Marine microorganisms have proven to be a rich source of natural products with unique structures and novel activities,due to their special living conditions.Macrolactins(MLNs),mostly produced by marine-derived microor...Marine microorganisms have proven to be a rich source of natural products with unique structures and novel activities,due to their special living conditions.Macrolactins(MLNs),mostly produced by marine-derived microorganisms,are a group of 24-membered lactone natural products,which exhibit potent antibacterial,antifungal,antiviral,anticancer,antiinfammatory,anti-angiogenic and other activities.Their extensive biological activities make them potential compounds for drug development.MLNs are biosynthesized via a type I polyketide synthase(PKS)pathway with diferent tailoring steps,such as epoxidation,glycosylation and acylation.These modifcation steps provide opportunities to diversify their structures by combinatorial biosynthesis strategies.This review mainly focuses on the newly discovered MLNs in the past fve years,including their biological activities and relevant biosynthetic studies.展开更多
Synthetic studies towards(he C(3)-C(13)and C(14)-C(24)segments(3,4)of the potent antiviral and antitumor compound macrolactin A(1)are presented.Compound 3 was constructed via a convergent and facile approach,exploitin...Synthetic studies towards(he C(3)-C(13)and C(14)-C(24)segments(3,4)of the potent antiviral and antitumor compound macrolactin A(1)are presented.Compound 3 was constructed via a convergent and facile approach,exploiting Wittig olefination to generate the sensitive E,Z-diene moiety.Compound 4 was synthesized from the chiral-pod derived sul-fone 39a via an o-alkylation-desulfonation reaction sequence.Cu(Ⅱ)-catalyzed coupling of a Grignard reagent with an al-lylic bromide and Julia olefination were also investigated for the preparation of compound 4.展开更多
基金This work was fnancially supported by the grants from the National Key R&D Program of China(2019YFC0312501)the National Natural Science Foundation of China(U1706206,31570032).
文摘Marine microorganisms have proven to be a rich source of natural products with unique structures and novel activities,due to their special living conditions.Macrolactins(MLNs),mostly produced by marine-derived microorganisms,are a group of 24-membered lactone natural products,which exhibit potent antibacterial,antifungal,antiviral,anticancer,antiinfammatory,anti-angiogenic and other activities.Their extensive biological activities make them potential compounds for drug development.MLNs are biosynthesized via a type I polyketide synthase(PKS)pathway with diferent tailoring steps,such as epoxidation,glycosylation and acylation.These modifcation steps provide opportunities to diversify their structures by combinatorial biosynthesis strategies.This review mainly focuses on the newly discovered MLNs in the past fve years,including their biological activities and relevant biosynthetic studies.
基金Project supported by the National Natural Science Foundation of Chinathe State Key Laboratory of Bio-organicNatural Products Chemistry
文摘Synthetic studies towards(he C(3)-C(13)and C(14)-C(24)segments(3,4)of the potent antiviral and antitumor compound macrolactin A(1)are presented.Compound 3 was constructed via a convergent and facile approach,exploiting Wittig olefination to generate the sensitive E,Z-diene moiety.Compound 4 was synthesized from the chiral-pod derived sul-fone 39a via an o-alkylation-desulfonation reaction sequence.Cu(Ⅱ)-catalyzed coupling of a Grignard reagent with an al-lylic bromide and Julia olefination were also investigated for the preparation of compound 4.
