Objective: This is to determine the plasma lipid profile status of patients diagnosed with gestational diabetes mellitus. Methodology: Seventy-nine pregnant women between gestational age of 24 and 28 weeks out of whic...Objective: This is to determine the plasma lipid profile status of patients diagnosed with gestational diabetes mellitus. Methodology: Seventy-nine pregnant women between gestational age of 24 and 28 weeks out of which 23 and 16 were diagnosed of having GDM using IADAPSG and WHO guidelines respectively were recruited into the study. Plasma lipid profile was determined among the study groups using standard laboratory techniques. Results: Higher numbers of women were diagnosed with GDM using IASDAPG criteria than when WHO criteria were used. Plasma lipid profile showed no significant difference between women with GDM and Non-GDM irrespective of guidelines used in the diagnosis of GDM. Conclusion: Pregnancy and Gestational Diabetes Mellitus may have influence on lipid metabolism but not likely in the second trimester of pregnancy as observed in our study.展开更多
Objective: To study the correlation between serum vitamin D levels with glycolipid metabolism, inflammatory factors secretion in pregnant women with gestational diabetes mellitus(GDM). Methods: GDM pregnant women diag...Objective: To study the correlation between serum vitamin D levels with glycolipid metabolism, inflammatory factors secretion in pregnant women with gestational diabetes mellitus(GDM). Methods: GDM pregnant women diagnosed in our hospital from March 2015 to February 2018 were selected as GDM group, and healthy pregnant women who underwent obstetric examination and delivered at the same time were selected as control group. Fasting venous blood was collected at 24 weeks of gestation and 25 (OH) D3, glucose and lipid metabolism indexes, inflammatory factors were measured. The placenta tissues after delivery were collected and the mRNA expression of biological signal molecules was measured. Results: Serum 25 (OH) D3, HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta of GDM group were significantly lower than those in control group, serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta were significantly higher than those in control group. Serum 25 (OH) D3 of GDM group was positively correlated with serum HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta, whereas negatively correlated with serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta. Conclusion: The decrease of serum vitamin D level in GDM pregnant women closely correlates with the disorder of glucose and lipid metabolism and abnormal secretion of inflammatory factors.展开更多
This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus(GDM),the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal p...This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus(GDM),the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM.From 2019–2020,21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital,Panyu District,Guangzhou.The general information such as weight,height,age,body mass index(BMI)before pregnancy were analyzed.Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma using LCMS method.The age,BMI,delivery methods,and infant weight were different between GDM and control.There were 167 lipid metabolites in umbilical cord blood associated with GDM.Among them,158 upregulated and 9 downregulated in GDM.There were 13 dysregulated metabolites with C<30,including Lyso-phosphatidyl-colines LPC 16:0,18:2,18:1,18:0,20:4 and 22:6,glycerophosphocholines PC O-16:1,oleoylcarnitine CAR 18:2 and 18:1,dihexosylceramides Hex2Cer 13:0;2O,phosphatidylethanolamine PE O-22:6_2:0 and PE O-22:6_3:0 and sphingomyelin SM 8:0;2O/11:0.Those metabolites were associated with glycerophospholipid metabolism and sphingolipid metabolism.Therefore,Lyso-phosphatidyl-colines,glycerophosphocholines,oleoylcarnitine,dihexosylceramides,phosphatidylethanolamine,and sphingomyelin were main lipid metabolites of GDM,which might be used for diagnosis and treatment of GDM.展开更多
Purpose: To compare the Lipid peroxidation and Total antioxidant status in women with gestational diabetes mellitus and normal pregnancy in our environment. Materials & Methods: This was a 2-year, cross sectional,...Purpose: To compare the Lipid peroxidation and Total antioxidant status in women with gestational diabetes mellitus and normal pregnancy in our environment. Materials & Methods: This was a 2-year, cross sectional, case control study of 25 gestational diabetes mellitus (GDM) and 75 matched normal pregnant women at Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Osogbo, Nigeria. The study protocol was reviewed and approved by our Institutional Ethical Review Committee and all participants gave their consents. The fasting serum of recruited patients were analysed for lipid peroxidetion product malondialdehyde(MDA), based on MDA reaction with thiobarbituric acid (TBA), with rapid, sensitive and specific Thiobarbituric Acid (TBA) assay, while the Total Anti-oxidant status (TAS) was determined using the capacity of the biological fluids to inhibit the production of thiobarbituric acid reactive substances (TBARS) from sodium benzoate under the influence of the free oxygen radicals derived from Fenton’s reaction. Results: The mean serum MDA was significantly higher in the GDM group (3.64 nmol/mL) than the value recorded (1.33 nmol/ mL) in the control group (P vs. 0.66 nmol/mL) was noticed in the GDM group (P < 0.0001). Conclusion: The study showed significant increase in lipid peroxidation and failure of compensatory antioxidant functions in GDM Nigerian women.展开更多
Background: GDM is a condition where there is an onset of carbohydrate intolerance during pregnancy. In this condition many changes will take place in carbohydrate metabolism and other metabolic pathways especially in...Background: GDM is a condition where there is an onset of carbohydrate intolerance during pregnancy. In this condition many changes will take place in carbohydrate metabolism and other metabolic pathways especially in lipid metabolism. These metabolic changes associated with insulin resistance and dyslipidemia. We have aim to study the association between dyslipidemia and glycated haemoglobin. Materials and Methods: The study was conducted in 80 pregnant women of rural population of Puducherry in two groups. Group 1 includes 40 newly diagnosed GDM patients by DIPSI and Group II with 40 normal pregnant women, age group were between 20 to 40 years. Fasting blood glucose, 2-hour post glucose and lipid profile were estimated by auto analyzer. HbA1c was analysis by HPLC method. For comparisons of means student t-test was used to determine the significance between GDM and controls. Results: There was statistically significant difference in lipid profiles (P = 0.05), HDL (P = 0.04), VLDL (P = 0.00), LDL (P = 0.04) HDL (P = 0.04) in GDM groups. HbA1c (P = 0.02) levels were statistically significant with GDM pregnant women. There was no statically significant difference between FG (P = 0.23), TG (P = 0.30) and lipids profiles ratio levels in GDM. Conclusion: This study was found to be associations between lipids profiles and Gestational diabetes mellitus in GDM groups.展开更多
Objective: To detect the serum Betatrophin level in patients with gestational diabetes mellitus (GDM), and to explore the relationship between Betatrophin level and disorders of glucose and lipid metabolism. Methods: ...Objective: To detect the serum Betatrophin level in patients with gestational diabetes mellitus (GDM), and to explore the relationship between Betatrophin level and disorders of glucose and lipid metabolism. Methods: 119 cases of GDM women in our hospital during August 2015 to March 2018 were selected as GDM group, 100 cases pregnant women with normal blood glucose were chosen as Normal control group. Serum level of Betatrophin, glucose metabolism and lipid metabolism between two groups were compared. Pearson test was used to evaluate the relationship between Betatrophin, glucose and lipid metabolism disorders in GDM pregnant women. Results: Serum content of Betatrophin in GDM group was significantly higher than that in Normal control group, levels of HbA1c, FINS and HOMA-IR in peripheral blood were significantly higher than those in Normal control group;contents of TC, LDL-C and Apo-B in peripheral blood were higher than those in Normal control group, contents of HDL-C, Apo-A1 were lower than those in Normal control group. Correlation analysis showed that serum level of Betatrophin in GDM pregnant women was positively correlated with the disorder of glucose and lipid metabolism. Conclusion: Abnormally high expression of Betatrophin in GDM pregnant women may be an important factor in promoting disorder of glucose and lipid metabolism.展开更多
Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for t...Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. Indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines.展开更多
<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.&...<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.展开更多
Background: Oxidative stress has been closely linked to the incidence of diabetic complications. Therefore, the aim of this research article was to study hyperglycemia and abnormal lipid profile in diabetic patient ty...Background: Oxidative stress has been closely linked to the incidence of diabetic complications. Therefore, the aim of this research article was to study hyperglycemia and abnormal lipid profile in diabetic patient type 2 and its correlation with oxidative stress development as measured by 8-iso-PGF2α and 8-OHdG. Methods: Fifty (50) patients confirmed type 2 diabetes mellitus and eighty (80) non-diabetic control individuals were included in this study. All individuals were tested for blood glucose, lipid profile, 8-iso-PGF2α and 8-OHdG HdG. Results: The age of diabetic patients was observed to be ≥40 yrs in 96% and diabetes was frequently detected in female than in male patients (76% vs. 24%, p ere elevated in diabetic patients compared with control individuals (p < 0.0001) except in HDL-C, a significant decrease was recorded (p = 0.04). Serum 8-iso-PGF2α and 8-OHdG were elevated significantly in diabetic patients compared with non-diabetic control and a significant correlation was recorded between them (r = 0.6, p α was associated with Age (r = 0.394, p < 0.0001), FBG (0.553, p < 0.0001), LDL-C (r = 0.2, p = 0.023), TG (r = 0.176, p = 0.045) and TC (r = 0.2, p = 0.02). Also, 8-OHdG was associated with age (r = 0.558, p < 0.0001), FBG (r = 0.67, p < 0.0001), LDL-C (r = 0.28, p = 0.001), TG (r = 0.358, p < 0.0001) and TC (r = 0.33, p < 0.0001). Age, FBG, HbA1c, LDL-C, TG and TC showed a significant linear regression with 8-iso-PGF2α and 8-OHdG recording its role as significant predictors for the elevation of 8-iso-PGF2α and 8-OHdG. Therefore, hyperglycemia with oxidative stress development may play a role for dyslipidemia and diabetic complications. Conclusion: Diabetic patient’s type 2 has a higher rate of abnormal serum lipids and correlates significantly with lipid peroxidation and oxidized DNA bases as measured by 8-iso-PGF2α and 8-OHdG. Therefore, 8-iso-PGF2α and 8-OHdG could be used as oxidative biomarkers for evaluating diabetic patients with early prediction of its complications and cancer development.展开更多
Gestational diabetes mellitus(GDM) is defined as any degree of hyperglycaemia that is recognized for the first time during pregnancy. This definition includes cases of undiagnosed type 2 diabetes mellitus(T2 DM) ident...Gestational diabetes mellitus(GDM) is defined as any degree of hyperglycaemia that is recognized for the first time during pregnancy. This definition includes cases of undiagnosed type 2 diabetes mellitus(T2 DM) identified early in pregnancy and true GDM which develops later. GDM constitutes a greater impact on diabetes epidemic as it carries a major risk of developing T2 DM to the mother and foetus later in life. In addition, GDM has also been linked with cardiometabolic risk factors such as lipid abnormalities, hypertensive disorders and hyperinsulinemia. These might result in later development of cardiovascular disease and metabolic syndrome. The understanding of the different risk factors, the pathophysiological mechanisms and the genetic factors of GDM, will help us to identify the women at risk, to develop effective preventive measures and to provide adequate management of the disease. Clinical trials have shown that T2 DM can be prevented in women with prior GDM, by intensive lifestyle modification and by using pioglitazone and metformin. However, a matter of controversy surrounding both screening and management of GDM continues to emerge, despite several recent welldesigned clinical trials tackling these issues. The aim of this manuscript is to critically review GDM in a detailed and comprehensive manner, in order to provide a scientific analysis and updated write-up of different related aspects.展开更多
目的研究孕早期妇女血清补体C1q/肿瘤坏死因子相关蛋白6(C1q/tumor necrosis factor-related protein 6,CTRP6)的表达水平,探讨其与妊娠糖尿病(gestational diabetes mellitus,GDM)的关系。方法前瞻性连续选取2021年3月至2022年3月在郑...目的研究孕早期妇女血清补体C1q/肿瘤坏死因子相关蛋白6(C1q/tumor necrosis factor-related protein 6,CTRP6)的表达水平,探讨其与妊娠糖尿病(gestational diabetes mellitus,GDM)的关系。方法前瞻性连续选取2021年3月至2022年3月在郑州大学第二附属医院门诊产检的孕10~13周孕妇,收集孕妇的年龄、身高、体质量、末次月经时间,检测孕早期总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low density lipoprotein,LDL)、空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、空腹胰岛素(fasting insulin,FINS)、CTRP6水平,计算孕前体质量指数(body mass index,BMI)、基线BMI、产前BMI和胰岛素抵抗指数(亦称胰岛素抵抗的稳态模型评估,homeostatic model assessment of insulin resistance,HOMA-IR)。所有孕妇均于孕24~28周行75g口服葡萄糖耐量试验,根据试验结果分为GDM组和糖耐量正常(normal glucose tolerance,NGT)组。比较两组孕妇孕早期的临床资料及实验室指标,分析孕早期血清CTRP6与各指标的相关性及其与GDM的关系。结果共纳入孕妇213例,完整随访203例,其中52例孕妇被诊断为GDM,GDM发病率25.62%。GDM组孕妇的孕早期血清CTRP6、年龄、孕前BMI、基线BMI、产前BMI、TC、LDL、FPG、HbA1c、FINS、HOMA-IR均较NGT组升高,差异有统计学意义(P<0.05)。孕早期CTRP6与年龄、孕前BMI、基线BMI、产前BMI、TG、LDL、FPG、HbA1c、FINS、HOMA-IR呈正相关,与HDL呈负相关(P<0.05)。校正年龄、BMI、糖脂代谢指标及HOMA-IR后,孕早期CTRP6为GDM发病的独立影响因素。结论孕早期血清CTRP6升高与GDM相关,是GDM的独立危险因素。展开更多
目的:探究有氧运动联合抗阻运动对妊娠期糖尿病患者胰岛细胞功能及糖脂代谢的影响。方法:将2021年5月—2023年6月松滋市人民医院的100例妊娠期糖尿病患者依据随机数字表法分为对照组50例和观察组50例。对照组进行常规妊娠期糖尿病干预,...目的:探究有氧运动联合抗阻运动对妊娠期糖尿病患者胰岛细胞功能及糖脂代谢的影响。方法:将2021年5月—2023年6月松滋市人民医院的100例妊娠期糖尿病患者依据随机数字表法分为对照组50例和观察组50例。对照组进行常规妊娠期糖尿病干预,观察组则在对照组的基础上加用有氧运动联合抗阻运动。比较两组的干预总有效率、干预前后的胰岛细胞功能[稳态模型评估胰岛素抵抗指数(HOMA-IR)及稳态模型评估β细胞功能指数(HOMA-β)]、糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)]及脂代谢指标[总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)]。结果:观察组的干预总有效率高于对照组(P<0.05)。干预前两组的胰岛细胞功能、糖代谢指标及脂代谢指标比较,差异均无统计学意义(P>0.05),干预4、8周后,两组的HOMA-β均高于干预前,且观察组均高于对照组,两组的HOMA-IR、糖代谢指标及脂代谢指标均低于干预前,且观察组均低于对照组(P<0.05)。结论:有氧运动联合抗阻运动在妊娠期糖尿病患者中的应用效果较好,且可显著改善患者的胰岛细胞功能及糖脂代谢状态。展开更多
文摘Objective: This is to determine the plasma lipid profile status of patients diagnosed with gestational diabetes mellitus. Methodology: Seventy-nine pregnant women between gestational age of 24 and 28 weeks out of which 23 and 16 were diagnosed of having GDM using IADAPSG and WHO guidelines respectively were recruited into the study. Plasma lipid profile was determined among the study groups using standard laboratory techniques. Results: Higher numbers of women were diagnosed with GDM using IASDAPG criteria than when WHO criteria were used. Plasma lipid profile showed no significant difference between women with GDM and Non-GDM irrespective of guidelines used in the diagnosis of GDM. Conclusion: Pregnancy and Gestational Diabetes Mellitus may have influence on lipid metabolism but not likely in the second trimester of pregnancy as observed in our study.
文摘Objective: To study the correlation between serum vitamin D levels with glycolipid metabolism, inflammatory factors secretion in pregnant women with gestational diabetes mellitus(GDM). Methods: GDM pregnant women diagnosed in our hospital from March 2015 to February 2018 were selected as GDM group, and healthy pregnant women who underwent obstetric examination and delivered at the same time were selected as control group. Fasting venous blood was collected at 24 weeks of gestation and 25 (OH) D3, glucose and lipid metabolism indexes, inflammatory factors were measured. The placenta tissues after delivery were collected and the mRNA expression of biological signal molecules was measured. Results: Serum 25 (OH) D3, HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta of GDM group were significantly lower than those in control group, serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta were significantly higher than those in control group. Serum 25 (OH) D3 of GDM group was positively correlated with serum HDL-C, apoA1/apoB, APN, Omentin-1 and mRNA expression of GLUT3, GLUT4, IRS-1 in placenta, whereas negatively correlated with serum F-INS, HOMA-IR, LDL-C, IL-6, TNF-a and the mRNA expressions of TLR4, NF-κB in placenta. Conclusion: The decrease of serum vitamin D level in GDM pregnant women closely correlates with the disorder of glucose and lipid metabolism and abnormal secretion of inflammatory factors.
基金This work was supported by Basic and Applied Basic Research Projects of Guangzhou Basic Research Program(Grant No.202102080582).
文摘This work aimed to clarify the interaction between the fetus and pregnant patients with gestational diabetes mellitus(GDM),the lipid metabolomics analysis of the fetal umbilical cord blood of GDM patients and normal pregnant women were performed to screen out the specific lipid metabolites for pathogenesis of GDM.From 2019–2020,21 patients with GDM and 22 normal pregnant women were enrolled in Hexian Memorial Hospital,Panyu District,Guangzhou.The general information such as weight,height,age,body mass index(BMI)before pregnancy were analyzed.Non-targeted metabonomic detection and analysis were performed in umbilical cord plasma using LCMS method.The age,BMI,delivery methods,and infant weight were different between GDM and control.There were 167 lipid metabolites in umbilical cord blood associated with GDM.Among them,158 upregulated and 9 downregulated in GDM.There were 13 dysregulated metabolites with C<30,including Lyso-phosphatidyl-colines LPC 16:0,18:2,18:1,18:0,20:4 and 22:6,glycerophosphocholines PC O-16:1,oleoylcarnitine CAR 18:2 and 18:1,dihexosylceramides Hex2Cer 13:0;2O,phosphatidylethanolamine PE O-22:6_2:0 and PE O-22:6_3:0 and sphingomyelin SM 8:0;2O/11:0.Those metabolites were associated with glycerophospholipid metabolism and sphingolipid metabolism.Therefore,Lyso-phosphatidyl-colines,glycerophosphocholines,oleoylcarnitine,dihexosylceramides,phosphatidylethanolamine,and sphingomyelin were main lipid metabolites of GDM,which might be used for diagnosis and treatment of GDM.
文摘Purpose: To compare the Lipid peroxidation and Total antioxidant status in women with gestational diabetes mellitus and normal pregnancy in our environment. Materials & Methods: This was a 2-year, cross sectional, case control study of 25 gestational diabetes mellitus (GDM) and 75 matched normal pregnant women at Ladoke Akintola University of Technology (LAUTECH) Teaching Hospital, Osogbo, Nigeria. The study protocol was reviewed and approved by our Institutional Ethical Review Committee and all participants gave their consents. The fasting serum of recruited patients were analysed for lipid peroxidetion product malondialdehyde(MDA), based on MDA reaction with thiobarbituric acid (TBA), with rapid, sensitive and specific Thiobarbituric Acid (TBA) assay, while the Total Anti-oxidant status (TAS) was determined using the capacity of the biological fluids to inhibit the production of thiobarbituric acid reactive substances (TBARS) from sodium benzoate under the influence of the free oxygen radicals derived from Fenton’s reaction. Results: The mean serum MDA was significantly higher in the GDM group (3.64 nmol/mL) than the value recorded (1.33 nmol/ mL) in the control group (P vs. 0.66 nmol/mL) was noticed in the GDM group (P < 0.0001). Conclusion: The study showed significant increase in lipid peroxidation and failure of compensatory antioxidant functions in GDM Nigerian women.
文摘Background: GDM is a condition where there is an onset of carbohydrate intolerance during pregnancy. In this condition many changes will take place in carbohydrate metabolism and other metabolic pathways especially in lipid metabolism. These metabolic changes associated with insulin resistance and dyslipidemia. We have aim to study the association between dyslipidemia and glycated haemoglobin. Materials and Methods: The study was conducted in 80 pregnant women of rural population of Puducherry in two groups. Group 1 includes 40 newly diagnosed GDM patients by DIPSI and Group II with 40 normal pregnant women, age group were between 20 to 40 years. Fasting blood glucose, 2-hour post glucose and lipid profile were estimated by auto analyzer. HbA1c was analysis by HPLC method. For comparisons of means student t-test was used to determine the significance between GDM and controls. Results: There was statistically significant difference in lipid profiles (P = 0.05), HDL (P = 0.04), VLDL (P = 0.00), LDL (P = 0.04) HDL (P = 0.04) in GDM groups. HbA1c (P = 0.02) levels were statistically significant with GDM pregnant women. There was no statically significant difference between FG (P = 0.23), TG (P = 0.30) and lipids profiles ratio levels in GDM. Conclusion: This study was found to be associations between lipids profiles and Gestational diabetes mellitus in GDM groups.
文摘Objective: To detect the serum Betatrophin level in patients with gestational diabetes mellitus (GDM), and to explore the relationship between Betatrophin level and disorders of glucose and lipid metabolism. Methods: 119 cases of GDM women in our hospital during August 2015 to March 2018 were selected as GDM group, 100 cases pregnant women with normal blood glucose were chosen as Normal control group. Serum level of Betatrophin, glucose metabolism and lipid metabolism between two groups were compared. Pearson test was used to evaluate the relationship between Betatrophin, glucose and lipid metabolism disorders in GDM pregnant women. Results: Serum content of Betatrophin in GDM group was significantly higher than that in Normal control group, levels of HbA1c, FINS and HOMA-IR in peripheral blood were significantly higher than those in Normal control group;contents of TC, LDL-C and Apo-B in peripheral blood were higher than those in Normal control group, contents of HDL-C, Apo-A1 were lower than those in Normal control group. Correlation analysis showed that serum level of Betatrophin in GDM pregnant women was positively correlated with the disorder of glucose and lipid metabolism. Conclusion: Abnormally high expression of Betatrophin in GDM pregnant women may be an important factor in promoting disorder of glucose and lipid metabolism.
文摘Gestational diabetes mellitus (GDM) and large for gestational age (LGA) offspring are two common pregnancy complications. Connections also exist between the two conditions, including mutual maternal risk factors for the conditions and an increased prevalence of LGA offspring amongst pregnancies affected by GDM. Thus, it is important to elucidate potential shared underlying mechanisms of both LGA and GDM. One potential mechanistic link relates to macronutrient metabolism. Indeed, derangement of carbohydrate and lipid metabolism is present in GDM, and maternal biomarkers of glucose and lipid control are associated with LGA neonates in such pregnancies. The aim of this paper is therefore to reflect on the existing nutritional guidelines for GDM in light of our understanding of the pathophysiological mechanisms of GDM and LGA offspring. Lifestyle modification is first line treatment for GDM, and while there is some promise that nutritional interventions may favourably impact outcomes, there is a lack of definitive evidence that changing the macronutrient composition of the diet reduces the incidence of either GDM or LGA offspring. The quality of the available evidence is a major issue, and rigorous trials are needed to inform evidence-based treatment guidelines.
文摘<strong>Background:</strong> Aberrant lipid metabolism presumed to have important relationship with gestational diabetes mellitus (GDM), though previous studies revealed inconsistent results on this area.<strong> Objectives:</strong> To identify the difference of serum lipid profile between gestational diabetes mellitus (GDM) and pregnant woman with normal glucose tolerance (NGT). <strong>Methods:</strong> This cross sectional study was conducted from January 2017 to December 2017 at Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh with 31 GDM and equal number of NGT pregnant women diagnosed on the basis of WHO criteria-2013, during 24 - 40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting serum lipid profile [Total cholesterol (TC), High Density Lipoprotein-cholesterol (HDL-C) and Triglyceride (TG)] was measured by enzymatic-colorimetric method. Data were analyzed and compared by statistical tests. <strong>Results: </strong>Among total sixty-two (62) study subjects, 31 were GDM (age: 27.52 ± 4.8 years, body mass index (BMI): 27.17 ± 3.3 kg/m<sup>2</sup>) and 31 were pregnant women with NGT (age: 24.94 ± 4.2 years, BMI: 25.43 ± 6.5 kg/m<sup>2</sup>). Mean age of GDM group was significantly higher than that of NGT group (p = 0.028). Women with GDM showed relatively higher BMI than NGT women but that was not statistically significant (p = 0.194). Fasting lipid profiles between GDM and NGT (GDM vs. NGT;total cholesterol: 194.21 ± 42.18 vs. 208.52 ± 42.18 mg/dl, p = 0.187;HDL-C: 47.50 ± 16.17 vs. 47.18 ± 11.71 mg/dl, p = 0.928;LDL-C: 109.25 ± 28.80 vs. 119.30 ± 34.76 mg/dl, p = 0.220 and triglyceride 204.78 ± 58.50 vs. 202.34 ± 79.18 mg/dl, p = 0.891) were not significantly different. The variations in all lipid fraction values were not statistically significant among GDM women when analyzed between BMI groups holding BMI cut-off at 23 kg/m<sup>2</sup>. No significant differences of any values of lipid profile were found in GDM women according to various age categories (Age < 25 years vs. ≥25 years). <strong>Conclusions: </strong>Lipid profile does not differ between women with GDM and pregnant woman with NGT.
文摘Background: Oxidative stress has been closely linked to the incidence of diabetic complications. Therefore, the aim of this research article was to study hyperglycemia and abnormal lipid profile in diabetic patient type 2 and its correlation with oxidative stress development as measured by 8-iso-PGF2α and 8-OHdG. Methods: Fifty (50) patients confirmed type 2 diabetes mellitus and eighty (80) non-diabetic control individuals were included in this study. All individuals were tested for blood glucose, lipid profile, 8-iso-PGF2α and 8-OHdG HdG. Results: The age of diabetic patients was observed to be ≥40 yrs in 96% and diabetes was frequently detected in female than in male patients (76% vs. 24%, p ere elevated in diabetic patients compared with control individuals (p < 0.0001) except in HDL-C, a significant decrease was recorded (p = 0.04). Serum 8-iso-PGF2α and 8-OHdG were elevated significantly in diabetic patients compared with non-diabetic control and a significant correlation was recorded between them (r = 0.6, p α was associated with Age (r = 0.394, p < 0.0001), FBG (0.553, p < 0.0001), LDL-C (r = 0.2, p = 0.023), TG (r = 0.176, p = 0.045) and TC (r = 0.2, p = 0.02). Also, 8-OHdG was associated with age (r = 0.558, p < 0.0001), FBG (r = 0.67, p < 0.0001), LDL-C (r = 0.28, p = 0.001), TG (r = 0.358, p < 0.0001) and TC (r = 0.33, p < 0.0001). Age, FBG, HbA1c, LDL-C, TG and TC showed a significant linear regression with 8-iso-PGF2α and 8-OHdG recording its role as significant predictors for the elevation of 8-iso-PGF2α and 8-OHdG. Therefore, hyperglycemia with oxidative stress development may play a role for dyslipidemia and diabetic complications. Conclusion: Diabetic patient’s type 2 has a higher rate of abnormal serum lipids and correlates significantly with lipid peroxidation and oxidized DNA bases as measured by 8-iso-PGF2α and 8-OHdG. Therefore, 8-iso-PGF2α and 8-OHdG could be used as oxidative biomarkers for evaluating diabetic patients with early prediction of its complications and cancer development.
文摘Gestational diabetes mellitus(GDM) is defined as any degree of hyperglycaemia that is recognized for the first time during pregnancy. This definition includes cases of undiagnosed type 2 diabetes mellitus(T2 DM) identified early in pregnancy and true GDM which develops later. GDM constitutes a greater impact on diabetes epidemic as it carries a major risk of developing T2 DM to the mother and foetus later in life. In addition, GDM has also been linked with cardiometabolic risk factors such as lipid abnormalities, hypertensive disorders and hyperinsulinemia. These might result in later development of cardiovascular disease and metabolic syndrome. The understanding of the different risk factors, the pathophysiological mechanisms and the genetic factors of GDM, will help us to identify the women at risk, to develop effective preventive measures and to provide adequate management of the disease. Clinical trials have shown that T2 DM can be prevented in women with prior GDM, by intensive lifestyle modification and by using pioglitazone and metformin. However, a matter of controversy surrounding both screening and management of GDM continues to emerge, despite several recent welldesigned clinical trials tackling these issues. The aim of this manuscript is to critically review GDM in a detailed and comprehensive manner, in order to provide a scientific analysis and updated write-up of different related aspects.
文摘目的研究孕早期妇女血清补体C1q/肿瘤坏死因子相关蛋白6(C1q/tumor necrosis factor-related protein 6,CTRP6)的表达水平,探讨其与妊娠糖尿病(gestational diabetes mellitus,GDM)的关系。方法前瞻性连续选取2021年3月至2022年3月在郑州大学第二附属医院门诊产检的孕10~13周孕妇,收集孕妇的年龄、身高、体质量、末次月经时间,检测孕早期总胆固醇(total cholesterol,TC)、三酰甘油(triglyceride,TG)、高密度脂蛋白(high density lipoprotein,HDL)、低密度脂蛋白(low density lipoprotein,LDL)、空腹血糖(fasting plasma glucose,FPG)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、空腹胰岛素(fasting insulin,FINS)、CTRP6水平,计算孕前体质量指数(body mass index,BMI)、基线BMI、产前BMI和胰岛素抵抗指数(亦称胰岛素抵抗的稳态模型评估,homeostatic model assessment of insulin resistance,HOMA-IR)。所有孕妇均于孕24~28周行75g口服葡萄糖耐量试验,根据试验结果分为GDM组和糖耐量正常(normal glucose tolerance,NGT)组。比较两组孕妇孕早期的临床资料及实验室指标,分析孕早期血清CTRP6与各指标的相关性及其与GDM的关系。结果共纳入孕妇213例,完整随访203例,其中52例孕妇被诊断为GDM,GDM发病率25.62%。GDM组孕妇的孕早期血清CTRP6、年龄、孕前BMI、基线BMI、产前BMI、TC、LDL、FPG、HbA1c、FINS、HOMA-IR均较NGT组升高,差异有统计学意义(P<0.05)。孕早期CTRP6与年龄、孕前BMI、基线BMI、产前BMI、TG、LDL、FPG、HbA1c、FINS、HOMA-IR呈正相关,与HDL呈负相关(P<0.05)。校正年龄、BMI、糖脂代谢指标及HOMA-IR后,孕早期CTRP6为GDM发病的独立影响因素。结论孕早期血清CTRP6升高与GDM相关,是GDM的独立危险因素。
文摘目的:探究有氧运动联合抗阻运动对妊娠期糖尿病患者胰岛细胞功能及糖脂代谢的影响。方法:将2021年5月—2023年6月松滋市人民医院的100例妊娠期糖尿病患者依据随机数字表法分为对照组50例和观察组50例。对照组进行常规妊娠期糖尿病干预,观察组则在对照组的基础上加用有氧运动联合抗阻运动。比较两组的干预总有效率、干预前后的胰岛细胞功能[稳态模型评估胰岛素抵抗指数(HOMA-IR)及稳态模型评估β细胞功能指数(HOMA-β)]、糖代谢指标[空腹血糖(FPG)、餐后2 h血糖(2 h PG)及糖化血红蛋白(HbA1c)]及脂代谢指标[总胆固醇(TC)、三酰甘油(TG)及低密度脂蛋白胆固醇(LDL-C)]。结果:观察组的干预总有效率高于对照组(P<0.05)。干预前两组的胰岛细胞功能、糖代谢指标及脂代谢指标比较,差异均无统计学意义(P>0.05),干预4、8周后,两组的HOMA-β均高于干预前,且观察组均高于对照组,两组的HOMA-IR、糖代谢指标及脂代谢指标均低于干预前,且观察组均低于对照组(P<0.05)。结论:有氧运动联合抗阻运动在妊娠期糖尿病患者中的应用效果较好,且可显著改善患者的胰岛细胞功能及糖脂代谢状态。
