Objective:To explore existing practices and challenges in the delivery of geriatric home medication review(HMR).The study was part of a larger study aimed to offer solution to expand the range of geriatric HMR.Methods...Objective:To explore existing practices and challenges in the delivery of geriatric home medication review(HMR).The study was part of a larger study aimed to offer solution to expand the range of geriatric HMR.Methods:This study employed qualitative exploratory design through semi-structured individual in-depth interviews with the public pharmacists involved in the delivery of geriatric HMR at public hospitals.The purpose of the interviews was to explore challenges faced by them in the delivery of geriatric HMR.Results:Based on the emerging themes from the qualitative data,the study reveals that geriatric HMR in Malaysia is integrated as part of multidisciplinary home care visits,encompassing a diverse patient population with various healthcare needs.However,it faces challenges such as the lack of outcome monitoring,formal training,and workforce constraints.Despite these hurdles,there is a pressing need for the expansion of this service to better serve the community,and collaboration with community pharmacists holds potential to broaden its scope.Ultimately,the findings suggest that pharmacist-led HMR is both warranted and feasible within the Malaysian healthcare context.In order to optimize medicine-use among older people living in the community,approaches for expanding geriatric HMR services in Malaysia must be developed.Conclusions:This study holds profound implications as it attempts to illuminate policy makers in developing countries,enabling them to formulate effective HMR plans.By considering the challenges highlighted within this research,policy makers can design a comprehensive HMR service that caters adeptly to the healthcare needs of the mass population.展开更多
In the Peninsular Malaysia and Northern Borneo island of Malaysia, various rich indigenous leafy vegetables and fruits grow and contribute to the nutritional and dietary values of the population. They have high water ...In the Peninsular Malaysia and Northern Borneo island of Malaysia, various rich indigenous leafy vegetables and fruits grow and contribute to the nutritional and dietary values of the population. They have high water contents, thus, naturally vulnerable to rapid food spoilage. Food preservation and processing play a vital role in the inhibition of food pathogens in fruits and vegetables that are prevalent in Malaysia. Lactic acid fermentation is generally a local-based bioprocess, among the oldest form and well-known for food-processing techniques among indigenous people there. The long shelf life of fermented vegetables and fruits improves their nutritional values and antioxidant potentials. Fermented leaves and vegetables can be utilized as a potential source of probiotics as they are host for several lactic acid bacteria such as Lactobacillus confusus, Weissella paramesenteroides, Enterococcus faecalis, Lactobacillus plantarum, Lactobacillus buchneri, Lactobacillus paracasei, Lactobacillus pentosus, Pediococcus acidilactici, Pediococcus pentosaceus and Leuconostoc mesenteroides. These strains may be more viable in metabolic systems whereby they can contribute to a substantial increase in essential biologically active element than industrial starter cultures. This review is aimed to address some essential fermented fruits and vegetables in Malaysia and their remarkable reputations as a potential sources of natural probiotics.展开更多
Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and genotype.Methods:In total,42 clinical isolates were colle...Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and genotype.Methods:In total,42 clinical isolates were collected between October 2017 and December 2019.Those isolates were analysed for antimicrobial susceptibility,serotype distribution,detection of pneumococcal virulence and pilus genes.Multilocus sequence typing was performed only for piliated isolates,followed by phylogenetic analysis.Results:The common isolation sites among the pneumococcal isolates were tracheal aspirate(28.6%),blood(26.2%),and sputum(23.8%).Fifty percent isolates were resistant to erythromycin,tetracycline(50.0%)and trimethoprim-sulfamethoxazole(43.0%).The most frequent were serotypes 19F(28.6%),6A/B(23.8%)and 19A(14.3%).Piliated isolates were detected in a small proportion(33.3%);64.3%were multidrug-resistant.ST320 was the prevalent sequence type among the piliated isolates and genetically related to the Pneumococcal Molecular Epidemiology Network clones Taiwan19F-14(CC271).In the phylogenetic analysis,some piliated isolates showed a close association having similar ST320,carrying serotype 19A and both pilus genes indicating their clonal spread.Conclusions:Pneumococcal lineages of piliated isolates have been globally disseminated and pili could have played a role in the spread of antibiotic resistant clones.展开更多
This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and Ae.albopictus in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophos...This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and Ae.albopictus in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophosphates and pyrethroids.Biological and environmental controls were summarized with an emphasis on the mosquito vector control strategies in Malaysia.The information in this review was extracted from several databases such as PubMed(MEDLINE),Science Direct and Scopus by using keywords including“insecticide resistance”,“carbamate resistance”,“organochlorine resistance”,“organophosphate resistance”,“pyrethroid resistance”,“Aedes”and“Malaysia”,between January 2022 and December 2022.Distribution of resistant Ae.aegypti and Ae.albopictus in Malaysia was mapped using QGIS software.Insecticide resistance in both Ae.aegypti and Ae.albopictus is widespread in Malaysia,although the rates vary by states.The most notable was the steep increase in permethrin resistance of Ae.aegypti in Selangor,Malaysia,over the past decade.Ae.albopictus also displayed moderate resistance to permethrin,though not as widespread as Ae.aegypti in Selangor,but showed sign of resistance in Sarawak,East Malaysia.Resistance towards four main classes of insecticides have been widely documented in Malaysia.The extensive resistance towards permethrin in Malaysia which is one of the current insecticides used in Malaysia suggested that policies supporting the widespread use of permethrin fogging needs further evaluation.展开更多
Objective:To determine the frequency and severity of the breakthrough infections and the associated factors in Malaysia.Methods:This cross-sectional study was conducted among the adult general population in Malaysia w...Objective:To determine the frequency and severity of the breakthrough infections and the associated factors in Malaysia.Methods:This cross-sectional study was conducted among the adult general population in Malaysia who completed at least one dose of vaccination.The validated online questionnaires were used for data collection between December 2022 to February 2023.The participants were recruited by a convenient sampling method.The data were analysed by descriptive statistics,and logistic regression by using SPSS(Version 27).Qualitative data from open-ended questions were analysed as thematic analysis by using RQDA software.Results:A total of 524 participants'data were analyzed and 77.5%of them completed three doses of COVID-19 vaccination.Breakthrough infections after vaccination were reported in 57.3%of the participants.Age group of 18 and 30 years(aOR 2.32,95%CI 1.01-5.32)and other ethnicities(aOR 2.00,95%CI 1.02-3.93)significantly associated with the occurrence of breakthrough infections.A total of 35.5%of the participants were not willing to take another booster dose in the future because of their attitudes towards fear of long-term side effects,lack of trust to the vaccine,less susceptibility to severe infection,belief in natural immunity,and myths.Conclusions:Future public health policies and interventions should be focused on disseminating the information about safety of booster doses of vaccine,management and re-assurance of side effects,and targeted vaccination to the working(younger age group)and ethnic minorities.展开更多
AIM:To derive a Malaysia guideline and consensus as part of the Malaysia Retina Group's efforts for diagnosis,treatment,and best practices of diabetic macular edema(DME).The experts'panel suggests that the tre...AIM:To derive a Malaysia guideline and consensus as part of the Malaysia Retina Group's efforts for diagnosis,treatment,and best practices of diabetic macular edema(DME).The experts'panel suggests that the treatment algorithm to be divided into groups according to involvement the central macula.The purpose of DME therapy is to improve edema and achieve the best visual results with the least amount of treatment load.METHODS:On two different occasions,a panel of 14 retinal specialists from Malaysia,together with an external expert,responded to a questionnaire on management of DME.A consensus was sought by voting after compiling,analyzing and discussion on first-phase replies on the round table discussion.A recommendation was deemed to have attained consensus when 12 out of the 14 panellists(85%)agreed with it.RESULTS:The terms target response,adequate response,nonresponse,and inadequate response were developed when the DME patients'treatment responses were first characterized.The panelists reached agreement on a number of DME treatment-related issues,including the need to classify patients prior to treatment,firstline treatment options,the right time to switch between treatment modalities,and side effects associated with steroids.From this agreement,recommendations were derived and a treatment algorithm was created.CONCLUSION:A detail and comprehensive treatment algorithm by Malaysia Retina Group for the Malaysian population provides guidance for treatment allocation of patients with DME.展开更多
Smartphone ownership among adolescents is getting common in this decade especially in Malaysia;Adolescent are strongly devoted to their smartphone and this may lead to smartphone addiction.Studies have reported that s...Smartphone ownership among adolescents is getting common in this decade especially in Malaysia;Adolescent are strongly devoted to their smartphone and this may lead to smartphone addiction.Studies have reported that smartphone addiction has become an emerging social and health problem especially among the youth in many countries however there is lack of study among adolescents in Malaysia.This study aimed to examine the prevalence and factors associated with smartphone addiction among adolescents in Malaysia.This was a cross-sectional study involving adolescents from 15 primary care clinics throughout the country.Respondents were assessed on their smartphone activities using the Malaysian short version of the Smartphone addiction scale(SAS-M-SV).Multiple logistic regression was used to determine the predictors of smartphone addiction among adolescents.The study was conducted among 921 adolescents with 49.6%male(n=457).The mean age of adolescents was 16.4±2.4 years.The ethnicity distribution were 74.6%Malay,7.3%Chinese,4.7%Indian and 13.4%other ethnicities.The prevalence of smartphone addiction was 37.1%(342/921);37.4%in male and 36.9%in female.Based on multiple logistic regression analysis,longer duration of smartphone use per week was associated with higher odds of smartphone addiction among adolescent(odd ratio=1.005%,95%confidence interval=1.000–1.009,p-value=0.039).Smartphone addiction is present in nearly four in ten adolescents in Malaysia.Adolescents who spend longer duration in smartphone usage per week were associated with higher odds of having smartphone addiction.Parents should be more alert and vigilant about this finding.Hence,parents should limit their children from spending too much of time with smartphone in order to prevent their children from getting smartphone addiction.展开更多
Rubber producers,consumers,traders,and those who are involved in the rubber industry face major risks of rubber price fluctuations.As a result,decision-makers are required to make an accurate estimation of the price o...Rubber producers,consumers,traders,and those who are involved in the rubber industry face major risks of rubber price fluctuations.As a result,decision-makers are required to make an accurate estimation of the price of rubber.This paper aims to propose hybrid intelligent models,which can be utilized to forecast the price of rubber in Malaysia by employing monthly Malaysia’s rubber pricing data,spanning from January 2016 to March 2021.The projected hybrid model consists of different algorithms with the symbolic Radial Basis Functions Neural Network k-Satisfiability Logic Mining(RBFNN-kSAT).These algorithms,including Grey Wolf Optimization Algorithm,Artificial Bee Colony Algorithm,and Particle Swarm Optimization Algorithm were utilized in the forecasting data analysis.Several factors,which affect the monthly price of rubber,such as rubber production,total exports of rubber,total imports of rubber,stocks of rubber,currency exchange rate,and crude oil prices were also considered in the analysis.To evaluate the results of the introduced model,a comparison has been conducted for each model to identify the most optimum model for forecasting the price of rubber.The findings showed that GWO with RBFNN-kSAT represents the most accurate and efficient model compared with ABC with RBFNNkSAT and PSO with RBFNN-kSAT in forecasting the price of rubber.The GWO with RBFNN-kSAT obtained the greatest average accuracy(92%),with a better correlation coefficient R=0.983871 than ABC with RBFNN-kSAT and PSO with RBFNN-kSAT.Furthermore,the empirical results of this study provided several directions for policymakers to make the right decision in terms of devising proper measures in the industry to address frequent price changes so that the Malaysian rubber industry maintains dominance in the international markets.展开更多
In the global medical industry,stem-cell therapy and regenerative medicine are two of the most popular topics at the moment.They have further attracted public attention as the research shows that stem-cell therapy may...In the global medical industry,stem-cell therapy and regenerative medicine are two of the most popular topics at the moment.They have further attracted public attention as the research shows that stem-cell therapy may be the best way to cure diseases such as strokes and type II diabetes.展开更多
With the adjustment of China's domestic policies,outbound travel by Chinese groups,with destinations of 20 countries including Malaysia,is getting recovery in an orderly way,and outbound travel by Chinese tour gro...With the adjustment of China's domestic policies,outbound travel by Chinese groups,with destinations of 20 countries including Malaysia,is getting recovery in an orderly way,and outbound travel by Chinese tour groups and free travel of"air ticket+hotel"have officially returned to Malaysia's tourist market.展开更多
Based on first-hand materials obtained from field investigations in Malaysia, the results show that: firstly, there are 17 initials in the Leizhou dialect of Malaysia, including the implosives initial and the [f] init...Based on first-hand materials obtained from field investigations in Malaysia, the results show that: firstly, there are 17 initials in the Leizhou dialect of Malaysia, including the implosives initial and the [f] initial. The pronunciation of Leizhou dialect in China is already rare, some of which are retained in the Leizhou dialect of Malaysia. Its initial consonant is borrowed from local Hua Yu or other Chinese dialects. Secondly, the Leizhou dialect of Malaysia has 46 finals. The pronunciation and timbre of some of its vowels are similar to the Yue dialect of Malaysia [ɐ] main vowel. Thirdly, there are 8 monosyllabic tones in the Leizhou dialect of Malaysia. The pronunciation and tone of some of its characters are similar to the Xia Yin entering tone of Yue dialect of Malaysia.展开更多
Objective:To study the epidemiology of Helicobacter pylori(H.pylori) infection according to age group.Methods:H.pylori infection data among 1 965 consecutive patients referred to the Endoscopy Unit collected at Sungai...Objective:To study the epidemiology of Helicobacter pylori(H.pylori) infection according to age group.Methods:H.pylori infection data among 1 965 consecutive patients referred to the Endoscopy Unit collected at Sungai Petani Hospital for oesophagogastro-duodenoscopy(OGD). The patients were divided into 9 age groups(10-19,20-29,30-39,40-49,50-59,60-69,70-79, 80-89 and 90-99 years).In addition these groups were further divided into three minor group namely young adults(10-39),older adults(40-69) and geriatric groups(70-99).Results:Overall prevalence of infection of H.pylori was analyzed and found that the prevalence increase with age (P【0.05).When the patients divided by ethnic and gender group with age,prevalence rate among young adults and older adults significantly higher(P【0.05) compared to geriatric groups across all races and gender(P【0.05).Furthermore,significantly higher number of males were infected compared to female(P【0.05) but such trend was only observed among older adult groups.In addition,there is a significant differences in H.pylori infection prevalence rates among ethnic groups(highest in Indians adults,followed Chinese and low in Malays,P【0.05).Conclusions: The overall prevalence of H.pylori did increase with age group across ethnicity and gender,in Northern Peninsular Malaysia.展开更多
BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type ...BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type 2 diabetes patients in a primary care clinic in Malaysia.METHODS This is a cross sectional study involving 322 patients with type 2 diabetes mellitus(DM)followed up in a primary care clinic.Systematic sampling method was used for patient recruitment.The Diabetes Empowerment Scale(DES)questionnaire was used to measure patient empowerment.It consists of three domains:(1)Managing the psychosocial aspect of diabetes(9 items);(2)Assessing dissatisfaction and readiness to change(9 items);and(3)Setting and achieving diabetes goal(10 items).A score was considered high if it ranged from 100 to 140.Data analysis was performed using SPSS version 25 and multiple linear regressions was used to identify the predictors of total diabetes empowerment scores.RESULTS The median age of the study population was 55 years old.56%were male and the mean duration of diabetes was 4 years.The total median score of the DES was 110[interquartile range(IQR)=10].The median scores of the three subscales were 40 with(IQR=4)for"Managing the psychosocial aspect of diabetes";36 with(IQR=3)for"Assessing dissatisfaction and readiness to change";and 34 with(IQR=5)for"Setting and achieving diabetes goal".According to multiple linear regressions,factors that had significant correlation with higher empowerment scores among type 2 diabetes patients included an above secondary education level(P<0.001),diabetes education exposure(P=0.003),lack of ischemic heart disease(P=0.017),and lower glycated hemoglobin(HbA1c)levels(P<0.001).CONCLUSION Diabetes empowerment scores were high among type 2 diabetes patients in this study population.Predictors for high empowerment scores included above secondary education level,diabetes education exposure,lack of ischemic heart disease status and lower HbA1c.展开更多
The contribution of phytoliths to total biogenic silica(BSi) volumes in rivers worldwide,and the associated implications for the biogeochemical cycle,require in-depth study.Based on samples from rivers in Peninsular M...The contribution of phytoliths to total biogenic silica(BSi) volumes in rivers worldwide,and the associated implications for the biogeochemical cycle,require in-depth study.Based on samples from rivers in Peninsular Malaysia,this project investigated the source and characteristics of B Si found in Asian tropical rivers,as well as the process of reverse weathering taking place in these fluvial systems.Results indicated that BSi samples collected in sediments consisted of phytolith,diatom and sponge spicules.Phytoliths,predominantly of the elongate form,comprised 92.8%-98.3% of BSi in the Pahang River.Diatom BSi in this river consisted mainly of pennatae diatoms,but represented a relatively small proportion of the total BSi volume.However,diatom BSi(predominantly of the Centricae form) was more prevalent in the Pontian and Endau Rivers with shares of 68.8% and 79.3% of the total BSi volumes,respectively,than Pahang River.Carbon contents of the BSi particulates ranged from 1.85% to 10.8% with an average of 4.79%.These values are higher than those recorded in other studies to date,and indicate that BSi plays a major role in controlling permanent carbon burial.This study suggests that phytoliths from terrestrial plants are the primary constituents of BSi in the rivers of Peninsular Malaysia,and therefore represent a significant proportion of the coastal silica budget.展开更多
Objective:To identify the circulating serotypes of human echovinis in Malaysia from 2002 in 2013.Methods:A toial of 31 retrospective samples from non-polio acute flacid paralysis,hand-food-and-mouth disease,viral meni...Objective:To identify the circulating serotypes of human echovinis in Malaysia from 2002 in 2013.Methods:A toial of 31 retrospective samples from non-polio acute flacid paralysis,hand-food-and-mouth disease,viral meningitis and enterovirus cases were subjected to amplification of partial VPI gene by RT-PCR.Results:Sequencing and phylogeneiic analysis of the partial sequences identified presence of human echovinis and human coxsackie viruses.It was found that echovinis 11 was the commonly circulating serotype followed by echovinis6.echovinis 7.echovinis 3.echovinis 9.echovinis 30 and echovinis I in decreasing order.Additionally two types of human coxsackie virus isolates were detected which were coxsackie A24 and B3.Condusions:From the findings,there is a possibility that echovinis 11 is the predominant serotype among Malaysian patients with echovinis infection.However,a larger sample size will yield a more confident result to support this evidence.____________________展开更多
Background For patients with cardiovascular disease (CVD), co-existence of peripheral artery disease (PAD) predicts increased mortality, and such patients are also more likely to benefit from aggressive therapy. Surve...Background For patients with cardiovascular disease (CVD), co-existence of peripheral artery disease (PAD) predicts increased mortality, and such patients are also more likely to benefit from aggressive therapy. Surveillance of PAD is often neglected at health clinics. Our aim is to highlight the importance and ease of surveillance of PAD in patients with CVD. Objective To determine the prevalence of symptomatic and asymptomatic PAD in a Malaysian patient population with documented CVD. Methods and Results A total of 393 subjects with established CVD were recruited from three centres (85 women and 308 men), as part of a larger international (AGATHA) survey. PAD, determined by presence of claudicant symptoms on interview and/or abnormal ankle-brachial index (ABI) score of less than 0.9, was present in 21.4% of patients-of whom 64% were asymptomatic. Abnormal ABI is associated with higher systolic blood pressure and number of arterial beds affected. Conclusions Concomitant PAD is prevalent among CVD patients in Malaysia. ABI screening is simple and yields a high proportion of patients with extensive atherosclerosis who may require more aggressive atherosclerotic risk management.(J Geriatr Cardiol 2007;4:195-199.)展开更多
Objective:To analyze trends of dengue incidences and deaths in Malaysia from 2000 to 2010 as well as the predominant dengue virus serotypes during the last decade.Methods:We used the national data on annual reported c...Objective:To analyze trends of dengue incidences and deaths in Malaysia from 2000 to 2010 as well as the predominant dengue virus serotypes during the last decade.Methods:We used the national data on annual reported cases,deaths,incidence rate,mortality rate,and case fatality rate of dengue fever(DF) and dengue hemorrhagic fever(DHF) as well as dengue virus serotypes prevalent in Malaysia during the last decade.Trend/ regression lines were fitted to investigate the trend of dengue incidences and deaths due to the disease for a 11-year period(2000-2010).For the distribution of national incidence rate,mortality rate,and case fatality rate of DF and DHF, descriptive statistics using mean and 95%confidence intervals(C/) for means,and range were applied.Results:The number of dengue cases and number of deaths have increased,on average, by 14%and 8%per year respectively.The average annual incidence rate of DF per 100 000 populations was higher as compared to that of DIIF.Conversely,the yearly mean mortality rate of DHF per 100 000 populations was greater than that of DF.The simultaneous circulation of all four dengue serotypes has been found in Malaysia.But a particular dengue virus serotype predominates for at least two years before it becomes replaced by another serotype.Conclusions: The dengue situation in Malaysia has worsened with an increasing number of reported oases and deaths during the last decade.The increasing trend of dengue highlights the need for a more systematic surveillance and reporting of the disease.展开更多
This paper provides an overview of the engineering geology of limestone. Limestone is of rather wide occurrence in Malaysia. It is interesting in view of the unique landforms and karstic features that are encountered ...This paper provides an overview of the engineering geology of limestone. Limestone is of rather wide occurrence in Malaysia. It is interesting in view of the unique landforms and karstic features that are encountered in limestone terrains, e.g. steep, subvertical limestone cliffs rising abruptly and majestically above the ground surface and highly variable and pinnacled subterranean limestone bedrock. The karstic features and associated engineering geological problems of both the limestone hills and the bedrock are discussed in the paper. Rockfalls, sinkholes, cavities, etc. are some of the common engineering geological problems associated with limestone terrains. Some local case studies are provided as illustrations. Finally the rock mechanical properties of limestone is discussed at the end of the paper.展开更多
Objective:To identify the acari present on pet Burmese pythons in Malaysia and to determine whether there is any potential public health risk related to handling of the snakes.Methods: Two sub-adult Burmese pythons ke...Objective:To identify the acari present on pet Burmese pythons in Malaysia and to determine whether there is any potential public health risk related to handling of the snakes.Methods: Two sub-adult Burmese pythons kept as pets for a period of about 6 to 7 months by different owners,were brought to an exotic animal practice for treatment.On a complete medical examination,some ticks and mites(acari) were detected beneath the dorsal and ventral scales along body length of the snakes.Ticks were directly identified and mites were mounted prior to identification.Results:A total of 12 ticks represented by 3 males,2 females and 7 nymphal stages of Rhipicephalus sanguineus(R.sanguineus) were extracted from the first python while the other one was with 25 female Ophionyssus natricis(O.natricis) mesostigmatid mites.Only adult female mites were found.These mites are common ectoparasites of Burmese pythons. Conclusions:Both the acarine species found on the Burmese pythons are known vectors of pathogens.This is the first record that R.sanguineus has been reported from a pet Burmese python in Malaysia.展开更多
基金funded by the Taylor’s University Flagship Research Grant(TUFR/2017/002/03).
文摘Objective:To explore existing practices and challenges in the delivery of geriatric home medication review(HMR).The study was part of a larger study aimed to offer solution to expand the range of geriatric HMR.Methods:This study employed qualitative exploratory design through semi-structured individual in-depth interviews with the public pharmacists involved in the delivery of geriatric HMR at public hospitals.The purpose of the interviews was to explore challenges faced by them in the delivery of geriatric HMR.Results:Based on the emerging themes from the qualitative data,the study reveals that geriatric HMR in Malaysia is integrated as part of multidisciplinary home care visits,encompassing a diverse patient population with various healthcare needs.However,it faces challenges such as the lack of outcome monitoring,formal training,and workforce constraints.Despite these hurdles,there is a pressing need for the expansion of this service to better serve the community,and collaboration with community pharmacists holds potential to broaden its scope.Ultimately,the findings suggest that pharmacist-led HMR is both warranted and feasible within the Malaysian healthcare context.In order to optimize medicine-use among older people living in the community,approaches for expanding geriatric HMR services in Malaysia must be developed.Conclusions:This study holds profound implications as it attempts to illuminate policy makers in developing countries,enabling them to formulate effective HMR plans.By considering the challenges highlighted within this research,policy makers can design a comprehensive HMR service that caters adeptly to the healthcare needs of the mass population.
基金Universiti Malaysia Sarawak for the support of this research。
文摘In the Peninsular Malaysia and Northern Borneo island of Malaysia, various rich indigenous leafy vegetables and fruits grow and contribute to the nutritional and dietary values of the population. They have high water contents, thus, naturally vulnerable to rapid food spoilage. Food preservation and processing play a vital role in the inhibition of food pathogens in fruits and vegetables that are prevalent in Malaysia. Lactic acid fermentation is generally a local-based bioprocess, among the oldest form and well-known for food-processing techniques among indigenous people there. The long shelf life of fermented vegetables and fruits improves their nutritional values and antioxidant potentials. Fermented leaves and vegetables can be utilized as a potential source of probiotics as they are host for several lactic acid bacteria such as Lactobacillus confusus, Weissella paramesenteroides, Enterococcus faecalis, Lactobacillus plantarum, Lactobacillus buchneri, Lactobacillus paracasei, Lactobacillus pentosus, Pediococcus acidilactici, Pediococcus pentosaceus and Leuconostoc mesenteroides. These strains may be more viable in metabolic systems whereby they can contribute to a substantial increase in essential biologically active element than industrial starter cultures. This review is aimed to address some essential fermented fruits and vegetables in Malaysia and their remarkable reputations as a potential sources of natural probiotics.
基金supported by Fundamental Research Grant Scheme(FRGS/1/2020/SKK0/UPM/02/10)of the Ministry of Higher Education Malaysia.
文摘Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and genotype.Methods:In total,42 clinical isolates were collected between October 2017 and December 2019.Those isolates were analysed for antimicrobial susceptibility,serotype distribution,detection of pneumococcal virulence and pilus genes.Multilocus sequence typing was performed only for piliated isolates,followed by phylogenetic analysis.Results:The common isolation sites among the pneumococcal isolates were tracheal aspirate(28.6%),blood(26.2%),and sputum(23.8%).Fifty percent isolates were resistant to erythromycin,tetracycline(50.0%)and trimethoprim-sulfamethoxazole(43.0%).The most frequent were serotypes 19F(28.6%),6A/B(23.8%)and 19A(14.3%).Piliated isolates were detected in a small proportion(33.3%);64.3%were multidrug-resistant.ST320 was the prevalent sequence type among the piliated isolates and genetically related to the Pneumococcal Molecular Epidemiology Network clones Taiwan19F-14(CC271).In the phylogenetic analysis,some piliated isolates showed a close association having similar ST320,carrying serotype 19A and both pilus genes indicating their clonal spread.Conclusions:Pneumococcal lineages of piliated isolates have been globally disseminated and pili could have played a role in the spread of antibiotic resistant clones.
基金support from Ministry of Higher Education Malaysia for funding Fundamental Research Grant Scheme FRGS 2020-1 (FRGS/1/2020/WAB02/MSU/02/1)Management and Science University for funding Seed Research Grant Phase 1/2020 (SG-008-012020-FHLS).
文摘This review aimed to determine the prevalence of the insecticide resistance status of the field-collected Aedes(Ae.)aegypti and Ae.albopictus in Malaysia from 2010 to 2022 towards carbamates,organochlorines,organophosphates and pyrethroids.Biological and environmental controls were summarized with an emphasis on the mosquito vector control strategies in Malaysia.The information in this review was extracted from several databases such as PubMed(MEDLINE),Science Direct and Scopus by using keywords including“insecticide resistance”,“carbamate resistance”,“organochlorine resistance”,“organophosphate resistance”,“pyrethroid resistance”,“Aedes”and“Malaysia”,between January 2022 and December 2022.Distribution of resistant Ae.aegypti and Ae.albopictus in Malaysia was mapped using QGIS software.Insecticide resistance in both Ae.aegypti and Ae.albopictus is widespread in Malaysia,although the rates vary by states.The most notable was the steep increase in permethrin resistance of Ae.aegypti in Selangor,Malaysia,over the past decade.Ae.albopictus also displayed moderate resistance to permethrin,though not as widespread as Ae.aegypti in Selangor,but showed sign of resistance in Sarawak,East Malaysia.Resistance towards four main classes of insecticides have been widely documented in Malaysia.The extensive resistance towards permethrin in Malaysia which is one of the current insecticides used in Malaysia suggested that policies supporting the widespread use of permethrin fogging needs further evaluation.
文摘Objective:To determine the frequency and severity of the breakthrough infections and the associated factors in Malaysia.Methods:This cross-sectional study was conducted among the adult general population in Malaysia who completed at least one dose of vaccination.The validated online questionnaires were used for data collection between December 2022 to February 2023.The participants were recruited by a convenient sampling method.The data were analysed by descriptive statistics,and logistic regression by using SPSS(Version 27).Qualitative data from open-ended questions were analysed as thematic analysis by using RQDA software.Results:A total of 524 participants'data were analyzed and 77.5%of them completed three doses of COVID-19 vaccination.Breakthrough infections after vaccination were reported in 57.3%of the participants.Age group of 18 and 30 years(aOR 2.32,95%CI 1.01-5.32)and other ethnicities(aOR 2.00,95%CI 1.02-3.93)significantly associated with the occurrence of breakthrough infections.A total of 35.5%of the participants were not willing to take another booster dose in the future because of their attitudes towards fear of long-term side effects,lack of trust to the vaccine,less susceptibility to severe infection,belief in natural immunity,and myths.Conclusions:Future public health policies and interventions should be focused on disseminating the information about safety of booster doses of vaccine,management and re-assurance of side effects,and targeted vaccination to the working(younger age group)and ethnic minorities.
文摘AIM:To derive a Malaysia guideline and consensus as part of the Malaysia Retina Group's efforts for diagnosis,treatment,and best practices of diabetic macular edema(DME).The experts'panel suggests that the treatment algorithm to be divided into groups according to involvement the central macula.The purpose of DME therapy is to improve edema and achieve the best visual results with the least amount of treatment load.METHODS:On two different occasions,a panel of 14 retinal specialists from Malaysia,together with an external expert,responded to a questionnaire on management of DME.A consensus was sought by voting after compiling,analyzing and discussion on first-phase replies on the round table discussion.A recommendation was deemed to have attained consensus when 12 out of the 14 panellists(85%)agreed with it.RESULTS:The terms target response,adequate response,nonresponse,and inadequate response were developed when the DME patients'treatment responses were first characterized.The panelists reached agreement on a number of DME treatment-related issues,including the need to classify patients prior to treatment,firstline treatment options,the right time to switch between treatment modalities,and side effects associated with steroids.From this agreement,recommendations were derived and a treatment algorithm was created.CONCLUSION:A detail and comprehensive treatment algorithm by Malaysia Retina Group for the Malaysian population provides guidance for treatment allocation of patients with DME.
文摘Smartphone ownership among adolescents is getting common in this decade especially in Malaysia;Adolescent are strongly devoted to their smartphone and this may lead to smartphone addiction.Studies have reported that smartphone addiction has become an emerging social and health problem especially among the youth in many countries however there is lack of study among adolescents in Malaysia.This study aimed to examine the prevalence and factors associated with smartphone addiction among adolescents in Malaysia.This was a cross-sectional study involving adolescents from 15 primary care clinics throughout the country.Respondents were assessed on their smartphone activities using the Malaysian short version of the Smartphone addiction scale(SAS-M-SV).Multiple logistic regression was used to determine the predictors of smartphone addiction among adolescents.The study was conducted among 921 adolescents with 49.6%male(n=457).The mean age of adolescents was 16.4±2.4 years.The ethnicity distribution were 74.6%Malay,7.3%Chinese,4.7%Indian and 13.4%other ethnicities.The prevalence of smartphone addiction was 37.1%(342/921);37.4%in male and 36.9%in female.Based on multiple logistic regression analysis,longer duration of smartphone use per week was associated with higher odds of smartphone addiction among adolescent(odd ratio=1.005%,95%confidence interval=1.000–1.009,p-value=0.039).Smartphone addiction is present in nearly four in ten adolescents in Malaysia.Adolescents who spend longer duration in smartphone usage per week were associated with higher odds of having smartphone addiction.Parents should be more alert and vigilant about this finding.Hence,parents should limit their children from spending too much of time with smartphone in order to prevent their children from getting smartphone addiction.
基金supported by the Ministry of Higher Education Malaysia (MOHE)through the Fundamental Research Grant Scheme (FRGS),FRGS/1/2022/STG06/USM/02/11 and Universiti Sains Malaysia.
文摘Rubber producers,consumers,traders,and those who are involved in the rubber industry face major risks of rubber price fluctuations.As a result,decision-makers are required to make an accurate estimation of the price of rubber.This paper aims to propose hybrid intelligent models,which can be utilized to forecast the price of rubber in Malaysia by employing monthly Malaysia’s rubber pricing data,spanning from January 2016 to March 2021.The projected hybrid model consists of different algorithms with the symbolic Radial Basis Functions Neural Network k-Satisfiability Logic Mining(RBFNN-kSAT).These algorithms,including Grey Wolf Optimization Algorithm,Artificial Bee Colony Algorithm,and Particle Swarm Optimization Algorithm were utilized in the forecasting data analysis.Several factors,which affect the monthly price of rubber,such as rubber production,total exports of rubber,total imports of rubber,stocks of rubber,currency exchange rate,and crude oil prices were also considered in the analysis.To evaluate the results of the introduced model,a comparison has been conducted for each model to identify the most optimum model for forecasting the price of rubber.The findings showed that GWO with RBFNN-kSAT represents the most accurate and efficient model compared with ABC with RBFNNkSAT and PSO with RBFNN-kSAT in forecasting the price of rubber.The GWO with RBFNN-kSAT obtained the greatest average accuracy(92%),with a better correlation coefficient R=0.983871 than ABC with RBFNN-kSAT and PSO with RBFNN-kSAT.Furthermore,the empirical results of this study provided several directions for policymakers to make the right decision in terms of devising proper measures in the industry to address frequent price changes so that the Malaysian rubber industry maintains dominance in the international markets.
文摘In the global medical industry,stem-cell therapy and regenerative medicine are two of the most popular topics at the moment.They have further attracted public attention as the research shows that stem-cell therapy may be the best way to cure diseases such as strokes and type II diabetes.
文摘With the adjustment of China's domestic policies,outbound travel by Chinese groups,with destinations of 20 countries including Malaysia,is getting recovery in an orderly way,and outbound travel by Chinese tour groups and free travel of"air ticket+hotel"have officially returned to Malaysia's tourist market.
文摘Based on first-hand materials obtained from field investigations in Malaysia, the results show that: firstly, there are 17 initials in the Leizhou dialect of Malaysia, including the implosives initial and the [f] initial. The pronunciation of Leizhou dialect in China is already rare, some of which are retained in the Leizhou dialect of Malaysia. Its initial consonant is borrowed from local Hua Yu or other Chinese dialects. Secondly, the Leizhou dialect of Malaysia has 46 finals. The pronunciation and timbre of some of its vowels are similar to the Yue dialect of Malaysia [ɐ] main vowel. Thirdly, there are 8 monosyllabic tones in the Leizhou dialect of Malaysia. The pronunciation and tone of some of its characters are similar to the Xia Yin entering tone of Yue dialect of Malaysia.
基金S.Jo Thy Lachumy was supported by Universiti Sains Malaysia fellowship from Institute for Postgraduate Studies,Universiti Sains Malaysiasupported by USM Incentive Grant from University Sains Malaysia
文摘Objective:To study the epidemiology of Helicobacter pylori(H.pylori) infection according to age group.Methods:H.pylori infection data among 1 965 consecutive patients referred to the Endoscopy Unit collected at Sungai Petani Hospital for oesophagogastro-duodenoscopy(OGD). The patients were divided into 9 age groups(10-19,20-29,30-39,40-49,50-59,60-69,70-79, 80-89 and 90-99 years).In addition these groups were further divided into three minor group namely young adults(10-39),older adults(40-69) and geriatric groups(70-99).Results:Overall prevalence of infection of H.pylori was analyzed and found that the prevalence increase with age (P【0.05).When the patients divided by ethnic and gender group with age,prevalence rate among young adults and older adults significantly higher(P【0.05) compared to geriatric groups across all races and gender(P【0.05).Furthermore,significantly higher number of males were infected compared to female(P【0.05) but such trend was only observed among older adult groups.In addition,there is a significant differences in H.pylori infection prevalence rates among ethnic groups(highest in Indians adults,followed Chinese and low in Malays,P【0.05).Conclusions: The overall prevalence of H.pylori did increase with age group across ethnicity and gender,in Northern Peninsular Malaysia.
基金Supported by research grant from University Putra Malaysia,No.GPIPS/2018/9612600
文摘BACKGROUND There are limited studies on diabetes empowerment among type 2 diabetes patients,particularly in the primary care setting.AIM To assess the diabetes empowerment scores and its correlated factors among type 2 diabetes patients in a primary care clinic in Malaysia.METHODS This is a cross sectional study involving 322 patients with type 2 diabetes mellitus(DM)followed up in a primary care clinic.Systematic sampling method was used for patient recruitment.The Diabetes Empowerment Scale(DES)questionnaire was used to measure patient empowerment.It consists of three domains:(1)Managing the psychosocial aspect of diabetes(9 items);(2)Assessing dissatisfaction and readiness to change(9 items);and(3)Setting and achieving diabetes goal(10 items).A score was considered high if it ranged from 100 to 140.Data analysis was performed using SPSS version 25 and multiple linear regressions was used to identify the predictors of total diabetes empowerment scores.RESULTS The median age of the study population was 55 years old.56%were male and the mean duration of diabetes was 4 years.The total median score of the DES was 110[interquartile range(IQR)=10].The median scores of the three subscales were 40 with(IQR=4)for"Managing the psychosocial aspect of diabetes";36 with(IQR=3)for"Assessing dissatisfaction and readiness to change";and 34 with(IQR=5)for"Setting and achieving diabetes goal".According to multiple linear regressions,factors that had significant correlation with higher empowerment scores among type 2 diabetes patients included an above secondary education level(P<0.001),diabetes education exposure(P=0.003),lack of ischemic heart disease(P=0.017),and lower glycated hemoglobin(HbA1c)levels(P<0.001).CONCLUSION Diabetes empowerment scores were high among type 2 diabetes patients in this study population.Predictors for high empowerment scores included above secondary education level,diabetes education exposure,lack of ischemic heart disease status and lower HbA1c.
基金Supported by the National Natural Science Foundation of China(Nos.41106072,41376093)the International Collaboration Science Plan(No.GASI-01-02-01-04)
文摘The contribution of phytoliths to total biogenic silica(BSi) volumes in rivers worldwide,and the associated implications for the biogeochemical cycle,require in-depth study.Based on samples from rivers in Peninsular Malaysia,this project investigated the source and characteristics of B Si found in Asian tropical rivers,as well as the process of reverse weathering taking place in these fluvial systems.Results indicated that BSi samples collected in sediments consisted of phytolith,diatom and sponge spicules.Phytoliths,predominantly of the elongate form,comprised 92.8%-98.3% of BSi in the Pahang River.Diatom BSi in this river consisted mainly of pennatae diatoms,but represented a relatively small proportion of the total BSi volume.However,diatom BSi(predominantly of the Centricae form) was more prevalent in the Pontian and Endau Rivers with shares of 68.8% and 79.3% of the total BSi volumes,respectively,than Pahang River.Carbon contents of the BSi particulates ranged from 1.85% to 10.8% with an average of 4.79%.These values are higher than those recorded in other studies to date,and indicate that BSi plays a major role in controlling permanent carbon burial.This study suggests that phytoliths from terrestrial plants are the primary constituents of BSi in the rivers of Peninsular Malaysia,and therefore represent a significant proportion of the coastal silica budget.
基金supported by Institute for Medical Research Operational Grant(Vol:040300/OS27403)
文摘Objective:To identify the circulating serotypes of human echovinis in Malaysia from 2002 in 2013.Methods:A toial of 31 retrospective samples from non-polio acute flacid paralysis,hand-food-and-mouth disease,viral meningitis and enterovirus cases were subjected to amplification of partial VPI gene by RT-PCR.Results:Sequencing and phylogeneiic analysis of the partial sequences identified presence of human echovinis and human coxsackie viruses.It was found that echovinis 11 was the commonly circulating serotype followed by echovinis6.echovinis 7.echovinis 3.echovinis 9.echovinis 30 and echovinis I in decreasing order.Additionally two types of human coxsackie virus isolates were detected which were coxsackie A24 and B3.Condusions:From the findings,there is a possibility that echovinis 11 is the predominant serotype among Malaysian patients with echovinis infection.However,a larger sample size will yield a more confident result to support this evidence.____________________
文摘Background For patients with cardiovascular disease (CVD), co-existence of peripheral artery disease (PAD) predicts increased mortality, and such patients are also more likely to benefit from aggressive therapy. Surveillance of PAD is often neglected at health clinics. Our aim is to highlight the importance and ease of surveillance of PAD in patients with CVD. Objective To determine the prevalence of symptomatic and asymptomatic PAD in a Malaysian patient population with documented CVD. Methods and Results A total of 393 subjects with established CVD were recruited from three centres (85 women and 308 men), as part of a larger international (AGATHA) survey. PAD, determined by presence of claudicant symptoms on interview and/or abnormal ankle-brachial index (ABI) score of less than 0.9, was present in 21.4% of patients-of whom 64% were asymptomatic. Abnormal ABI is associated with higher systolic blood pressure and number of arterial beds affected. Conclusions Concomitant PAD is prevalent among CVD patients in Malaysia. ABI screening is simple and yields a high proportion of patients with extensive atherosclerosis who may require more aggressive atherosclerotic risk management.(J Geriatr Cardiol 2007;4:195-199.)
基金funded and supported by the Dana Operasi Universiti Penyelidikan(Ref No.UKM-OUP-PI-25-114/2011)Arus Perdana(Ref.No.UKM-AP-PI -18-2009/3>)Crant Universiti Penynlidikan(Ref.No.UKM-GUP-PI-08-35-083)
文摘Objective:To analyze trends of dengue incidences and deaths in Malaysia from 2000 to 2010 as well as the predominant dengue virus serotypes during the last decade.Methods:We used the national data on annual reported cases,deaths,incidence rate,mortality rate,and case fatality rate of dengue fever(DF) and dengue hemorrhagic fever(DHF) as well as dengue virus serotypes prevalent in Malaysia during the last decade.Trend/ regression lines were fitted to investigate the trend of dengue incidences and deaths due to the disease for a 11-year period(2000-2010).For the distribution of national incidence rate,mortality rate,and case fatality rate of DF and DHF, descriptive statistics using mean and 95%confidence intervals(C/) for means,and range were applied.Results:The number of dengue cases and number of deaths have increased,on average, by 14%and 8%per year respectively.The average annual incidence rate of DF per 100 000 populations was higher as compared to that of DIIF.Conversely,the yearly mean mortality rate of DHF per 100 000 populations was greater than that of DF.The simultaneous circulation of all four dengue serotypes has been found in Malaysia.But a particular dengue virus serotype predominates for at least two years before it becomes replaced by another serotype.Conclusions: The dengue situation in Malaysia has worsened with an increasing number of reported oases and deaths during the last decade.The increasing trend of dengue highlights the need for a more systematic surveillance and reporting of the disease.
文摘This paper provides an overview of the engineering geology of limestone. Limestone is of rather wide occurrence in Malaysia. It is interesting in view of the unique landforms and karstic features that are encountered in limestone terrains, e.g. steep, subvertical limestone cliffs rising abruptly and majestically above the ground surface and highly variable and pinnacled subterranean limestone bedrock. The karstic features and associated engineering geological problems of both the limestone hills and the bedrock are discussed in the paper. Rockfalls, sinkholes, cavities, etc. are some of the common engineering geological problems associated with limestone terrains. Some local case studies are provided as illustrations. Finally the rock mechanical properties of limestone is discussed at the end of the paper.
文摘Objective:To identify the acari present on pet Burmese pythons in Malaysia and to determine whether there is any potential public health risk related to handling of the snakes.Methods: Two sub-adult Burmese pythons kept as pets for a period of about 6 to 7 months by different owners,were brought to an exotic animal practice for treatment.On a complete medical examination,some ticks and mites(acari) were detected beneath the dorsal and ventral scales along body length of the snakes.Ticks were directly identified and mites were mounted prior to identification.Results:A total of 12 ticks represented by 3 males,2 females and 7 nymphal stages of Rhipicephalus sanguineus(R.sanguineus) were extracted from the first python while the other one was with 25 female Ophionyssus natricis(O.natricis) mesostigmatid mites.Only adult female mites were found.These mites are common ectoparasites of Burmese pythons. Conclusions:Both the acarine species found on the Burmese pythons are known vectors of pathogens.This is the first record that R.sanguineus has been reported from a pet Burmese python in Malaysia.
