Induced abortion signifies that pregnancy has been tempered with. Abortion is the removal of an embryo or fetus weighing less than 500 grams from its mother. It can either be spontaneous (unprompted) or induced. Abort...Induced abortion signifies that pregnancy has been tempered with. Abortion is the removal of an embryo or fetus weighing less than 500 grams from its mother. It can either be spontaneous (unprompted) or induced. Abortion remains one of the leading causes of maternal deaths in developing countries with induced abortion being the key cause. In 2014 from January to August, 9 abortion related deaths occurred in Botswana. There are several reasons female students in tertiary institutions resort to seeking induced abortion which include the socio-demographics like age and socio-economic factors like financial instability. Parental fears, unintended pregnancy and pressure from the partner also force females to terminate pregnancy. Induced abortion has claimed many women’s lives especially in developing countries with very restrictive abortion laws like Botswana as women do not access safe abortion care services. The study intends to establish the determinants of induced abortion among female students in selected tertiary learning institutions in Gaborone City, Botswana. It concentrated primarily on determining the prevalence of induced abortion. This was a descriptive cross-sectional study using both quantitative and qualitative data collection techniques. Systematic random sampling technique was used to come up with 278 participants. Prior to commencement of data collection, all ethical and logistical prerequisites were satisfied. Informed consent was solicited from all the study participants and the purpose of the study was fully explained. A self-administered questionnaire was used to collect data. Microsoft Excel spread sheet was used to code, clean, and enter the data, which was then exported for analysis to the statistical package for social sciences version 24. Frequency distribution tables, percentages graphs, and pie charts were used to illustrate the descriptive information. The study revealed that prevalence of induced abortion among female students in Gaborone City is 7.9%. They even suggested that induced abortion be liberalized. Age was the only socio-demographic factor associated with induced abortion with p = 0.047 using Chi Square test χ<sup>2</sup> = 7.609, df = 3. The study findings concluded that female students resort to induced abortion as a result of pressure from both parents and male partners especially when the pregnancy is unintended. The study recommends that the abortion law in Botswana be made liberal to ease access to safe abortion care services. It also recommends that contraceptive commodities should consistently be available in public health facilities.展开更多
<b>Background: </b>Though painless abortion is a safe, effective and excellent method of artificial abortion, intravenous anesthesia cannot effectively expand the cervix. Hard and tight cervix often affect...<b>Background: </b>Though painless abortion is a safe, effective and excellent method of artificial abortion, intravenous anesthesia cannot effectively expand the cervix. Hard and tight cervix often affects the operation and easily inducesabortion complications. Misoprostol can induce uterine contraction and soften the cervix. <b>Objective:</b> To investigate the clinical effect of misoprostol on abortion before and after painless induced abortion. <b>Methods:</b> 600 case pregnant women were divided into three groups: A, B and C, 200 case in each group. All patients were anesthetized. In group A, misoprostol 0.2 ug was placed in the posterior fornix of vagina 2 hours before the operation of induced abortion;in group B, misoprostol 0.2 ug was not only placed in the posterior fornix of vagina 2 hours before the operation of induced abortion but also taken orally 2 hours and 6 hours after the operation;in group C, misoprostol was not used before and after the operation. The operation time, intraoperative bleeding volume, postoperative bleeding, the percentage of cervical relaxation and the rate of incomplete abortion among the three groups were compared. <b>Results:</b> Compared with group A and group B, the operation time of group C was longer and the amount of bleeding was more (P < 0.05), but there was no significant difference between group A and group B (P > 0.05). The duration of bleeding in group B was less than that in group A (P < 0.05). The percentage of cervical relaxation in group A and B was higher than that in group C (P < 0.05). The rate of incomplete abortion in group B < group A < group C (P < 0.05), and there was no residual uterine cavity in group B. <b>Conclusion:</b> The use of misoprostol before and after painless induced abortion can not only shorten the time of operation, reduce intraoperative and postoperative vaginal bleeding, but also has not incurred incomplete abortion(primary outcome).展开更多
There is no credible scientific opposition to the fact that a genetically distinct human life begins at conception and that an induced abortion is a death. Yet, abortion is not reported as a cause of death in the U.S....There is no credible scientific opposition to the fact that a genetically distinct human life begins at conception and that an induced abortion is a death. Yet, abortion is not reported as a cause of death in the U.S. vital statistics system. Mortality patterns have profound implications for public policy. As a cause of death, we found abortion to be highly consequential, with large racial and ethnic disparities. Abortion represented 16.4% of non-Hispanic White deaths, but 61.1% and 64.0% of non-Hispanic Black and Hispanic deaths respectively. For Years of Potential Life Lost (YPLL), the ubiquitous measure of premature death, abortion accumulated 63.1% of non-Hispanic White YPLL and 86.5% and 87.4% of non-Hispanic Black and Hispanic YPLL respectively. Further, as measured by the availability of valid data and resources allocated for research, there is evidence that the science community is not appropriately engaged on this crucial public health problem.展开更多
In the era of the second demographic transition,“diverging destinies”theory states that women with the most economic opportunities often obtain gains while women with the least economic opportunities suffer from los...In the era of the second demographic transition,“diverging destinies”theory states that women with the most economic opportunities often obtain gains while women with the least economic opportunities suffer from losses.Using nationally represent-ative data from the 2017 China Fertility Survey,we attempted to examine if diverg-ing destinies theory can explain differences in the incidence of induced abortion among women with differing economic opportunities.We found that women with good economic opportunities(i.e.,well-educated and holding urban hukou)were more likely to have induced abortions between 1980 and 2010 and less likely to do so between 2015 and 2017.Moreover,younger cohorts were far more likely to have induced abortions at a younger age and before marriage.These findings provide sup-portive evidence for diverging destinies in induced abortion scenarios in China.We thus advocate that sexual and reproductive health policy making shows an overarch-ing concern for the interests of disadvantaged groups.展开更多
This study uses a literature review to probe the prevalence and trends of induced abortions among unmarried women since the 1980s.Premarital pregnancy has become more and more common,and this has pushed the premarital...This study uses a literature review to probe the prevalence and trends of induced abortions among unmarried women since the 1980s.Premarital pregnancy has become more and more common,and this has pushed the premarital abortion rate still higher.With the premarital abortion rate remaining markedly high in China,the percentage of women who have experienced premarital abortions has risen stead-ily with the passage of time.Not only has the prevalence of premarital abortions increased in China on the whole,but there is evidence that some young women have had multiple abortions.Premarital abortion is more prevalent in urban areas and among migrants and less-educated women.The huge number of premarital abor-tions not only signifies a palpable,unmet need for contraceptives,but also repre-sents an immense number of unrealized births.In the years to come,it is imperative to strengthen research into premarital abortions,to optimize the approaches to data collection and analysis,and to improve reproductive health services for unmarried women.展开更多
This study uses four sets of data from China Fertility Surveys completed during the years 1997-2017 to analyze the trend of induced abortion,with a focus on the twenty-first century.Married women of reproductive age w...This study uses four sets of data from China Fertility Surveys completed during the years 1997-2017 to analyze the trend of induced abortion,with a focus on the twenty-first century.Married women of reproductive age who had a history of pregnancy during the 5 years prior to participating in a survey were the research object.The study also examines the variation of abortion proportions among different subgroups during different time periods,including an examination of the number and gender of children,place of residence,and contraceptive use of women who had induced abortions.The results show that the occurrence of induced abortion has decreased gradually,and that the risk of induced abortion was higher for those who had given birth to fewer children.However,induced abortion among women with two children has increased in recent years.It is noteworthy that induced abortions among childless premarital women have continued to increase in recent years,and that the sexual and reproductive health problems of adolescents remain of great concern.The occurrence of induced abortions after childbirth increased for those with one or two children,showing that the unmet need for contraception after childbirth should receive more attention.In addition,sex-selective abortion has been decreasing gradually,but still exists today.展开更多
OBJECTIVE: To explore the effects of Taohong Siwu decoction(桃红四物汤, THSWD) on the extracellular matrix of endometrium in rats following drug-induced abortion.METHODS: Thirty-six pregnant female rats were administe...OBJECTIVE: To explore the effects of Taohong Siwu decoction(桃红四物汤, THSWD) on the extracellular matrix of endometrium in rats following drug-induced abortion.METHODS: Thirty-six pregnant female rats were administered mifepristone and misoprostol to induce abortion, and amounts of uterine bleeding were recorded. Pathological damage and collagen accumulation were detected by hematoxylin-eosin staining and Masson’s trichrome staining in uterus, respectively. Myeloperoxidase was evaluated by immunohistochemistry.The expression levels of fibronectin, laminin, matrix metalloproteinase 9(MMP-9), and tissue inhibitor of metalloproteinase 1(TIMP-1) were quantified using western blotting.RESULTS: THSWD could promote endometrial protection in rats following drug-induced abortion.The contents of cellulose and myeloperoxidase were significantly decreased in uterine tissue of THSWD-treated groups. Moreover, THSWD significantly decreased the expression levels of fibronectin, laminin, and TIMP-1. THSWD also significantly increased MMP-9 expression and the MMP-9/TIMP-1 ratio.CONCLUSION: THSWD plays a critical role in endometrial protection by reducing extracellular matrix deposition and uterine fibrosis. These effects may have been achieved by increasing MMP-9, reducing TIMP-1, and/or altering the ratio of MMP-9/TIMP-1.展开更多
Objective: To compare the clinical effects of uterine cavity observation and suction surgery system with ultrasound guided induced abortion in very early pregnancy induced abortion surgery. Method: Select 80 patients ...Objective: To compare the clinical effects of uterine cavity observation and suction surgery system with ultrasound guided induced abortion in very early pregnancy induced abortion surgery. Method: Select 80 patients who requested termination of pregnancy due to early pregnancy from August 2022 to April 2023, and analyze the data. 40 patients who underwent ultrasound-guided induced abortion to terminate pregnancy were included in the control group, and 40 patients who underwent uterine cavity observation surgery to terminate pregnancy were included in the observation group. Compare the surgical time, number of times the straw enters the uterine cavity, incidence of complications, and menstrual recovery time between the two groups. Results: There was no statistically significant difference in the surgical time between the observation group and the control group, but the number of times negative pressure straws entered the uterine cavity and the incidence of surgical complications in the observation group were significantly lower than those in the control group (P Conclusion: Applying the uterine cavity observation and suction surgical system to terminate pregnancy in very early pregnancy has the advantages of minimal damage to the uterus and low incidence of surgical complications, greatly protecting the patient’s fertility.展开更多
Objective: To determine the effect of intervention on contraceptive efficacy. Method: The study is composed of three phases: (1) A baseline survey was conducted from Aug. to Dec., 1991. (2) An intervention program, wh...Objective: To determine the effect of intervention on contraceptive efficacy. Method: The study is composed of three phases: (1) A baseline survey was conducted from Aug. to Dec., 1991. (2) An intervention program, which included strengthening education and introducing new contraceptive methods, was implemented from Jan. to Feb., 1992. (3 ) From Feb. to March, 1994, the second survey was carried out. Results: Main results are very successful. The rate of induced abortion decreased after intervention. The rate of contraceptive discontinuation after intervention was lower than that before intervention. Conclusion: The intervention program was very effective.展开更多
Objective:Mifepristone(RU486),one of the most common medications for artificial abortion,attenuates the immunoregulatory effects of progesterone.However,the specific immune regulatory mechanism of RU486 in abortion re...Objective:Mifepristone(RU486),one of the most common medications for artificial abortion,attenuates the immunoregulatory effects of progesterone.However,the specific immune regulatory mechanism of RU486 in abortion remains unknown.We intended to investigate the immunomodulatory effects of RU486 on abortion.Methods:Sixty female mice were divided into the control group(0 mg RU486)and RU486 group(2 mg/kg RU486).The uterus,peripheral blood,and spleen were obtained for isolation of specific cell types.The population and phenotype of immune cells in the decidua,peripheral blood,and spleen were analyzed using flow cytometry.Statistical differences between groups were determined using two-tailed t-test.For all statistical tests,P<0.05 was considered statistically significant.Results:RU486 effectively induced abortion in pregnant mice,with a significantly higher number of decidual macrophages(dMφ)(control group=25.55%±2.467%,RU486 group=19.41%±1.423%;P<0.05),especially the major histocompatibility complex II high subset.No difference in Mφnumber was observed in the spleen or peripheral blood.Moreover,the dMφfrom mice with RU486-induced abortion displayed a remarkable activated phenotype,with increased expressions of inducible nitric oxide synthase,tumor necrosis factor-α,and interleukin(IL)-12 but decreased expressions of arginase-1 and IL-10.We also found elevated levels of decidual CD4+T-cells in the RU486 group that exhibited a higher level of the proinflammatory cytokine interferon-γand a lower level of the anti-inflammatory cytokines,IL-4 and IL-10.Conclusions:We report a new mechanism of RU486-induced abortion via the regulation of innate cell Mφactivation and the adaptive response of CD4+T-cells present in the decidua but not the periphery.展开更多
Unintended pregnancy often ends with induced abortion,an outcome that affects a woman’s physical and mental health and consumes social resources.A national fertility survey conducted by the former National Health and...Unintended pregnancy often ends with induced abortion,an outcome that affects a woman’s physical and mental health and consumes social resources.A national fertility survey conducted by the former National Health and Family Planning Com-mission in 2017,gathered data on pregnancies among married women aged 15-49 to analyze the changing circumstances of such pregnancies and the factors that influ-ence their occurrence.The analysis found that the incidence of unintended pregnan-cies among married women in China was 42.4‰in 2017,and that such pregnancies accounted for 22.9%of all pregnancies in China for the years 2010-2017.Of all abortions,91.9%were used to terminate unintended pregnancies,and of unintended pregnancies,67.1%ended with induced abortions.The incidence of unintended pregnancy and that of induced abortion to terminate the unintended pregnancy were higher among women living in an urban rather than a rural area,having previously given birth to a boy,having a large number of children,being at the older end of their childbearing years,or having a shorter interpregnancy interval.Only 37.3%of women chose long-term contraceptive methods after an induced abortion caused by an unintended pregnancy;their sense of self-protection was not strong.It is neces-sary to strengthen education and advocacy,enhance women’s awareness of the pro-tection contraceptives offer,and improve the quality of and access to contraceptive services to reduce the incidence of unintended pregnancy,and reduce the incidence of induced abortion to terminate unintended pregnancy.展开更多
文摘Induced abortion signifies that pregnancy has been tempered with. Abortion is the removal of an embryo or fetus weighing less than 500 grams from its mother. It can either be spontaneous (unprompted) or induced. Abortion remains one of the leading causes of maternal deaths in developing countries with induced abortion being the key cause. In 2014 from January to August, 9 abortion related deaths occurred in Botswana. There are several reasons female students in tertiary institutions resort to seeking induced abortion which include the socio-demographics like age and socio-economic factors like financial instability. Parental fears, unintended pregnancy and pressure from the partner also force females to terminate pregnancy. Induced abortion has claimed many women’s lives especially in developing countries with very restrictive abortion laws like Botswana as women do not access safe abortion care services. The study intends to establish the determinants of induced abortion among female students in selected tertiary learning institutions in Gaborone City, Botswana. It concentrated primarily on determining the prevalence of induced abortion. This was a descriptive cross-sectional study using both quantitative and qualitative data collection techniques. Systematic random sampling technique was used to come up with 278 participants. Prior to commencement of data collection, all ethical and logistical prerequisites were satisfied. Informed consent was solicited from all the study participants and the purpose of the study was fully explained. A self-administered questionnaire was used to collect data. Microsoft Excel spread sheet was used to code, clean, and enter the data, which was then exported for analysis to the statistical package for social sciences version 24. Frequency distribution tables, percentages graphs, and pie charts were used to illustrate the descriptive information. The study revealed that prevalence of induced abortion among female students in Gaborone City is 7.9%. They even suggested that induced abortion be liberalized. Age was the only socio-demographic factor associated with induced abortion with p = 0.047 using Chi Square test χ<sup>2</sup> = 7.609, df = 3. The study findings concluded that female students resort to induced abortion as a result of pressure from both parents and male partners especially when the pregnancy is unintended. The study recommends that the abortion law in Botswana be made liberal to ease access to safe abortion care services. It also recommends that contraceptive commodities should consistently be available in public health facilities.
文摘<b>Background: </b>Though painless abortion is a safe, effective and excellent method of artificial abortion, intravenous anesthesia cannot effectively expand the cervix. Hard and tight cervix often affects the operation and easily inducesabortion complications. Misoprostol can induce uterine contraction and soften the cervix. <b>Objective:</b> To investigate the clinical effect of misoprostol on abortion before and after painless induced abortion. <b>Methods:</b> 600 case pregnant women were divided into three groups: A, B and C, 200 case in each group. All patients were anesthetized. In group A, misoprostol 0.2 ug was placed in the posterior fornix of vagina 2 hours before the operation of induced abortion;in group B, misoprostol 0.2 ug was not only placed in the posterior fornix of vagina 2 hours before the operation of induced abortion but also taken orally 2 hours and 6 hours after the operation;in group C, misoprostol was not used before and after the operation. The operation time, intraoperative bleeding volume, postoperative bleeding, the percentage of cervical relaxation and the rate of incomplete abortion among the three groups were compared. <b>Results:</b> Compared with group A and group B, the operation time of group C was longer and the amount of bleeding was more (P < 0.05), but there was no significant difference between group A and group B (P > 0.05). The duration of bleeding in group B was less than that in group A (P < 0.05). The percentage of cervical relaxation in group A and B was higher than that in group C (P < 0.05). The rate of incomplete abortion in group B < group A < group C (P < 0.05), and there was no residual uterine cavity in group B. <b>Conclusion:</b> The use of misoprostol before and after painless induced abortion can not only shorten the time of operation, reduce intraoperative and postoperative vaginal bleeding, but also has not incurred incomplete abortion(primary outcome).
文摘There is no credible scientific opposition to the fact that a genetically distinct human life begins at conception and that an induced abortion is a death. Yet, abortion is not reported as a cause of death in the U.S. vital statistics system. Mortality patterns have profound implications for public policy. As a cause of death, we found abortion to be highly consequential, with large racial and ethnic disparities. Abortion represented 16.4% of non-Hispanic White deaths, but 61.1% and 64.0% of non-Hispanic Black and Hispanic deaths respectively. For Years of Potential Life Lost (YPLL), the ubiquitous measure of premature death, abortion accumulated 63.1% of non-Hispanic White YPLL and 86.5% and 87.4% of non-Hispanic Black and Hispanic YPLL respectively. Further, as measured by the availability of valid data and resources allocated for research, there is evidence that the science community is not appropriately engaged on this crucial public health problem.
文摘In the era of the second demographic transition,“diverging destinies”theory states that women with the most economic opportunities often obtain gains while women with the least economic opportunities suffer from losses.Using nationally represent-ative data from the 2017 China Fertility Survey,we attempted to examine if diverg-ing destinies theory can explain differences in the incidence of induced abortion among women with differing economic opportunities.We found that women with good economic opportunities(i.e.,well-educated and holding urban hukou)were more likely to have induced abortions between 1980 and 2010 and less likely to do so between 2015 and 2017.Moreover,younger cohorts were far more likely to have induced abortions at a younger age and before marriage.These findings provide sup-portive evidence for diverging destinies in induced abortion scenarios in China.We thus advocate that sexual and reproductive health policy making shows an overarch-ing concern for the interests of disadvantaged groups.
文摘This study uses a literature review to probe the prevalence and trends of induced abortions among unmarried women since the 1980s.Premarital pregnancy has become more and more common,and this has pushed the premarital abortion rate still higher.With the premarital abortion rate remaining markedly high in China,the percentage of women who have experienced premarital abortions has risen stead-ily with the passage of time.Not only has the prevalence of premarital abortions increased in China on the whole,but there is evidence that some young women have had multiple abortions.Premarital abortion is more prevalent in urban areas and among migrants and less-educated women.The huge number of premarital abor-tions not only signifies a palpable,unmet need for contraceptives,but also repre-sents an immense number of unrealized births.In the years to come,it is imperative to strengthen research into premarital abortions,to optimize the approaches to data collection and analysis,and to improve reproductive health services for unmarried women.
文摘This study uses four sets of data from China Fertility Surveys completed during the years 1997-2017 to analyze the trend of induced abortion,with a focus on the twenty-first century.Married women of reproductive age who had a history of pregnancy during the 5 years prior to participating in a survey were the research object.The study also examines the variation of abortion proportions among different subgroups during different time periods,including an examination of the number and gender of children,place of residence,and contraceptive use of women who had induced abortions.The results show that the occurrence of induced abortion has decreased gradually,and that the risk of induced abortion was higher for those who had given birth to fewer children.However,induced abortion among women with two children has increased in recent years.It is noteworthy that induced abortions among childless premarital women have continued to increase in recent years,and that the sexual and reproductive health problems of adolescents remain of great concern.The occurrence of induced abortions after childbirth increased for those with one or two children,showing that the unmet need for contraception after childbirth should receive more attention.In addition,sex-selective abortion has been decreasing gradually,but still exists today.
基金Supported by Natural Science Foundation-funded Projects: Regulation Effect of Taohong-Siwu Decoction on Alpha-granule Release of Platelet in Postpartum Blood Stasis, its Active Compounds and Action Pathway (No. 81473387)Mechanism Research of Taohong-Siwu Decoction in Regulating Brain Microvascular Angiogenesis of MACO Rats Based on Platelet Microparticles as a Plaletet-Brain Microvascular Cell Messenger (No. 81503291)Natural Science Foundation Projects of Anhui Colleges and Universities: Based on the Crosstalk of NLRP3-Caspase-1 and VEGF-Notch to Explore the Effect of THSWD Regulation of "Dispelling Stasis to Promote Regeneration" by the Interaction Between Pyroptosis and Angiogenesis After Cerebral Ischemia and Reperfusion (No. KJ2019A0467)。
文摘OBJECTIVE: To explore the effects of Taohong Siwu decoction(桃红四物汤, THSWD) on the extracellular matrix of endometrium in rats following drug-induced abortion.METHODS: Thirty-six pregnant female rats were administered mifepristone and misoprostol to induce abortion, and amounts of uterine bleeding were recorded. Pathological damage and collagen accumulation were detected by hematoxylin-eosin staining and Masson’s trichrome staining in uterus, respectively. Myeloperoxidase was evaluated by immunohistochemistry.The expression levels of fibronectin, laminin, matrix metalloproteinase 9(MMP-9), and tissue inhibitor of metalloproteinase 1(TIMP-1) were quantified using western blotting.RESULTS: THSWD could promote endometrial protection in rats following drug-induced abortion.The contents of cellulose and myeloperoxidase were significantly decreased in uterine tissue of THSWD-treated groups. Moreover, THSWD significantly decreased the expression levels of fibronectin, laminin, and TIMP-1. THSWD also significantly increased MMP-9 expression and the MMP-9/TIMP-1 ratio.CONCLUSION: THSWD plays a critical role in endometrial protection by reducing extracellular matrix deposition and uterine fibrosis. These effects may have been achieved by increasing MMP-9, reducing TIMP-1, and/or altering the ratio of MMP-9/TIMP-1.
文摘Objective: To compare the clinical effects of uterine cavity observation and suction surgery system with ultrasound guided induced abortion in very early pregnancy induced abortion surgery. Method: Select 80 patients who requested termination of pregnancy due to early pregnancy from August 2022 to April 2023, and analyze the data. 40 patients who underwent ultrasound-guided induced abortion to terminate pregnancy were included in the control group, and 40 patients who underwent uterine cavity observation surgery to terminate pregnancy were included in the observation group. Compare the surgical time, number of times the straw enters the uterine cavity, incidence of complications, and menstrual recovery time between the two groups. Results: There was no statistically significant difference in the surgical time between the observation group and the control group, but the number of times negative pressure straws entered the uterine cavity and the incidence of surgical complications in the observation group were significantly lower than those in the control group (P Conclusion: Applying the uterine cavity observation and suction surgical system to terminate pregnancy in very early pregnancy has the advantages of minimal damage to the uterus and low incidence of surgical complications, greatly protecting the patient’s fertility.
文摘Objective: To determine the effect of intervention on contraceptive efficacy. Method: The study is composed of three phases: (1) A baseline survey was conducted from Aug. to Dec., 1991. (2) An intervention program, which included strengthening education and introducing new contraceptive methods, was implemented from Jan. to Feb., 1992. (3 ) From Feb. to March, 1994, the second survey was carried out. Results: Main results are very successful. The rate of induced abortion decreased after intervention. The rate of contraceptive discontinuation after intervention was lower than that before intervention. Conclusion: The intervention program was very effective.
基金supported by the National Key R&D Program of China(Grant nos.2017YFC1001403 to MRD and 2017YFC1001404 to DJL)the Nature Science Foundation from National Nature Science Foundation of China(Grant Nos.31970859,81630036 to MRD,and 31900663 to YHL)+1 种基金the Program of Shanghai Academic/Technology Research Leader(Grant No.17XD 1400900 to MRD)the Innovation oriented Science and Technology Grant from NPFPC Key Laboratory of Reproduction Regulation(Grant No.CX20172 to MRD).
文摘Objective:Mifepristone(RU486),one of the most common medications for artificial abortion,attenuates the immunoregulatory effects of progesterone.However,the specific immune regulatory mechanism of RU486 in abortion remains unknown.We intended to investigate the immunomodulatory effects of RU486 on abortion.Methods:Sixty female mice were divided into the control group(0 mg RU486)and RU486 group(2 mg/kg RU486).The uterus,peripheral blood,and spleen were obtained for isolation of specific cell types.The population and phenotype of immune cells in the decidua,peripheral blood,and spleen were analyzed using flow cytometry.Statistical differences between groups were determined using two-tailed t-test.For all statistical tests,P<0.05 was considered statistically significant.Results:RU486 effectively induced abortion in pregnant mice,with a significantly higher number of decidual macrophages(dMφ)(control group=25.55%±2.467%,RU486 group=19.41%±1.423%;P<0.05),especially the major histocompatibility complex II high subset.No difference in Mφnumber was observed in the spleen or peripheral blood.Moreover,the dMφfrom mice with RU486-induced abortion displayed a remarkable activated phenotype,with increased expressions of inducible nitric oxide synthase,tumor necrosis factor-α,and interleukin(IL)-12 but decreased expressions of arginase-1 and IL-10.We also found elevated levels of decidual CD4+T-cells in the RU486 group that exhibited a higher level of the proinflammatory cytokine interferon-γand a lower level of the anti-inflammatory cytokines,IL-4 and IL-10.Conclusions:We report a new mechanism of RU486-induced abortion via the regulation of innate cell Mφactivation and the adaptive response of CD4+T-cells present in the decidua but not the periphery.
文摘Unintended pregnancy often ends with induced abortion,an outcome that affects a woman’s physical and mental health and consumes social resources.A national fertility survey conducted by the former National Health and Family Planning Com-mission in 2017,gathered data on pregnancies among married women aged 15-49 to analyze the changing circumstances of such pregnancies and the factors that influ-ence their occurrence.The analysis found that the incidence of unintended pregnan-cies among married women in China was 42.4‰in 2017,and that such pregnancies accounted for 22.9%of all pregnancies in China for the years 2010-2017.Of all abortions,91.9%were used to terminate unintended pregnancies,and of unintended pregnancies,67.1%ended with induced abortions.The incidence of unintended pregnancy and that of induced abortion to terminate the unintended pregnancy were higher among women living in an urban rather than a rural area,having previously given birth to a boy,having a large number of children,being at the older end of their childbearing years,or having a shorter interpregnancy interval.Only 37.3%of women chose long-term contraceptive methods after an induced abortion caused by an unintended pregnancy;their sense of self-protection was not strong.It is neces-sary to strengthen education and advocacy,enhance women’s awareness of the pro-tection contraceptives offer,and improve the quality of and access to contraceptive services to reduce the incidence of unintended pregnancy,and reduce the incidence of induced abortion to terminate unintended pregnancy.
