试验选用初始体重为(44.34±1.58)g的津新鲤1 260尾,随机分为6组,每组3个重复,每个重复70尾鱼。6组饲料分别含有豆油、鸡油、玉米油、棕榈油、菜籽油、棉籽油。饲养8周后探讨饲料中不同脂肪源对津新鲤生长、相关脂代谢酶活性及脂肪...试验选用初始体重为(44.34±1.58)g的津新鲤1 260尾,随机分为6组,每组3个重复,每个重复70尾鱼。6组饲料分别含有豆油、鸡油、玉米油、棕榈油、菜籽油、棉籽油。饲养8周后探讨饲料中不同脂肪源对津新鲤生长、相关脂代谢酶活性及脂肪酸合成酶(FAS)、脂蛋白脂酶(LPL)基因表达的影响。结果表明:玉米油组的相对增重率、特定生长率及蛋白质效率显著高于其它5组(P<0.05),但玉米油组饵料系数则最低。不同脂肪源饲料对肝胰脏及肾脏中LPL、肝脂酶(HL)、总脂酶(GE)、脂肪代谢酶活性影响很大(P<0.05),且玉米油组酶活性均最高;各组肝胰脏及肾脏FAS变化不大(P>0.05)。从基因表达来看,玉米油组更容易诱导和调节肝胰脏和肾脏中FAS及LPL m RNA的表达(P<0.05),再次投喂后6 h,肝胰脏和肾脏中LPL m RNA表达丰度均达到峰值,而肝胰脏中FASm RNA表达丰度达到最低值,肾脏中FAS m RNA表达丰度逐渐下降。总之,玉米油可作为津新鲤优质脂肪源。展开更多
BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese me...BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently needed. Thus, we explored the protective effects of Jian-Pi Qing-Chang (JPQC) decoction on UC based on systems pharmacology approach, which might fill the current innovation gap in drug discovery and clinical practice pertaining to TCM. AIM To investigate the protective mechanisms of JPQC decoction on UC based on systems pharmacology approach. METHODS We performed systems pharmacology to predict the active ingredients, the matched targets, and the potential pharmacological mechanism of JPQC on UC. In vivo, we explored the effects of JPQC in a colitis model induced by dextran sulfate sodium. In vitro, we adopted the bone marrow-derived macrophages (BMDMs) as well as BMDMs co-cultured with Caco2 cells to verify the underlying mechanisms and effects of JPQC on UC under TNF-α stimulation. RESULTS Systems pharmacology revealed 170 targets for the 107 active ingredients of JPQC and 112 candidate targets of UC. Protein-protein interaction networks were established to identify the underlying therapeutic targets of JPQC on UC. Based on enrichment analyses, we proposed our hypothesis that JPQC might have a protective effect on UC via the NF-κB/HIF-1α signalling pathway. Subsequent experimental validation revealed that treatment with TNFα activated the NF-κB/HIF-1α signalling pathway in BMDMs, thereby damaging the epithelial barrier permeability in co-cultured Caco2 cells, while JPQC rescued this situation. The findings were also confirmed in a dextran sulfate sodium-induced colitis model. CONCLUSION JPQC could improve the mucosal inflammatory response and intestinal epithelial barrier function via the NF-κB/HIF-1α signalling pathway, which provides new perspectives on the pharmaceutical development and clinical practice of TCM.展开更多
“Kan”and“Jian”are both sense verbs in Chinese,but they can develop into multiple meanings and usage.In order to prove that the language in communication assumes the collective cultural experience and historical ba...“Kan”and“Jian”are both sense verbs in Chinese,but they can develop into multiple meanings and usage.In order to prove that the language in communication assumes the collective cultural experience and historical background,this article attempts,from the connection and differentiation between various meanings,to sort out how the semantic structure is defined in accordance with the situations where the words are used.In addition,based on the methods of the diachronic research and synchronic research,this article also observes the semantic evolution and the extensive concepts of imitation and implication.展开更多
Objective: To detect the effect of BiJia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis. Methods: A total of 94 patients with chronic hepat...Objective: To detect the effect of BiJia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis. Methods: A total of 94 patients with chronic hepatitis B combined with cirrhosis admitted in the hospital from January 2017 to December 2017 were selected as the subjects, and they were randomly divided into 47 cases in the observation group and 47 cases in the control group. The control group was given Adefovir Dipivoxil Tablets, and the observation group was treated with Bijia Jian pills on the basis of control group. The changes of liver function, inflammatory factors and liver fibrosis indexes were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in AST, ALT, TBIL and ALB between the two groups. After treatment, the AST, ALT and TBIL of the two groups were all decreased, and the AST, ALT and TBIL in the observation group were lower than those of the control group;the ALB of the two groups increased, and the ALB of the observation group was higher than that of the control group. Before treatment, there was no significant difference in TNF-α, IL-1 βand IL-10 between the two groups. After treatment, the TNF-α and IL-1β of the two groups were decreased, and the TNF-α and IL-1β in the observation group were lower than those of the control group;the IL-10 of the two groups increased, and the IL-10 in the observation group was higher than that in the control group. Before treatment, there was no significant difference in HA, LN, IV-C and PCIII between the two groups. After treatment, the HA, LN, IV-C and PCIII of the two groups were all decreased, and the HA, LN, IV-C and PCIII of the observation group were lower than those of the control group. Conclusion Bijia Jian pills can effectively improve the inflammatory factors and liver fibrosis in patients with chronic hepatitis B complicated with cirrhosis.展开更多
Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at...Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.展开更多
正Cafiu's Secretary-General Ni Jian attended UN Sustainable Development Conference (Rio +20) held in Rio de Janeiro, Brazil from June 16 to 21. This is another large-scale, high-level event in global sustainable d...正Cafiu's Secretary-General Ni Jian attended UN Sustainable Development Conference (Rio +20) held in Rio de Janeiro, Brazil from June 16 to 21. This is another large-scale, high-level event in global sustainable development after the 1992 UN Environment and Development Conference.展开更多
At the invitation of National Strategy Institute of ROK (NSI), Japan&China Technological Youth Interchange Society and Sri Lanka-China Friendship Association (SLCFA), CAFIU’s Secretary-General Ni Jian headed a fi...At the invitation of National Strategy Institute of ROK (NSI), Japan&China Technological Youth Interchange Society and Sri Lanka-China Friendship Association (SLCFA), CAFIU’s Secretary-General Ni Jian headed a five-member delegation to visit the three countries from March 24 to April 2.展开更多
Co-sponsored by the China International Culture Exchange Center(CICEC),Chinese Society of Cultural Relics,and Institute for Advanced Humanistic Studies(IFAUS),Peking University,etc,the Songshan Forum 2016 was held in ...Co-sponsored by the China International Culture Exchange Center(CICEC),Chinese Society of Cultural Relics,and Institute for Advanced Humanistic Studies(IFAUS),Peking University,etc,the Songshan Forum 2016 was held in Henan Province from Oct 27th to 29th.Zhang Baowen,Vice-Chairman of the NPC Standing展开更多
On June 29 this year, Mr. Song Jian, State Councillor and Minister of the State Scientific and Technology Commission, was elected chairman at the 1995 Annual Meeting of the Chinese Group of the Association for the Int...On June 29 this year, Mr. Song Jian, State Councillor and Minister of the State Scientific and Technology Commission, was elected chairman at the 1995 Annual Meeting of the Chinese Group of the Association for the International Protection of Industrial Property (AIPPI). A leader in China’s scientific field and world-renowned expert, Mr. Song fully recognizes the positive role played by the Chinese Group of the AIPPI in promoting the establishment and development of China’s intellectual property system, expanding relations展开更多
As an experienced translator and theorist, GAO Jian has translated numerous English works into Chinese and published a series of theoretical thoughts concerning the most fundamental problems in translation studies. He...As an experienced translator and theorist, GAO Jian has translated numerous English works into Chinese and published a series of theoretical thoughts concerning the most fundamental problems in translation studies. He has formed a unique style in translation and proposed some theoretical concepts with great expertise. Gao represents the translators' spirit of the time. His theories are highly comprehensive and pragmatic. His discussion of translatability of style, relativity and the Language Characteristics Theory reflect the academic thinking among translators in China, which inspires many young translators and theorists.展开更多
文摘试验选用初始体重为(44.34±1.58)g的津新鲤1 260尾,随机分为6组,每组3个重复,每个重复70尾鱼。6组饲料分别含有豆油、鸡油、玉米油、棕榈油、菜籽油、棉籽油。饲养8周后探讨饲料中不同脂肪源对津新鲤生长、相关脂代谢酶活性及脂肪酸合成酶(FAS)、脂蛋白脂酶(LPL)基因表达的影响。结果表明:玉米油组的相对增重率、特定生长率及蛋白质效率显著高于其它5组(P<0.05),但玉米油组饵料系数则最低。不同脂肪源饲料对肝胰脏及肾脏中LPL、肝脂酶(HL)、总脂酶(GE)、脂肪代谢酶活性影响很大(P<0.05),且玉米油组酶活性均最高;各组肝胰脏及肾脏FAS变化不大(P>0.05)。从基因表达来看,玉米油组更容易诱导和调节肝胰脏和肾脏中FAS及LPL m RNA的表达(P<0.05),再次投喂后6 h,肝胰脏和肾脏中LPL m RNA表达丰度均达到峰值,而肝胰脏中FASm RNA表达丰度达到最低值,肾脏中FAS m RNA表达丰度逐渐下降。总之,玉米油可作为津新鲤优质脂肪源。
基金Supported by the National Natural Science Funds of China,No.81573892,No.81873253,and No.81704009
文摘BACKGROUND Given the complex pathogenesis of ulcerative colitis (UC), the conventional therapeutic methods are not fully curative. As a sort of systematic complementary and alternative medicine, traditional Chinese medicine (TCM) provides new options for the standard therapy. Nevertheless, there are still numerous problems with the promotion of TCM attributed to its complexity, and consequently, new research approaches are urgently needed. Thus, we explored the protective effects of Jian-Pi Qing-Chang (JPQC) decoction on UC based on systems pharmacology approach, which might fill the current innovation gap in drug discovery and clinical practice pertaining to TCM. AIM To investigate the protective mechanisms of JPQC decoction on UC based on systems pharmacology approach. METHODS We performed systems pharmacology to predict the active ingredients, the matched targets, and the potential pharmacological mechanism of JPQC on UC. In vivo, we explored the effects of JPQC in a colitis model induced by dextran sulfate sodium. In vitro, we adopted the bone marrow-derived macrophages (BMDMs) as well as BMDMs co-cultured with Caco2 cells to verify the underlying mechanisms and effects of JPQC on UC under TNF-α stimulation. RESULTS Systems pharmacology revealed 170 targets for the 107 active ingredients of JPQC and 112 candidate targets of UC. Protein-protein interaction networks were established to identify the underlying therapeutic targets of JPQC on UC. Based on enrichment analyses, we proposed our hypothesis that JPQC might have a protective effect on UC via the NF-κB/HIF-1α signalling pathway. Subsequent experimental validation revealed that treatment with TNFα activated the NF-κB/HIF-1α signalling pathway in BMDMs, thereby damaging the epithelial barrier permeability in co-cultured Caco2 cells, while JPQC rescued this situation. The findings were also confirmed in a dextran sulfate sodium-induced colitis model. CONCLUSION JPQC could improve the mucosal inflammatory response and intestinal epithelial barrier function via the NF-κB/HIF-1α signalling pathway, which provides new perspectives on the pharmaceutical development and clinical practice of TCM.
文摘“Kan”and“Jian”are both sense verbs in Chinese,but they can develop into multiple meanings and usage.In order to prove that the language in communication assumes the collective cultural experience and historical background,this article attempts,from the connection and differentiation between various meanings,to sort out how the semantic structure is defined in accordance with the situations where the words are used.In addition,based on the methods of the diachronic research and synchronic research,this article also observes the semantic evolution and the extensive concepts of imitation and implication.
文摘Objective: To detect the effect of BiJia Jian Pill on inflammatory factors and liver fibrosis indexes in patients with chronic hepatitis B complicated with cirrhosis. Methods: A total of 94 patients with chronic hepatitis B combined with cirrhosis admitted in the hospital from January 2017 to December 2017 were selected as the subjects, and they were randomly divided into 47 cases in the observation group and 47 cases in the control group. The control group was given Adefovir Dipivoxil Tablets, and the observation group was treated with Bijia Jian pills on the basis of control group. The changes of liver function, inflammatory factors and liver fibrosis indexes were compared between the two groups before and after treatment. Results Before treatment, there was no significant difference in AST, ALT, TBIL and ALB between the two groups. After treatment, the AST, ALT and TBIL of the two groups were all decreased, and the AST, ALT and TBIL in the observation group were lower than those of the control group;the ALB of the two groups increased, and the ALB of the observation group was higher than that of the control group. Before treatment, there was no significant difference in TNF-α, IL-1 βand IL-10 between the two groups. After treatment, the TNF-α and IL-1β of the two groups were decreased, and the TNF-α and IL-1β in the observation group were lower than those of the control group;the IL-10 of the two groups increased, and the IL-10 in the observation group was higher than that in the control group. Before treatment, there was no significant difference in HA, LN, IV-C and PCIII between the two groups. After treatment, the HA, LN, IV-C and PCIII of the two groups were all decreased, and the HA, LN, IV-C and PCIII of the observation group were lower than those of the control group. Conclusion Bijia Jian pills can effectively improve the inflammatory factors and liver fibrosis in patients with chronic hepatitis B complicated with cirrhosis.
文摘Forty patients with multi-infarct dementia (MID) were randomly assigned to the treatment group (25 cases) treated with Jian Nao Ning (健脑宁JNN) and the duxil control group (15 cases). Memory function were assessed at baseline and endpoint using memory subscales of a battery of New Psychometric Tests (Chinese version) including mini-mental state examination (MMSE), verbal memory, and non-verbal memory, etc. After treatment, the mean scores of verbal memory in the Hopkins Verbal Learning Test (P<0.05) and total memory scores of memory items (P<0.001) in JNN group increased significantly; and improvement in episodic memory function including story recall (immediate and delayed), delayed word recall, verbal learning and verbal recognition and visual recognition in the JNN group was better than that in the duxil control group, suggesting that JNN can obviously improve memory function for the patients with mild or moderate multi-infarct dementia.
文摘正Cafiu's Secretary-General Ni Jian attended UN Sustainable Development Conference (Rio +20) held in Rio de Janeiro, Brazil from June 16 to 21. This is another large-scale, high-level event in global sustainable development after the 1992 UN Environment and Development Conference.
文摘At the invitation of National Strategy Institute of ROK (NSI), Japan&China Technological Youth Interchange Society and Sri Lanka-China Friendship Association (SLCFA), CAFIU’s Secretary-General Ni Jian headed a five-member delegation to visit the three countries from March 24 to April 2.
文摘Co-sponsored by the China International Culture Exchange Center(CICEC),Chinese Society of Cultural Relics,and Institute for Advanced Humanistic Studies(IFAUS),Peking University,etc,the Songshan Forum 2016 was held in Henan Province from Oct 27th to 29th.Zhang Baowen,Vice-Chairman of the NPC Standing
文摘On June 29 this year, Mr. Song Jian, State Councillor and Minister of the State Scientific and Technology Commission, was elected chairman at the 1995 Annual Meeting of the Chinese Group of the Association for the International Protection of Industrial Property (AIPPI). A leader in China’s scientific field and world-renowned expert, Mr. Song fully recognizes the positive role played by the Chinese Group of the AIPPI in promoting the establishment and development of China’s intellectual property system, expanding relations
文摘As an experienced translator and theorist, GAO Jian has translated numerous English works into Chinese and published a series of theoretical thoughts concerning the most fundamental problems in translation studies. He has formed a unique style in translation and proposed some theoretical concepts with great expertise. Gao represents the translators' spirit of the time. His theories are highly comprehensive and pragmatic. His discussion of translatability of style, relativity and the Language Characteristics Theory reflect the academic thinking among translators in China, which inspires many young translators and theorists.
