functions on the imaginary axis y with?z=x+iy. This does not touch the results for the Omega function to the Riemann hypothesis by application of the second mean-value theorem of calculus and the majority of other Omega functions in the suppositions, but makes their derivation correct. The corresponding calculations together with a short recapitulation of the main steps to the basic equations for the restrictions of the mean-value functions and the application to piece-wise constant Omega functions (staircase functions) are represented.展开更多
By the second mean-value theorem of calculus (Gauss-Bonnet theorem) we prove that the class of functionswith an integral representation of the form with a real-valued function which is non-increasing a...By the second mean-value theorem of calculus (Gauss-Bonnet theorem) we prove that the class of functionswith an integral representation of the form with a real-valued function which is non-increasing and decreases in infinity more rapidly than any exponential functions , possesses zeros only on the imaginary axis. The Riemann zeta function as it is known can be related to an entire functionwith the same non-trivial zeros as . Then after a trivial argument displacement we relate it to a function with a representation of the form where is rapidly decreasing in infinity and satisfies all requirements necessary for the given proof of the position of its zeros on the imaginary axis z=iy by the second mean-value theorem. Besides this theorem we apply the Cauchy-Riemann differential equation in an integrated operator form derived in the Appendix B. All this means that we prove a theorem for zeros of on the imaginary axis z=iy for a whole class of function which includes in this way the proof of the Riemann hypothesis. This whole class includes, in particular, also the modified Bessel functions for which it is known that their zeros lie on the imaginary axis and which affirms our conclusions that we intend to publish at another place. In the same way a class of almost-periodic functions to piece-wise constant non-increasing functions belong also to this case. At the end we give shortly an equivalent way of a more formal description of the obtained results using the Mellin transform of functions with its variable substituted by an operator.展开更多
Lexical developmental hypothesis arouses many linguists' interests and stimulates them to test it in various ways.However,in testing this model,quite a few collisions emerge between different research conclusions....Lexical developmental hypothesis arouses many linguists' interests and stimulates them to test it in various ways.However,in testing this model,quite a few collisions emerge between different research conclusions.This essay critically reviews three researches which focus on how bilingual's L2 vocabulary processing way varies with proficiency level,and sorts out the discrepancies between results concerning the effect of concept mediation on L2 lexical processing.After a close analysis of the researches' variables,including yardstick of subjects' proficiency,subjects' L2 learning strategies,word imageability,and translation direction,the writer proposes possible causes of the discrepancies,and justifies the hypotheses implicated by the lexical developmental model.展开更多
Krashen's Input hypothesis and Long's Interaction hypothesis are both valuable research results in the field of language acquisition and play a significant role in language teaching and learning instruction.Th...Krashen's Input hypothesis and Long's Interaction hypothesis are both valuable research results in the field of language acquisition and play a significant role in language teaching and learning instruction.Through comparing them,their similarities lie in same goal and basis,same focus on comprehension and same challenge the traditional teaching concept.While the differences lie in Different ways to make exposure comprehensible and different roles that learners play.It is meaningful to make the comparison because the results can be valuable guidance and highlights for language teachers and learners to teach or acquire a new language more efficiently.展开更多
基金supported by grants to DD from Agencia Nacional de Promoción de la Investigación,el desarrollo tecnológico y la innovación(ANPCyT,PICT N°03893).
文摘In light of the rising evidence of the association between viral and bacterial infections and neurodegeneration,we aimed at revisiting the infectious hypothesis of Alzheimer’s disease and analyzing the possible implications of COVID-19 neurological sequelae in long-term neurodegeneration.We wondered how SARS-CoV-2 could be related to the amyloid-βcascade and how it could lead to the pathological hallmarks of the disease.We also predict a paradigm change in clinical medicine,which now has a great opportunity to conduct prospective surveillance of cognitive sequelae and progression to dementia in people who suffered severe infections together with other risk factors for Alzheimer’s disease.
文摘Soil liquefaction is one of the complex research topics in geotechnical engineering and engineering geology. Especially after the 1964 Niigata earthquake (Japan) induced many soil liquefaction incidents, a variety of soil liquefaction studies were conducted and reported, including the liquefaction potential assessment methods utilizing the shear wave velocity (V<sub>s</sub>) or SPT-N profiles (SPT: standard penetration test). This study used the V<sub>s</sub> and SPT methods recommended by the National Center for Earthquake Engineering Research (NCEER) to examine which is more conservative according to the assessment results on 41 liquefiable soil layers at sites in two major cities in Taiwan. Statistical hypothesis testing was used to make the analysis more quantitative and objective. Based on three sets of hypothesis tests, it shows that the hypothesis—the SPT method is more conservative than the V<sub>s</sub> method—was not rejected on a 5% level of significance.
文摘In this research we are going to define two new concepts: a) “The Potential of Events” (EP) and b) “The Catholic Information” (CI). The term CI derives from the ancient Greek language and declares all the Catholic (general) Logical Propositions (<img src="Edit_5f13a4a5-abc6-4bc5-9e4c-4ff981627b2a.png" width="33" height="21" alt="" />) which will true for every element of a set A. We will study the Riemann Hypothesis in two stages: a) By using the EP we will prove that the distribution of events e (even) and o (odd) of Square Free Numbers (SFN) on the axis Ax(N) of naturals is Heads-Tails (H-T) type. b) By using the CI we will explain the way that the distribution of prime numbers can be correlated with the non-trivial zeros of the function <em>ζ</em>(<em>s</em>) of Riemann. The Introduction and the Chapter 2 are necessary for understanding the solution. In the Chapter 3 we will present a simple method of forecasting in many very useful applications (e.g. financial, technological, medical, social, etc) developing a generalization of this new, proven here, theory which we finally apply to the solution of RH. The following Introduction as well the Results with the Discussion at the end shed light about the possibility of the proof of all the above. The article consists of 9 chapters that are numbered by 1, 2, …, 9.
文摘“Sapir-Whorf hypothesis"holds that human thoughts are shaped by their native languages,and speakers of different languages think differently relevantly.The hypothesis is controversial partly because it seems to deny the possibility of a general principle for human cognition,and partly because some findings taken to support it have not reliably replicated.The author argued that considering this hypothesis through the lens of probabilistic inference has the potential to figure out both issues,at least with respect to certain prominent findings in the two languages—Chinese and English.After exploring on the inner relationship among language,thought and culture with the comparison between English and Chinese based on a series of examples including“numbers,Wuhan dialect and some different understandings of idioms”,the author made an inference that language can somewhat affect human thought under the different culture contexts.Besides,it also provides some reference for educators to take in-depth studies on the relationship among language,thought and culture,which is vitally significant for ESL educators and learners.
文摘Sapir-Whorf hypothesis has its implication in translation studies. Each language is a peculiar whole. It is a product, even an expression, of the spiritual personality and the cultural particularity. Translation is a kind of interlingual and intercultural communication. It involves not only the transference from one language into another, but a whole set of extra-linguistic criteria. In translating we are always crossing a greater or lesser barrier or divide.
文摘The researches on Critical Period Hypothesis(CPH) aims to explain the importance of the age factor in the process of learning a second language.In this essay,a critical review of the theoretical issues and empirical research on the CPH will spread out.Meanwhile,the discussion of implication and limitation of the CPH research will be concerned as well.
文摘Krashen has developed the Input Hypothesis, which has deep influence on teaching method of second language. This thesis focuses on the Krashen's Input Hypothesis, which includes the following five hypotheses: the acquisition- learning hypothesis, the monitor hypothesis, the natural order hypothesis, the input hypothesis and the effective filter hypothesis. The thesis tries to explore the pedagogical implications of Krashen's Input Hypothesis on second language teaching in the aspects of the input quantity and input quality. The thesis tries to explore the most effective methods of second language teaching, in the hope that it will help to improve the efficiency of second language teaching.
基金National Natural Science Foundation of China,No.398709323967086539570870 and 39100139.
文摘AIM To propose a hypothesis defining theabsorption,distribution,metabolism andelimination of traditional Chinese recipe（TCR）-component in blood of healthy subjects andpatients,and estimate its correctness.METHODS The pharmacokinetics（PK）of samedose of drug was studied in the animal model oftraditional Chinese syndrome（S）and healthyanimals.The classification,terminology,concept and significance of the hypothesis wereset forth with evidence provided in the presentstudy.The hypotheses consisted of traditionalChinese syndrome PK（S-PK）and traditionalChinese recipe PK（R-PK）.Firstly,the observedtetramethylpyrazine（TMP）PK in healthy,chronically reserpinized rats（rat model ofspleen deficiency syndrome,RMSDS）andRMSDS treated with Sijunzi decoction（SJZD）forconfirmation were used to verify S-PK; secondly,the ferulic acid（FA）PK in healthy andhigh molecular weight dextran（HMWD）-inducedrabbit model with blood stasis syndrome（RDBSS）was also used to verify S-PK;andlastly,TMP PK parameters in serum of healthyrats after orally taken Ligusticum wallichii（LW）,LW and Salvia miltiorrhiza（LW&SM）decoctions were compared to verify R-PK.RESULTS The apparent first-order absorption[Ka,（13.61±2.56）h<sup>-1</sup>,area under the blooddrug concentration-time curve[AUC,（24.88±9.76）μg.h<sup>-1</sup>mL<sup>-1</sup>],maximum drug concentration[C<sub>max</sub>,（4.82±1.23）μg·mL<sup>-1</sup>]of serum TMP inRMSDS were increased markedly（P【0.05）compared with those[Ka=（5.41±1.91）h<sup>-1</sup>,AUC=（5.20±2.57）μg·h<sup>-1</sup>·mL<sup>-1</sup>,C<sub>max</sub>=（2.33±1.77）μg·mL<sup>-1</sup>]of healthy rats（HR）.Theapparent first-order rate constant for α and βdistribution phase[α=（0.38±0.09）h<sup>-1</sup>,β=（0.06±0.03）h<sup>-1</sup>,the apparent first-orderintercompartmental transfer rate constants[K<sub>10</sub>=（0.24±0.07）h<sup>-1</sup>,K<sub>12</sub>=（0.11±0.02）h<sup>-1</sup>,K<sub>21</sub>=（0.11±0.02）h<sup>-1</sup>]of serum TMP in RMSDS weredecreased significantly（P【0.01）comparedwith those[K<sub>10</sub>=（0.88±0.20）h<sup>-1</sup>,K<sub>12</sub>=（1.45±0.47）h<sup>-1</sup>,K<sub>21</sub>=（0.72±0.22）h<sup>-1</sup>]of HR.However,no apparent differences occurredbetween HR and RMSDS treated with SJZD.Theserum FA concentration and its AUC[（5.6690±2.3541）μg·h<sup>-1</sup>·mL<sup>-1</sup>] in RMBSS were also higherthan those[AUC=（2.7566±0.8232）μg·h<sup>-1</sup>·mL<sup>-1</sup>]of healthy rabbits（P【0.05）.The Ka（11.51±2.82）h<sup>-1</sup>,AUC（0.84±0.17）μg·h<sup>-1</sup>·mL<sup>-1</sup>of LW & SM-derived TMP in serum weremuch lower（P【0.05）than those[Ka=（19.58±4.14）h<sup>-1</sup>,AUC=（1.27±0.26）μg·h<sup>-1</sup>·mL<sup>-1</sup>]ofLW-derived TMP in serum after oral decoctions.CONCLUSION The SDS and blood stasissyndrome state could affect significantly thepharmacokinetic parameters of drugs and theabnormal SDS pharmacokinetic parameters couldbe normalized by SJZD.The combination ofChinese medicine in TCR could reciprocallyaffect the pharmacokinetic parameters of othercomponents absorbed into the systemiccirculation.These results support the S-and R-PK hypothesis.
基金supported by the National Natural Science Foundation of China(61703228)
文摘With the increment of the number of Gaussian components, the computation cost increases in the Gaussian mixture probability hypothesis density(GM-PHD) filter. Based on the theory of Chen et al, we propose an improved pruning algorithm for the GM-PHD filter, which utilizes not only the Gaussian components' means and covariance, but their weights as a new criterion to improve the estimate accuracy of the conventional pruning algorithm for tracking very closely proximity targets. Moreover, it solves the end-less while-loop problem without the need of a second merging step. Simulation results show that this improved algorithm is easier to implement and more robust than the formal ones.
文摘Independent of their etiology, all chronic liver diseases ultimately lead to liver cirrhosis, which is a majorhealth problem worldwide. The underlying molecular mechanisms are still poorly understood and no efficient treatment strategies are available. This paper introduces the sinusoidal pressure hypothesis(SPH), which identifies an elevated sinusoidal pressure(SP) as cause of fibrosis. SPH has been mainly derived from recent studies on liver stiffness. So far, pressure changes have been exclusively seen as a consequ-ence of cirrhosis. According to the SPH, however, an elevated SP is the major upstream event that initiates fibrosis via biomechanic signaling by stretching of perisinusoidal cells such as hepatic stellate cells or fibroblasts(SPH part?Ⅰ: initiation). Fibrosis progression is determined by the degree and time of elevated SP. The SPH predicts that the degree of extracellular matrix eventually matches SP with critical thresholds > 12 mmH g and > 4 wk. Elevated arterial flow and final arterialization of the cirrhotic liver represents the self-perpetuating key event exposing the low-pressure-organ to pathologically high pressures(SPH part?Ⅱ: perpetuation). It also defines the "point of no return" where fibrosis progression becomes irreversible. The SPH is able to explain the macroscopic changes of cirrhotic livers and the uniform fibrotic response to various etiologies. It also opens up new views on the role of fat and disease mechanisms in other organs. The novel concept will hopefully stimulate the search for new treatment strategies.
基金supported in part by the Teaching Reform Research Foundation of Shengli College in China University of Petroleum(East China)(JG201725)the Natural Science Foundation Shandong Province of China(ZR2018PEE009)the Project of Science and Technology of Shandong Universities in China(J17KA044,J17KB061)。
文摘Many effective optimization algorithms require partial derivatives of objective functions, while some optimization problems' objective functions have no derivatives. According to former research studies, some search directions are obtained using the quadratic hypothesis of objective functions. Based on derivatives, quadratic function assumptions, and directional derivatives, the computational formulas of numerical first-order partial derivatives, second-order partial derivatives, and numerical second-order mixed partial derivatives were constructed. Based on the coordinate transformation relation, a set of orthogonal vectors in the fixed coordinate system was established according to the optimization direction. A numerical algorithm was proposed, taking the second order approximation direction as an example. A large stepsize numerical algorithm based on coordinate transformation was proposed. Several algorithms were validated by an unconstrained optimization of the two-dimensional Rosenbrock objective function. The numerical second order approximation direction with the numerical mixed partial derivatives showed good results. Its calculated amount is 0.2843% of that of without second-order mixed partial derivative. In the process of rotating the local coordinate system 360°, because the objective function is more complex than the quadratic function, if the numerical direction derivative is used instead of the analytic partial derivative, the optimization direction varies with a range of 103.05°. Because theoretical error is in the numerical negative gradient direction, the calculation with the coordinate transformation is 94.71% less than the calculation without coordinate transformation. If there is no theoretical error in the numerical negative gradient direction or in the large-stepsize numerical optimization algorithm based on the coordinate transformation, the sawtooth phenomenon occurs. When each numerical mixed partial derivative takes more than one point, the optimization results cannot be improved. The numerical direction based on the quadratic hypothesis only requires the objective function to be obtained, but does not require derivability and does not take into account truncation error and rounding error. Thus, the application scopes of many optimization methods are extended.
文摘"The Input Hypothesis"and"The Affective Filter Hypothesis"are the most important branches of the"Monitor The ory"declared by the famous American linguist Krashen in 1980s.This thesis is based on Krashen's Input Hypothesis and Affec tive Filter Hypothesis,aiming to provide an applicable guide for foreign language teachers and learners in China.
文摘Krashen's Input Hypothesis and Pienemann's Teachability Hypothesis are two fairly important L2 acquisition theories.They catch more and more educators' attention and really contribute a lot to the teaching field.By elaborating the two theories and analyzing their similarities and differences,this paper aims to better the application of them into teaching and learning practices.
基金Supported by the National Natural Science Foundation of China (No.60772154)the President Foundation of Graduate University of Chinese Academy of Sciences (No.085102GN00)
文摘Probability Hypothesis Density (PHD) filtering approach has shown its advantages in tracking time varying number of targets even when there are noise,clutter and misdetection. For linear Gaussian Mixture (GM) system,PHD filter has a closed form recursion (GMPHD). But PHD filter cannot estimate the trajectories of multi-target because it only provides identity-free estimate of target states. Existing data association methods still remain a big challenge mostly because they are com-putationally expensive. In this paper,we proposed a new data association algorithm using GMPHD filter,which significantly alleviated the heavy computing load and performed multi-target trajectory tracking effectively in the meantime.
文摘The original online version of this article (Durmagambetov, A.A. (2016) The Riemann Hypothesis-Millennium Prize Problem. Advances in Pure Mathematics, 6, 915-920. 10.4236/apm.2016.612069) unfortunately contains a mistake. The author wishes to correct the errors in Theorem 2 of the result part.
文摘From the theorem 1 formulated in [1], a set of functions of measure zero within the set of all corresponding functions has to be excluded. These are the cases where the Omega functions Ω(u)?are piece-wise constant on intervals of equal length and non-increasing due to application of second mean-value theorem or, correspondingly, where for the Xi functions Ξ(z)?the functions Ξ(y)y are periodic functions on the imaginary axis y with?z=x+iy. This does not touch the results for the Omega function to the Riemann hypothesis by application of the second mean-value theorem of calculus and the majority of other Omega functions in the suppositions, but makes their derivation correct. The corresponding calculations together with a short recapitulation of the main steps to the basic equations for the restrictions of the mean-value functions and the application to piece-wise constant Omega functions (staircase functions) are represented.
文摘By the second mean-value theorem of calculus (Gauss-Bonnet theorem) we prove that the class of functionswith an integral representation of the form with a real-valued function which is non-increasing and decreases in infinity more rapidly than any exponential functions , possesses zeros only on the imaginary axis. The Riemann zeta function as it is known can be related to an entire functionwith the same non-trivial zeros as . Then after a trivial argument displacement we relate it to a function with a representation of the form where is rapidly decreasing in infinity and satisfies all requirements necessary for the given proof of the position of its zeros on the imaginary axis z=iy by the second mean-value theorem. Besides this theorem we apply the Cauchy-Riemann differential equation in an integrated operator form derived in the Appendix B. All this means that we prove a theorem for zeros of on the imaginary axis z=iy for a whole class of function which includes in this way the proof of the Riemann hypothesis. This whole class includes, in particular, also the modified Bessel functions for which it is known that their zeros lie on the imaginary axis and which affirms our conclusions that we intend to publish at another place. In the same way a class of almost-periodic functions to piece-wise constant non-increasing functions belong also to this case. At the end we give shortly an equivalent way of a more formal description of the obtained results using the Mellin transform of functions with its variable substituted by an operator.
文摘Lexical developmental hypothesis arouses many linguists' interests and stimulates them to test it in various ways.However,in testing this model,quite a few collisions emerge between different research conclusions.This essay critically reviews three researches which focus on how bilingual's L2 vocabulary processing way varies with proficiency level,and sorts out the discrepancies between results concerning the effect of concept mediation on L2 lexical processing.After a close analysis of the researches' variables,including yardstick of subjects' proficiency,subjects' L2 learning strategies,word imageability,and translation direction,the writer proposes possible causes of the discrepancies,and justifies the hypotheses implicated by the lexical developmental model.
文摘Krashen's Input hypothesis and Long's Interaction hypothesis are both valuable research results in the field of language acquisition and play a significant role in language teaching and learning instruction.Through comparing them,their similarities lie in same goal and basis,same focus on comprehension and same challenge the traditional teaching concept.While the differences lie in Different ways to make exposure comprehensible and different roles that learners play.It is meaningful to make the comparison because the results can be valuable guidance and highlights for language teachers and learners to teach or acquire a new language more efficiently.
