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MKEAH:Multimodal knowledge extraction and accumulation based on hyperplane embedding for knowledge-based visual question answering
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作者 Heng ZHANG Zhihua WEI +6 位作者 Guanming LIU Rui WANG Ruibin MU Chuanbao LIU Aiquan YUAN Guodong CAO Ning HU 《虚拟现实与智能硬件(中英文)》 EI 2024年第4期280-291,共12页
Background External knowledge representations play an essential role in knowledge-based visual question and answering to better understand complex scenarios in the open world.Recent entity-relationship embedding appro... Background External knowledge representations play an essential role in knowledge-based visual question and answering to better understand complex scenarios in the open world.Recent entity-relationship embedding approaches are deficient in representing some complex relations,resulting in a lack of topic-related knowledge and redundancy in topic-irrelevant information.Methods To this end,we propose MKEAH:Multimodal Knowledge Extraction and Accumulation on Hyperplanes.To ensure that the lengths of the feature vectors projected onto the hyperplane compare equally and to filter out sufficient topic-irrelevant information,two losses are proposed to learn the triplet representations from the complementary views:range loss and orthogonal loss.To interpret the capability of extracting topic-related knowledge,we present the Topic Similarity(TS)between topic and entity-relations.Results Experimental results demonstrate the effectiveness of hyperplane embedding for knowledge representation in knowledge-based visual question answering.Our model outperformed state-of-the-art methods by 2.12%and 3.24%on two challenging knowledge-request datasets:OK-VQA and KRVQA,respectively.Conclusions The obvious advantages of our model in TS show that using hyperplane embedding to represent multimodal knowledge can improve its ability to extract topic-related knowledge. 展开更多
关键词 knowledge-based visual question answering HYPERPLANE Topic-related
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Knowledge-Based Efficient N-1 Analysis Calculation Method for Urban Distribution Networks with CIM File Data
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作者 Lingyu Liang Xiangyu Zhao +3 位作者 Wenqi Huang Liming Sun Ziyao Wang Yaosen Zhan 《Energy Engineering》 EI 2023年第12期2839-2856,共18页
The N-1 criterion is a critical factor for ensuring the reliable and resilient operation of electric power distribution networks.However,the increasing complexity of distribution networks and the associated growth in ... The N-1 criterion is a critical factor for ensuring the reliable and resilient operation of electric power distribution networks.However,the increasing complexity of distribution networks and the associated growth in data size have created a significant challenge for distribution network planners.To address this issue,we propose a fast N-1 verification procedure for urban distribution networks that combines CIM file data analysis with MILP-based mathematical modeling.Our proposed method leverages the principles of CIM file analysis for distribution network N-1 analysis.We develop a mathematical model of distribution networks based on CIM data and transfer it into MILP.We also take into account the characteristics of medium voltage distribution networks after a line failure and select the feeder section at the exit of each substation with a high load rate to improve the efficiency of N-1 analysis.We validate our approach through a series of case studies and demonstrate its scalability and superiority over traditional N-1 analysis and heuristic optimization algorithms.By enabling online N-1 analysis,our approach significantly improves the work efficiency of distribution network planners.In summary,our proposed method provides a valuable tool for distribution network planners to enhance the accuracy and efficiency of their N-1 analyses.By leveraging the advantages of CIM file data analysis and MILP-based mathematical modeling,our approach contributes to the development of more resilient and reliable electric power distribution networks. 展开更多
关键词 MILP CIM fast analytical method N-1 distribution networks knowledge-based method
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Perceived stress among staff in Saudi Arabian dental colleges before and after an accreditation process: A cross-sectional study
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作者 Amal S Shaiban 《World Journal of Clinical Cases》 SCIE 2024年第4期758-765,共8页
BACKGROUND Accreditation processes are extensively employed to guarantee the quality of higher education institutions.However,this process can potentially generate a stressful atmosphere for staff,thus impacting their... BACKGROUND Accreditation processes are extensively employed to guarantee the quality of higher education institutions.However,this process can potentially generate a stressful atmosphere for staff,thus impacting their ability to perform optimally under pressure.AIM To examine the knowledge of the National Commission for Academic Assessment and Accreditation(NCAAA)and its effects on perceived stress among dental college staff before and after the program accreditation process.METHODS The present cross-sectional questionnaire-based study included 300 employees from three dental colleges.The same employees had to fill out the questionnaire 1 mo after the NCAAA process.RESULTS Approximately 51.33%of the included employees believed that NCAAA is essential to attract quality students to join the program before and after the program.A total of 44.67%felt that their stress was high before,and 31.33%had low stress levels before and after NCAAA.These findings were statistically significant(P≤0.05).CONCLUSION NCAAA raised the prestige of the institution and specific programmes and increased prospects to attract better students,staff,and money,according to the employees.In addition to their needed teaching,research,and other service responsibilities,this work requires a tremendous amount of faculty effort and may cause them stress. 展开更多
关键词 National Commission for Academic Assessment and Accreditation Accreditation process Perceived stress staff
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The Impact of Nursing Staff’s Work Attitude on the Fear of Patients Recovering from Benign Tumors:Family Support as a Mediating Variable
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作者 Chengzhe Guo Aihua Cheng +1 位作者 Jian Chen Gaojie Cheng 《Psycho-Oncologie》 SCIE 2024年第4期291-303,共13页
The perception of nursing staff’s attitude influences patient fear.Understanding this dynamic is crucial for fostering a supportive environment conducive to patient well-being and effective healthcare practices.The p... The perception of nursing staff’s attitude influences patient fear.Understanding this dynamic is crucial for fostering a supportive environment conducive to patient well-being and effective healthcare practices.The purpose of this research is to investigate how the attitudes and behaviours of nursing staff influence the fear and anxiety levels of patients recovering from benign tumors,aiming to improve patient care and recovery outcomes.Data was collected from a sample of 100 participants,comprising 20 nursing staff and 80 patients recovering from benign tumors.Surveys were administered to gather quantitative data on attitudes and fear levels.Participants were selected randomly from hospital records and outpatient clinics.Our analysis encompassed nursing staff attitude,patient fear levels,the influence of family support,progression of tumor recovery,patient-reported satisfaction,and the quality of healthcare services provided.The quantitative aspect utilized PLS-SEM software to perform regression analysis,evaluating both direct and indirect effects.Statistical analysis assessed the relationships between nursing staff attitudes,patient fear during benign tumor recovery,and the mediating role of family support.The findings of the study demonstrate that better nurse attitudes(Hypothesis 1,β=0.45,p<0.001)and stronger family support(Hypothesis 2,β=0.32;p<0.001) are linked to lower levels of patient fear.Partially mediating the relationship between nurse attitudes and patient fear,according to Hypothesis 3(β=0.28,p<0.002),is family support.Patients’perceptions of family support are highly influenced by nursing behaviour,as demonstrated by Hypothesis 4(β=0.38;p<0.001).Our research showed a strong relationship between the attitudes of nursing personnel and patient fear levels.Family support demonstrated a strong mediating effect on patient fear.Patient-reported satisfaction is positively correlated with family support.However,no significant relationship was found between healthcare service quality and patient fear. 展开更多
关键词 Nursing staff’s work attitude fear of patients benign tumors recovery family support statistical analysis
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Research Progress on Career Development of Nursing Staff
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作者 Jie Liu Yuying Hao +2 位作者 Rui Song Li Cao Can Deng 《Journal of Clinical and Nursing Research》 2024年第5期180-187,共8页
There are few studies on career development as an exclusive concept in the field of nursing in China.Currently,research related to the career development of nursing staff primarily relies on inductive evaluation tools... There are few studies on career development as an exclusive concept in the field of nursing in China.Currently,research related to the career development of nursing staff primarily relies on inductive evaluation tools,and there is less systematic summarization of this research.This paper reviews the concept,evaluation tools,and influencing factors of nursing career development,aiming to provide a reference for future research in this area. 展开更多
关键词 Career development Nursing staff SUMMARY
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Analysis of The Impact of The Healthcare Roundtable Model on the Major Disease Perceptions and Competencies of Cardiovascular Medicine Nursing Staff
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作者 Xianxiao Liu 《Journal of Clinical and Nursing Research》 2024年第4期180-185,共6页
Objective: To analyze the impact of the healthcare roundtable model on the major disease perceptions and competencies of cardiovascular nursing staff. Methods: Forty female nursing staff working in the hospital from A... Objective: To analyze the impact of the healthcare roundtable model on the major disease perceptions and competencies of cardiovascular nursing staff. Methods: Forty female nursing staff working in the hospital from April to June 2023 were selected and were randomly divided into a control group and an observation group, with 20 in each group. For 60 days, the control group used the conventional learning and communication model and the observation group used the medical and nursing roundtable model. The cognitive scores of cardiovascular disease-related knowledge, competency scores, and satisfaction with the learning and communication model before and after the implementation of the model in both groups were compared. Results: After the implementation, the cognitive scores related to cardiovascular disease-related knowledge, competency scores, and satisfaction with the learning and communication model in the observation group were significantly higher than those in the control group (P < 0.05). Conclusion: The healthcare roundtable model improved the knowledge and competence of cardiovascular internal medicine nursing staff in major diseases, and it is worth popularizing. 展开更多
关键词 Roundtable model Nursing staff Disease awareness COMPETENCE
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Knowledge-Based Classification in Automated Soil Mapping 被引量:10
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作者 ZHOU BIN and WANG RENCHAOInstitute of Agricultural Remote Sensing and Information Technology Application, Zhejiang University, Hangzhou 310029 (China) 《Pedosphere》 SCIE CAS CSCD 2003年第3期209-218,共10页
A machine-learning approach was developed for automated building of knowledgebases for soil resources mapping by using a classification tree to generate knowledge from trainingdata. With this method, building a knowle... A machine-learning approach was developed for automated building of knowledgebases for soil resources mapping by using a classification tree to generate knowledge from trainingdata. With this method, building a knowledge base for automated soil mapping was easier than usingthe conventional knowledge acquisition approach. The knowledge base built by classification tree wasused by the knowledge classifier to perform the soil type classification of Longyou County,Zhejiang Province, China using Landsat TM bi-temporal images and CIS data. To evaluate theperformance of the resultant knowledge bases, the classification results were compared to existingsoil map based on a field survey. The accuracy assessment and analysis of the resultant soil mapssuggested that the knowledge bases built by the machine-learning method was of good quality formapping distribution model of soil classes over the study area. 展开更多
关键词 CLASSIFICATION classification tree knowledge-based rule extracting soilmapping
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Knowledge-based bridge detection from SAR images 被引量:5
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作者 Wang Wenguang Sun Jinping Hu Rui Mao Shiyi 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第5期929-936,共8页
Automatic bridge detection is an important application of SAR images. Differed from the classical CFAR method, a new knowledge-based bridge detection approach is proposed. The method not only uses the backscattering i... Automatic bridge detection is an important application of SAR images. Differed from the classical CFAR method, a new knowledge-based bridge detection approach is proposed. The method not only uses the backscattering intensity difference between targets and background but also applies the contextual information and spatial relationship between objects. According to bridges' special characteristics and scattering properties in SAR images, the new knowledge-based method includes three processes: river segmentation, potential bridge areas detection and bridge discrimination. The application to AIRSAR data shows that the new method is not sensitive to rivers' shape. Moreover, this method can detect bridges successfully when river segmentation is not very exact and is more robust than the radius projection method. 展开更多
关键词 knowledge-based bridge detection SAR contextual information mathematical morphology.
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New Knowledge-based Genetic Algorithm for Excavator Boom Structural Optimization 被引量:6
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作者 HUA Haiyan LIN Shuwen 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第2期392-401,共10页
Due to the insufficiency of utilizing knowledge to guide the complex optimal searching, existing genetic algorithms fail to effectively solve excavator boom structural optimization problem. To improve the optimization... Due to the insufficiency of utilizing knowledge to guide the complex optimal searching, existing genetic algorithms fail to effectively solve excavator boom structural optimization problem. To improve the optimization efficiency and quality, a new knowledge-based real-coded genetic algorithm is proposed. A dual evolution mechanism combining knowledge evolution with genetic algorithm is established to extract, handle and utilize the shallow and deep implicit constraint knowledge to guide the optimal searching of genetic algorithm circularly. Based on this dual evolution mechanism, knowledge evolution and population evolution can be connected by knowledge influence operators to improve the conflgurability of knowledge and genetic operators. Then, the new knowledge-based selection operator, crossover operator and mutation operator are proposed to integrate the optimal process knowledge and domain culture to guide the excavator boom structural optimization. Eight kinds of testing algorithms, which include different genetic operators, arc taken as examples to solve the structural optimization of a medium-sized excavator boom. By comparing the results of optimization, it is shown that the algorithm including all the new knowledge-based genetic operators can more remarkably improve the evolutionary rate and searching ability than other testing algorithms, which demonstrates the effectiveness of knowledge for guiding optimal searching. The proposed knowledge-based genetic algorithm by combining multi-level knowledge evolution with numerical optimization provides a new effective method for solving the complex engineering optimization problem. 展开更多
关键词 boom structural optimization dual evolution mechanism knowledge-based genetic strategies deep implicit knowledge domain culture
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Structural Topology Design of Container Ship Based on Knowledge-Based Engineering and Level Set Method 被引量:5
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作者 崔进举 王德禹 史琪琪 《China Ocean Engineering》 SCIE EI CSCD 2015年第4期551-564,共14页
Knowledge-Based Engineering (KBE) is introduced into the ship structural design in this paper. From the implementation of KBE, the design solutions for both Rules Design Method (RDM) and Interpolation Design Meth... Knowledge-Based Engineering (KBE) is introduced into the ship structural design in this paper. From the implementation of KBE, the design solutions for both Rules Design Method (RDM) and Interpolation Design Method (IDM) are generated. The corresponding Finite Element (FE) models are generated. Topological design of the longitudinal structures is studied where the Gaussian Process (GP) is employed to build the surrogate model for FE analysis. Multi-objective optimization methods inspired by Pareto Front are used to reduce the design tank weight and outer surface area simultaneously. Additionally, an enhanced Level Set Method (LSM) which employs implicit algorithm is applied to the topological design of typical bracket plate which is used extensively in ship structures. Two different sets of boundary conditions are considered. The proposed methods show satisfactory efficiency and accuracy. 展开更多
关键词 knowledge-based Engineering (KBE) Level Set Method (LSM) Gaussian Process GP)
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FAULT DIAGNOSIS OF ROTATING MACHINERY USING KNOWLEDGE-BASED FUZZY NEURAL NETWORK 被引量:2
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作者 李如强 陈进 伍星 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2006年第1期99-108,共10页
A novel knowledge-based fuzzy neural network (KBFNN) for fault diagnosis is presented. Crude rules were extracted and the corresponding dependent factors and antecedent coverage factors were calculated firstly from ... A novel knowledge-based fuzzy neural network (KBFNN) for fault diagnosis is presented. Crude rules were extracted and the corresponding dependent factors and antecedent coverage factors were calculated firstly from the diagnostic sample based on rough sets theory. Then the number of rules was used to construct partially the structure of a fuzzy neural network and those factors were implemented as initial weights, with fuzzy output parameters being optimized by genetic algorithm. Such fuzzy neural network was called KBFNN. This KBFNN was utilized to identify typical faults of rotating machinery. Diagnostic results show that it has those merits of shorter training time and higher right diagnostic level compared to general fuzzy neural networks. 展开更多
关键词 rotating machinery fault diagnosis rough sets theory fuzzy sets theory generic algorithm knowledge-based fuzzy neural network
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Knowledge-based potentials in bioinformatics: From a physicist's viewpoint 被引量:1
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作者 郑伟谋 《Chinese Physics B》 SCIE EI CAS CSCD 2015年第12期22-27,共6页
Biological raw data are growing exponentially, providing a large amount of information on what life is. It is believed that potential functions and the rules governing protein behaviors can be revealed from analysis o... Biological raw data are growing exponentially, providing a large amount of information on what life is. It is believed that potential functions and the rules governing protein behaviors can be revealed from analysis on known native structures of proteins. Many knowledge-based potentials for proteins have been proposed. Contrary to most existing review articles which mainly describe technical details and applications of various potential models, the main foci for the discussion here are ideas and concepts involving the construction of potentials, including the relation between free energy and energy, the additivity of potentials of mean force and some key issues in potential construction. Sequence analysis is briefly viewed from an energetic viewpoint. 展开更多
关键词 knowledge-based potentials for proteins protein native structures sequence signals
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A Knowledge-based System for the Analysis of the Ability of Paying back Loans 被引量:1
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作者 Zhu Ming(朱明) +1 位作者 Yang Baoan(杨保安) 《Journal of Donghua University(English Edition)》 EI CAS 2001年第1期123-126,共4页
This paper describes the development of a knowledgebased system (KBS) for determining whether or not, and under what conditions, a bank Ioan officer should grant a business loan to a company. The prototype system deve... This paper describes the development of a knowledgebased system (KBS) for determining whether or not, and under what conditions, a bank Ioan officer should grant a business loan to a company. The prototype system developed focuses on what is bank loans risks management, how to prevent risk by the analysis of the ability of paying back loans. The paper makes the structural analysis involved in the system's decision situation, the structured situation diagram or model, dependency diagram and the document needed by the KBS prototype system thus are developed. Through testing the samples from loan business, the quality for the analysis of the ability of paying back loans can be effectively evaluated by the KBS prototype system. 展开更多
关键词 knowledge-based SYSTEM (KBS) the KBS prototype system the ABILITY of paying BACK loans bank LOANS risk management.
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Integration of Decision-Support and Knowledge-Based Techniques in a Problem-Solving Strategy for Selection Problems 被引量:1
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作者 David McSherry(School of Information and Software Engineering,Faculty of Informatics, University of Ulster,Coleraine BT52 1SA, Northern Ireland) 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 1996年第2期35-54,共20页
The limitations of traditional approaches to selection problems are examined. A problemsolving strategy is presented in which decision-support and knowledge-based techniques play complementary roles. An approach to th... The limitations of traditional approaches to selection problems are examined. A problemsolving strategy is presented in which decision-support and knowledge-based techniques play complementary roles. An approach to the representation of knowledge to support the problem-solving strategy is presented which avoids commitment to a specific programming language or implementation environment. The problem of choosing a home is used to illustrate the representation of knowledge in a specific problem domain. Techniques for implementation of the problem-solving strategy are described. Knowledge elicitation techniques and their implementation in a development shell for application of the problem-solving strategy to any selection problem are also described. 展开更多
关键词 knowledge-based systems Decision-support systems Knowledge acquisition Multiple criteria decision making Operational research Analytic hierarchy process
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Yarn Quality Prediction and Diagnosis Based on Rough Set and Knowledge-Based Artificial Neural Network 被引量:1
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作者 杨建国 徐兰 +1 位作者 项前 刘彬 《Journal of Donghua University(English Edition)》 EI CAS 2014年第6期817-823,共7页
In the spinning process, some key process parameters( i. e.,raw material index inputs) have very strong relationship with the quality of finished products. The abnormal changes of these process parameters could result... In the spinning process, some key process parameters( i. e.,raw material index inputs) have very strong relationship with the quality of finished products. The abnormal changes of these process parameters could result in various categories of faulty products. In this paper, a hybrid learning-based model was developed for on-line intelligent monitoring and diagnosis of the spinning process. In the proposed model, a knowledge-based artificial neural network( KBANN) was developed for monitoring the spinning process and recognizing faulty quality categories of yarn. In addition,a rough set( RS)-based rule extraction approach named RSRule was developed to discover the causal relationship between textile parameters and yarn quality. These extracted rules were applied in diagnosis of the spinning process, provided guidelines on improving yarn quality,and were used to construct KBANN. Experiments show that the proposed model significantly improve the learning efficiency, and its prediction precision is improved by about 5. 4% compared with the BP neural network model. 展开更多
关键词 yarn quality prediction rough set(RS) knowledge discovery knowledge-based artificial neural network(KBANN)
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MY PERSONAL STUDY ON KNOWLEDGE-BASED ECONOMY 被引量:2
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作者 Deng Shuhui(Institute of Systems Science, the CAS) 《Bulletin of the Chinese Academy of Sciences》 1999年第2期119-120,共2页
The Financial Crisis in Asia is having a negative impacion the economic development of China, but it also enlightens us. It makes us consider and take measures to avoid such a crisis. I have put forward six measures, ... The Financial Crisis in Asia is having a negative impacion the economic development of China, but it also enlightens us. It makes us consider and take measures to avoid such a crisis. I have put forward six measures, one of which is to promote the transformation of S&T knowledge into productive forces. 展开更多
关键词 MODE MY PERSONAL STUDY ON knowledge-based ECONOMY
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Research on Knowledge-based Connecting Elements Modeling
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作者 HUANG Xiang, YAN Chong-jing (College of Mechanical and Electrical Engineering, Nanjing University o f Aeronautics and Astronautics, Nanjing 210016, China) 《厦门大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第S1期162-163,共2页
Steps of manipulation is required to complete the m od eling of the connection elements such as bolt, pin and the like in commerce CAD system. It leads to low efficiency, difficulty to assure the relative position, im... Steps of manipulation is required to complete the m od eling of the connection elements such as bolt, pin and the like in commerce CAD system. It leads to low efficiency, difficulty to assure the relative position, impossibility to express rules and knowledge. Based on the inner character analy sis of interpart, detail modification and assembly relation of mechanical connec ting element, the idea, which extends the feature modeling of part to the interp art feature modeling for assembly purpose, is presented, and virtual part based connecting element modeling is proposed. Virtual part is a complement set of lo cal modification of part to be connected. In assembly modeling, base part is mod ified by Boolean operation between base part and virtual part. The modeling and assembly is finished just in one operation, at the same time the rules and knowl edge of the connection elements are encapsulated through virtual part. According to this mechanism, a knowledge-based connecting elements rapid design module i s developed on commerce software package UG with satisfying results. 展开更多
关键词 CAD knowledge-based engineering ASSEMBLY conn ecting element
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Optimizing the atom types of proteins through iterative knowledge-based potentials
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作者 汪心享 黄胜友 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第2期43-50,共8页
Knowledge-based scoring functions have been widely used for protein structure prediction, protein-small molecule, and protein-nucleic acid interactions, in which one critical step is to find an appropriate representat... Knowledge-based scoring functions have been widely used for protein structure prediction, protein-small molecule, and protein-nucleic acid interactions, in which one critical step is to find an appropriate representation of protein structures. A key issue is to determine the minimal protein representations, which is important not only for developing of scoring func- tions but also for understanding the physics of protein folding. Despite significant progresses in simplifying residues into alphabets, few studies have been done to address the optimal number of atom types for proteins. Here, we have investigated the atom typing issue by classifying the 167 heavy atoms of proteins through 11 schemes with 1 to 20 atom types based on their physicochemical and functional environments. For each atom typing scheme, a statistical mechanics-based iterative method was used to extract atomic distance-dependent potentials from protein structures. The atomic distance-dependent pair potentials for different schemes were illustrated by several typical atom pairs with different physicochemical proper- ties. The derived potentials were also evaluated on a high-resolution test set of 148 diverse proteins for native structure recognition. It was found that there was a crossover around the scheme of four atom types in terms of the success rate as a function of the number of atom types, which means that four atom types may be used when investigating the basic folding mechanism of proteins. However, it was revealed by a close examination of typical potentials that 14 atom types were needed to describe the protein interactions at atomic level. The present study will be beneficial for the development of protein related scoring functions and the understanding of folding mechanisms. 展开更多
关键词 atom types knowledge-based potentials statistical mechanics ITERATION
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A knowledge-based decision support system for engineering design
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作者 JIANG Hua, GAO Guo-an (Advanced Manufacturing Technology Center, Harbin Institute of Technology, Harbin 150001, China) 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2000年第S1期41-44,共4页
A knowledge-based decision supporting system, used for engineering design is introduced by describing the architecture, function, workflow of the system and its way of implementation. Based upon information composed o... A knowledge-based decision supporting system, used for engineering design is introduced by describing the architecture, function, workflow of the system and its way of implementation. Based upon information composed of knowledge, models, data, cases, methods, etc, the system is designed to use such methods as knowledge-based reasoning, case-based reasoning, and multi-criteria evaluation techniques to provide effective tools to support the decision-making process. 展开更多
关键词 intelligent SUPPORTING SYSTEM knowledge-based REASONING multiple CRITERIA DECISION evaluation support SYSTEM
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A novel knowledge-based potential for RNA 3D structure evaluation
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作者 Yi Yang Qi Gu +2 位作者 Ben-Gong Zhang Ya-Zhou Shi Zhi-Gang Shao 《Chinese Physics B》 SCIE EI CAS CSCD 2018年第3期526-533,共8页
Ribonucleic acids(RNAs)play a vital role in biology,and knowledge of their three-dimensional(3D)structure is required to understand their biological functions.Recently structural prediction methods have been developed... Ribonucleic acids(RNAs)play a vital role in biology,and knowledge of their three-dimensional(3D)structure is required to understand their biological functions.Recently structural prediction methods have been developed to address this issue,but a series of RNA 3D structures are generally predicted by most existing methods.Therefore,the evaluation of the predicted structures is generally indispensable.Although several methods have been proposed to assess RNA 3D structures,the existing methods are not precise enough.In this work,a new all-atom knowledge-based potential is developed for more accurately evaluating RNA 3D structures.The potential not only includes local and nonlocal interactions but also fully considers the specificity of each RNA by introducing a retraining mechanism.Based on extensive test sets generated from independent methods,the proposed potential correctly distinguished the native state and ranked near-native conformations to effectively select the best.Furthermore,the proposed potential precisely captured RNA structural features such as base-stacking and base-pairing.Comparisons with existing potential methods show that the proposed potential is very reliable and accurate in RNA 3D structure evaluation. 展开更多
关键词 RNA 3D structure evaluation knowledge-based potential
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