In recent years, the antibacterial and anti-inflammatory effects of the Labiatae plants have been widely recognized, and have been used in clinical practice, and their anti-tumor effects are also very significant, and...In recent years, the antibacterial and anti-inflammatory effects of the Labiatae plants have been widely recognized, and have been used in clinical practice, and their anti-tumor effects are also very significant, and receiving more and more attention. At present, malignant tumors are still the first killer threatening human health. Because of the long-term use of chemical anti-tumor drugs with certain drug resistance and obvious side effects, finding high-efficiency anti-tumor active ingredients from natural plants and Chinese herbal medicines has become a hot spot in the field of pharmacy. Literature survey indicates that the active ingredients in Labiatae plants have anti-tumor effects. Therefore, this paper summarized and discussed the anti-tumor types, mechanisms and active components of the Labiatae plants, so as to provide a basis and reference for the development of new anti-tumor drugs or preparations.展开更多
Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v...Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v)methanol.The methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay.Results:All the extracts showed moderate to potent antioxidant activity,among which the root extract demonstrated the strongest antioxidant activity with the IC_(50)value of 6.552μg/mL.Methanol extract of root possessed antioxidant activity near the range of vitamin E and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of root,flower,leaf and stem showed notable antibacterial activity against tested microorganisms.The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms,at a concentration of 100 mg/mL.In the brine shrimp lethality bioassay,it was evident that the methanol root extract did not show significant toxicity.The LC_(50)value for 12 h and 24 h observation was 2.890 mg/mL and 1.417 mg/mL,respectively.Conclusions:The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products.展开更多
Five ent-6,7-seco-karuene diterpenoids-enmein,epinodosin,sculponeatin A,C,D,were isolated from thedried leaves of Rabdosia sculponeata One of the compounds,named sculponeatin D,was previously unreported.Itsstructre wa...Five ent-6,7-seco-karuene diterpenoids-enmein,epinodosin,sculponeatin A,C,D,were isolated from thedried leaves of Rabdosia sculponeata One of the compounds,named sculponeatin D,was previously unreported.Itsstructre was elucidated by the spectral data including 2D COSY,<sup>1</sup>H-<sup>13</sup>C correlation,2D NOESY spectroscopy.展开更多
One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray cryst...One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis.展开更多
A new 1β-hydroxy-ent-kauren diterpenoid, enanderianin C1, has been isolated from the leaves of Isodon enanderianus, and its structure has been elucidated by spectroscopic evidences.
Two new 19-oxygenated ent-kaurane diterpenoids,pharicinins D and E(1 and 2),together with an artifact,pharicinin D acetal (3) were isolated from the leaves of Isodon pharicus.Their structures were determined by 1D and...Two new 19-oxygenated ent-kaurane diterpenoids,pharicinins D and E(1 and 2),together with an artifact,pharicinin D acetal (3) were isolated from the leaves of Isodon pharicus.Their structures were determined by 1D and 2D NMR spectroscopic analysis. All of them were evaluated for their cytotoxicity.展开更多
On the basis of spectroscopic evidence (MS, <sup>1</sup>HNMR, <sup>13</sup>CNMR, CD, <sup>1</sup>H-<sup>1</sup>H and <sup>1</sup>H-<sup>13</sup>C...On the basis of spectroscopic evidence (MS, <sup>1</sup>HNMR, <sup>13</sup>CNMR, CD, <sup>1</sup>H-<sup>1</sup>H and <sup>1</sup>H-<sup>13</sup>C cosy NMR) and chemical synthesis, the structure of isodopharicin E （1）, isolated from the dry leaves and tender branches of Isodon pharicus （Prain） Murata was elucidated as 3R, 3’R, 13S, 13’S-tetrahydroxy-11S, 11’S-diacetoxy（16S-O-15’）-bisentkaur-15’-en-15-one.展开更多
Two new ent-kaurane diterpenoids, xerophilusin E (1) and xerophilusin F (2), were isolated from the leaves of Isodon xerophilus. Their structures were determined as 3, 20: 7, 20diepoxy-ent-kaur- 16-en- 15-one and 70, ...Two new ent-kaurane diterpenoids, xerophilusin E (1) and xerophilusin F (2), were isolated from the leaves of Isodon xerophilus. Their structures were determined as 3, 20: 7, 20diepoxy-ent-kaur- 16-en- 15-one and 70, 146, 20 (R)-trihydroxy- 11-acetoxy-7, 20-cyclo-ent- kaurl 6-en-6, 15-dione, respectively, by spectral methods and X-ray crystallographic analysis.展开更多
A nco—clcrodane diterpcne, teuponin, was isolated from the aerial parts of Teucrium japonicum. Its structure was established as (12S)—19—nor—neo—clcroda— 15a—hydroxy—4,13-diene— 16,15;18,6β;20,12-triolide by...A nco—clcrodane diterpcne, teuponin, was isolated from the aerial parts of Teucrium japonicum. Its structure was established as (12S)—19—nor—neo—clcroda— 15a—hydroxy—4,13-diene— 16,15;18,6β;20,12-triolide by spcctroscopic means. The absolute configuration was determined by X—ray diffraction analysis and CD spectrum.展开更多
Three new diterpenoids, eriocalyxins C-E, were isolated from Isodon eriocalyx. Their structures were elucidated as 66-hydroxy- 15β-acetoxy-3α, 20-epoxy-16β, 17-epoxy-ent-kaur-1,7-dione, 1α, 7β-dihydroxy-6β, 15β...Three new diterpenoids, eriocalyxins C-E, were isolated from Isodon eriocalyx. Their structures were elucidated as 66-hydroxy- 15β-acetoxy-3α, 20-epoxy-16β, 17-epoxy-ent-kaur-1,7-dione, 1α, 7β-dihydroxy-6β, 15β-diacetoxy-7, 20-epoxy-ent-kaur-16-ene, and 15β-acetoxy-1, 6-dioxo-6, 7-seco-ent-kaur-2, 16-dien-7, 20-olide by means of spectroscopic methods, including two-dimensional NMR techniques.展开更多
A new abietane quinone diterpenoid was isolated. together with horminone. 16- acetoxy-7-0-acetyhorminone. β-sitosterol. stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosia Serra MAXLM. Hara. The ...A new abietane quinone diterpenoid was isolated. together with horminone. 16- acetoxy-7-0-acetyhorminone. β-sitosterol. stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosia Serra MAXLM. Hara. The new compound was elucidated as 16-acetoxy- 7α-ethoxyroyleanone.展开更多
A new ursane-type triterpene, 3β-hydroxy-urs-5(6)-en-28-oic acid 1, was isolated from the aerial palls of Teucrium integnglium and characterized. The structure of this new compound was mainly established by 2D NMR te...A new ursane-type triterpene, 3β-hydroxy-urs-5(6)-en-28-oic acid 1, was isolated from the aerial palls of Teucrium integnglium and characterized. The structure of this new compound was mainly established by 2D NMR techniques (COSY, HETCOR, HMBC).展开更多
Three new lignan glucosides, baicalensinosides A–C(1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemic...Three new lignan glucosides, baicalensinosides A–C(1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofurantype lignan glycoside with a mono-hydroxyl substitution at the 70-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin(OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.展开更多
A Chinese herb called Donglincao was identified as Rabdosia rubescens (Hemsl) Hara (Labiatae). It is widely distributed in the Yellow River valley and used in folk medicine for the treatment of esophageal carcinoma. E...A Chinese herb called Donglincao was identified as Rabdosia rubescens (Hemsl) Hara (Labiatae). It is widely distributed in the Yellow River valley and used in folk medicine for the treatment of esophageal carcinoma. Experiments showed that the water and alcoholic extracts of this herb exhibited cytotoxic, antitumor and antibacterial activities. Clinically, it is also effective in the treatment of展开更多
58. Rumex tenuifolius (Wallr.) Love (Polygonaceae) Nuova stazione per il BrescianoReperto Alta Val Camonica (5a-97291)~1, comune di Ponte di Legno, pendici montuosea N del P.so del Tonale, terreni smossi lungo le scio...58. Rumex tenuifolius (Wallr.) Love (Polygonaceae) Nuova stazione per il BrescianoReperto Alta Val Camonica (5a-97291)~1, comune di Ponte di Legno, pendici montuosea N del P.so del Tonale, terreni smossi lungo le sciovie, m 2100 ca. s. l. m.,25. VIII. 1990, A. Crescini, S. Danieli e F. Tagliaferri, HbTF (Erbario TagliaferriFilippo).展开更多
基金Supported by Project of National Natural Science Foundation(81560659)Science and Technology Research Project of Jiangxi Provincial Department of Education(GJJ170722)+2 种基金Traditional Chinese Medicine Science and Technology Program of Jiangxi Provincial Health and Family Planning Commission(2018B139)Young Teacher Training Program for Key Discipline of Jiangxi University of Traditional Chinese Medicine(2017jzzdxk001)Traditional Chinese Medicine First-class Discipline Special Research Fund Project of Jiangxi Province(JXSYLXK-ZHYAO 061)
文摘In recent years, the antibacterial and anti-inflammatory effects of the Labiatae plants have been widely recognized, and have been used in clinical practice, and their anti-tumor effects are also very significant, and receiving more and more attention. At present, malignant tumors are still the first killer threatening human health. Because of the long-term use of chemical anti-tumor drugs with certain drug resistance and obvious side effects, finding high-efficiency anti-tumor active ingredients from natural plants and Chinese herbal medicines has become a hot spot in the field of pharmacy. Literature survey indicates that the active ingredients in Labiatae plants have anti-tumor effects. Therefore, this paper summarized and discussed the anti-tumor types, mechanisms and active components of the Labiatae plants, so as to provide a basis and reference for the development of new anti-tumor drugs or preparations.
基金financially supported by Higher Institution Centerof Excellence(HICoE)of the Ministry of Higher Education Malaysia(grant No.311/CIPPM/440105)
文摘Objective:To evaluate antioxidant,antimicrobial and cytotoxic activity of different parts(root, flower,leaf and stem)of Leucas aspera(L.aspera)(Labiatae).Methods:Different parts of L.aspera were extracted with 80%(v/v)methanol.The methanol extracts were subjected to antioxidant, antimicrobial and brine shrimp lethality assay.Results:All the extracts showed moderate to potent antioxidant activity,among which the root extract demonstrated the strongest antioxidant activity with the IC_(50)value of 6.552μg/mL.Methanol extract of root possessed antioxidant activity near the range of vitamin E and thus could be a potential rich source of natural antioxidant.In case of antimicrobial screening,crude extracts of root,flower,leaf and stem showed notable antibacterial activity against tested microorganisms.The root extract showed the highest mean zone of inhibition ranging from 9.0-11.0 mm against tested microorganisms,at a concentration of 100 mg/mL.In the brine shrimp lethality bioassay,it was evident that the methanol root extract did not show significant toxicity.The LC_(50)value for 12 h and 24 h observation was 2.890 mg/mL and 1.417 mg/mL,respectively.Conclusions:The present finding suggests that the methanol root extract of L.aspera could be developed as pharmaceutical products.
文摘Five ent-6,7-seco-karuene diterpenoids-enmein,epinodosin,sculponeatin A,C,D,were isolated from thedried leaves of Rabdosia sculponeata One of the compounds,named sculponeatin D,was previously unreported.Itsstructre was elucidated by the spectral data including 2D COSY,<sup>1</sup>H-<sup>13</sup>C correlation,2D NOESY spectroscopy.
文摘One new ent-kaurane diterpenoid,named maoyecrystal L was isolated from the EtOAc extract of the dried leaves of lsodon japonica.Its structure was established by various spectroscopic means and confirmed by X-ray crystallographic analysis.
文摘A new 1β-hydroxy-ent-kauren diterpenoid, enanderianin C1, has been isolated from the leaves of Isodon enanderianus, and its structure has been elucidated by spectroscopic evidences.
基金supported financially by the NSFC(No.30772637 to H.-D.Sun)the NSFC-joint Foundation of Yunnan Province(No.U0832602 to H.-D.Sun)+2 种基金the Major State Basic Research Development Program of China(No. 2009CB522303 and 2009CB940900)the Natural Science Foundation of Yunnan Province(No.2008CD 162)the Key Project of Knowledge Innovation Project of CAS(No.KSCX2-YW-R-25).
文摘Two new 19-oxygenated ent-kaurane diterpenoids,pharicinins D and E(1 and 2),together with an artifact,pharicinin D acetal (3) were isolated from the leaves of Isodon pharicus.Their structures were determined by 1D and 2D NMR spectroscopic analysis. All of them were evaluated for their cytotoxicity.
文摘On the basis of spectroscopic evidence (MS, <sup>1</sup>HNMR, <sup>13</sup>CNMR, CD, <sup>1</sup>H-<sup>1</sup>H and <sup>1</sup>H-<sup>13</sup>C cosy NMR) and chemical synthesis, the structure of isodopharicin E （1）, isolated from the dry leaves and tender branches of Isodon pharicus （Prain） Murata was elucidated as 3R, 3’R, 13S, 13’S-tetrahydroxy-11S, 11’S-diacetoxy（16S-O-15’）-bisentkaur-15’-en-15-one.
文摘Two new ent-kaurane diterpenoids, xerophilusin E (1) and xerophilusin F (2), were isolated from the leaves of Isodon xerophilus. Their structures were determined as 3, 20: 7, 20diepoxy-ent-kaur- 16-en- 15-one and 70, 146, 20 (R)-trihydroxy- 11-acetoxy-7, 20-cyclo-ent- kaurl 6-en-6, 15-dione, respectively, by spectral methods and X-ray crystallographic analysis.
文摘A nco—clcrodane diterpcne, teuponin, was isolated from the aerial parts of Teucrium japonicum. Its structure was established as (12S)—19—nor—neo—clcroda— 15a—hydroxy—4,13-diene— 16,15;18,6β;20,12-triolide by spcctroscopic means. The absolute configuration was determined by X—ray diffraction analysis and CD spectrum.
文摘Three new diterpenoids, eriocalyxins C-E, were isolated from Isodon eriocalyx. Their structures were elucidated as 66-hydroxy- 15β-acetoxy-3α, 20-epoxy-16β, 17-epoxy-ent-kaur-1,7-dione, 1α, 7β-dihydroxy-6β, 15β-diacetoxy-7, 20-epoxy-ent-kaur-16-ene, and 15β-acetoxy-1, 6-dioxo-6, 7-seco-ent-kaur-2, 16-dien-7, 20-olide by means of spectroscopic methods, including two-dimensional NMR techniques.
文摘A new abietane quinone diterpenoid was isolated. together with horminone. 16- acetoxy-7-0-acetyhorminone. β-sitosterol. stigmasterol. ursolic acid and palmitic acid from the leaves of Rabdosia Serra MAXLM. Hara. The new compound was elucidated as 16-acetoxy- 7α-ethoxyroyleanone.
文摘A new ursane-type triterpene, 3β-hydroxy-urs-5(6)-en-28-oic acid 1, was isolated from the aerial palls of Teucrium integnglium and characterized. The structure of this new compound was mainly established by 2D NMR techniques (COSY, HETCOR, HMBC).
基金supported by grants from National Natural Science Foundation of China(No.81361138020)
文摘Three new lignan glucosides, baicalensinosides A–C(1–3), were isolated from the roots of Scutellaria baicalensis. The structural elucidation was achieved by in-depth spectroscopic examinations and qualitative chemical test. Structurally, these compounds belong to the 3,4-dibenzyltetrahydrofurantype lignan glycoside with a mono-hydroxyl substitution at the 70-position of benzylidene group on the numbering system of lignans being one of their shared critical features. The anti-osteoporotic activity of the isolated compounds was assessed in an in vitro osteoprotegerin(OPG) transcriptional activity assay using dual luciferase reporter detection. At 10 μmol/L, compounds 1–3 increased the relative activating ratio of OPG transcription to 1.83, 0.84 and 0.98 times that of the control group, respectively.
文摘A Chinese herb called Donglincao was identified as Rabdosia rubescens (Hemsl) Hara (Labiatae). It is widely distributed in the Yellow River valley and used in folk medicine for the treatment of esophageal carcinoma. Experiments showed that the water and alcoholic extracts of this herb exhibited cytotoxic, antitumor and antibacterial activities. Clinically, it is also effective in the treatment of
文摘58. Rumex tenuifolius (Wallr.) Love (Polygonaceae) Nuova stazione per il BrescianoReperto Alta Val Camonica (5a-97291)~1, comune di Ponte di Legno, pendici montuosea N del P.so del Tonale, terreni smossi lungo le sciovie, m 2100 ca. s. l. m.,25. VIII. 1990, A. Crescini, S. Danieli e F. Tagliaferri, HbTF (Erbario TagliaferriFilippo).
