Objective:To investigate the expression and significance of IL-38 protein in gastric carcinoma and normal tissues adjacent to carcinoma and to evaluate the relationship between the expressions and the clinical patholo...Objective:To investigate the expression and significance of IL-38 protein in gastric carcinoma and normal tissues adjacent to carcinoma and to evaluate the relationship between the expressions and the clinical pathologic factors.Methods:High throughput technology of tissue microarray and immunohistochemical SP method were applied to detect the expressions of IL-38 protein in 78 gastric carcinoma specimens that did not have a history of chemo-radiotherapy and 72 non-tumor gastric tissues.The followed-up cases were used for prognosis analysis.Results:The positive expression rate of IL-38 in gastric cancer tissues was 84.6%,and the expression rate in adjacent tissues was 45.8%.The difference between the two groups was statistically significant.IL-38 protein showed relationship with tumor TNM stage and lymph node metastasis.Kaplan-Meier survival analysis showed that the high expression of IL-38 was associated with poor prognosis of gastric cancer.Cox proportional hazard regression analysis showed that IL-38,tumor TNM clinical stage and lymph node metastasis were associated with prognosis,and IL-38 and lymph node metastasis could be used as independent prognostic factors.Conclusion:IL-38 is highly expressed in gastric cancer tissues,and the positive expression of IL-38 is associated with tumor TNM stage and lymph node metastasis.High expression of IL-38 is associated with poor prognosis in patients with gastric cancer,and IL-38 and lymph node metastasis can be used as independent prognostic factors.This experiment clarifies the relationship between IL-38 and clinicopathological parameters and prognosis of gastric cancer,and provides a new target for clinical diagnosis and treatment of gastric cancer.展开更多
基金National Natural Science Foundation of China(81502030).
文摘Objective:To investigate the expression and significance of IL-38 protein in gastric carcinoma and normal tissues adjacent to carcinoma and to evaluate the relationship between the expressions and the clinical pathologic factors.Methods:High throughput technology of tissue microarray and immunohistochemical SP method were applied to detect the expressions of IL-38 protein in 78 gastric carcinoma specimens that did not have a history of chemo-radiotherapy and 72 non-tumor gastric tissues.The followed-up cases were used for prognosis analysis.Results:The positive expression rate of IL-38 in gastric cancer tissues was 84.6%,and the expression rate in adjacent tissues was 45.8%.The difference between the two groups was statistically significant.IL-38 protein showed relationship with tumor TNM stage and lymph node metastasis.Kaplan-Meier survival analysis showed that the high expression of IL-38 was associated with poor prognosis of gastric cancer.Cox proportional hazard regression analysis showed that IL-38,tumor TNM clinical stage and lymph node metastasis were associated with prognosis,and IL-38 and lymph node metastasis could be used as independent prognostic factors.Conclusion:IL-38 is highly expressed in gastric cancer tissues,and the positive expression of IL-38 is associated with tumor TNM stage and lymph node metastasis.High expression of IL-38 is associated with poor prognosis in patients with gastric cancer,and IL-38 and lymph node metastasis can be used as independent prognostic factors.This experiment clarifies the relationship between IL-38 and clinicopathological parameters and prognosis of gastric cancer,and provides a new target for clinical diagnosis and treatment of gastric cancer.
