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Carrimycin in the treatment of acute promyelocytic leukemia combined with pulmonary tuberculosis: A case report
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作者 Fu-Yu Yang Lei Shao +1 位作者 Jie Su Zhen-Meng Zhang 《World Journal of Clinical Cases》 SCIE 2024年第3期623-629,共7页
BACKGROUND Pulmonary tuberculosis(PTB)is prevalent in immunocompromised populations,including patients with hematologic malignancies,human immunodeficiency virus infections,and chronic diseases.Effective treatment for... BACKGROUND Pulmonary tuberculosis(PTB)is prevalent in immunocompromised populations,including patients with hematologic malignancies,human immunodeficiency virus infections,and chronic diseases.Effective treatment for acute promyelocytic leukemia(APL)combined with PTB is lacking.These patients show an extremely poor prognosis.Therefore,studies should establish efficient treatment options to improve patient survival and prognosis.CASE SUMMARY A 60-year-old male with pain in the right side of his chest and a fever for 4 d visited the outpatient department of our hospital.Peripheral blood smear revealed 54%blasts.Following bone marrow examinations,variant APL with TNRC18-RARA fusion gene was diagnosed.Chest computed tomography scan showed bilateral pneumonitis with bilateral pleural effusions,partial atelectasis in the lower lobes of both lungs,and the bronchoalveolar lavage fluid gene X-Pert test was positive,indicative of PTB.Carrimycin,ethambutol(EMB),and isoniazid(INH)were administered since he could not receive chemotherapy as the WBC count decreased continuously.After one week of treatment with carrimycin,the patient recovered from fever and received chemotherapy.Chemotherapy was very effective and his white blood cells counts got back to normal.After being given five months with rifampin,EMB and INH and chemotherapy,the patient showed complete remission from pneumonia and APL.CONCLUSION We report a case of PTB treated successfully with carrimycin with APL that requires chemotherapy. 展开更多
关键词 Carrimycin Hematologic disease Acute myeloid leukemia Acute promyelocytic leukemia Pulmonary tuberculosis Case report
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A New Method for Diagnosis of Leukemia Utilizing a Hybrid DL-ML Approach for Binary and Multi-Class Classification on a Limited-Sized Database
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作者 Nilkanth Mukund Deshpande Shilpa Gite +2 位作者 Biswajeet Pradhan Abdullah Alamri Chang-Wook Lee 《Computer Modeling in Engineering & Sciences》 SCIE EI 2024年第4期593-631,共39页
Infection of leukemia in humans causes many complications in its later stages.It impairs bone marrow’s ability to produce blood.Morphological diagnosis of human blood cells is a well-known and well-proven technique f... Infection of leukemia in humans causes many complications in its later stages.It impairs bone marrow’s ability to produce blood.Morphological diagnosis of human blood cells is a well-known and well-proven technique for diagnosis in this case.The binary classification is employed to distinguish between normal and leukemiainfected cells.In addition,various subtypes of leukemia require different treatments.These sub-classes must also be detected to obtain an accurate diagnosis of the type of leukemia.This entails using multi-class classification to determine the leukemia subtype.This is usually done using a microscopic examination of these blood cells.Due to the requirement of a trained pathologist,the decision process is critical,which leads to the development of an automated software framework for diagnosis.Researchers utilized state-of-the-art machine learning approaches,such as Support Vector Machine(SVM),Random Forest(RF),Na飗e Bayes,K-Nearest Neighbor(KNN),and others,to provide limited accuracies of classification.More advanced deep-learning methods are also utilized.Due to constrained dataset sizes,these approaches result in over-fitting,reducing their outstanding performances.This study introduces a deep learning-machine learning combined approach for leukemia diagnosis.It uses deep transfer learning frameworks to extract and classify features using state-of-the-artmachine learning classifiers.The transfer learning frameworks such as VGGNet,Xception,InceptionResV2,Densenet,and ResNet are employed as feature extractors.The extracted features are given to RF and XGBoost classifiers for the binary and multi-class classification of leukemia cells.For the experimentation,a very popular ALL-IDB dataset is used,approaching a maximum accuracy of 100%.A private real images dataset with three subclasses of leukemia images,including Acute Myloid Leukemia(AML),Chronic Lymphocytic Leukemia(CLL),and Chronic Myloid Leukemia(CML),is also employed to generalize the system.This dataset achieves an impressive multi-class classification accuracy of 97.08%.The proposed approach is robust and generalized by a standardized dataset and the real image dataset with a limited sample size(520 images).Hence,this method can be explored further for leukemia diagnosis having a limited number of dataset samples. 展开更多
关键词 leukemia diagnosis deep learning machine learning random forest XGBoost
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Bone marrow microRNA-34a is a good indicator for response to treatment in acute myeloid leukemia
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作者 MONA SA BDELLATEIF NAGLAA MHASSAN +1 位作者 MAHMOUD MKAMEL YOMNA MEL-MELIGUI 《Oncology Research》 SCIE 2024年第3期577-584,共8页
Background:microRNA 34a(miR 34a)had been reported to have a diagnostic role in acute myeloid leukemia(AML).However,its value in the bone marrow(BM)of AML patients,in addition to its role in response to therapy is stil... Background:microRNA 34a(miR 34a)had been reported to have a diagnostic role in acute myeloid leukemia(AML).However,its value in the bone marrow(BM)of AML patients,in addition to its role in response to therapy is still unclear.The current study was designed to assess the diagnostic,prognostic,and predictive significance of miR 34a in the BM of AML patients.Methods:The miR.34a was assed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using qRT-PCR.The data were assessed for correlation with the relevant dinical critenia,response to therapy,disease-free survival(DFS),and overall survival(OS)rates.Results:miR.34a was significantly downregulated in AML patients[0.005(3.3×10^(-6)-1.32)],compared to the control subjects[0.108(3.2× 10^(-4)-1.64),p=0.021].The.median relative quantification(RQ)of miR-34a was 0.106(range;0-32.12).The specifaity,sensitivity,and area under the curve(AUC)for the diagnosis of AML were(58.3%,69.5%,0.707,respectively,p=0.021).patients with upregulated miR-34a showed decreased platelets count<34.5 × 10^(9)/L,and achieved early complete remission(CR,p=0.031,p=0.044,respectively).Similarly,patients who were refractory to therapy showed decreased miR 34a levels in comparison to those who achieved CR[0.002(0-0.01)and 0.12(0-32.12),respectively,p=0.002].Therefore,miR 34a could significantly identify patients with CR with a specificity of 75%and sensitivity of 100%at a cut-off of 0.014(AUC=0.927,p=0.005).There was no considerable association between miR-34a expression and survival rates of the induded AML patients.Condusion:miR-34a could be a beneficial diagnostic biomarker for AML patients.In addition,it serves as a good indicator for response to therapy,which could possibly identify patients who are refractory to treatment with 100%sensitivity and 75%specificity. 展开更多
关键词 AML miR 34a MICRORNA leukemia
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Adult rhabdomyosarcoma combined with acute myeloid leukemia: A case report
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作者 Lu Zheng Fen-Juan Zhang 《World Journal of Clinical Cases》 SCIE 2024年第3期582-586,共5页
BACKGROUND Rhabdomyosarcoma is a tumor of mesenchymal origin.Secondary leukemia is a complication of previous transformation to other hematologic disorders or is a treatment-related acute myeloid leukemia secondary to... BACKGROUND Rhabdomyosarcoma is a tumor of mesenchymal origin.Secondary leukemia is a complication of previous transformation to other hematologic disorders or is a treatment-related acute myeloid leukemia secondary to cytotoxic chemotherapy or radiation therapy for other malignancies.CASE SUMMARY We present the case of a 36-year-old female patient who was diagnosed with rhabdomyosarcoma and acute myeloid leukemia.Further disease progression was observed after multiline chemotherapy.Eventually,the patient suffered cerebral hemorrhage,which resulted in death.CONCLUSION The incidence of rhabdomyosarcoma in adults is extremely low,and secondary leukemia caused by rhabdomyosarcoma is even rarer.Secondary leukemia has a very poor prognosis and a low overall survival rate. 展开更多
关键词 RHABDOMYOSARCOMA Secondary acute myeloid leukocytes CHEMOTHERAPEUTICS Secondary leukemia Case report
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Suspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia:A case report
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作者 Ke-Qiang Yu Hui-Xiang Li Jing Wu 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第4期1176-1183,共8页
BACKGROUND Chronic myelomonocytic leukemia(CMML)complicated with Sweet syndrome(SS)is a rare hematological neoplasm.However,cases of concomitant development of perianal necrotizing SS(NSS)have not been reported.CASE S... BACKGROUND Chronic myelomonocytic leukemia(CMML)complicated with Sweet syndrome(SS)is a rare hematological neoplasm.However,cases of concomitant development of perianal necrotizing SS(NSS)have not been reported.CASE SUMMARY We report a case of a 49-year-old male patient who underwent sequential procedures for hemorrhoids and perianal abscess.He developed postoperative incision infection and was referred to the department where the authors work.Initially,perianal necrotizing fasciitis secondary to incision infection after perianal abscess surgery was suspected.Despite receiving antibiotic therapy and undergoing surgical debridement,deeper necrotic areas formed in the patient’s perianal wounds,accompanied by persistent high fever.Blood and fungal cultures yielded negative results.The final diagnosis was corrected to be CMML with suspected concomitant perianal NSS.CONCLUSION CMML with perianal NSS is a rare condition,often misdiagnosed as perianal abscess or perianal necrotizing fasciitis.Conventional antibiotic therapy and surgical debridement are ineffective in managing this condition. 展开更多
关键词 Chronic myelomonocytic leukemia Sweet syndrome Necrotizing fasciitis Perianal abscess Case report
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Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction
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作者 Cheng-Jin Ai Ling-Juan Chen +2 位作者 Li-Xuan Guo Ya-Ping Wang Zi-Yi Zhao 《World Journal of Stem Cells》 SCIE 2024年第4期444-458,共15页
BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against... BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against conventional therapies.Gossypol acetic acid(GAA),which is extracted from the seeds of cotton plants,exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting Bcl2.AIM To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact mechanism.METHODS In this study,LSCs were magnetically sorted from AML cell lines and the CD34+CD38-population was obtained.The expression of leucine-rich pentatricopeptide repeat-containing protein(LRPPRC)and forkhead box M1(FOXM1)was evaluated in LSCs,and the effects of GAA on malignancies and mitochondrial RESULTS LRPPRC was found to be upregulated,and GAA inhibited cell proliferation by degrading LRPPRC.GAA induced LRPPRC degradation and inhibited the activation of interleukin 6(IL-6)/janus kinase(JAK)1/signal transducer and activator of transcription(STAT)3 signaling,enhancing chemosensitivity in LSCs against conventional chemotherapies,including L-Asparaginase,Dexamethasone,and cytarabine.GAA was also found to downregulate FOXM1 indirectly by regulating LRPPRC.Furthermore,GAA induced reactive oxygen species accumulation,disturbed mitochondrial homeostasis,and caused mitochondrial dysfunction.By inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC,GAA resulted in the elimination of LSCs.Meanwhile,GAA induced oxidative stress and subsequent cell damage by causing mitochondrial damage.CONCLUSION Taken together,the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML. 展开更多
关键词 leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling
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Damage Mechanism of CK2 and IKAROS in Philadelphia Like Acute Lymphoblastic Leukemia
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作者 Ignacio Vélez-Rodríguez Victoria Carranza-Aranda 《Journal of Biosciences and Medicines》 2024年第4期49-59,共11页
Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated B lymphocytes in large numbers in the blood. B cells are distinct from the cell types involved in their development (common lym... Acute lymphoblastic leukemia (ALL) is characterized by immature and poorly differentiated B lymphocytes in large numbers in the blood. B cells are distinct from the cell types involved in their development (common lymphoid progenitor cells, pro-B cells, pre-B cells, and mature cells). The process of B cell maturation depends on precise communication within the cell: signals activate specific genes that are essential for proper development. Errors in this intricate signaling network can lead to issues with B cell function and contribute to disease. B-lineage acute lymphoid leukemias, malignancies of precursor-stage B lymphoid cells inhibit lymphoid differentiation, leading to abnormal cell proliferation and survival. The process of developing leukemia (leukemogenesis) can be triggered by an overproduction of both hematopoietic stem cells (the cells that form all blood cells) and the immature versions of white blood cells called lymphoblasts. Acute lymphoblastic leukemia (ALL) with the presence of the Philadelphia chromosome (ALL Ph) is classified as a high-risk manifestation of the disease, this chromosome is the product of the reciprocal translocation, whose product is a BCR-ABL fusion protein. It is a highly active tyrosine kinase that can transform hematopoietic cells into cytokine-independent. Hyperphosphorylation cascades inhibit the differentiating function of IKZF1 as a tumor suppressor gene which leads to an abnormal proliferation of B cells due to the presence of the Philadelphia chromosome;it inhibits the differentiating process, leukemogenesis involving immature B cells in the bloodstream can result from the uncontrolled growth and division of hematopoietic stem cells and immature lymphoblasts (the precursors to B cells). 展开更多
关键词 Acute Lymphoblastic leukemia IKAROS DEPHOSPHORYLATION Philadelphia Chromosome CK2
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Incidence and Survivability of Acute Lymphocytic Leukemia Patients in the United States: Analysis of SEER Data Set from 2000-2019
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作者 Ishan Ghosh Sudipto Mukherjee 《Journal of Cancer Therapy》 2024年第4期141-163,共23页
The main goal of this research is to assess the impact of race, age at diagnosis, sex, and phenotype on the incidence and survivability of acute lymphocytic leukemia (ALL) among patients in the United States. By takin... The main goal of this research is to assess the impact of race, age at diagnosis, sex, and phenotype on the incidence and survivability of acute lymphocytic leukemia (ALL) among patients in the United States. By taking these factors into account, the study aims to explore how existing cancer registry data can aid in the early detection and effective treatment of ALL in patients. Our hypothesis was that statistically significant correlations exist between race, age at which patients were diagnosed, sex, and phenotype of the ALL patients, and their rate of incidence and survivability data were evaluated using SEER*Stat statistical software from National Cancer Institute. Analysis of the incidence data revealed that a higher prevalence of ALL was among the Caucasian population. The majority of ALL cases (59%) occurred in patients aged between 0 to 19 years at the time of diagnosis, and 56% of the affected individuals were male. The B-cell phenotype was predominantly associated with ALL cases (73%). When analyzing survivability data, it was observed that the 5-year survival rates slightly exceeded the 10-year survival rates for the respective demographics. Survivability rates of African Americans patients were the lowest compared to Caucasian, Asian, Pacific Islanders, Alaskan Native, Native Americans and others. Survivability rates progressively decreased for older patients. Moreover, this study investigated the typical treatment methods applied to ALL patients, mainly comprising chemotherapy, with occasional supplementation of radiation therapy as required. The study demonstrated the considerable efficacy of chemotherapy in enhancing patients’ chances of survival, while those who remained untreated faced a less favorable prognosis from the disease. Although a significant amount of data and information exists, this study can help doctors in the future by diagnosing patients with certain characteristics. It will further assist the health care professionals in screening potential patients and early detection of cases. This could also save the lives of elderly patients who have a higher mortality rate from this disease. 展开更多
关键词 Acute Lymphocytic leukemia SURVIVABILITY INCIDENCE DEMOGRAPHY SEER Data Set
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Congenital leukemia: A case report and review of literature
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作者 Chun-Xia Yang Ying Yang +5 位作者 Fen-Li Zhang Ding-Huan Wang Qiu-Han Bian Man Zhou Ming-Xiang Zhou Xiao-Yan Yang 《World Journal of Clinical Cases》 SCIE 2023年第29期7227-7233,共7页
BACKGROUND Acute leukemia in newborns is also known as neonatal or congenital leukemia(CL)and is a rare disease with an incidence rate of 1-5 per 1000000 live births.After birth,infants with CL exhibit infiltrative cu... BACKGROUND Acute leukemia in newborns is also known as neonatal or congenital leukemia(CL)and is a rare disease with an incidence rate of 1-5 per 1000000 live births.After birth,infants with CL exhibit infiltrative cutaneous nodules,hepatosplenomegaly,thrombocytopenia,and immature leukocytes in the peripheral blood.These symptoms are frequently accompanied by congenital abnormalities including trisomy 21,trisomy 9,trisomy 13,or Turner syndrome.Despite significant advances in disease management,the survival rate is approximately 25%at 2 years.CASE SUMMARY Here,we document a case of trisomy 21-related acute myeloid leukemia(AML)in a female neonate.The baby was sent to the neonatal intensive care unit because of anorexia,poor responsiveness,and respiratory distress.She was diagnosed with AML based on bone marrow aspiration and immunophenotyping.Genetic sequencing identified a mutation in the GATA1 gene.After receiving the diagnosis,the parents decided against medical care for their child,and the baby died at home on day 9 after birth.CONCLUSIONS The newborn infant was diagnosed with trisomy 21-related AML.Genetic sequencing identified a mutation in the GATA1 gene.The parents abandoned medical treatment for their infant after receiving the diagnosis,and the infant died at home on the 9th day after birth. 展开更多
关键词 Congenital leukemia Trisomy 21 GATA1 Acute myeloid leukemia Literature review Case report
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Focal lymphoblastic transformation of chronic myelogenous leukemia develops into erythroid leukemia:A case report
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作者 Wei Wang Ya-Ling Chen +3 位作者 Pan-Pan Gou Pei-Lin Wu Kun-Sheng Shan Dong-Liang Zhang 《World Journal of Clinical Cases》 SCIE 2023年第24期5780-5788,共9页
BACKGROUND We present a case of focal lymphoblastic transformation to erythroid leukemia following acute myeloblastic transformation in a patient with chronic myelogenous leukemia(CML)and discuss its mechanism of occu... BACKGROUND We present a case of focal lymphoblastic transformation to erythroid leukemia following acute myeloblastic transformation in a patient with chronic myelogenous leukemia(CML)and discuss its mechanism of occurrence and development.CASE SUMMARY The presence of the Philadelphia(Ph)chromosome was identified through karyotype analysis,while the BCR-ABL fusion gene was detected using quantitative real-time polymerase chain reaction of the peripheral blood sample.Fluorescence in situ hybridization was used to detect the expression of the BCRABL gene in the lymphoma.Antigen expression and gene mutations in the primitive cells were detected by flow cytometry.The analysis confirmed the presence of CML along with focal lymphoblastic transformation to erythroid leukemia.Additionally,the patient was found to have secondary erythroid leukemia,along with multiple new gene mutations and abnormalities in complex karyotypes of chromosomes.CONCLUSION Our findings suggest a possible molecular basis for the focal lymphoblastic transformation secondary to myeloblastic transformation in patients with CML. 展开更多
关键词 Chronic myelogenous leukemia Blast crisis Focal lymphoblastic transformation Pure erythroid leukemia Case report
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Myeloid sarcoma as the only manifestation in a rare mixed lineage leukemia-fusion-driven acute myeloid leukemia:A case report
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作者 Sheng-Jie Tang Qi-Guo Zhang 《World Journal of Clinical Cases》 SCIE 2023年第25期6000-6004,共5页
BACKGROUND The mixed lineage leukemia(MLL)-eleven-nineteen lysine-rich leukemia(ELL)fusion gene is a rare occurrence among the various MLL fusion genes.We present the first case in which myeloid sarcoma(MS)was the onl... BACKGROUND The mixed lineage leukemia(MLL)-eleven-nineteen lysine-rich leukemia(ELL)fusion gene is a rare occurrence among the various MLL fusion genes.We present the first case in which myeloid sarcoma(MS)was the only manifestation of adult MLL-ELL-positive acute myeloid leukemia(AML).CASE SUMMARY We report a case of a 33-year-old male patient who was admitted in June 2022 with a right occipital area mass measuring approximately 7 cm×8 cm.Blood work was normal.The patient underwent right occipital giant subscalp mass excision and incisional flap grafting.Immunohistochemistry was positive for myeloperoxidase,CD43 and CD45 and negative for CD3,CD20,CD34,and CD56.The bone marrow aspirate showed hypercellularity with 20%myeloblasts.Flow cytometry showed that myeloblasts accounted for 27.21%of the nucleated cells,which expressed CD33,CD38,and CD117.The karyotype was 46,XY,t(11,19)(q23;p13.1),-12,+mar/46,XY.Next-generation sequencing showed a fusion of MLL exon 7 to exon 2 of ELL.A diagnosis of MLL-ELL-positive AML(M2 subtype)with subcutaneous MS was made.CONCLUSION MLL-ELL-positive AML with MS is a rare clinical entity.Additional research is needed to elucidate the molecular mechanisms of the pathogenesis of MS. 展开更多
关键词 Myeloid sarcoma Acute myeloid leukemia Mixed lineage leukemia-elevennineteen lysine-rich leukemia TRANSPLANTATION Case report
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Allogeneic stem cell transplantation in the treatment of acute myeloid leukemia: An overview of obstacles and opportunities 被引量:1
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作者 Yong-Feng Chen Jing Li +2 位作者 Ling-Long Xu Mihnea-Alexandru Găman Zhen-You Zou 《World Journal of Clinical Cases》 SCIE 2023年第2期268-291,共24页
As an important treatment for acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation(allo-HSCT) plays an important role in reducing relapse and improving long-term survival. With rapid advancements... As an important treatment for acute myeloid leukemia, allogeneic hematopoietic stem cell transplantation(allo-HSCT) plays an important role in reducing relapse and improving long-term survival. With rapid advancements in basic research in molecular biology and immunology and with deepening understanding of the biological characteristics of hematopoietic stem cells, allo-HSCT has been widely applied in clinical practice. During allo-HSCT, preconditioning, the donor, and the source of stem cells can be tailored to the patient’s conditions, greatly broadening the indications for HSCT, with clear survival benefits. However, the risks associated with allo-HSCT remain high, i.e. hematopoietic reconstitution failure, delayed immune reconstitution, graft-versus-host disease, and posttransplant relapse, which are bottlenecks for further improvements in allo-HSCT efficacy and have become hot topics in the field of HSCT. Other bottlenecks recognized in the current treatment of individuals diagnosed with acute myeloid leukemia and subjected to allo-HSCT include the selection of the most appropriate conditioning regimen and post-transplantation management. In this paper, we reviewed the progress of relevant research regarding these aspects. 展开更多
关键词 Hematopoietic stem cell TRANSPLANTATION Allogeneic hematopoietic stem cell transplantation leukemia TREATMENT
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CD71-mediated liposomal arsenic-nickel complex combined with all-trans retinoic acid for the efficacy of acute promyelocytic leukemia
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作者 Xiao Liu Lili Zhang +7 位作者 Yueying Yang Weiwei Yin Yunhu Liu Chunyi Luo Ruizhe Zhang Zhiguo Long Yanyan Jiang Bing Wang 《Asian Journal of Pharmaceutical Sciences》 SCIE CAS 2023年第4期80-95,共16页
Clinically,arsenic trioxide(ATO)was applied to the treatment of acute promyelocytic leukemia(APL)as a reliable and effective frontline drug.However,the administration regimen of AsⅢwas limited due to its fast clearan... Clinically,arsenic trioxide(ATO)was applied to the treatment of acute promyelocytic leukemia(APL)as a reliable and effective frontline drug.However,the administration regimen of AsⅢwas limited due to its fast clearance,short therapeutic window and toxicity as well.Based on CD71 overexpressed on APL cells,in present study,a transferrin(Tf)-modified liposome(LP)was established firstly to encapsulate AsⅢin arsenic-nickel complex by nickel acetate gradient method.The AsⅢ-loaded liposomes(AsLP)exhibited the feature of acid-sensitive release in vitro.Tf-modified AsLP(Tf-AsLP)were specifically taken up by APL cells and the acidic intracellular environment triggered liposome to release AsⅢwhich stimulated reactive oxygen species level and caspase-3 activity.Tf-AsLP prolonged half-life of AsⅢin blood circulation,lowered systemic toxicity,and promoted apoptosis and induced cell differentiation at lesion site in vivo.Considering that ATO combined with RA is usually applied as the first choice in clinic for APL treatment to improve the therapeutic effect,accordingly,a Tf-modified RA liposome(Tf-RALP)was designed to reduce the severe side effects of free RA and assist Tf-AsLP for better efficacy.As expected,the tumor inhibition rate of Tf-AsLP was improved significantly with the combination of Tf-RALP on subcutaneous tumor model.Furthermore,APL orthotopic NOD/SCID mice model was established by 60CO irradiation and HL-60 cells intravenously injection.The effect of co-administration(Tf-AsLP+Tf-RALP)was also confirmed to conspicuous decrease the number of leukemia cells in the circulatory system and prolong the survival time of APL mice by promoting the APL cells’apoptosis and differentiation in peripheral blood and bone marrow.Collectively,Tf-modified acid-sensitive AsLP could greatly reduce the systemic toxicity of free drug.Moreover,Tf-AsLP combined with Tf-RALP could achieve better efficacy.Thus,transferrinmodified AsⅢliposome would be a novel clinical strategy to improve patient compliance,with promising translation prospects. 展开更多
关键词 TRANSFERRIN Arsenic trioxide Acute promyelocytic leukemia All-trans retinoic acid LIPOSOME
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A model based on eight iron metabolism-related genes accurately predicts acute myeloid leukemia prognosis
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作者 ZHANSHU LIU XI HUANG 《BIOCELL》 SCIE 2023年第3期593-605,共13页
Purpose:Iron metabolism maintains the balance between iron absorption and excretion.Abnormal iron metabolism can cause numerous diseases,including tumor.This study determined the iron metabolism-related genes(IMRGs)si... Purpose:Iron metabolism maintains the balance between iron absorption and excretion.Abnormal iron metabolism can cause numerous diseases,including tumor.This study determined the iron metabolism-related genes(IMRGs)signature that can predict the prognosis of acute myeloid leukemia(AML).The roles of these genes in the immune microenvironment were also explored.Methods:A total of 514 IMRGs were downloaded from the Molecular Characteristics Database(MSigDB).IMRGs related to AML prognosis were identified using Cox regression and LASSO analyses and were used to construct the risk score model.AML patients were stratified into high-risk groups(cluster 1)and low-risk groups(cluster 2)based on the mean value of the risk score.The accuracy and prognosis prediction potential of the risk-score model was evaluated using Kaplan-Meier and receiver operating characteristics analysis.The stromal score,immune scores,and immune cells infiltrated in AML samples were estimated using CIBERSORT,MCPcountre,and Xcell algorithms.The role of immune checkpoint genes in the AML microenvironment and the prognostic value of the IMRGs were also evaluated.Results:An AML prognosis prediction model was established based on the eight most critical IMRGs.Further analyses revealed that the model could accurately predict AML prognosis.The expression of IMRGs correlated with the infiltration of several immune cells and could influence response to certain chemotherapy drugs and immunotherapy.Conclusion:A model based on IMRGs can accurately predict the overall survival and disease-free survival of AML patients. 展开更多
关键词 Acute myeloid leukemia IMRGs Prognostic signature Infiltrating immune cells BIOINFORMATICS
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Latent Space Representational Learning of Deep Features for Acute Lymphoblastic Leukemia Diagnosis
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作者 Ghada Emam Atteia 《Computer Systems Science & Engineering》 SCIE EI 2023年第4期361-376,共16页
Acute Lymphoblastic Leukemia(ALL)is a fatal malignancy that is featured by the abnormal increase of immature lymphocytes in blood or bone marrow.Early prognosis of ALL is indispensable for the effectual remediation of... Acute Lymphoblastic Leukemia(ALL)is a fatal malignancy that is featured by the abnormal increase of immature lymphocytes in blood or bone marrow.Early prognosis of ALL is indispensable for the effectual remediation of this disease.Initial screening of ALL is conducted through manual examination of stained blood smear microscopic images,a process which is time-consuming and prone to errors.Therefore,many deep learning-based computer-aided diagnosis(CAD)systems have been established to automatically diagnose ALL.This paper proposes a novel hybrid deep learning system for ALL diagnosis in blood smear images.The introduced system integrates the proficiency of autoencoder networks in feature representational learning in latent space with the superior feature extraction capability of standard pretrained convolutional neural networks(CNNs)to identify the existence of ALL in blood smears.An augmented set of deep image features are formed from the features extracted by GoogleNet and Inception-v3 CNNs from a hybrid dataset of microscopic blood smear images.A sparse autoencoder network is designed to create an abstract set of significant latent features from the enlarged image feature set.The latent features are used to perform image classification using Support Vector Machine(SVM)classifier.The obtained results show that the latent features improve the classification performance of the proposed ALL diagnosis system over the original image features.Moreover,the classification performance of the system with various sizes of the latent feature set is evaluated.The retrieved results reveal that the introduced ALL diagnosis system superiorly compete the state of the art. 展开更多
关键词 Autoencoder deep learning CNN leukemia DIAGNOSIS computeraided diagnosis
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Serum anti-leukemia inhibitory factor antibody and recurrent pregnancy loss in Iranian women
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作者 Seyed Mohammad Seifati Hossein Ansariniya +4 位作者 Fateme Rahmani Ali Akbar Saboor-Yaraghi Farzaneh Fesahat Hossein Hadinedoushan Fateme Zare 《Asian pacific Journal of Reproduction》 2023年第1期49-50,共2页
Recurrent pregnancy loss is defined by the World Health Orgnization as the loss of three or more consecutive pregnancies before the 20th week[1].According to studies,the prevalence of this disorder in Europe and Ameri... Recurrent pregnancy loss is defined by the World Health Orgnization as the loss of three or more consecutive pregnancies before the 20th week[1].According to studies,the prevalence of this disorder in Europe and America is between 1%and 4%for women of reproductive age.Various etiologies including uterine factors,thrombophilia,endocrine,physiological,genetic,and immunological factors are considered risk factors for recurrent pregnancy loss. 展开更多
关键词 PREGNANCY SERUM leukemia
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MayGAN:Mayfly Optimization with Generative Adversarial Network-Based Deep Learning Method to Classify Leukemia Form Blood Smear Images
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作者 Neenavath Veeraiah Youseef Alotaibi Ahmad F.Subahi 《Computer Systems Science & Engineering》 SCIE EI 2023年第8期2039-2058,共20页
Leukemia,often called blood cancer,is a disease that primarily affects white blood cells(WBCs),which harms a person’s tissues and plasma.This condition may be fatal when if it is not diagnosed and recognized at an ea... Leukemia,often called blood cancer,is a disease that primarily affects white blood cells(WBCs),which harms a person’s tissues and plasma.This condition may be fatal when if it is not diagnosed and recognized at an early stage.The physical technique and lab procedures for Leukaemia identification are considered time-consuming.It is crucial to use a quick and unexpected way to identify different forms of Leukaemia.Timely screening of the morphologies of immature cells is essential for reducing the severity of the disease and reducing the number of people who require treatment.Various deep-learning(DL)model-based segmentation and categorization techniques have already been introduced,although they still have certain drawbacks.In order to enhance feature extraction and classification in such a practical way,Mayfly optimization with Generative Adversarial Network(MayGAN)is introduced in this research.Furthermore,Generative Adversarial System(GAS)is integrated with Principal Component Analysis(PCA)in the feature-extracted model to classify the type of blood cancer in the data.The semantic technique and morphological procedures using geometric features are used to segment the cells that makeup Leukaemia.Acute lymphocytic Leukaemia(ALL),acute myelogenous Leukaemia(AML),chronic lymphocytic Leukaemia(CLL),chronic myelogenous Leukaemia(CML),and aberrant White Blood Cancers(WBCs)are all successfully classified by the proposed MayGAN model.The proposed MayGAN identifies the abnormal activity in the WBC,considering the geometric features.Compared with the state-of-the-art methods,the proposed MayGAN achieves 99.8%accuracy,98.5%precision,99.7%recall,97.4%F1-score,and 98.5%Dice similarity coefficient(DSC). 展开更多
关键词 leukemia blood smear images OPTIMIZATION classification neural networks
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Histogram-Based Decision Support System for Extraction and Classification of Leukemia in Blood Smear Images
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作者 Neenavath Veeraiah Youseef Alotaibi Ahmad FSubahi 《Computer Systems Science & Engineering》 SCIE EI 2023年第8期1879-1900,共22页
An abnormality that develops in white blood cells is called leukemia.The diagnosis of leukemia is made possible by microscopic investigation of the smear in the periphery.Prior training is necessary to complete the mo... An abnormality that develops in white blood cells is called leukemia.The diagnosis of leukemia is made possible by microscopic investigation of the smear in the periphery.Prior training is necessary to complete the morphological examination of the blood smear for leukemia diagnosis.This paper proposes a Histogram Threshold Segmentation Classifier(HTsC)for a decision support system.The proposed HTsC is evaluated based on the color and brightness variation in the dataset of blood smear images.Arithmetic operations are used to crop the nucleus based on automated approximation.White Blood Cell(WBC)segmentation is calculated using the active contour model to determine the contrast between image regions using the color transfer approach.Through entropy-adaptive mask generation,WBCs accurately detect the circularity region for identification of the nucleus.The proposed HTsC addressed the cytoplasm region based on variations in size and shape concerning addition and rotation operations.Variation in WBC imaging characteristics depends on the cytoplasmic and nuclear regions.The computation of the variation between image features in the cytoplasm and nuclei regions of the WBCs is used to classify blood smear images.The classification of the blood smear is performed with conventional machine-learning techniques integrated with the features of the deep-learning regression classifier.The designed HTsC classifier comprises the binary classifier with the classification of the lymphocytes,monocytes,neutrophils,eosinophils,and abnormalities in the WBCs.The proposed HTsC identifies the abnormal activity in the WBC,considering the color and shape features.It exhibits a higher classification accuracy value of 99.6%when combined with the other classifiers.The comparative analysis expressed that the proposed HTsC model exhibits an overall accuracy value of 98%,which is approximately 3%–12%higher than the conventional technique. 展开更多
关键词 White blood cells leukemia SEGMENTATION HISTOGRAM blood smear
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Expression and clinical significance of CANX in acute myeloid leukemia based on TCGA database
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作者 LI Bo-ya LI Tong +2 位作者 ZU Xiang-yang WANG Chong QIN Ling 《Journal of Hainan Medical University》 CAS 2023年第5期53-60,共8页
Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of... Objective:To explore relationships between CANX expression,prognosis and immune infiltration of acute myeloid leukemia(AML)patients.Methods:The TIMER database was used to compare the CANX expression among a variety of TCGA tumor and normal tissue samples.The difference of CANX expression between AML and normal samples was found by R software.The Kaplan-Meier method and Log-Rank test were used to assess the relationship between CANX expression and patient survival.The R software was used to find correlations between CANX expression,clinical characteristics,drug sensitivity,and immune infiltration in AML.Results:The differential expression of CANX in 13 tumor and normal tissue samples were statistically significant(P<0.05).The high CANX expression was associated with a favorable prognosis(P<0.05),which was validated in GSE37642.The expression of CANX was correlated with age,survival status,FAB stage,and karyotype(P<0.05).High CANX expression,low age and favorable karyotype were independent predictors of a favorable prognosis(P<0.05).CANX expression may affect the sensitivity of AML patients to multiple drugs(P<0.05).The expression of CANX was positively correlated with that of M1 macrophages and CD8 T cells.Conclusion:CANX may be used as a novel potential biomarker,and could benefit AML patients by predicting patient prognosis and providing precise treatment indications. 展开更多
关键词 CANX Acute myeloid leukemia PROGNOSIS Immune cell BIOMARKER
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Acute pancreatitis as initial presentation of acute myeloid leukemia-M2 subtype:A case report
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作者 Wen-Xin Yang Kang An +2 位作者 Gai-Fang Liu Heng-Yu Zhou Jun-Cha Gao 《World Journal of Clinical Cases》 SCIE 2023年第6期1385-1392,共8页
BACKGROUND Direct infiltration of the pancreas by acute myeloid leukemia(AML)with acute pancreatitis(AP)as an initial symptom is extremely rare.Only once in the literature,the leukemia cells in AML have been implicate... BACKGROUND Direct infiltration of the pancreas by acute myeloid leukemia(AML)with acute pancreatitis(AP)as an initial symptom is extremely rare.Only once in the literature,the leukemia cells in AML have been implicated as the cause of AP.Pancreatitis caused by a rare predisposing factor is often misdiagnosed as idiopathic pancreatitis or pancreatitis of other common causes.Severe AP(SAP)progresses rapidly with a high fatality rate.Therefore,it is important to identify the predisposing factors in the early stage of SAP,evaluate the condition,determine prognosis,formulate treatment plans,and prevent a recurrence.Here,we describe a case of SAP due to AML.CASE SUMMARY A 61-year-old man presented to the hospital with fever and persistent abdominal pain.Blood analysis presented significantly elevated serum amylase and severe thrombocytopenia.Computed tomography examination of the abdomen revealed peripancreatic inflammatory effusion.The patient had no common etiologies and risk factors for AP,but the concurrent severe thrombocytopenia could not be explained by pancreatitis.Finally,the bone marrow aspirate and biopsy inspection revealed the underlying reason for pancreatitis,AML(M2 type based on the French-American-British classifications system).CONCLUSION Direct infiltration of the pancrease by acute leukemia,particularly AML cells,is an infrequent cause of AP.Therefore,although AP is a rare extramedullary infilt-ration characteristic for AML patients,it should be considered when determining the etiology of AP. 展开更多
关键词 Acute pancreatitis Acute myeloid leukemia Abdominal pain Extramedullary infiltration ETIOLOGY Case report
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