Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and chemosensitivity.Particularly,in pancreatic ductal adenocarcinoma,tumor-resident Ga...Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and chemosensitivity.Particularly,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ineffective.Herein,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal model.An antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 nm.The micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem metabolism.In a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem resistance.This research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.展开更多
The therapeutic drugs,agents or techniques for the treatment of cancer could be misled since tumor tissues are frequently heterogeneous and hard to characterize.The changing of tumor microenvironments and epigenetics ...The therapeutic drugs,agents or techniques for the treatment of cancer could be misled since tumor tissues are frequently heterogeneous and hard to characterize.The changing of tumor microenvironments and epigenetics can mediate immunoescape and dampen the efficacy of adjuvant treatment.This short review highlights the recent important findings in cancer heterogeneity,including cancer immunology,epigenetics and genetic mutations,intratumoral microbiota and cancer stem cells,and contributing to the design of innovative cancer treatment strategy.展开更多
基金National Natural Science Foundation of China,Grant/Award Numbers:52273300,82102062,81930047China Postdoctoral Science Foundation,Grant/Award Number:2020TQ0008。
文摘Increasing evidence suggests that intratumoral microbiota plays a pivotal role in tumor progression,immunosurveillance,metastasis,and chemosensitivity.Particularly,in pancreatic ductal adenocarcinoma,tumor-resident Gammaproteobacteria could transform the chemotherapeutic drug gemcitabine(Gem)into its inactive form,thus rendering chemotherapy ineffective.Herein,a strategy for selectively eradicating intratumoral bacteria was described for overcoming Gem resistance in a pancreatic cancer animal model.An antimicrobial peptide was linked with photosensitizer through a poly(ethylene glycol)chain,which can self-assemble into micelles with a diameter of∼20 nm.The micelles could efficiently kill bacteria under light irradiation by inducing membrane depolarization,thereby inhibiting Gem metabolism.In a bacteria-resident pancreatic cancer animal model,the selective photodynamic eradication of intratumoral bacteria was demonstrated to efficiently reverse Gem resistance.This research highlights antibacterial photodynamic therapy as a promising adjuvant strategy for cancer therapy by modulating intratumoral microbiota.
文摘The therapeutic drugs,agents or techniques for the treatment of cancer could be misled since tumor tissues are frequently heterogeneous and hard to characterize.The changing of tumor microenvironments and epigenetics can mediate immunoescape and dampen the efficacy of adjuvant treatment.This short review highlights the recent important findings in cancer heterogeneity,including cancer immunology,epigenetics and genetic mutations,intratumoral microbiota and cancer stem cells,and contributing to the design of innovative cancer treatment strategy.
