The accumulated evidence indicates that head and neck cancers arise due to multiple genetic changes in both dominant oncogenes and tumor suppressor genes. In this report we examined whether the wild-type p53 gene was ...The accumulated evidence indicates that head and neck cancers arise due to multiple genetic changes in both dominant oncogenes and tumor suppressor genes. In this report we examined whether the wild-type p53 gene was able to suppress in vitro and in vivo cellular growth of laryngocarcinoma cell line and fibrosarcoma which carried multiple genetic abnormalities. Introduction of retroviral mediated wild-type p53 complementary DNA into laryngocarcinoma cell line (Hep2) and fibrosarcoma cell line (MDAH 041) carrying either a homozygous deletion or a missense in the p53 gene greatly suppressed tumor cell growth and the malignant phenotype of the cancer cells was reversed.展开更多
Two hundred and sixty-seven cases of female laryngocarcinoma, treated in our hospital in the past 33 years, were analysed. It is suggested that a relating preponderance of male sex hormonal influence after menopause s...Two hundred and sixty-seven cases of female laryngocarcinoma, treated in our hospital in the past 33 years, were analysed. It is suggested that a relating preponderance of male sex hormonal influence after menopause should be a contributing factor responsible for the high prevalemce of laryngeal cancer in women. The other etiological factor was cigarette smoking. The pathological types and patterns of metastasis to cervical lymphnodes in the female laryngocarcinoma were similar to those observed in male patients but the superglottic cancer was more common than the flottic type. However, no significant difference in prognosis was observed between superglottic and glottic cancers. Provided indications are strictly adhered to, partial laryngectomy that can give therapeutic resulrs similar or even superior to total laryngocarcinoma.展开更多
Objective： To observe the effect of general anaesthesia with combination of acupuncture [ conducted with Han＇s acupoint nerve stimulator （HANS） applied] and enflurane in radical operation of laryngocarcinoma （LC...Objective： To observe the effect of general anaesthesia with combination of acupuncture [ conducted with Han＇s acupoint nerve stimulator （HANS） applied] and enflurane in radical operation of laryngocarcinoma （LC）. Methods： Sixty patients with LC of grade Ⅰ -Ⅱ, classified according to the standard of American Society of Anesthesiologists （ASA）, were assigned by randomizing number table to the control group and the tested group, 30 patients in each group. The control group received anaesthesia with enflurane alone for inducing and maintaining; the tested group was anaesthetized with enflurane like that given to the control group but also received additionally needling stimulation conducted by HANS. The dosage of enflurane used, the minimum effective concentration of enflurane in alveolar air （MACEnf） and the changes of heart rate （HR） as well as blood pressure （BP） in patients at different time points in the operational process were observed. Results： As compared with those in the control group, in the tested group, both the MACEnf and the dosage of enflurane were reduced, with the difference between the two groups significant （ P〈0.01 ）. The changes of HR and BP among different time points in the tested group were slight, and as compared with those in the control group at the corresponding time points, the difference was significant （ P〈 0. 05 or P〈0.01）. Conclusion： General anaesthesia with combination of enflurane and needling conducted by HANS applied in radical operation of LC has definite effect with less complication. Needling could be cooperated with narcotics, and so it could be taken as an auxiliary measure of anaesthesia for radical operation of LC.展开更多
目的探讨由美国国家医学中心和贝克曼研究所研制的癌症患者照顾者生活质量量表(Quality of LifeFamily Version,QOLScale-FAMILY)用于中国喉癌患者照顾者生活质量测量的可能性,为喉癌患者照顾者生活质量的评定提供一个量化工具。方法通...目的探讨由美国国家医学中心和贝克曼研究所研制的癌症患者照顾者生活质量量表(Quality of LifeFamily Version,QOLScale-FAMILY)用于中国喉癌患者照顾者生活质量测量的可能性,为喉癌患者照顾者生活质量的评定提供一个量化工具。方法通过对QOLScale-FAMILY量表的翻译、回译、文化调试制定出中文版的QOL Scale-FAMILY量表,并采用信访、电话访谈、面对面问卷访谈的方法,对100例喉癌患者照顾者(主要是患者配偶和子女)的生活质量进行测定,考核QOL Scale-FAMILY的可行性以及信度与效度。结果中文版的QOL Scale-FAMILY具有良好的内部一致性,总量表的Cronbach′sα系数为0.794,除了精神健康维度α=0.649外,其他3个维度满足群组比较的要求;重测信度γ=0.841。因子分析产生的4个公共因子与理论结构基本一致,结构效度的累积方差贡献率为60.2%。结论QOLScale-FAMILY中文版具有较好的信度和效度,对部分条目进行调整后,可以应用于喉癌患者照顾者生活质量的测定。展开更多
基金Supported by the High Technology Research and Development Programme of China.
文摘The accumulated evidence indicates that head and neck cancers arise due to multiple genetic changes in both dominant oncogenes and tumor suppressor genes. In this report we examined whether the wild-type p53 gene was able to suppress in vitro and in vivo cellular growth of laryngocarcinoma cell line and fibrosarcoma which carried multiple genetic abnormalities. Introduction of retroviral mediated wild-type p53 complementary DNA into laryngocarcinoma cell line (Hep2) and fibrosarcoma cell line (MDAH 041) carrying either a homozygous deletion or a missense in the p53 gene greatly suppressed tumor cell growth and the malignant phenotype of the cancer cells was reversed.
文摘Two hundred and sixty-seven cases of female laryngocarcinoma, treated in our hospital in the past 33 years, were analysed. It is suggested that a relating preponderance of male sex hormonal influence after menopause should be a contributing factor responsible for the high prevalemce of laryngeal cancer in women. The other etiological factor was cigarette smoking. The pathological types and patterns of metastasis to cervical lymphnodes in the female laryngocarcinoma were similar to those observed in male patients but the superglottic cancer was more common than the flottic type. However, no significant difference in prognosis was observed between superglottic and glottic cancers. Provided indications are strictly adhered to, partial laryngectomy that can give therapeutic resulrs similar or even superior to total laryngocarcinoma.
文摘Objective： To observe the effect of general anaesthesia with combination of acupuncture [ conducted with Han＇s acupoint nerve stimulator （HANS） applied] and enflurane in radical operation of laryngocarcinoma （LC）. Methods： Sixty patients with LC of grade Ⅰ -Ⅱ, classified according to the standard of American Society of Anesthesiologists （ASA）, were assigned by randomizing number table to the control group and the tested group, 30 patients in each group. The control group received anaesthesia with enflurane alone for inducing and maintaining; the tested group was anaesthetized with enflurane like that given to the control group but also received additionally needling stimulation conducted by HANS. The dosage of enflurane used, the minimum effective concentration of enflurane in alveolar air （MACEnf） and the changes of heart rate （HR） as well as blood pressure （BP） in patients at different time points in the operational process were observed. Results： As compared with those in the control group, in the tested group, both the MACEnf and the dosage of enflurane were reduced, with the difference between the two groups significant （ P〈0.01 ）. The changes of HR and BP among different time points in the tested group were slight, and as compared with those in the control group at the corresponding time points, the difference was significant （ P〈 0. 05 or P〈0.01）. Conclusion： General anaesthesia with combination of enflurane and needling conducted by HANS applied in radical operation of LC has definite effect with less complication. Needling could be cooperated with narcotics, and so it could be taken as an auxiliary measure of anaesthesia for radical operation of LC.
