Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients re...Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients referred for percutaneous coronary intervention (PCI).Methods Following aspirin and heparin, 166 patients were randomized to a 50 mg bolus of recombinant tissue type plasminogen activator(rt PA) or to a same volume sodium chloride injection followed by immediate primary PCI. The end points included patency rates on catheterization laboratory (cath lab) arrival, revascularization results when PCI was performed, complication rates, left ventricular function and restored patency rate following PCI. Results Patency on cath lab arrival was 64% with rt PA (34% TIMI 3,30% TIMI 2), while 31% of placebo (13% TIMI 3, 18% TIMI 2). There was no difference in the restored TIMI 3 rates of IRA between the two groups (85% vs 87%). No difference were observed in stroke or major bleeding. Left ventricular function was similar in both groups (52±9% vs 50±8%), but left ventricular ejection fraction fraction (LVEF) was higher with patent IRA (TIMI 3) on cath lab arrival than that of others (56±12% vs 48±10%).Conclusions Strategy thrombolytic regimens were compatible with subsequent PCI lead to more frequenc early recanalization (before cath lab arrival), which facilitates greater left ventricular function preservation with no augmentation of adverse events.展开更多
Purpose:To compare the effectiveness of the interventional limb raising management strategy(ILRMS)to elastic bandage compression at radial vascular access sites following coronary angiographies(CAGs)and percutaneous c...Purpose:To compare the effectiveness of the interventional limb raising management strategy(ILRMS)to elastic bandage compression at radial vascular access sites following coronary angiographies(CAGs)and percutaneous coronary interventions(PCIs).Methods:Patients with ischemic coronary heart disease whose condition was stable over three months were enrolled in this clinical study(n=590;aged 25e80).All participants had just undergone CAG and PCI.Patients were randomized into either the ILRMS group(n=360)or standard post-intervention care with an elastic bandage(n=230).Overall comfort and wrist pain was assessed and the degree of index finger swelling and oxygen saturation was measured on the affected arm.All variables were measured prior to postintervention treatment and again at six hours after CAG and PCI.Results:We found that patients receiving ILRMS had significantly lower wrist pain scores and swelling around the index finger compared to the elastic bandage group(p<0.05).Oxygen saturation of the index finger was not statistically significant(p>0.05).We also found that 19.57%of the elastic bandage patients were comfortable,while ILRMS patients were significantly more comfortable(93.06%;p<0.05).Conclusions:We find that ILRMS alleviates swelling and pain of the wrist more effectively than current practices and improves the degree of overall comfort of patients who undergo CAG and PCI.展开更多
It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that t...It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and brain.This review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota dysbiosis.These topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and diets.While research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.展开更多
<span style="font-family:Verdana;"><strong>Intro</strong></span><span style="font-family:Verdana;"><strong>duction:</strong></span><span style=&qu...<span style="font-family:Verdana;"><strong>Intro</strong></span><span style="font-family:Verdana;"><strong>duction:</strong></span><span style="font-family:Verdana;"> Excessive masturbation has for long been reported to affect youths with intervention strategies to intervene </span><span style="font-family:Verdana;">with </span><span style="font-family:Verdana;">this problem rema</span><span style="font-family:""><span style="font-family:Verdana;">ining unclear. This study aimed at determining the underlying factors for excessive masturbation, its effects and intervention strategies used. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a case study design for a youth aged 19 years;affected by excessive masturbation. Data were collected through individual counseling and intervention. It i</span><span style="font-family:Verdana;">nvolved 15 counseling sessions which w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:Verdana;"> run in nine month</span><span style="font-family:""><span style="font-family:Verdana;">s in a three weeks interval. The sessions involved narration and exploration of the causes and effects of masturbation. Counseling intervention was built in a vicious circle. </span><b><span style="font-family:Verdana;">R</span><span style="font-family:Verdana;">esults:</span></b><span style="font-family:Verdana;"> Several factors, effects and intervention strategies were identified, r</span><span style="font-family:Verdana;">e</span><span style="font-family:Verdana;">ported and discussed in this study. Main causes were such as stories fro</span><span style="font-family:Verdana;">m friends and pornographic videos. Effects were multiple risk behaviors and hea</span><span style="font-family:Verdana;">lth problems. Counseling model for individual was developed. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The study indicates that there are multiple causes and effects of excessive masturbation. Since masturbation is secretly done, the effects are not widely known to many people. Most of these effects are long-term which affects a person psychologically, physically, socially and morally.</span></span>展开更多
Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm l...Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm lockdown program,but the region still observed stringent lockdown close to two months.This paper analyzed major measures in public health preparedness and responses in those countries in the pandemic.The research was based on a situation analysis to discuss appropriate plan for epidemic preparedness,strategies for prevention and control measures,and adequate response management mechanism.Based on the data from March 21 to June 26,2020,it appeared lockdown program along with other control measures were not as effective to arrest the exponential growth of fortnightly COVID-19 cases in Afghanistan,Bangladesh,India,Nepal and Pakistan.However,Bhutan,Maldives and Sri Lanka have been successfully limiting the spread of the disease.The in-depth analysis of prevention and control measures espoused densely populated context of South Asia needs community-led intervention strategy,such as case containment,in order to reverse the growing trend,and adopt the policy of mitigation instead of suppression to formulate COVID-19 action plan.On the other hand,mechanism for response management encompassed a four-tier approach of governance to weave community-led local bodies with state,national and international governance actors for enhancing the countries’emergency operation system.It is concluded resource-crunch countries in South Asia are unable to cope with the disproportionate demand of capital and skilled health care workforce at the time of the pandemic.Hence,response management needs an approach of governance maximization instead of resource maximization.The epidemiologic management of population coupled with suitable public health prevention and control measures may be a more appropriate strategy to strike a balance between economy and population health during the time of pandemic.展开更多
Job burnout is an important factor affecting the work attitude and professional behavior of family doctors.This paper reviews the measurement tools,influencing factors and intervention strategies of job burnout,it is ...Job burnout is an important factor affecting the work attitude and professional behavior of family doctors.This paper reviews the measurement tools,influencing factors and intervention strategies of job burnout,it is suggested that improving job burnout can improve job satisfaction,work efficiency and reduce turnover intention of family doctors,and it is of great significance to the construction of family doctor team and the improvement of work quality.展开更多
The Millennium Development Goals(MDGs)with their holistic perspective of development are focused on different issues of vulnerability.This article highlights the situation of women in disasters and the challenges in a...The Millennium Development Goals(MDGs)with their holistic perspective of development are focused on different issues of vulnerability.This article highlights the situation of women in disasters and the challenges in achieving the MDGs with special reference to India.It is accepted that there is no disaster without human engagement and that issues of differential impact on genders is an essential consideration for recovery.The international guidelines on disaster management and intervention have a considerable focus on gender equality,balance,mainstreaming,and sensitive programing,yet the situation is quite grim.India still lacks separate policy guidelines on gender aspects in disaster.In the twenty-first century,India has witnessed a series of disasters in different parts of the country.The author's personal experiences of working in intervention programs of these disasters showed that gender vulnerability depends on various factors like the intensity of the disaster impact,local sociocultural perspectives,effective disaster intervention strategies,the specific focus on issues of women in training of personnel,and gender-sensitive disaster intervention programs in the community.In the context of the MDGs,while development has become a priority concern to end age-old inequalities in society,the added challenge of disasters needs considerable focus on gender inequalities to achieve the goal of gender equity.展开更多
The Corona Virus Disease 2019(COVID-19)pandemic is still imposing a devastating impact on public health,the economy,and society.Predicting the development of epidemics and exploring the effects of various mitigation s...The Corona Virus Disease 2019(COVID-19)pandemic is still imposing a devastating impact on public health,the economy,and society.Predicting the development of epidemics and exploring the effects of various mitigation strategies have been a research focus in recent years.However,the spread simulation of COVID-19 in the dynamic social system is relatively unexplored.To address this issue,considering the outbreak of COVID-19 at Nanjing Lukou Airport in 2021,we constructed an artificial society of Nanjing Lukou Airport based on the Artificial societies,Computational experiments,and Parallel execution(ACP)approach.Specifically,the artificial society includes an environmental model,population model,contact networks model,disease spread model,and intervention strategy model.To reveal the dynamic variation of individuals in the airport,we first modeled the movement of passengers and designed an algorithm to generate the moving traces.Then,the mobile contact networks were constructed and aggregated with the static networks of staff and passengers.Finally,the complex dynamical network of contacts between individuals was generated.Based on the artificial society,we conducted large-scale computational experiments to study the spread characteristics of COVID-19 in an airport and to investigate the effects of different intervention strategies.Learned from the reproduction of the outbreak,it is found that the increase in cumulative incidence exhibits a linear growth mode,different from that(an exponential growth mode)in a static network.In terms of mitigation measures,promoting unmanned security checks and boarding in an airport is recommended,as to reduce contact behaviors between individuals and staff.展开更多
文摘Objective This study was to evaluate the efficacy and safety of a short acting reduced dose fibrinolytic regimen to promote early infarct related artery (IRA) patency for acyute myocardial infarction (AMI) patients referred for percutaneous coronary intervention (PCI).Methods Following aspirin and heparin, 166 patients were randomized to a 50 mg bolus of recombinant tissue type plasminogen activator(rt PA) or to a same volume sodium chloride injection followed by immediate primary PCI. The end points included patency rates on catheterization laboratory (cath lab) arrival, revascularization results when PCI was performed, complication rates, left ventricular function and restored patency rate following PCI. Results Patency on cath lab arrival was 64% with rt PA (34% TIMI 3,30% TIMI 2), while 31% of placebo (13% TIMI 3, 18% TIMI 2). There was no difference in the restored TIMI 3 rates of IRA between the two groups (85% vs 87%). No difference were observed in stroke or major bleeding. Left ventricular function was similar in both groups (52±9% vs 50±8%), but left ventricular ejection fraction fraction (LVEF) was higher with patent IRA (TIMI 3) on cath lab arrival than that of others (56±12% vs 48±10%).Conclusions Strategy thrombolytic regimens were compatible with subsequent PCI lead to more frequenc early recanalization (before cath lab arrival), which facilitates greater left ventricular function preservation with no augmentation of adverse events.
基金This work was supported by the National Natural Science Foundation of China(GrantNos.81170279,81370408,81370409)the Social Development Projects of Jiangsu Province(WS074,LJ201116,Q201308)the Projects from Social Development of Zhenjiang(SS2012002,SH2013023,SH2013024).
文摘Purpose:To compare the effectiveness of the interventional limb raising management strategy(ILRMS)to elastic bandage compression at radial vascular access sites following coronary angiographies(CAGs)and percutaneous coronary interventions(PCIs).Methods:Patients with ischemic coronary heart disease whose condition was stable over three months were enrolled in this clinical study(n=590;aged 25e80).All participants had just undergone CAG and PCI.Patients were randomized into either the ILRMS group(n=360)or standard post-intervention care with an elastic bandage(n=230).Overall comfort and wrist pain was assessed and the degree of index finger swelling and oxygen saturation was measured on the affected arm.All variables were measured prior to postintervention treatment and again at six hours after CAG and PCI.Results:We found that patients receiving ILRMS had significantly lower wrist pain scores and swelling around the index finger compared to the elastic bandage group(p<0.05).Oxygen saturation of the index finger was not statistically significant(p>0.05).We also found that 19.57%of the elastic bandage patients were comfortable,while ILRMS patients were significantly more comfortable(93.06%;p<0.05).Conclusions:We find that ILRMS alleviates swelling and pain of the wrist more effectively than current practices and improves the degree of overall comfort of patients who undergo CAG and PCI.
基金supported by the State Key Program of National Natural Science Foundation of China(31530056)the National First-class Discipline Program of Food Science and Technology(JUFSTR20180102)the Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province,China.
文摘It is well known that the gut microbiota plays an extremely important role in modulating host physiological functions such as immunity and metabolic homeostasis.In recent years,accumulated evidence has revealed that the gut microbiota can regulate the functions of the central nervous system(CNS)through the gut-brain axis,which provides a novel insight into the interactions between the gut and brain.This review focuses on the molecular mechanism of the crosstalk between the gut microbiota and the brain via the gut-brain axis,and on the onset and development of neurological disorders triggered by gut microbiota dysbiosis.These topics are followed by a critical analysis of potential intervention strategies targeting gut microbiota dysbiosis,including the use of probiotics,prebiotics,synbiotics,and diets.While research on the microbiota-gut-brain axis is still in its relative infancy,clarifying the molecular mechanism that underlies how the gut microbiota regulates neurological functions not only holds the promise of revealing potentially novel pathogeneses of neurological disorders,but also may lead to the development of potential diagnosis biomarkers and intervention strategies targeting microbiota dysbiosis for neurological disorders.
文摘<span style="font-family:Verdana;"><strong>Intro</strong></span><span style="font-family:Verdana;"><strong>duction:</strong></span><span style="font-family:Verdana;"> Excessive masturbation has for long been reported to affect youths with intervention strategies to intervene </span><span style="font-family:Verdana;">with </span><span style="font-family:Verdana;">this problem rema</span><span style="font-family:""><span style="font-family:Verdana;">ining unclear. This study aimed at determining the underlying factors for excessive masturbation, its effects and intervention strategies used. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> This was a case study design for a youth aged 19 years;affected by excessive masturbation. Data were collected through individual counseling and intervention. It i</span><span style="font-family:Verdana;">nvolved 15 counseling sessions which w</span></span><span style="font-family:Verdana;">ere</span><span style="font-family:Verdana;"> run in nine month</span><span style="font-family:""><span style="font-family:Verdana;">s in a three weeks interval. The sessions involved narration and exploration of the causes and effects of masturbation. Counseling intervention was built in a vicious circle. </span><b><span style="font-family:Verdana;">R</span><span style="font-family:Verdana;">esults:</span></b><span style="font-family:Verdana;"> Several factors, effects and intervention strategies were identified, r</span><span style="font-family:Verdana;">e</span><span style="font-family:Verdana;">ported and discussed in this study. Main causes were such as stories fro</span><span style="font-family:Verdana;">m friends and pornographic videos. Effects were multiple risk behaviors and hea</span><span style="font-family:Verdana;">lth problems. Counseling model for individual was developed. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The study indicates that there are multiple causes and effects of excessive masturbation. Since masturbation is secretly done, the effects are not widely known to many people. Most of these effects are long-term which affects a person psychologically, physically, socially and morally.</span></span>
基金supported by the National Natural Science Foundation of China(No.72042014).
文摘Like rest of the world,the South Asian region is facing enormous challenges with the coronavirus disease 2019(COVID-19)pandemic.The socio-economic context of the eight South Asian countries is averse to any longterm lockdown program,but the region still observed stringent lockdown close to two months.This paper analyzed major measures in public health preparedness and responses in those countries in the pandemic.The research was based on a situation analysis to discuss appropriate plan for epidemic preparedness,strategies for prevention and control measures,and adequate response management mechanism.Based on the data from March 21 to June 26,2020,it appeared lockdown program along with other control measures were not as effective to arrest the exponential growth of fortnightly COVID-19 cases in Afghanistan,Bangladesh,India,Nepal and Pakistan.However,Bhutan,Maldives and Sri Lanka have been successfully limiting the spread of the disease.The in-depth analysis of prevention and control measures espoused densely populated context of South Asia needs community-led intervention strategy,such as case containment,in order to reverse the growing trend,and adopt the policy of mitigation instead of suppression to formulate COVID-19 action plan.On the other hand,mechanism for response management encompassed a four-tier approach of governance to weave community-led local bodies with state,national and international governance actors for enhancing the countries’emergency operation system.It is concluded resource-crunch countries in South Asia are unable to cope with the disproportionate demand of capital and skilled health care workforce at the time of the pandemic.Hence,response management needs an approach of governance maximization instead of resource maximization.The epidemiologic management of population coupled with suitable public health prevention and control measures may be a more appropriate strategy to strike a balance between economy and population health during the time of pandemic.
文摘Job burnout is an important factor affecting the work attitude and professional behavior of family doctors.This paper reviews the measurement tools,influencing factors and intervention strategies of job burnout,it is suggested that improving job burnout can improve job satisfaction,work efficiency and reduce turnover intention of family doctors,and it is of great significance to the construction of family doctor team and the improvement of work quality.
文摘The Millennium Development Goals(MDGs)with their holistic perspective of development are focused on different issues of vulnerability.This article highlights the situation of women in disasters and the challenges in achieving the MDGs with special reference to India.It is accepted that there is no disaster without human engagement and that issues of differential impact on genders is an essential consideration for recovery.The international guidelines on disaster management and intervention have a considerable focus on gender equality,balance,mainstreaming,and sensitive programing,yet the situation is quite grim.India still lacks separate policy guidelines on gender aspects in disaster.In the twenty-first century,India has witnessed a series of disasters in different parts of the country.The author's personal experiences of working in intervention programs of these disasters showed that gender vulnerability depends on various factors like the intensity of the disaster impact,local sociocultural perspectives,effective disaster intervention strategies,the specific focus on issues of women in training of personnel,and gender-sensitive disaster intervention programs in the community.In the context of the MDGs,while development has become a priority concern to end age-old inequalities in society,the added challenge of disasters needs considerable focus on gender inequalities to achieve the goal of gender equity.
基金supported by the National Natural Science Foundation of China(Nos.62173337,21808181 and 72071207)the Hunan Key Laboratory of Intelligent Decision-Making Technology for Emergency Management(No.2020TP1013)Humanity and Social Science Youth Foundation of Ministry of China(No.19YJCZH073).
文摘The Corona Virus Disease 2019(COVID-19)pandemic is still imposing a devastating impact on public health,the economy,and society.Predicting the development of epidemics and exploring the effects of various mitigation strategies have been a research focus in recent years.However,the spread simulation of COVID-19 in the dynamic social system is relatively unexplored.To address this issue,considering the outbreak of COVID-19 at Nanjing Lukou Airport in 2021,we constructed an artificial society of Nanjing Lukou Airport based on the Artificial societies,Computational experiments,and Parallel execution(ACP)approach.Specifically,the artificial society includes an environmental model,population model,contact networks model,disease spread model,and intervention strategy model.To reveal the dynamic variation of individuals in the airport,we first modeled the movement of passengers and designed an algorithm to generate the moving traces.Then,the mobile contact networks were constructed and aggregated with the static networks of staff and passengers.Finally,the complex dynamical network of contacts between individuals was generated.Based on the artificial society,we conducted large-scale computational experiments to study the spread characteristics of COVID-19 in an airport and to investigate the effects of different intervention strategies.Learned from the reproduction of the outbreak,it is found that the increase in cumulative incidence exhibits a linear growth mode,different from that(an exponential growth mode)in a static network.In terms of mitigation measures,promoting unmanned security checks and boarding in an airport is recommended,as to reduce contact behaviors between individuals and staff.
