BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last thr...BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three decades.METHODS A descriptive epidemiological study was done.Pancreatic cancer incidence and mortality data were obtained from the database of the World Health Organization.Analysis of pancreatic cancer incidence and mortality during 2020 was performed.The age-standardized rates(ASRs,expressed per 100000)were presented.To estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Additionally,analysis was performed by sex and age.In this paper,the trend analysis included only countries with high and medium data quality.RESULTS A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in 2020.In both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific Region.In both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia Region.The general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed period.Out of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without significance.Out of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasing in both sexes only in Canada and Mexico.CONCLUSION Further research is needed to explain the cause of large international differences in incidence and mortality trends of pancreatic cancer in last three decades.展开更多
BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes worldwide.In a number of countries,hanging mortality has increased over the last decades.Nevertheless,there is a scarcity of studie...BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes worldwide.In a number of countries,hanging mortality has increased over the last decades.Nevertheless,there is a scarcity of studies that have explored the patterns and trends for mortality of suicide by hanging on global,regional and national levels,as most evaluations are limited to certain populations.AIM To assess the trends of suicide mortality by hanging,strangulation,and suffocation in Serbia,from 1991 to 2020.METHODS This nationwide study,with epidemiological descriptive study design,was carried out based on official data.The age-standardized rates(ASRs,expressed per 100000 persons)were calculated by direct standardization,using the World Standard Population.Mortality trends from suicide by hanging were assessed using the joinpoint regression analysis:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed suicide trends.RESULTS Over the 30-year period studied,there were 24340 deaths by hanging(17750 males and 6590 females)in Serbia.In 2020,the ASR of deaths by hanging was 4.5 per 100000 persons in both sexes together(7.6 in males vs 1.7 in females).The trends of suicide mortality by hanging decreased significantly between 1991 and 2020 in both males(AAPC=-1.7%per year;95%CI:-2.0 to-1.4)and females(AAPC=-3.5%per year;95%CI:-3.9 to-3.1).Mortality rates of suicide by hanging had a continuously decreasing tendency in both sexes together in all age groups:The only exception was among males in 40-49 age group,with an increasing trend of suicide by hanging from 1991 to 2011(by+0.3%per year).CONCLUSION The trends in suicide mortality by hanging have been decreasing in Serbia in the last three decades in both sexes,but this was more pronounced in women than in men.Despite the decreasing trends observed in mortality of suicide by hanging,further research is needed for better clarification of trends and help in suicide prevention in the future.展开更多
BACKGROUND Studies exploring suicide mortality on a global scale are sparse,and most evaluations were limited to certain populations.AIM To assess global,regional and national trends of suicide mortality.METHODS Suici...BACKGROUND Studies exploring suicide mortality on a global scale are sparse,and most evaluations were limited to certain populations.AIM To assess global,regional and national trends of suicide mortality.METHODS Suicide mortality data for the period 2000-2019 were obtained from the mortality database of the World Health Organization and the Global Burden of Disease Study.Age-standardized rates(ASRs;expressed per 100000)were presented.To assess trends of suicide mortality,joinpoint regression analysis was used:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.RESULTS A total of 759028(523883 male and 235145 female)suicide deaths were reported worldwide in 2019.The global ASR of mortality of suicide was 9.0/100000 population in both sexes(12.6 in males vs 5.4 in females).In both sexes,the highest rates were found in the region of Africa(ASR=11.2),while the lowest rates were reported in Eastern Mediterranean(ASR=6.4).Globally,from 2000 to 2019,ASRs of mortality of suicide had a decreasing tendency in both sexes together[AAPC=-2.4%per year;95%CI:(-2.6)-(-2.3)].The region of the Americas experienced a significant increase in suicide mortality over 2000-2019 unlike other regions that had a declining trend.Out of all 133 countries with a decline in suicide mortality,Barbados(AAPC=-10.0%),Grenada(AAPC=-8.5%),Serbia(AAPC=-7.6%),and Venezuela(AAPC=-6.2%)showed the most marked reduction in mortality rates.Out of all 26 countries with a rise in suicide mortality,Lesotho(AAPC=+6.0%),Cyprus(AAPC=+5.1%),Paraguay(AAPC=+3.0%),Saudi Arabia(AAPC=+2.8%),Brunei(AAPC=+2.6%),Greece(AAPC=+2.6%),Georgia(AAPC=+2.1%),and Mexico(AAPC=+2.0%),are among those with the highest increase in mortality.CONCLUSION Decreasing trends in suicide mortality were observed in most countries across the world.Unfortunately,the mortality of suicide showed an increasing trend in a number of populations.Further research should explore the reasons for these unfavorable trends,in order to consider and recommend more efforts for suicide prevention in these countries.展开更多
Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health proble...Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health problems.The aim of this study was to assess cancer mortality trends in Serbia.Methods:This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using offi-cial data.The age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by Segi.The average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression analysis.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal trends.Results:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in Serbia.Overall cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both sexes.For almost all major cancers except stomach cancer,cancer mortality in Serbia demonstrated upward trends during the study period.The largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in Serbia.Despite this,these rates place Serbia among the countries with the highest cancer mortality in the world.展开更多
基金Supported by Ministry of Education,Science and Technological development,Republic of Serbia,2011-2020,No.175042.
文摘BACKGROUND Pancreatic cancer,as the one of most fatal malignancies,remains a critical issue in the global burden of disease.AIM To estimate trends in pancreatic cancer incidence and mortality worldwide in the last three decades.METHODS A descriptive epidemiological study was done.Pancreatic cancer incidence and mortality data were obtained from the database of the World Health Organization.Analysis of pancreatic cancer incidence and mortality during 2020 was performed.The age-standardized rates(ASRs,expressed per 100000)were presented.To estimate trends of incidence and mortality of pancreatic cancer,joinpoint regression analysis was used:the average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Additionally,analysis was performed by sex and age.In this paper,the trend analysis included only countries with high and medium data quality.RESULTS A total of 495773(262865 male and 232908 female)new cases and 466003(246840 male and 219163 female)deaths from pancreatic cancer were reported worldwide in 2020.In both sexes,most of the new cases(191348;38.6%of the total)and deaths(182074;39.1%of the total)occurred in the Western Pacific Region.In both sexes,the highest ASRs were found in the European Region,while the lowest rates were reported in the South-East Asia Region.The general pattern of rising pancreatic cancer incidence and mortality was seen across countries worldwide in observed period.Out of all countries with an increase in pancreatic cancer incidence,females in France and India showed the most marked rise in incidence rates(AAPC=+3.9%and AAPC=+3.7%,respectively).Decreasing incidence trends for pancreatic cancer were observed in some countries,but without significance.Out of all countries with an increase in pancreatic cancer mortality rates,Turkmenistan showed the most marked rise both in males(AAPC=+10.0%,95%CI:7.4–12.5)and females(AAPC=+6.4%,95%CI:3.5–9.5).The mortality trends of pancreatic cancer were decreasing in both sexes only in Canada and Mexico.CONCLUSION Further research is needed to explain the cause of large international differences in incidence and mortality trends of pancreatic cancer in last three decades.
基金Supported by Ministry of Education,Science and Technological Development,Republic of Serbia, 2011–2020, No. 175042
文摘BACKGROUND Hanging is one of the most commonly used methods for suicide in both sexes worldwide.In a number of countries,hanging mortality has increased over the last decades.Nevertheless,there is a scarcity of studies that have explored the patterns and trends for mortality of suicide by hanging on global,regional and national levels,as most evaluations are limited to certain populations.AIM To assess the trends of suicide mortality by hanging,strangulation,and suffocation in Serbia,from 1991 to 2020.METHODS This nationwide study,with epidemiological descriptive study design,was carried out based on official data.The age-standardized rates(ASRs,expressed per 100000 persons)were calculated by direct standardization,using the World Standard Population.Mortality trends from suicide by hanging were assessed using the joinpoint regression analysis:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed suicide trends.RESULTS Over the 30-year period studied,there were 24340 deaths by hanging(17750 males and 6590 females)in Serbia.In 2020,the ASR of deaths by hanging was 4.5 per 100000 persons in both sexes together(7.6 in males vs 1.7 in females).The trends of suicide mortality by hanging decreased significantly between 1991 and 2020 in both males(AAPC=-1.7%per year;95%CI:-2.0 to-1.4)and females(AAPC=-3.5%per year;95%CI:-3.9 to-3.1).Mortality rates of suicide by hanging had a continuously decreasing tendency in both sexes together in all age groups:The only exception was among males in 40-49 age group,with an increasing trend of suicide by hanging from 1991 to 2011(by+0.3%per year).CONCLUSION The trends in suicide mortality by hanging have been decreasing in Serbia in the last three decades in both sexes,but this was more pronounced in women than in men.Despite the decreasing trends observed in mortality of suicide by hanging,further research is needed for better clarification of trends and help in suicide prevention in the future.
基金Supported by the Ministry of Education,Science and Technological development,Republic of Serbia, 2011–2020, No. 175042
文摘BACKGROUND Studies exploring suicide mortality on a global scale are sparse,and most evaluations were limited to certain populations.AIM To assess global,regional and national trends of suicide mortality.METHODS Suicide mortality data for the period 2000-2019 were obtained from the mortality database of the World Health Organization and the Global Burden of Disease Study.Age-standardized rates(ASRs;expressed per 100000)were presented.To assess trends of suicide mortality,joinpoint regression analysis was used:The average annual percent change(AAPC)with the corresponding 95%confidence interval(95%CI)was calculated.RESULTS A total of 759028(523883 male and 235145 female)suicide deaths were reported worldwide in 2019.The global ASR of mortality of suicide was 9.0/100000 population in both sexes(12.6 in males vs 5.4 in females).In both sexes,the highest rates were found in the region of Africa(ASR=11.2),while the lowest rates were reported in Eastern Mediterranean(ASR=6.4).Globally,from 2000 to 2019,ASRs of mortality of suicide had a decreasing tendency in both sexes together[AAPC=-2.4%per year;95%CI:(-2.6)-(-2.3)].The region of the Americas experienced a significant increase in suicide mortality over 2000-2019 unlike other regions that had a declining trend.Out of all 133 countries with a decline in suicide mortality,Barbados(AAPC=-10.0%),Grenada(AAPC=-8.5%),Serbia(AAPC=-7.6%),and Venezuela(AAPC=-6.2%)showed the most marked reduction in mortality rates.Out of all 26 countries with a rise in suicide mortality,Lesotho(AAPC=+6.0%),Cyprus(AAPC=+5.1%),Paraguay(AAPC=+3.0%),Saudi Arabia(AAPC=+2.8%),Brunei(AAPC=+2.6%),Greece(AAPC=+2.6%),Georgia(AAPC=+2.1%),and Mexico(AAPC=+2.0%),are among those with the highest increase in mortality.CONCLUSION Decreasing trends in suicide mortality were observed in most countries across the world.Unfortunately,the mortality of suicide showed an increasing trend in a number of populations.Further research should explore the reasons for these unfavorable trends,in order to consider and recommend more efforts for suicide prevention in these countries.
基金supported by Ministry of Education,Science and Technological Development,Republic of Serbia,2011-2016(Contract No.175042).
文摘Background:As the result of dramatic political changes,civil wars,and a long-term refugee crisis from the end of the last to beginning of this century,the population of Serbia has experienced significant health problems.The aim of this study was to assess cancer mortality trends in Serbia.Methods:This nationwide study was carried out to analyze cancer mortality in Serbia during 1991-2015 using offi-cial data.The age-standardized mortality rates(per 100,000)were calculated by direct standardization,using the world standard population by Segi.The average annual percent change(AAPC)and corresponding 95%confidence interval(CI)were computed using joinpoint regression analysis.Age-period-cohort analysis was performed to address the possible underlying reasons for the observed temporal trends.Results:Over the 25-year study period,there were 466,075 cancer deaths(266,043 males and 200,032 females)in Serbia.Overall cancer mortality increased between 1991 and 2009 in both males(by+0.9%per year)and females(by+0.8%per year)and has been decreasing since then,by−0.9%annually in both sexes.For almost all major cancers except stomach cancer,cancer mortality in Serbia demonstrated upward trends during the study period.The largest increases were noted in lung cancer among females(AAPC=+3.7,95%CI 3.5-3.9)and prostate cancer in males(AAPC=+1.9,95%CI 1.4-2.3).Conclusions:After two decades of increase,cancer mortality rates are finally declining in Serbia.Despite this,these rates place Serbia among the countries with the highest cancer mortality in the world.
