Objective Tumors with accelerated growth or high malignancy are thought to undergo active angio- genesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor...Objective Tumors with accelerated growth or high malignancy are thought to undergo active angio- genesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor angiogenesis in carcinomas to show their significance in relate to clinicopathological parameters. In the present study, we evaluated the significance or MIB-1 PI and angiogenesis in early stage of gastric cancer. Our focus was es- pecially on the combination of MIB-1 PI and angiogenesis in relate to lymph node metastasis. Method Specimens from 95 patients with early gastric cancer were studied by means or immunohistochemistry using monoclonal MIB-1 and factor Ⅷ related antigen antibodies. Results The mean MIB-1 PI and microvessel count were 22.9% and 34.7, respectively. The MIB-1 PI did not correlate with microvessel count. Both correlated with depth of tumor invasion, lymphatic vessel invasion and lymph node metastasis. Multivarlate analysis showed that combined high MIB-1 PI/hy- pervascularity, as well as lymphatic vessel invasion and tumor size were independent factors that impact on lymph node metastasis. Conclusion A combination of the high MIB-1 PI/hypervascularity is a factor that related to lymph node metastasis in early gastric cancer.展开更多
Objective:To evaluate the relation between argyrophilic nucleolar organizer region(Ag NOR)-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer(NSCLC).Methods:A total of 20...Objective:To evaluate the relation between argyrophilic nucleolar organizer region(Ag NOR)-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer(NSCLC).Methods:A total of 207 surgical specimens diagnosed as NSCLC were included in this study.Double-staining procedures were performed using antigen Ki-67(clone MIB-1)and silver nitrate by immunohistochemical and Ag NOR-staining methods.Results:The Ag NOR area in MIB-1-positive cells of NSCLC is related to clinicopathological parameters under the TNM(tumor,node,and metastasis)system.The survival of patients with small Ag NOR area in MIB-1-positive cells is better than that of patients with large Ag NOR area.Molecular,biological(Ag NOR area in MIB-1-positive cells),and clinicopathological(greatest tumor dimension,metastases to regional lymph nodes,histology,and differentiation)parameters are independent prognostic factors of NSCLC.Conclusion:The Ag NOR area in MIB-1-positive cells is related to clinicopathological parameters and survival in NSCLC.展开更多
文摘Objective Tumors with accelerated growth or high malignancy are thought to undergo active angio- genesis. Whereas by far, there is few study concerning the combination of MIB-1 proliferation index (MIB-1 PI) and tumor angiogenesis in carcinomas to show their significance in relate to clinicopathological parameters. In the present study, we evaluated the significance or MIB-1 PI and angiogenesis in early stage of gastric cancer. Our focus was es- pecially on the combination of MIB-1 PI and angiogenesis in relate to lymph node metastasis. Method Specimens from 95 patients with early gastric cancer were studied by means or immunohistochemistry using monoclonal MIB-1 and factor Ⅷ related antigen antibodies. Results The mean MIB-1 PI and microvessel count were 22.9% and 34.7, respectively. The MIB-1 PI did not correlate with microvessel count. Both correlated with depth of tumor invasion, lymphatic vessel invasion and lymph node metastasis. Multivarlate analysis showed that combined high MIB-1 PI/hy- pervascularity, as well as lymphatic vessel invasion and tumor size were independent factors that impact on lymph node metastasis. Conclusion A combination of the high MIB-1 PI/hypervascularity is a factor that related to lymph node metastasis in early gastric cancer.
文摘Objective:To evaluate the relation between argyrophilic nucleolar organizer region(Ag NOR)-associated proteins and clinicopathological parameters and survival in non-small-cell lung cancer(NSCLC).Methods:A total of 207 surgical specimens diagnosed as NSCLC were included in this study.Double-staining procedures were performed using antigen Ki-67(clone MIB-1)and silver nitrate by immunohistochemical and Ag NOR-staining methods.Results:The Ag NOR area in MIB-1-positive cells of NSCLC is related to clinicopathological parameters under the TNM(tumor,node,and metastasis)system.The survival of patients with small Ag NOR area in MIB-1-positive cells is better than that of patients with large Ag NOR area.Molecular,biological(Ag NOR area in MIB-1-positive cells),and clinicopathological(greatest tumor dimension,metastases to regional lymph nodes,histology,and differentiation)parameters are independent prognostic factors of NSCLC.Conclusion:The Ag NOR area in MIB-1-positive cells is related to clinicopathological parameters and survival in NSCLC.
