In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms.To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus ...In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms.To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm,environmental zeitgebers are used by the circadian system.This is done primarily by signals from the retina via the retinohypothalamic tract,but other cues like exercise,feeding,temperature,anxiety,and social events have also been shown to act as non-photic zeitgebers.The recently identified myokine irisin is proposed to serve as an entraining non-photic signal of exercise.Irisin is a product of cleavage and modification from its precursor membrane fibronectin typeⅢdomain-containing protein 5(FNDC5)in response to exercise.Apart from well-known peripheral effects,such as inducing the"browning"of white adipocytes,irisin can penetrate the blood-brain barrier and display the effects on the brain.Experimental data suggest that FNDC5/irisin mediates the positive effects of physical activity on brain functions.In several brain areas,irisin induces the production of brain-derived neurotrophic factor(BDNF).In the master clock,a significant role in gating photic stimuli in the retinohypothalamic synapse for BDNF is suggested.However,the brain receptor for irisin remains unknown.In the current review,the interactions of physical activity and the irisin/BDNF axis with the circadian system are reconceptualized.展开更多
FNDC5(跨膜蛋白Ⅲ型纤连蛋白结构域5,fibronectin typeⅢdomain-containing protein 5),也称为纤连蛋白III型重复蛋白含蛋白(FRCP2)和过氧化物酶体蛋白(Pep),在2002年由两个独立的实验室分别发现并命名,研究显示该蛋白可在骨骼肌,心脏...FNDC5(跨膜蛋白Ⅲ型纤连蛋白结构域5,fibronectin typeⅢdomain-containing protein 5),也称为纤连蛋白III型重复蛋白含蛋白(FRCP2)和过氧化物酶体蛋白(Pep),在2002年由两个独立的实验室分别发现并命名,研究显示该蛋白可在骨骼肌,心脏和大脑中表达。2012年的一项研究揭示了FNDC5的裂解和作用形式,并将其裂解形成的分泌结构域命名为Irisin(鸢尾素)。自Irisin被发现在体内有各种生理作用,引起了世界各地研究人员的兴趣,并得到了广泛的研究,文章综述重点介绍Irisin的结构、表达、功能及其与肿瘤发生发展相关的作用。展开更多
基金supported by the Russian Science Foundation(Grant No.23-25-00152).
文摘In mammals,the timing of physiological,biochemical and behavioral processes over a 24-h period is controlled by circadian rhythms.To entrain the master clock located in the suprachiasmatic nucleus of the hypothalamus to a precise 24-h rhythm,environmental zeitgebers are used by the circadian system.This is done primarily by signals from the retina via the retinohypothalamic tract,but other cues like exercise,feeding,temperature,anxiety,and social events have also been shown to act as non-photic zeitgebers.The recently identified myokine irisin is proposed to serve as an entraining non-photic signal of exercise.Irisin is a product of cleavage and modification from its precursor membrane fibronectin typeⅢdomain-containing protein 5(FNDC5)in response to exercise.Apart from well-known peripheral effects,such as inducing the"browning"of white adipocytes,irisin can penetrate the blood-brain barrier and display the effects on the brain.Experimental data suggest that FNDC5/irisin mediates the positive effects of physical activity on brain functions.In several brain areas,irisin induces the production of brain-derived neurotrophic factor(BDNF).In the master clock,a significant role in gating photic stimuli in the retinohypothalamic synapse for BDNF is suggested.However,the brain receptor for irisin remains unknown.In the current review,the interactions of physical activity and the irisin/BDNF axis with the circadian system are reconceptualized.
文摘FNDC5(跨膜蛋白Ⅲ型纤连蛋白结构域5,fibronectin typeⅢdomain-containing protein 5),也称为纤连蛋白III型重复蛋白含蛋白(FRCP2)和过氧化物酶体蛋白(Pep),在2002年由两个独立的实验室分别发现并命名,研究显示该蛋白可在骨骼肌,心脏和大脑中表达。2012年的一项研究揭示了FNDC5的裂解和作用形式,并将其裂解形成的分泌结构域命名为Irisin(鸢尾素)。自Irisin被发现在体内有各种生理作用,引起了世界各地研究人员的兴趣,并得到了广泛的研究,文章综述重点介绍Irisin的结构、表达、功能及其与肿瘤发生发展相关的作用。
