A robust estimation of the earthquake location, seismic moment, and fault geometry is essential for objective seismic hazard assessment. Seismic events in a remote location, specifically in the absence of seismic and ...A robust estimation of the earthquake location, seismic moment, and fault geometry is essential for objective seismic hazard assessment. Seismic events in a remote location, specifically in the absence of seismic and GNSS networks, can be investigated effectively using the In SAR-based technique. This study adopts the Differential Interferometric SAR(DIn SAR) technique to quantify the co-seismic surface displacement caused by the June 21, 2022, Khōst M_(W)6 earthquake that occurred along the western plate boundary between the Indian and Eurasian plate. The interferograms show that the maximum surface deformation occurred on the northwest and southwest of the fault line. From coherence, the Line of Sight(LOS) displacement, and the co-seismic surface displacement analysis, it has been observed that surface deformation was most pronounced in the southwest region of the fault line, and the surface has moved to the opposite direction along the fault line, which indicates a sinistral slightly oblique strike-slip movement. This In SAR-based observation appears consistent with the seismic waveforms derived from co-seismic surface displacements. Further, it has been argued that the slip deficit accumulated during the period of the last about 48 years along the frontal region of the northward extension of the Suleiman range and associated fault zone is qualitatively estimated at about 1.5 m, which is consistent with the seismic waveforms derived finite slip model.展开更多
背景与目的:可变剪接在细胞增殖、生长、凋亡及分化等复杂的蛋白质功能调控中发挥着至关重要的作用,能参与包括肿瘤在内的多种疾病的发生、发展过程,目前大多数可变剪接调控因子的功能及其作用机制尚不清楚。本研究旨在探讨KH型剪接调...背景与目的:可变剪接在细胞增殖、生长、凋亡及分化等复杂的蛋白质功能调控中发挥着至关重要的作用,能参与包括肿瘤在内的多种疾病的发生、发展过程,目前大多数可变剪接调控因子的功能及其作用机制尚不清楚。本研究旨在探讨KH型剪接调控蛋白(KH-type splicing regulatory protein,KHSRP)在肺腺癌中的差异剪接靶基因及靶基因的表达与患者预后及免疫细胞功能的相关性。方法:通过高通量可变剪接测序,筛选KHSRP下游差异剪接靶基因。通过肿瘤免疫评估资源(Tumor IMmune Estimation Resource,TIMER)和阿拉巴马大学伯明翰分校癌症数据分析门户(the University of Alabama at Birmingham cancer data analysis portal,ULCAN)分析KHSRP下游差异剪接靶基因在肺腺癌中的表达。通过Kaplan数据库分析KHSRP下游差异剪接靶基因的表达与患者预后的相关性。通过TIMER免疫模块分析KHSRP下游差异剪接靶基因与免疫细胞功能的相关性。结果:NUMB、ADD3及LIMCH1为KHSRP的下游关键可变剪接靶基因。NUMB、ADD3及LIMCH1在肺腺癌肿瘤组织中均呈低表达,其低表达者预后不良。NUMB、ADD3及LIMCH1与免疫细胞功能呈正相关。结论:在肺腺癌中,NUMB、ADD3及LIMCH1为KHSRP的差异剪接靶基因,且NUMB、ADD3及LIMCH1低表达会导致预后不良,并且与免疫细胞功能呈正相关。展开更多
利用硅烷偶联剂KH550对白炭黑纳米粉体进行表面接枝改性,并制备改性白炭黑(m Si O_(2))/环氧树脂(EP)浇铸体,利用傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)、粒度分析、拉伸性能测试、热重分析(TG)、扫描电镜(SEM)等手段对改性前后的...利用硅烷偶联剂KH550对白炭黑纳米粉体进行表面接枝改性,并制备改性白炭黑(m Si O_(2))/环氧树脂(EP)浇铸体,利用傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)、粒度分析、拉伸性能测试、热重分析(TG)、扫描电镜(SEM)等手段对改性前后的白炭黑粒、m Si O_(2)/EP浇铸体进行表征分析,探究了KH550对白炭黑的改性效果以及m Si O_(2)用量对浇铸体力学性能、耐热性和结构的影响。结果表明:以异丙醇作为分散剂,当KH550质量分数为20%,反应温度为90℃,反应时间为5h,在醇、水混合溶剂中可以实现KH550对白炭黑的表面改性;当改性白炭黑用量为8%(wt.)时,浇铸体综合性能最好,拉伸强度为41.29MPa,较纯EP提升了95.2%;其最大分解速率时的温度为377℃,较纯EP提升了14℃。展开更多
文摘A robust estimation of the earthquake location, seismic moment, and fault geometry is essential for objective seismic hazard assessment. Seismic events in a remote location, specifically in the absence of seismic and GNSS networks, can be investigated effectively using the In SAR-based technique. This study adopts the Differential Interferometric SAR(DIn SAR) technique to quantify the co-seismic surface displacement caused by the June 21, 2022, Khōst M_(W)6 earthquake that occurred along the western plate boundary between the Indian and Eurasian plate. The interferograms show that the maximum surface deformation occurred on the northwest and southwest of the fault line. From coherence, the Line of Sight(LOS) displacement, and the co-seismic surface displacement analysis, it has been observed that surface deformation was most pronounced in the southwest region of the fault line, and the surface has moved to the opposite direction along the fault line, which indicates a sinistral slightly oblique strike-slip movement. This In SAR-based observation appears consistent with the seismic waveforms derived from co-seismic surface displacements. Further, it has been argued that the slip deficit accumulated during the period of the last about 48 years along the frontal region of the northward extension of the Suleiman range and associated fault zone is qualitatively estimated at about 1.5 m, which is consistent with the seismic waveforms derived finite slip model.
文摘背景与目的:可变剪接在细胞增殖、生长、凋亡及分化等复杂的蛋白质功能调控中发挥着至关重要的作用,能参与包括肿瘤在内的多种疾病的发生、发展过程,目前大多数可变剪接调控因子的功能及其作用机制尚不清楚。本研究旨在探讨KH型剪接调控蛋白(KH-type splicing regulatory protein,KHSRP)在肺腺癌中的差异剪接靶基因及靶基因的表达与患者预后及免疫细胞功能的相关性。方法:通过高通量可变剪接测序,筛选KHSRP下游差异剪接靶基因。通过肿瘤免疫评估资源(Tumor IMmune Estimation Resource,TIMER)和阿拉巴马大学伯明翰分校癌症数据分析门户(the University of Alabama at Birmingham cancer data analysis portal,ULCAN)分析KHSRP下游差异剪接靶基因在肺腺癌中的表达。通过Kaplan数据库分析KHSRP下游差异剪接靶基因的表达与患者预后的相关性。通过TIMER免疫模块分析KHSRP下游差异剪接靶基因与免疫细胞功能的相关性。结果:NUMB、ADD3及LIMCH1为KHSRP的下游关键可变剪接靶基因。NUMB、ADD3及LIMCH1在肺腺癌肿瘤组织中均呈低表达,其低表达者预后不良。NUMB、ADD3及LIMCH1与免疫细胞功能呈正相关。结论:在肺腺癌中,NUMB、ADD3及LIMCH1为KHSRP的差异剪接靶基因,且NUMB、ADD3及LIMCH1低表达会导致预后不良,并且与免疫细胞功能呈正相关。
文摘利用硅烷偶联剂KH550对白炭黑纳米粉体进行表面接枝改性,并制备改性白炭黑(m Si O_(2))/环氧树脂(EP)浇铸体,利用傅里叶变换红外光谱(FTIR)、X射线衍射(XRD)、粒度分析、拉伸性能测试、热重分析(TG)、扫描电镜(SEM)等手段对改性前后的白炭黑粒、m Si O_(2)/EP浇铸体进行表征分析,探究了KH550对白炭黑的改性效果以及m Si O_(2)用量对浇铸体力学性能、耐热性和结构的影响。结果表明:以异丙醇作为分散剂,当KH550质量分数为20%,反应温度为90℃,反应时间为5h,在醇、水混合溶剂中可以实现KH550对白炭黑的表面改性;当改性白炭黑用量为8%(wt.)时,浇铸体综合性能最好,拉伸强度为41.29MPa,较纯EP提升了95.2%;其最大分解速率时的温度为377℃,较纯EP提升了14℃。
