There is a strong correlation between bisphenol A(BPA)and the risks of endocrine disruption in humans.However,the mechanism behind this correlation is still unknown due to the challenge of accurately assessing BPA lev...There is a strong correlation between bisphenol A(BPA)and the risks of endocrine disruption in humans.However,the mechanism behind this correlation is still unknown due to the challenge of accurately assessing BPA levels in biological matrices.Herein,we demonstrate a molecularly imprinted polymer(MIP)modified impedimetric sensor treated with bovine serum albumin(BSA)not only reduces the impact of protein interference but also maintains both specificity and sensitivity for the precise analysis of BPA.The platinum disc electrode was coated with MIP via electrochemical polymerization of o-phenylenediamine(o-PD)in the presence of BPA as a template,and free sites were then blocked with 1%BSA.Electrochemical impedance spectroscopy(EIS)was utilized for the detection of BPA.The linear range for detection was between 1.0 pg/L and 10.0 ng/L,with a detection limit(LOD)of 0.28 pg/L.The sensor presented a good selectivity over structurally similar steroid hormones and BPA metabolites.To validate the performance of the proposed sensor in the presence of possible interfering proteins,it was used to quantify BPA in real samples without any prior treatment.These findings indicate that such an impedimetric sensor can be used to measure BPA in complex matrices.展开更多
The aim of this work was to study the electrochemical behavior of gold electrode which was modified with p-tert-butylcalix[6]arene membrane and this in the presence of different nickel ions based concentrations in ord...The aim of this work was to study the electrochemical behavior of gold electrode which was modified with p-tert-butylcalix[6]arene membrane and this in the presence of different nickel ions based concentrations in order to form a nickel electrochemical sensor. For that, impedance-spec- troscopy characteristics have been investigated. The obtained results were then modeled by appropriate equivalent circuit aiming at elucidating the electrical properties of the modified gold transducer. A correlation between the present impedimetric results and previous potentiometric ones was achieved traducing then a fast ionic transfer.展开更多
The COVID-19 outbreak led to an uncontrollable situation and was later declared a global pandemic.RT-PCR is one of the reliable methods for the detection of COVID-19,but it requires transporting samples to sophisticat...The COVID-19 outbreak led to an uncontrollable situation and was later declared a global pandemic.RT-PCR is one of the reliable methods for the detection of COVID-19,but it requires transporting samples to sophisticated laboratories and takes a significant amount of time to amplify the viral genome.Therefore,there is an urgent need for a large-scale,rapid,specific,and portable detection kit.Nowadays nanomaterials-based detection technology has been developed and it showed advancement over the conventional methods in selectivity and sensitivity.This review aims at summarising some of the most promising nanomaterial-based sensing technologies for detecting SARS-CoV-2.Nanomaterials possess unique physical,chemical,electrical and optical properties,which can be exploited for the application in biosensors.Furthermore,nanomaterials work on the same scale as biological processes and can be easily functionalized with substrates of interest.These devices do not require extraordinary sophistication and are suitable for use by common individuals without high-tech laboratories.Electrochemical and colorimetric methods similar to glucometer and pregnancy test kits are discussed and reviewed as potential diagnostic devices for COVID-19.Other devices working on the principle of immune response and microarrays are also discussed as possible candidates.Nanomaterials such as metal nanoparticles,graphene,quantum dots,and CNTs enhance the limit of detection and accuracy of the biosensors to give spontaneous results.The challenges of industrial-scale production of these devices are also discussed.If mass production is successfully developed,these sensors can ramp up the testing to provide the accurate number of people aff ected by the virus,which is extremely critical in today’s scenario.展开更多
基金supported by the Foundation of Liaoning Province Education Administration(LJKZ1145)the Natural Science Foundation of Liaoning Province(2022–NLTS–14–02)。
文摘There is a strong correlation between bisphenol A(BPA)and the risks of endocrine disruption in humans.However,the mechanism behind this correlation is still unknown due to the challenge of accurately assessing BPA levels in biological matrices.Herein,we demonstrate a molecularly imprinted polymer(MIP)modified impedimetric sensor treated with bovine serum albumin(BSA)not only reduces the impact of protein interference but also maintains both specificity and sensitivity for the precise analysis of BPA.The platinum disc electrode was coated with MIP via electrochemical polymerization of o-phenylenediamine(o-PD)in the presence of BPA as a template,and free sites were then blocked with 1%BSA.Electrochemical impedance spectroscopy(EIS)was utilized for the detection of BPA.The linear range for detection was between 1.0 pg/L and 10.0 ng/L,with a detection limit(LOD)of 0.28 pg/L.The sensor presented a good selectivity over structurally similar steroid hormones and BPA metabolites.To validate the performance of the proposed sensor in the presence of possible interfering proteins,it was used to quantify BPA in real samples without any prior treatment.These findings indicate that such an impedimetric sensor can be used to measure BPA in complex matrices.
文摘The aim of this work was to study the electrochemical behavior of gold electrode which was modified with p-tert-butylcalix[6]arene membrane and this in the presence of different nickel ions based concentrations in order to form a nickel electrochemical sensor. For that, impedance-spec- troscopy characteristics have been investigated. The obtained results were then modeled by appropriate equivalent circuit aiming at elucidating the electrical properties of the modified gold transducer. A correlation between the present impedimetric results and previous potentiometric ones was achieved traducing then a fast ionic transfer.
文摘The COVID-19 outbreak led to an uncontrollable situation and was later declared a global pandemic.RT-PCR is one of the reliable methods for the detection of COVID-19,but it requires transporting samples to sophisticated laboratories and takes a significant amount of time to amplify the viral genome.Therefore,there is an urgent need for a large-scale,rapid,specific,and portable detection kit.Nowadays nanomaterials-based detection technology has been developed and it showed advancement over the conventional methods in selectivity and sensitivity.This review aims at summarising some of the most promising nanomaterial-based sensing technologies for detecting SARS-CoV-2.Nanomaterials possess unique physical,chemical,electrical and optical properties,which can be exploited for the application in biosensors.Furthermore,nanomaterials work on the same scale as biological processes and can be easily functionalized with substrates of interest.These devices do not require extraordinary sophistication and are suitable for use by common individuals without high-tech laboratories.Electrochemical and colorimetric methods similar to glucometer and pregnancy test kits are discussed and reviewed as potential diagnostic devices for COVID-19.Other devices working on the principle of immune response and microarrays are also discussed as possible candidates.Nanomaterials such as metal nanoparticles,graphene,quantum dots,and CNTs enhance the limit of detection and accuracy of the biosensors to give spontaneous results.The challenges of industrial-scale production of these devices are also discussed.If mass production is successfully developed,these sensors can ramp up the testing to provide the accurate number of people aff ected by the virus,which is extremely critical in today’s scenario.
