Neurologists define the transmission of nerve impulses across the membranes of the neural cells as a result of difference in the concentration of ions while they measured an electric potential, called as an action pot...Neurologists define the transmission of nerve impulses across the membranes of the neural cells as a result of difference in the concentration of ions while they measured an electric potential, called as an action potential, which allows the propagation of such nerve impulses as electrical signals. Such measurements should guide them to a logical explanation of the nerve impulses as electric charges driven by the measured action potential. However, such logical conclusion, or explanation, is ignored due to a wrong definition of the flow of electric charges as a flow of electrons that cannot pass through neural networks. According to recent studies, electric charges are properly defined as electromagnetic (EM) waves whose energy is expressed as the product of its propagating electric potential times their entropy flow which is adhered to the flow of such energy. Such definition matches the logical conclusion of the nerve impulses as electric charges, as previously explained, and defines the entropy of the neural network, measured by Ammeters, in Watt or Joule/Volt. The measured entropy represents a neurodiagnostic property of the neural networks that measures its capacity to allow the flow of energy per unit action potential. Theoretical verification of the innovative definition of nerve impulses is presented by following an advanced entropy approach. A proper review of the machine records of the stimulating electric charges, used in the diagnosis of the neural networks, and the stimulated nerve impulses or stimulated responses, represents practical verifications of the innovative definitions of the electric charges and the nerve impulses. Comparing the functioning of the thermoelectric generators and the brain neurons, such neurons are defined as thermoelectric generators of the electric nerve impulses and their propagating, or action, potential.展开更多
Isolationism and expansionism are two themes of American diplomacy. From the beginning of the state’s history, isolationism and expansionism have manifested themselves as two policy imperatives in American diplomacy....Isolationism and expansionism are two themes of American diplomacy. From the beginning of the state’s history, isolationism and expansionism have manifested themselves as two policy imperatives in American diplomacy. On the surface, isolationism and expansionism represent contradictory attitudes and assumptions about America’s proper relationship with the outside world: isolationism advocates diplomatic and military non-entanglement in world affairs; expansionism urges active involvement in external affairs. But in a deeper sense, both isolationism and expansionism are manifestations of American sense of mission, the belief that the US has a special role to perform for all nations in the world. Isolationism is a passive approach to accomplish that mission: it emphasizes the exemplary nature of their country. Expansionism stresses the need for active involvement to achieve that mission; thus, is an active approach to American mission.展开更多
Hearing loss is a common military health problem and it is closely related to exposures to impulse noises from blast explosions and weapon firings. In a study based on test data of chinchillas and scaled to humans (Mi...Hearing loss is a common military health problem and it is closely related to exposures to impulse noises from blast explosions and weapon firings. In a study based on test data of chinchillas and scaled to humans (Military Medicine, 181: 59-69), an empirical injury model was constructed for exposure to multiple sound impulses of equal intensity. Building upon the empirical injury model, we conduct a mathematical study of the hearing loss injury caused by multiple impulses of non-uniform intensities. We adopt the theoretical framework of viewing individual sound exposures as separate injury causing events, and in that framework, we examine synergy for causing injury (fatigue) or negative synergy (immunity) or independence among a sequence of doses. Starting with the empirical logistic dose-response relation and the empirical dose combination rule, we show that for causing injury, a sequence of sound exposure events are not independent of each other. The phenomenological effect of a preceding event on the subsequent event is always immunity. We extend the empirical dose combination rule, which is applicable only in the case of homogeneous impulses of equal intensity, to accommodate the general case of multiple heterogeneous sound exposures with non-uniform intensities. In addition to studying and extending the empirical dose combination rule, we also explore the dose combination rule for the hypothetical case of independent events, and compare it with the empirical one. We measure the effect of immunity quantitatively using the immunity factor defined as the percentage of decrease in injury probability attributed to the sound exposure in the preceding event. Our main findings on the immunity factor are: 1) the immunity factor is primarily a function of the difference in SELA (A- weighted sound exposure level) between the two sound exposure events;it is virtually independent of the magnitude of the two SELA values as long as the difference is fixed;2) the immunity factor increases monotonically from 0 to 100% as the first dose is varied from being significantly below the second dose, to being moderately above the second dose. The extended dose-response formulation developed in this study provides a theoretical framework for assessing the injury risk in realistic situations.展开更多
We consider the hearing loss injury among subjects in a crowd with a wide spectrum of individual intrinsic injury probabilities due to biovariability. For multiple acoustic impulses, the observed injury risk of a crow...We consider the hearing loss injury among subjects in a crowd with a wide spectrum of individual intrinsic injury probabilities due to biovariability. For multiple acoustic impulses, the observed injury risk of a crowd vs the effective combined dose follows the logistic dose-response relation. The injury risk of a crowd is the average fraction of injured. The injury risk was measured in experiments as follows: each subject is individually exposed to a sequence of acoustic impulses of a given intensity and the injury is recorded;results of multiple individual subjects were assembled into data sets to mimic the response of a crowd. The effective combined dose was adjusted by varying the number of impulses in the sequence. The most prominent feature observed in experiments is that the injury risk of the crowd caused by multiple impulses is significantly less than the value predicted based on assumption that all impulses act independently in causing injury and all subjects in the crowd are statistically identical. Previously, in the case where all subjects are statistically identical (i.e., no biovariability), we interpreted the observed injury risk caused by multiple impulses in terms of the immunity effects of preceding impulses on subsequent impulses. In this study, we focus on the case where all sound exposure events act independently in causing injury regardless of whether one is preceded by another (i.e., no immunity effect). Instead, we explore the possibility of interpreting the observed logistic dose-response relation in the framework of biovariability of the crowd. Here biovariability means that subjects in the crowd have their own individual injury probabilities. That is, some subjects are biologically less or more susceptible to hearing loss injury than others. We derive analytically the distribution of individual injury probability that produces the observed logistic dose-response relation. For several parameter values, we prove that the derived distribution is mathematically a proper density function. We further study the asymptotic approximations for the density function and discuss their significance in practical numerical computation with finite precision arithmetic. Our mathematical analysis implies that the observed logistic dose-response relation can be theoretically explained in the framework of biovariability in the absence of immunity effect.展开更多
The results of research on influence of an irradiation of a liquid phase by nanosecond electromagnetic impulses(NEMI) on processes of crystallization and structurization,physicomechanical and operational properties of...The results of research on influence of an irradiation of a liquid phase by nanosecond electromagnetic impulses(NEMI) on processes of crystallization and structurization,physicomechanical and operational properties of copper,aluminium and alloys on their basis(bronze and silumin) were presented.展开更多
The author aimed to investigate the solvability for nonlinear differential equations with not instantaneous impulses.Variational approach was adopted to obtain the existence of weak solutions as critical points. The f...The author aimed to investigate the solvability for nonlinear differential equations with not instantaneous impulses.Variational approach was adopted to obtain the existence of weak solutions as critical points. The findings of this study may serve as a reference for multiplicity of impulsive problems.展开更多
A fixed mesh variational formulation is used to establish existence and uniqueness of the solution of ordinary differential equations with (in finitely many) state-dependent in pulses on the right-hand side. This appr...A fixed mesh variational formulation is used to establish existence and uniqueness of the solution of ordinary differential equations with (in finitely many) state-dependent in pulses on the right-hand side. This approach gives a natural numerical scheme to approximate the solution.The convergence of the approximation is proved and its asymptatic order obtained.展开更多
Considering the mutual interference between species, a stochastic predator-prey model with impulses and Holling-II functional response is proposed in this paper. Firstly, by constructing an equivalent system without i...Considering the mutual interference between species, a stochastic predator-prey model with impulses and Holling-II functional response is proposed in this paper. Firstly, by constructing an equivalent system without impulses, the existence of a globally unique positive solution is proved. Secondly, in cases of the mutual coefficient m = 1 and 0 m < 1, by constructing suitable Lyapunov functional, the existence of T-periodic solution is investigated under some certain conditions. Finally, numerical simulation is introduced to verify our main results.展开更多
For many control systems in real life, impulses and delays are intrinsic phenomena that do not modify their controllability. So we conjecture that under certain conditions the abrupt changes and delays as perturbation...For many control systems in real life, impulses and delays are intrinsic phenomena that do not modify their controllability. So we conjecture that under certain conditions the abrupt changes and delays as perturbations of a system do not destroy its controllability. There are many practical examples of impulsive control systems with delays, such as a chemical reactor system, a financial system with two state variables, the amount of money in a market and the savings rate of a central bank, and the growth of a population diffusing throughout its habitat modeled by a reaction-diffusion equation. In this paper we apply the Rothe’s Fixed Point Theorem to prove the interior approximate controllability of the following Benjamin Bona-Mohany(BBM) type equation with impulses and delay where and are constants, Ω is a domain in , ω is an open non-empty subset of Ω , denotes the characteristic function of the set ω , the distributed control , are continuous functions and the nonlinear functions are smooth enough functions satisfying some additional conditions.展开更多
In this paper, astochastic predator-prey systems with nonlinear harvesting and impulsive effect are investigated. Firstly, we show the existence and uniqueness of the global positive solution of the system. Secondly, ...In this paper, astochastic predator-prey systems with nonlinear harvesting and impulsive effect are investigated. Firstly, we show the existence and uniqueness of the global positive solution of the system. Secondly, by constructing appropriate Lyapunov function and using comparison theorem with an impulsive differential equation, we study that a positive periodic solution exists. Thirdly, we prove that system is globally attractive. Finally, numerical simulations are presented to show the feasibility of the obtained results.展开更多
In this paper, by using the contraction mapping principle and constructing a suitable Lyapunov functional, we established a set of easily applicable criteria for the existence, uniqueness and global attractivity of po...In this paper, by using the contraction mapping principle and constructing a suitable Lyapunov functional, we established a set of easily applicable criteria for the existence, uniqueness and global attractivity of positive periodic solution and positive almost periodic solution of a neutral multi-species Logarithmic population model with multiple delays and impulses. The results improve and generalize the known ones in [1], as an application, we also give an example to illustrate the feasibility of our main results.展开更多
Information from the brain travels back and forth along peripheral nerves in the form of electrical impulses generated by neurons and these impulses have repetitive patterns. Schwann cells in peripheral nerves receive...Information from the brain travels back and forth along peripheral nerves in the form of electrical impulses generated by neurons and these impulses have repetitive patterns. Schwann cells in peripheral nerves receive molecular signals from axons to coordinate the process of myelination. There is evidence, however,that non-molecular signals play an important role in myelination in the form of patterned electrical impulses generated by neuronal activity. The role of patterned electrical impulses has been investigated in the literature using co-cultures of neurons and myelinating cells. The co-culturing method, however, prevents the uncoupling of the direct effect of patterned electrical impulses on myelinating cells from the indirect effect mediated by neurons. To uncouple these effects and focus on the direct response of Schwann cells,we developed an in vitro model where an electroconductive carbon fiber acts as an artificial axon. The fiber provides only the biophysical characteristics of an axon but does not contribute any molecular signaling.In our "suspended wire model", the carbon fiber is suspended in a liquid media supported by a 3D printed scaffold. Patterned electrical impulses are generated by an Arduino 101 microcontroller. In this study, we describe the technology needed to set-up and eventually replicate this model. We also report on our initial in vitro tests where we were able to document the adherence and ensheath of human Schwann cells to the carbon fiber in the presence of patterned electrical impulses(hSCs were purchased from ScienCell Research Laboratories, Carlsbad, CA, USA; ScienCell fulfills the ethic requirements, including donor's consent). This technology will likely make feasible to investigate the response of Schwann cells to patterned electrical impulses in the future.展开更多
Dear editor,Along with the progress of science and technology and the development of social civilization,control system brings an increasingly significant function in daily life.The application field of control system...Dear editor,Along with the progress of science and technology and the development of social civilization,control system brings an increasingly significant function in daily life.The application field of control system is very wide,for instance,in mobile technology[1],artificial earth satellite[2],pest control[3],etc.Ribeiro[4]first put forward the concept of random pulse in 1967.At present,impulsive control is used in networked control[5],secure communication[6],etc.In the 21st century,the impulsive control has been used in synchronization of coupled system,intelligent fault identification,image encryption.展开更多
In this paper, the qualitative properties of general nonautonomous Lotka-Volterran-species competitive systems with impulsive e?ects are studied. Some new criteria on thepermanence, extinction and global attractivity ...In this paper, the qualitative properties of general nonautonomous Lotka-Volterran-species competitive systems with impulsive e?ects are studied. Some new criteria on thepermanence, extinction and global attractivity of partial species are established by used themethods of inequalities estimate and Liapunov functions. As applications, nonautonomous twospecies Lotka-Volterra systems with impulses are discussed.展开更多
This paper investigates the exponential stability and performance analysis of nonlinear time-delay impulsive systems subject to actuator saturation. When continuous dynamics is unstable, under some conditions, it is s...This paper investigates the exponential stability and performance analysis of nonlinear time-delay impulsive systems subject to actuator saturation. When continuous dynamics is unstable, under some conditions, it is shown that the system can be stabilized by a class of saturated delayed-impulses regardless of the length of input delays. Conversely, when the system is originally stable, it is shown that under some conditions, the system is robust with respect to sufficient small delayed-impulses. Moreover, the design problem of the controller with the goal of obtaining a maximized estimate of the domain of attraction is formulated via a convex optimization problem. Three examples are provided to demonstrate the validity of the main results.展开更多
The sources of ultra low frequency (ULF) waves in the magnetosphere are generally believed to be either the external solar wind perturbations or the internal plasma instabilities. When a sudden impulse of the solar wi...The sources of ultra low frequency (ULF) waves in the magnetosphere are generally believed to be either the external solar wind perturbations or the internal plasma instabilities. When a sudden impulse of the solar wind dynamic pressure impinges on the magnetopause, ULF waves might be excited and thus the solar wind energy is transported into the earth's magnetosphere. In this paper, we study the ULF waves excited by different kinds of sudden solar wind pressure impulses through an MHD simulation. We primarily focus on the responses of the earth's magnetosphere to positive/negative impulses of solar wind dynamic pressure, and positive-negative impulse pairs. The simulation results show that the ULF waves excited by positive and negative impulse have the same amplitude and frequency, with 180° difference in phase, if the amplitude and durations of the input impulses are the same. In addition, it is found that field line resonances (FLRs) occur at certain L-shell regions of the earth's magneto-sphere after the impact of different positive-negative impulse pairs, which appear to be related to the duration of the impulses and the time interval between the sequential impulses. Another result is that the energy from the solar wind could be transported deeper into the inner magnetosphere by an impulse pair than by a single pulse impact. The results presented in this paper could help us to better understand how energy is transported from solar wind to the earth's magnetosphere via ULF waves. Also, these results provide some new clues to understanding of how energetic particles in the inner magnetosphere response to different kinds of solar wind pressure impulse impacts including inter-planetary shocks.展开更多
Sufficient conditions to guarantee the oscillations of fourth order ODE with impulses are obtained. The importance of the impulsive effect on the oscillations of higher order differential equations is stressed.
Near-fault impulsive ground-shaking is highly destructive to engineering structures,so its accurate identification ground-shaking is a top priority in the engineering field.However,due to the lack of a comprehensive c...Near-fault impulsive ground-shaking is highly destructive to engineering structures,so its accurate identification ground-shaking is a top priority in the engineering field.However,due to the lack of a comprehensive consideration of the ground-shaking characteristics in traditional methods,the generalization and accuracy of the identification process are low.To address these problems,an impulsive ground-shaking identification method combined with deep learning named PCA-LSTM is proposed.Firstly,ground-shaking characteristics were analyzed and groundshaking the data was annotated using Baker’smethod.Secondly,the Principal Component Analysis(PCA)method was used to extract the most relevant features related to impulsive ground-shaking.Thirdly,a Long Short-Term Memory network(LSTM)was constructed,and the extracted features were used as the input for training.Finally,the identification results for the Artificial Neural Network(ANN),Convolutional Neural Network(CNN),LSTM,and PCA-LSTMmodels were compared and analyzed.The experimental results showed that the proposed method improved the accuracy of pulsed ground-shaking identification by>8.358%and identification speed by>26.168%,compared to other benchmark models ground-shaking.展开更多
文摘Neurologists define the transmission of nerve impulses across the membranes of the neural cells as a result of difference in the concentration of ions while they measured an electric potential, called as an action potential, which allows the propagation of such nerve impulses as electrical signals. Such measurements should guide them to a logical explanation of the nerve impulses as electric charges driven by the measured action potential. However, such logical conclusion, or explanation, is ignored due to a wrong definition of the flow of electric charges as a flow of electrons that cannot pass through neural networks. According to recent studies, electric charges are properly defined as electromagnetic (EM) waves whose energy is expressed as the product of its propagating electric potential times their entropy flow which is adhered to the flow of such energy. Such definition matches the logical conclusion of the nerve impulses as electric charges, as previously explained, and defines the entropy of the neural network, measured by Ammeters, in Watt or Joule/Volt. The measured entropy represents a neurodiagnostic property of the neural networks that measures its capacity to allow the flow of energy per unit action potential. Theoretical verification of the innovative definition of nerve impulses is presented by following an advanced entropy approach. A proper review of the machine records of the stimulating electric charges, used in the diagnosis of the neural networks, and the stimulated nerve impulses or stimulated responses, represents practical verifications of the innovative definitions of the electric charges and the nerve impulses. Comparing the functioning of the thermoelectric generators and the brain neurons, such neurons are defined as thermoelectric generators of the electric nerve impulses and their propagating, or action, potential.
文摘Isolationism and expansionism are two themes of American diplomacy. From the beginning of the state’s history, isolationism and expansionism have manifested themselves as two policy imperatives in American diplomacy. On the surface, isolationism and expansionism represent contradictory attitudes and assumptions about America’s proper relationship with the outside world: isolationism advocates diplomatic and military non-entanglement in world affairs; expansionism urges active involvement in external affairs. But in a deeper sense, both isolationism and expansionism are manifestations of American sense of mission, the belief that the US has a special role to perform for all nations in the world. Isolationism is a passive approach to accomplish that mission: it emphasizes the exemplary nature of their country. Expansionism stresses the need for active involvement to achieve that mission; thus, is an active approach to American mission.
文摘Hearing loss is a common military health problem and it is closely related to exposures to impulse noises from blast explosions and weapon firings. In a study based on test data of chinchillas and scaled to humans (Military Medicine, 181: 59-69), an empirical injury model was constructed for exposure to multiple sound impulses of equal intensity. Building upon the empirical injury model, we conduct a mathematical study of the hearing loss injury caused by multiple impulses of non-uniform intensities. We adopt the theoretical framework of viewing individual sound exposures as separate injury causing events, and in that framework, we examine synergy for causing injury (fatigue) or negative synergy (immunity) or independence among a sequence of doses. Starting with the empirical logistic dose-response relation and the empirical dose combination rule, we show that for causing injury, a sequence of sound exposure events are not independent of each other. The phenomenological effect of a preceding event on the subsequent event is always immunity. We extend the empirical dose combination rule, which is applicable only in the case of homogeneous impulses of equal intensity, to accommodate the general case of multiple heterogeneous sound exposures with non-uniform intensities. In addition to studying and extending the empirical dose combination rule, we also explore the dose combination rule for the hypothetical case of independent events, and compare it with the empirical one. We measure the effect of immunity quantitatively using the immunity factor defined as the percentage of decrease in injury probability attributed to the sound exposure in the preceding event. Our main findings on the immunity factor are: 1) the immunity factor is primarily a function of the difference in SELA (A- weighted sound exposure level) between the two sound exposure events;it is virtually independent of the magnitude of the two SELA values as long as the difference is fixed;2) the immunity factor increases monotonically from 0 to 100% as the first dose is varied from being significantly below the second dose, to being moderately above the second dose. The extended dose-response formulation developed in this study provides a theoretical framework for assessing the injury risk in realistic situations.
文摘We consider the hearing loss injury among subjects in a crowd with a wide spectrum of individual intrinsic injury probabilities due to biovariability. For multiple acoustic impulses, the observed injury risk of a crowd vs the effective combined dose follows the logistic dose-response relation. The injury risk of a crowd is the average fraction of injured. The injury risk was measured in experiments as follows: each subject is individually exposed to a sequence of acoustic impulses of a given intensity and the injury is recorded;results of multiple individual subjects were assembled into data sets to mimic the response of a crowd. The effective combined dose was adjusted by varying the number of impulses in the sequence. The most prominent feature observed in experiments is that the injury risk of the crowd caused by multiple impulses is significantly less than the value predicted based on assumption that all impulses act independently in causing injury and all subjects in the crowd are statistically identical. Previously, in the case where all subjects are statistically identical (i.e., no biovariability), we interpreted the observed injury risk caused by multiple impulses in terms of the immunity effects of preceding impulses on subsequent impulses. In this study, we focus on the case where all sound exposure events act independently in causing injury regardless of whether one is preceded by another (i.e., no immunity effect). Instead, we explore the possibility of interpreting the observed logistic dose-response relation in the framework of biovariability of the crowd. Here biovariability means that subjects in the crowd have their own individual injury probabilities. That is, some subjects are biologically less or more susceptible to hearing loss injury than others. We derive analytically the distribution of individual injury probability that produces the observed logistic dose-response relation. For several parameter values, we prove that the derived distribution is mathematically a proper density function. We further study the asymptotic approximations for the density function and discuss their significance in practical numerical computation with finite precision arithmetic. Our mathematical analysis implies that the observed logistic dose-response relation can be theoretically explained in the framework of biovariability in the absence of immunity effect.
基金This work is financially supported by Program of Russian Foundation For Basic Research(No 05-08-01357)
文摘The results of research on influence of an irradiation of a liquid phase by nanosecond electromagnetic impulses(NEMI) on processes of crystallization and structurization,physicomechanical and operational properties of copper,aluminium and alloys on their basis(bronze and silumin) were presented.
基金National Natural Science Foundations of China(No.11601143,11801160)School Level Scientific Research Project of Hunan First Normal University,China(No.XYS14N15)
文摘The author aimed to investigate the solvability for nonlinear differential equations with not instantaneous impulses.Variational approach was adopted to obtain the existence of weak solutions as critical points. The findings of this study may serve as a reference for multiplicity of impulsive problems.
文摘A fixed mesh variational formulation is used to establish existence and uniqueness of the solution of ordinary differential equations with (in finitely many) state-dependent in pulses on the right-hand side. This approach gives a natural numerical scheme to approximate the solution.The convergence of the approximation is proved and its asymptatic order obtained.
文摘Considering the mutual interference between species, a stochastic predator-prey model with impulses and Holling-II functional response is proposed in this paper. Firstly, by constructing an equivalent system without impulses, the existence of a globally unique positive solution is proved. Secondly, in cases of the mutual coefficient m = 1 and 0 m < 1, by constructing suitable Lyapunov functional, the existence of T-periodic solution is investigated under some certain conditions. Finally, numerical simulation is introduced to verify our main results.
文摘For many control systems in real life, impulses and delays are intrinsic phenomena that do not modify their controllability. So we conjecture that under certain conditions the abrupt changes and delays as perturbations of a system do not destroy its controllability. There are many practical examples of impulsive control systems with delays, such as a chemical reactor system, a financial system with two state variables, the amount of money in a market and the savings rate of a central bank, and the growth of a population diffusing throughout its habitat modeled by a reaction-diffusion equation. In this paper we apply the Rothe’s Fixed Point Theorem to prove the interior approximate controllability of the following Benjamin Bona-Mohany(BBM) type equation with impulses and delay where and are constants, Ω is a domain in , ω is an open non-empty subset of Ω , denotes the characteristic function of the set ω , the distributed control , are continuous functions and the nonlinear functions are smooth enough functions satisfying some additional conditions.
文摘In this paper, astochastic predator-prey systems with nonlinear harvesting and impulsive effect are investigated. Firstly, we show the existence and uniqueness of the global positive solution of the system. Secondly, by constructing appropriate Lyapunov function and using comparison theorem with an impulsive differential equation, we study that a positive periodic solution exists. Thirdly, we prove that system is globally attractive. Finally, numerical simulations are presented to show the feasibility of the obtained results.
文摘In this paper, by using the contraction mapping principle and constructing a suitable Lyapunov functional, we established a set of easily applicable criteria for the existence, uniqueness and global attractivity of positive periodic solution and positive almost periodic solution of a neutral multi-species Logarithmic population model with multiple delays and impulses. The results improve and generalize the known ones in [1], as an application, we also give an example to illustrate the feasibility of our main results.
基金supported by the New Jersey Health Foundation under Grant#PC94-17the National Institute of Biomedical Imaging And Bioengineering of the National Institutes of Health under Award Number P41EB001046(both to JK)
文摘Information from the brain travels back and forth along peripheral nerves in the form of electrical impulses generated by neurons and these impulses have repetitive patterns. Schwann cells in peripheral nerves receive molecular signals from axons to coordinate the process of myelination. There is evidence, however,that non-molecular signals play an important role in myelination in the form of patterned electrical impulses generated by neuronal activity. The role of patterned electrical impulses has been investigated in the literature using co-cultures of neurons and myelinating cells. The co-culturing method, however, prevents the uncoupling of the direct effect of patterned electrical impulses on myelinating cells from the indirect effect mediated by neurons. To uncouple these effects and focus on the direct response of Schwann cells,we developed an in vitro model where an electroconductive carbon fiber acts as an artificial axon. The fiber provides only the biophysical characteristics of an axon but does not contribute any molecular signaling.In our "suspended wire model", the carbon fiber is suspended in a liquid media supported by a 3D printed scaffold. Patterned electrical impulses are generated by an Arduino 101 microcontroller. In this study, we describe the technology needed to set-up and eventually replicate this model. We also report on our initial in vitro tests where we were able to document the adherence and ensheath of human Schwann cells to the carbon fiber in the presence of patterned electrical impulses(hSCs were purchased from ScienCell Research Laboratories, Carlsbad, CA, USA; ScienCell fulfills the ethic requirements, including donor's consent). This technology will likely make feasible to investigate the response of Schwann cells to patterned electrical impulses in the future.
基金supported by the Foundation of Chongqing Municipal Key Laboratory of Institutions of Higher Education([2017]3)Foundation of Chongqing Development and Reform Commission(2017[1007])。
文摘Dear editor,Along with the progress of science and technology and the development of social civilization,control system brings an increasingly significant function in daily life.The application field of control system is very wide,for instance,in mobile technology[1],artificial earth satellite[2],pest control[3],etc.Ribeiro[4]first put forward the concept of random pulse in 1967.At present,impulsive control is used in networked control[5],secure communication[6],etc.In the 21st century,the impulsive control has been used in synchronization of coupled system,intelligent fault identification,image encryption.
基金Supported by The National Natural Science Foundation of P.R. China [60764003]The Scientific Research Programmes of Colleges in Xinjiang [XJEDU2007G01, XJEDU2006I05]+1 种基金The National Key Technologies R & D Program of China [2008BAI68B01]The Natural Science Foundation of Jiangxi Province [2008GZS0027]
文摘In this paper, the qualitative properties of general nonautonomous Lotka-Volterran-species competitive systems with impulsive e?ects are studied. Some new criteria on thepermanence, extinction and global attractivity of partial species are established by used themethods of inequalities estimate and Liapunov functions. As applications, nonautonomous twospecies Lotka-Volterra systems with impulses are discussed.
基金supported by National Natural Science Foundation of China (62173215)Major Basic Research Program of the Natural Science Foundation of Shandong Province in China(ZR2021ZD04, ZR2020ZD24)the Support Plan for Outstanding Youth Innovation Team in Shandong Higher Education Institutions (2019KJI008)。
文摘This paper investigates the exponential stability and performance analysis of nonlinear time-delay impulsive systems subject to actuator saturation. When continuous dynamics is unstable, under some conditions, it is shown that the system can be stabilized by a class of saturated delayed-impulses regardless of the length of input delays. Conversely, when the system is originally stable, it is shown that under some conditions, the system is robust with respect to sufficient small delayed-impulses. Moreover, the design problem of the controller with the goal of obtaining a maximized estimate of the domain of attraction is formulated via a convex optimization problem. Three examples are provided to demonstrate the validity of the main results.
基金Supported by the National Natural Science Foundation of China (Grant No. 40831061)
文摘The sources of ultra low frequency (ULF) waves in the magnetosphere are generally believed to be either the external solar wind perturbations or the internal plasma instabilities. When a sudden impulse of the solar wind dynamic pressure impinges on the magnetopause, ULF waves might be excited and thus the solar wind energy is transported into the earth's magnetosphere. In this paper, we study the ULF waves excited by different kinds of sudden solar wind pressure impulses through an MHD simulation. We primarily focus on the responses of the earth's magnetosphere to positive/negative impulses of solar wind dynamic pressure, and positive-negative impulse pairs. The simulation results show that the ULF waves excited by positive and negative impulse have the same amplitude and frequency, with 180° difference in phase, if the amplitude and durations of the input impulses are the same. In addition, it is found that field line resonances (FLRs) occur at certain L-shell regions of the earth's magneto-sphere after the impact of different positive-negative impulse pairs, which appear to be related to the duration of the impulses and the time interval between the sequential impulses. Another result is that the energy from the solar wind could be transported deeper into the inner magnetosphere by an impulse pair than by a single pulse impact. The results presented in this paper could help us to better understand how energy is transported from solar wind to the earth's magnetosphere via ULF waves. Also, these results provide some new clues to understanding of how energetic particles in the inner magnetosphere response to different kinds of solar wind pressure impulse impacts including inter-planetary shocks.
基金Project supported by Natural Science Foundation of Guangdong(011471)Natural Science Foundation of Guangdong Higher Education(0120).
文摘Sufficient conditions to guarantee the oscillations of fourth order ODE with impulses are obtained. The importance of the impulsive effect on the oscillations of higher order differential equations is stressed.
文摘Near-fault impulsive ground-shaking is highly destructive to engineering structures,so its accurate identification ground-shaking is a top priority in the engineering field.However,due to the lack of a comprehensive consideration of the ground-shaking characteristics in traditional methods,the generalization and accuracy of the identification process are low.To address these problems,an impulsive ground-shaking identification method combined with deep learning named PCA-LSTM is proposed.Firstly,ground-shaking characteristics were analyzed and groundshaking the data was annotated using Baker’smethod.Secondly,the Principal Component Analysis(PCA)method was used to extract the most relevant features related to impulsive ground-shaking.Thirdly,a Long Short-Term Memory network(LSTM)was constructed,and the extracted features were used as the input for training.Finally,the identification results for the Artificial Neural Network(ANN),Convolutional Neural Network(CNN),LSTM,and PCA-LSTMmodels were compared and analyzed.The experimental results showed that the proposed method improved the accuracy of pulsed ground-shaking identification by>8.358%and identification speed by>26.168%,compared to other benchmark models ground-shaking.
