OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of ...OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship.展开更多
Traditional Chinese Medicine(TCM)has been extensively used as a mainstay for treating various pathologies.Combing the pharmacology and systems biology approaches,the network pharmacology(NP)approach was developed to p...Traditional Chinese Medicine(TCM)has been extensively used as a mainstay for treating various pathologies.Combing the pharmacology and systems biology approaches,the network pharmacology(NP)approach was developed to predict the probable mechanism underlying the therapeutic effect of TCM.However,approaches solely based on NP cannot effectively elucidate the curative mechanism in a holistic and reliable manner due to limitations in NP-based methods and complexity of TCM components.Thus,integration strategies combining NP with other approaches are increasingly being used.Since the interdisciplinary research in TCM has received much attention in the advent of the big data era of which the NPbased integration strategy is broadly used,the strategy is clearly elaborated in the present review.We summarized several NP-based integration strategies and their applications in TCM studies,including multi-omics approach,gut microbiota study,chemical information analysis,data-mining,and network toxicology study.展开更多
OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment...OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment,on the immunological nonresponse(INR)in people living with human immunodeficiency virus(HIV)(PLWH).METHODS:Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI),Wanfang Digital Journal,Chinese Medical Journal Database(CMJD),Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane,and Embase was reviewed by two independent investigators.Data were extracted from the studies according to the eligible criteria and analyzed using Review Manager 5.3.RESULTS:Nine randomized controlled trials(RCTs)with 1078 patients were analyzed.Our analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group[mean difference(MD)=13.51,95%confidence interval(CI):7.42-19.60,P<0.0001].There was no significant difference between the treated and control groups after 3 months(MD=25.31,95%CI:-2.78 to 53.41,P=0.08).However,after 6 and 12 months,the response of the treatment group was superior to the control group(MD=27.45,95%CI:7.09-47.81,P=0.008 and MD=27.34,95%CI:6.31–48.37,P=0.01,respectively).The clinical efficacy of the treatment group was also higher than that of the control group(RR=1.75,95%CI:1.16-2.65,P=0.007).However,CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD=12.37,95%CI:-6.71 to 31.45,P=0.20 and MD=5.67,95%CI:-3.00 to14.35,P=0.20,respectively).CONCLUSION:The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus,is beneficial and has potential use for improving INR in PLWH.However,large-scale RCTs are required to provide evidence for optimal intervention strategies.展开更多
OBJECTIVE:To describe a protocol to assess the effects of Traditional Chinese Medicine(TCM)on patients with coronary heart disease(CHD)showing symptoms of phlegm-heat-stasis symptom pattern.METHODS:This is a single-bl...OBJECTIVE:To describe a protocol to assess the effects of Traditional Chinese Medicine(TCM)on patients with coronary heart disease(CHD)showing symptoms of phlegm-heat-stasis symptom pattern.METHODS:This is a single-blind randomized controlled trial that will be conducted in the First Teaching Hospital of Tianjin University of TCM and 60 patients with CHD showing phlegm-heat-stasis symptom pattern will be included.Patients will be randomly divided into either a treatment group(Qingre Huatan formulae+Western Medicine)or to acontrol group(conventional Western Medicine only)for 7-14 d.Primary patient outcomes will be vascular endothelial function and quality of life.Measurement data will be expressed as mean±standard deviation using t-test analysis or repeated-measure variance analysis.Enumeration data will be expressed by cases and percentages,usingχ^(2) analysis,and rank sum test will be used for ranked data.RESULTS:This study further verified the effectiveness and safety of Qingre Huatan formulae for the phlegm-heat-stasis syndrome pattern of CHD on the basis of previous studies on the characteristics of syndromes and medication rules.DISCUSSION:Phlegm-heat-stasis symptom pattern has become a common manifestation in CHD.Standardized Western medications together with TCM have been extensively used in China and have developed into a comprehensive treatment model.Our trial will help formulate recommendations for symptom maintenance and provide clinical evidence for the application of TCM for patients with CHD showing phlegm-heat-stasis symptom pattern.展开更多
OBJECTIVE:To explore the factors influencing physicians’intentions to use Traditional Chinese Medicine(TCM)to treat coronavirus disease 2019(COVID-19).METHODS:A cross-sectional,self-report online survey was conducted...OBJECTIVE:To explore the factors influencing physicians’intentions to use Traditional Chinese Medicine(TCM)to treat coronavirus disease 2019(COVID-19).METHODS:A cross-sectional,self-report online survey was conducted from March 16,2020,to April 2,2020,in China.Participants were recruited through convenience and snowball sampling.Data were collected by using a self-designed questionnaire based on the Theory of Planned Behavior.Structural equation modeling was used for data analysis.RESULTS:A total of 494 physicians were enrolled in this study.Overall,the model explained 75.4%and 75.5%of the total variance in intention and attitude,respectively.Specifically,attitudes(β=0.467,P<0.001),past behavior(β=0.384,P<0.05),subjective norms(SN)(β=0.177,P<0.001),and perceived behavioral control(PBC)(β=0.133,P<0.05)significantly affected physicians’intention to use TCM.Cognition(β=0.606,P<0.001)and PBC(β=0.569,P<0.01)significantly influenced physicians’attitudes toward using TCM.SN(β=0.064,P=0.263)was not a factor affecting attitude.CONCLUSION:Physicians’intention to use TCM was significantly associated with attitude,past behavior,PBC,and SN.The findings may not only be useful for understanding the influencing factors and paths of physicians’intention to use TCM to treat COVID-19 but also provide a reference for health authorities and policymakers to promote physicians to utilize TCM.展开更多
OBJECTIVE:To explore the advantages of Traditional Chinese Medicine(TCM)in"prevention"and"control"of coronavirus disease 2019(COVID-19)pandemic.METHODS:In this paper,we wish to estimate the effect ...OBJECTIVE:To explore the advantages of Traditional Chinese Medicine(TCM)in"prevention"and"control"of coronavirus disease 2019(COVID-19)pandemic.METHODS:In this paper,we wish to estimate the effect on the virus transmission of scenarios assuming TCM were used to build the first defense line at the very early stage of the spread in Wuhan.We therefore first developed a classic susceptible infected removed(susceptible infected removed,SIR)transmission model based on the national data in China and then updated it to a TCM-SIR model to assess the potential impact of such assumptions,i.e.the underlying risk of lives lost and social economy loss.RESULTS:(a)With the nationwide community lockdown,the risk value was from 90000 to 250000 without TCM intervention and the risk value was from 70000 to 220000 with TCM intervention;(b)Based the risk assessment method,we forecasted that the infections peak would be 58016 without TCM intervention,which happened on February 172020.However,the infections peak would be 45713 with TCM intervention,which happened on 16 February 2020.CONCLUSIONS:The adoption of nationwide community lockdown is conducive to timely control the epidemic and protect people’s lives and safety.At the same time,we can get lower infections if TCM intervention can be considered.We can also get the benefits from TCM prevention of COVID-19 pandemic by the basic number of infections.展开更多
OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture healing.METHODS:An open fracture was created at the mid-shaft of...OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture healing.METHODS:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was prepared.The rats were treated with either CDR topically on the fracture site,or Sr R orally,or their combinations.Bone turnover biochemical markers in serum were measured.Microarchitecture of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical analysis.RESULTS:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of treatment.This result was consistent with the histomorphometrical analysis on the osteoid volume.Analysis of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after fracture.CONCLUSION:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption.展开更多
The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individua...The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM.展开更多
OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical ...OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue.Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included.Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue.On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control groups.Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer patients.No severe adverse effects occurred in traditional Chinese medical therapy groups.CONCLUSION:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.展开更多
OBJECTIVE:To explore the core herbs of two illustrious senior Traditional Chinese Medicine(TCM)Physicians for the treatment of liver cancer,and to further clarify the gene targets and pathway mechanisms of liver cance...OBJECTIVE:To explore the core herbs of two illustrious senior Traditional Chinese Medicine(TCM)Physicians for the treatment of liver cancer,and to further clarify the gene targets and pathway mechanisms of liver cancer that the core prescription(CP)may regulate.METHODS:We used the patient information of two illustrious senior TCM physicians from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and the Affiliated Hospital of Capital Medical University as the database.The CP was analyzed using the community network algorithm.The pathway mechanism was analyzed using network pharmacology method.And the prognostic survival genes were identified using Single factor cox regression analysis.Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP),Herb,Online Mendelian Inheritance in Man(OMIM),Genecards,Kyoto Encyclopedia of Genes and Genomes(KEGG),Genomic Data Commons(GDC),The Cancer Genome Atlas(TCGA),Gephi and R were used to mine CP,building a pathway network diagram.All the analyses were visualized.RESULTS:We found that the CP consistes of Huangqi(Radix Astragali Mongolici),Danshen(Radix Salviae Miltiorrhizae),Shuihonghuazi(Polygoni Orientalis Fructus),Baihuasheshecao(Herba Hedyotdis),Banzhilian(Herba Scutellariae Barbatae),and Ezhu(Rhizoma Curcumae Phaeocaulis),which were attributed to the two physicians respectively.The CP played an anticancer role through such pathways as signal transduction,energy metabolism,immune system and other pathways,covering a total of 112 pathways and 176 herb-diseaserelated genes.Fourteen genes have a significant impact on the prognosis and survival of liver cancer.CONCLUSION:Based on the liver cancer cases of two illustrious senior TCM physicians,we obtained the CP through data mining.The CP may mainly exert anticancer effects by inhibiting inflammatory response,angiogenesis,and enhancing the body’s immune response.We screened out 14 genes in the CP that may be related to the prognosis of liver cancer,and these genes may play an important regulatory role in the prognosis of liver cancer.展开更多
OBJECTIVE:To investigate the in vitro and in vivo studies of natural compounds and medicinal plants with anti-coronavirus activity.METHODS:A systematic review was performed based on Preferred Reporting Items for Syste...OBJECTIVE:To investigate the in vitro and in vivo studies of natural compounds and medicinal plants with anti-coronavirus activity.METHODS:A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research:Reporting of in vivo experiments guidelines to find data for medicinal plants and natural products effective against human coronaviruses in in vitro or in vivo studies.Studies published up to September 6,2020 were included.Studies(in vitro or in vivo)reporting the effect of medicinal plants and natural products or their derivatives on human coronavirus were included RESULTS:Promising anti-coronavirus effects are seen with different herbal compounds like some diterpenoids,sesquiterpenoids,and three compounds in tea with 3 CLpro inhibiting effect of Severe Acute Respiratory Syndrome Coronavirus(SARS-Co V);Hirsutenone,Six cinnamic amides and bavachinin are PLpro inhibitors and Tanshinones are active on both 3 CLpro and PLpro.Some flavonoid compounds of Citrus fruits act on Immunoregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for entry.Virus helicase is possibly inhibited by two compounds myricetin and scutellarein.CONCLUSION:This review shows that complementary medicine have the potential for new drug discovery against coronavirus.Further research is needed before definitive conclusions can be made concerning the safety and efficacy of the use of these medicinal plants.展开更多
OBJECTIVE: To explore the relationships between different lifestyle-behavioral factors and phlegm wetness type of Traditional Chinese Medicine constitution,so as to provide health management strategies for phlegm-wetn...OBJECTIVE: To explore the relationships between different lifestyle-behavioral factors and phlegm wetness type of Traditional Chinese Medicine constitution,so as to provide health management strategies for phlegm-wetness constitution.METHODS: A case-control study was conducted with the cases selected from the database of Chinese constitution survey in 9 provinces or municipalities of China. 1380 cases met the diagnostic criteria of phlegm-wetness type were taken as the case group, and 1380 cases were randomly selected from gentleness type as the control group. Using Chi-square test to compare the differences of lifestyle-behavior composition in each group; single factor and multiple logistic regression analysis were used to compare the relationships of life-style-behavioral factors and phlegm-wetness type.RESULTS: There were statistically significant differences between phlegm-wetness type group and gentleness type group in lifestyle behaviors(dietary habits, tobacco and liquor consumptions, exercise habits, sleeping habits). The results of single factor logistic regression analysis demonstrated that the risk of phlegm-wetness constitution decreased significantly in light diet(odds ratio, OR=0.68);The risk factors of phlegm-wetness type were fatty food intake(OR=2.36), sleeping early and getting up late(OR=1.87), tobacco smoking(OR=1.83),barbecued food intake(OR=1.68), alcohol drinking(OR=1.63), salty food intake(OR=1.44), sleeping erratically(OR=1.43), less physical activities(OR=1.42), sweet food intake(OR=1.29), sleeping and getting up late(OR=1.26), and pungent food intake(OR=1.21), respectively. Regardless of the interaction among lifestyle-behavioral factors, the results of the multiple logistic regression analysis revealed that the risk factors of phlegm-wetness type were sleeping early and getting up late(OR=1.94), fatty food intake(OR=1.80), tobacco smoking(OR=1.50),sleeping erratically(OR=1.50), barbecued food intake(OR=1.40), sleeping and getting up late(OR=1.40), less physical activities(OR=1.31), sleeping late and getting up early(OR=1.27),and sweet food intake(OR=1.27), respectively, and the risk ofphlegm-wetness type still decreased significantly inlightfoodintake(OR=0.79).CONCLUSION: Light diet can decrease the risk of being phlegm-wetness constitution, and bad lifestyle behaviors such as sleeping early and getting up late, sleeping erratically, fatty food, barbecued food or sweet food intake, tobacco and liquor consumptions, and less physical activities can increase the risks of becoming phlegm-wetness constitution.展开更多
Objective: To introduce a new method using calcium phosphate cement/Danshen drug delivery system for treating ischemic necrosis of the femoral head and evaluate its curative effect.Methods: From May 2000 to June 2005,...Objective: To introduce a new method using calcium phosphate cement/Danshen drug delivery system for treating ischemic necrosis of the femoral head and evaluate its curative effect.Methods: From May 2000 to June 2005, 48 adult patients (54 hips) with ischemic necrosis of the femoral head at Stages Ⅰ,Ⅱ and Ⅲ of antigen reactive cell opsonization (ARCO) were treated with implantation of calcium phosphate cement/Danshen drug delivery system in the involved femoral head. The operation consisted of removal of the necrotic bone under weight-loading cartilage and the implantation of phosphate cement/Danshen drug delivery system, and all manipulations were made percutaneously through a bone tunnel in the trochanter. The functions of the hip joint were evaluated and X-ray films were taken preoperatively and postoperatively.Results: Postoperative follow-up was 45.5 months on average, ranging from 27 to 78 months. According to the evaluation criterion of "Dandong 1995" for therapeutic effect of adult ischemic necrosis of the femoral head, the therapeutic effects were excellent in 33 hips, good in 17, fair in 3 and poor in 1, with the excellent and good rate of 92.6 %.Conclusions: This method is relatively simple with little invasion. It not only improves the microcirculation of the femoral head by local application of traditional Chinese medicine, but also provides mechanic buttress in the weightloading area to prevent collapse during repairing, which is beneficial to repair and reconstruction of femoral head. It may be a choice of minimal invasion surgery for ischemic necrosis of the femoral head at Stages Ⅰ, Ⅱ and Ⅲ of ARCO.展开更多
On May 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 Should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scienti...On May 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 Should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scientific response. We believe these types of reports will unfairly and negatively impact the field of integrative medicine as a whole, and must be answered with facts and statistics that more accurately represent the current situation.展开更多
基金the Key Program of the National Natural Science Foundation of China(the Biological Basis of Phlegm-dampness Constitution Susceptible to Metabolic Disease and Mechanism of Preventive Treatment of Disease by Adjusting Constitution,No.81730112)Innovation Team Project of Beijing University of Chinese Medicine(Basic Research on Prevention and Treatment of Diseases by Regulating TCM Constitution,No.2019-JYB-TD010)。
文摘OBJECTIVE:To analyze clinical studies on correlations between Traditional Chinese Medicine(TCM)body constitution types and diseases published in the past 10 years,and to provide an evidence base to support the use of such correlations for health maintenance and disease prevention.METHODS:We searched five databases for the period April 2009 to December 2019:China National Knowledge Infrastructure Database,Wanfang Database,China Science and Technology Journal Database,PubMed and Embase.Three types of observational studies on correlation between constitution types and diseases were included:cross-sectional,case-control and cohort studies.Descriptive statistical methods were employed for data analysis.RESULTS:A total of 1639 clinical studies were identified:1452(88.59%)cross-sectional studies,115(7.02%)case-control studies and 72(4.39%)cohort studies covering 30 regions of China and five other countries(Malaysia,South Korea,Singapore,Thailand and France).The collection of studies comprised 19 disease categories and 333 different diseases.The 10 most commonly studied diseases were hypertension,diabetes,stroke,coronary atherosclerotic heart disease(CAHD),sleep disorders,neoplasm of the breast,dysmenorrhea,fatty liver disease,chronic viral hepatitis B and dyslipidemia.We found high distributions for each biased constitution type in different patient populations as follows:Qi-deficiency constitution in stroke,diabetes,chronic obstructive pulmonary disease,acquired immunodeficiency syndrome and hypertension;Yang-deficiency constitution in female infertility,osteoporosis,irritable bowel syndrome,gonarthrosis and dysmenorrhea;Yin-deficiency constitution in hypertension,diabetes,constipation,female climacteric states and osteoporosis;phlegm-dampness constitution in hypertension,stroke,fatty liver disease,diabetes and metabolic syndrome;damp-heat constitution in acne,chronic gastritis,chronic viral hepatitis B,human papillomavirus infection and hyperuricemia;blood-stasis constitution in CAHD,endometriosis and stroke;Qi-stagnation constitution in hyperplasia and neoplasms of the breast,insomnia,depression and thyroid nodules;and inherited-special constitution in asthma and allergic rhinitis.CONCLUSION:Eight biased TCM constitutions were closely related to specific diseases,and could be used to guide individualized prevention and treatment.More rigorously designed studies are recommended to further verify the constitution-disease relationship.
文摘Traditional Chinese Medicine(TCM)has been extensively used as a mainstay for treating various pathologies.Combing the pharmacology and systems biology approaches,the network pharmacology(NP)approach was developed to predict the probable mechanism underlying the therapeutic effect of TCM.However,approaches solely based on NP cannot effectively elucidate the curative mechanism in a holistic and reliable manner due to limitations in NP-based methods and complexity of TCM components.Thus,integration strategies combining NP with other approaches are increasingly being used.Since the interdisciplinary research in TCM has received much attention in the advent of the big data era of which the NPbased integration strategy is broadly used,the strategy is clearly elaborated in the present review.We summarized several NP-based integration strategies and their applications in TCM studies,including multi-omics approach,gut microbiota study,chemical information analysis,data-mining,and network toxicology study.
基金Supported by National Science and Technology Major Project of China During the 13th Five-year Plan Period:New Adjuvant Strategies of Traditional Chinese Medicine on Immune Reconstruction for Long-term ART-treated People Living with HIV(No.2017ZX10205501)Study of AIDS-related Early Biomarkers for Disease Progression and Epidemic Predicting Model(No.2017ZX10201101)the Beijing Excellent Talent Plan(No.2018000021223ZK04)。
文摘OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment,on the immunological nonresponse(INR)in people living with human immunodeficiency virus(HIV)(PLWH).METHODS:Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI),Wanfang Digital Journal,Chinese Medical Journal Database(CMJD),Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane,and Embase was reviewed by two independent investigators.Data were extracted from the studies according to the eligible criteria and analyzed using Review Manager 5.3.RESULTS:Nine randomized controlled trials(RCTs)with 1078 patients were analyzed.Our analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group[mean difference(MD)=13.51,95%confidence interval(CI):7.42-19.60,P<0.0001].There was no significant difference between the treated and control groups after 3 months(MD=25.31,95%CI:-2.78 to 53.41,P=0.08).However,after 6 and 12 months,the response of the treatment group was superior to the control group(MD=27.45,95%CI:7.09-47.81,P=0.008 and MD=27.34,95%CI:6.31–48.37,P=0.01,respectively).The clinical efficacy of the treatment group was also higher than that of the control group(RR=1.75,95%CI:1.16-2.65,P=0.007).However,CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD=12.37,95%CI:-6.71 to 31.45,P=0.20 and MD=5.67,95%CI:-3.00 to14.35,P=0.20,respectively).CONCLUSION:The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus,is beneficial and has potential use for improving INR in PLWH.However,large-scale RCTs are required to provide evidence for optimal intervention strategies.
基金Supported by the National Administration of Traditional Chinese Medicine,Research Project for Practice Development of National Traditional Chinese Medicine Clinical Research Bases:the effects of Traditional Chinese Medicine on Vascular Endothelial Function and Quality of Life in coronary heart disease showing phlegm-heat-stasis symptom pattern(No.JDZX2015003)。
文摘OBJECTIVE:To describe a protocol to assess the effects of Traditional Chinese Medicine(TCM)on patients with coronary heart disease(CHD)showing symptoms of phlegm-heat-stasis symptom pattern.METHODS:This is a single-blind randomized controlled trial that will be conducted in the First Teaching Hospital of Tianjin University of TCM and 60 patients with CHD showing phlegm-heat-stasis symptom pattern will be included.Patients will be randomly divided into either a treatment group(Qingre Huatan formulae+Western Medicine)or to acontrol group(conventional Western Medicine only)for 7-14 d.Primary patient outcomes will be vascular endothelial function and quality of life.Measurement data will be expressed as mean±standard deviation using t-test analysis or repeated-measure variance analysis.Enumeration data will be expressed by cases and percentages,usingχ^(2) analysis,and rank sum test will be used for ranked data.RESULTS:This study further verified the effectiveness and safety of Qingre Huatan formulae for the phlegm-heat-stasis syndrome pattern of CHD on the basis of previous studies on the characteristics of syndromes and medication rules.DISCUSSION:Phlegm-heat-stasis symptom pattern has become a common manifestation in CHD.Standardized Western medications together with TCM have been extensively used in China and have developed into a comprehensive treatment model.Our trial will help formulate recommendations for symptom maintenance and provide clinical evidence for the application of TCM for patients with CHD showing phlegm-heat-stasis symptom pattern.
基金Supported by National Social Science Fund of National Emergency Management System Construction Research Project:Research on the Management Mechanism of Integrating Traditional and Western Medicine to Responsed to Major Epidemic(No.20VYJ069)
文摘OBJECTIVE:To explore the factors influencing physicians’intentions to use Traditional Chinese Medicine(TCM)to treat coronavirus disease 2019(COVID-19).METHODS:A cross-sectional,self-report online survey was conducted from March 16,2020,to April 2,2020,in China.Participants were recruited through convenience and snowball sampling.Data were collected by using a self-designed questionnaire based on the Theory of Planned Behavior.Structural equation modeling was used for data analysis.RESULTS:A total of 494 physicians were enrolled in this study.Overall,the model explained 75.4%and 75.5%of the total variance in intention and attitude,respectively.Specifically,attitudes(β=0.467,P<0.001),past behavior(β=0.384,P<0.05),subjective norms(SN)(β=0.177,P<0.001),and perceived behavioral control(PBC)(β=0.133,P<0.05)significantly affected physicians’intention to use TCM.Cognition(β=0.606,P<0.001)and PBC(β=0.569,P<0.01)significantly influenced physicians’attitudes toward using TCM.SN(β=0.064,P=0.263)was not a factor affecting attitude.CONCLUSION:Physicians’intention to use TCM was significantly associated with attitude,past behavior,PBC,and SN.The findings may not only be useful for understanding the influencing factors and paths of physicians’intention to use TCM to treat COVID-19 but also provide a reference for health authorities and policymakers to promote physicians to utilize TCM.
基金Supported by“CACMS Innovation Fund(CI2021A05042):Research and Application of Multi-source Heterogeneous Database Integration Method Based on Heterogeneous Graph Neural Network”and“Fundamental Research Funds for the Central public welfare research institutes(Z0688):Method research on TCM Clinical big data.”
文摘OBJECTIVE:To explore the advantages of Traditional Chinese Medicine(TCM)in"prevention"and"control"of coronavirus disease 2019(COVID-19)pandemic.METHODS:In this paper,we wish to estimate the effect on the virus transmission of scenarios assuming TCM were used to build the first defense line at the very early stage of the spread in Wuhan.We therefore first developed a classic susceptible infected removed(susceptible infected removed,SIR)transmission model based on the national data in China and then updated it to a TCM-SIR model to assess the potential impact of such assumptions,i.e.the underlying risk of lives lost and social economy loss.RESULTS:(a)With the nationwide community lockdown,the risk value was from 90000 to 250000 without TCM intervention and the risk value was from 70000 to 220000 with TCM intervention;(b)Based the risk assessment method,we forecasted that the infections peak would be 58016 without TCM intervention,which happened on February 172020.However,the infections peak would be 45713 with TCM intervention,which happened on 16 February 2020.CONCLUSIONS:The adoption of nationwide community lockdown is conducive to timely control the epidemic and protect people’s lives and safety.At the same time,we can get lower infections if TCM intervention can be considered.We can also get the benefits from TCM prevention of COVID-19 pandemic by the basic number of infections.
基金Supported by the Health and Medical Research Fund of the Hong Kong Government(Ref:12130581)
文摘OBJECTIVE:To investigate the efficacy on the combination of oral strontium ranelate(Sr R)with a topical Chinese herbal paste on facilitation of fracture healing.METHODS:An open fracture was created at the mid-shaft of the right tibia of rat.A herbal pastecalled CDR containing Honghua(Flos Carthami),Chuanxuduan(Radix Dipsaci Asperoidis)and Dahuang(Radix Et Rhizoma Rhei Palmati)was prepared.The rats were treated with either CDR topically on the fracture site,or Sr R orally,or their combinations.Bone turnover biochemical markers in serum were measured.Microarchitecture of the fracture was analyzed using micro-CT after 14 and 28 d,followed by histomorphometrical analysis.RESULTS:Micro-computed tomography analysis revealed that the combined treatment of CDR with600 mg/g Sr R significantly increased the total callus density,mineralized callus volume fraction,mineralized callus mineral content and mineralized callus density of the callus after 28 d of treatment.This result was consistent with the histomorphometrical analysis on the osteoid volume.Analysis of biochemical markers showed that the combined treatments reduced the bone resorption that occurs temporarily after fracture.CONCLUSION:This study demonstrated that the combined treatment of oral Sr R and topical CDR is effective to promote fracture healing by their additive effect on promoting bone formation and retarding bone resorption.
文摘The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM.
基金Supported by Grants from the Natural Science Foundation of China(No.81903991,No.81974543)the Natural Science Foundation of Guangdong Province(No.2017A030310326,No.2019A1515011362)+3 种基金the Guangzhou science and technology plan project(No.201804010149,No.202002030155)the Chinese medicine science and technology research project of Guangdong Provincial Hospital of Chinese Medicine(No.YN2019MJ09)the Major Research Projects in First-class Disciplines of Guangzhou University of Chinese Medicine(No.A1260619111001)the Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome(No.ZH2020KF03)
文摘OBJECTIVE:To assess the effectiveness and safety of traditional Chinese medical therapy for cancer-related fatigue.METHODS:We systematically searched eight electronic databases up to June 2017 for randomized clinical trials of traditional Chinese medical therapy for cancer-related fatigue.Two authors independently extracted data and assessed the risk bias of the included trials using the Cochrane Handbook.Data were analyzed by Rev Man 5.2 software.RESULTS:A total of 23 trials involving 1832 participants identified with cancer-related fatigue were included.Twenty trials reported a beneficial effect of traditional Chinese medical therapy on cancer-related fatigue.On pooling the data from Chinese herbal medicine therapy and acupuncture or moxibustion therapy,respectively,significant differences were found between experimental groups and control groups.Fatigue improvement rates showed significant differences between traditional Chinese medical therapy and control groups[odds ratio(OR),7.62;95%confidence interval(CI),3.75-15.49;P<0.00001;and OR,3.78;95%CI,2.29-6.23;P<0.00001).Fatigue change scores also showed significant differences between the two groups(mean difference,-0.91;95%CI,-1.16 to-0.65;P<0.00001).Eleven trials demonstrated that traditional Chinese medical therapy improved the quality of life of cancer patients.No severe adverse effects occurred in traditional Chinese medical therapy groups.CONCLUSION:Meta-analysis showed that Chinese medical therapy seems to be effective and safe in the treatment of cancer-related fatigue.
基金Supported by National Key R&D Program of China(Research on Inheritance and Innovation of Experience(Integration of Tao and Shu)of Illustrious Senior Traditional Chinese Medicine Practitioners by adopting Multiple Research Methods 2018YFC1704100 and Research on Methodology System and Paradigms for Mining and Inheriting Illustrious Senior Traditional Chinese Medicine Practitioners’Experience 2018YFC1704101)。
文摘OBJECTIVE:To explore the core herbs of two illustrious senior Traditional Chinese Medicine(TCM)Physicians for the treatment of liver cancer,and to further clarify the gene targets and pathway mechanisms of liver cancer that the core prescription(CP)may regulate.METHODS:We used the patient information of two illustrious senior TCM physicians from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and the Affiliated Hospital of Capital Medical University as the database.The CP was analyzed using the community network algorithm.The pathway mechanism was analyzed using network pharmacology method.And the prognostic survival genes were identified using Single factor cox regression analysis.Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine(TCMIP),Herb,Online Mendelian Inheritance in Man(OMIM),Genecards,Kyoto Encyclopedia of Genes and Genomes(KEGG),Genomic Data Commons(GDC),The Cancer Genome Atlas(TCGA),Gephi and R were used to mine CP,building a pathway network diagram.All the analyses were visualized.RESULTS:We found that the CP consistes of Huangqi(Radix Astragali Mongolici),Danshen(Radix Salviae Miltiorrhizae),Shuihonghuazi(Polygoni Orientalis Fructus),Baihuasheshecao(Herba Hedyotdis),Banzhilian(Herba Scutellariae Barbatae),and Ezhu(Rhizoma Curcumae Phaeocaulis),which were attributed to the two physicians respectively.The CP played an anticancer role through such pathways as signal transduction,energy metabolism,immune system and other pathways,covering a total of 112 pathways and 176 herb-diseaserelated genes.Fourteen genes have a significant impact on the prognosis and survival of liver cancer.CONCLUSION:Based on the liver cancer cases of two illustrious senior TCM physicians,we obtained the CP through data mining.The CP may mainly exert anticancer effects by inhibiting inflammatory response,angiogenesis,and enhancing the body’s immune response.We screened out 14 genes in the CP that may be related to the prognosis of liver cancer,and these genes may play an important regulatory role in the prognosis of liver cancer.
文摘OBJECTIVE:To investigate the in vitro and in vivo studies of natural compounds and medicinal plants with anti-coronavirus activity.METHODS:A systematic review was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Animal Research:Reporting of in vivo experiments guidelines to find data for medicinal plants and natural products effective against human coronaviruses in in vitro or in vivo studies.Studies published up to September 6,2020 were included.Studies(in vitro or in vivo)reporting the effect of medicinal plants and natural products or their derivatives on human coronavirus were included RESULTS:Promising anti-coronavirus effects are seen with different herbal compounds like some diterpenoids,sesquiterpenoids,and three compounds in tea with 3 CLpro inhibiting effect of Severe Acute Respiratory Syndrome Coronavirus(SARS-Co V);Hirsutenone,Six cinnamic amides and bavachinin are PLpro inhibitors and Tanshinones are active on both 3 CLpro and PLpro.Some flavonoid compounds of Citrus fruits act on Immunoregulation and target angiotensin-converting enzyme 2 which is used by SARS-COV for entry.Virus helicase is possibly inhibited by two compounds myricetin and scutellarein.CONCLUSION:This review shows that complementary medicine have the potential for new drug discovery against coronavirus.Further research is needed before definitive conclusions can be made concerning the safety and efficacy of the use of these medicinal plants.
基金Supported by Research of Traditional Chinese Medicine Health cognition theory and Constitution Classification from the National Basic Research Program(973 Program)(No.2011CB505403)
文摘OBJECTIVE: To explore the relationships between different lifestyle-behavioral factors and phlegm wetness type of Traditional Chinese Medicine constitution,so as to provide health management strategies for phlegm-wetness constitution.METHODS: A case-control study was conducted with the cases selected from the database of Chinese constitution survey in 9 provinces or municipalities of China. 1380 cases met the diagnostic criteria of phlegm-wetness type were taken as the case group, and 1380 cases were randomly selected from gentleness type as the control group. Using Chi-square test to compare the differences of lifestyle-behavior composition in each group; single factor and multiple logistic regression analysis were used to compare the relationships of life-style-behavioral factors and phlegm-wetness type.RESULTS: There were statistically significant differences between phlegm-wetness type group and gentleness type group in lifestyle behaviors(dietary habits, tobacco and liquor consumptions, exercise habits, sleeping habits). The results of single factor logistic regression analysis demonstrated that the risk of phlegm-wetness constitution decreased significantly in light diet(odds ratio, OR=0.68);The risk factors of phlegm-wetness type were fatty food intake(OR=2.36), sleeping early and getting up late(OR=1.87), tobacco smoking(OR=1.83),barbecued food intake(OR=1.68), alcohol drinking(OR=1.63), salty food intake(OR=1.44), sleeping erratically(OR=1.43), less physical activities(OR=1.42), sweet food intake(OR=1.29), sleeping and getting up late(OR=1.26), and pungent food intake(OR=1.21), respectively. Regardless of the interaction among lifestyle-behavioral factors, the results of the multiple logistic regression analysis revealed that the risk factors of phlegm-wetness type were sleeping early and getting up late(OR=1.94), fatty food intake(OR=1.80), tobacco smoking(OR=1.50),sleeping erratically(OR=1.50), barbecued food intake(OR=1.40), sleeping and getting up late(OR=1.40), less physical activities(OR=1.31), sleeping late and getting up early(OR=1.27),and sweet food intake(OR=1.27), respectively, and the risk ofphlegm-wetness type still decreased significantly inlightfoodintake(OR=0.79).CONCLUSION: Light diet can decrease the risk of being phlegm-wetness constitution, and bad lifestyle behaviors such as sleeping early and getting up late, sleeping erratically, fatty food, barbecued food or sweet food intake, tobacco and liquor consumptions, and less physical activities can increase the risks of becoming phlegm-wetness constitution.
文摘Objective: To introduce a new method using calcium phosphate cement/Danshen drug delivery system for treating ischemic necrosis of the femoral head and evaluate its curative effect.Methods: From May 2000 to June 2005, 48 adult patients (54 hips) with ischemic necrosis of the femoral head at Stages Ⅰ,Ⅱ and Ⅲ of antigen reactive cell opsonization (ARCO) were treated with implantation of calcium phosphate cement/Danshen drug delivery system in the involved femoral head. The operation consisted of removal of the necrotic bone under weight-loading cartilage and the implantation of phosphate cement/Danshen drug delivery system, and all manipulations were made percutaneously through a bone tunnel in the trochanter. The functions of the hip joint were evaluated and X-ray films were taken preoperatively and postoperatively.Results: Postoperative follow-up was 45.5 months on average, ranging from 27 to 78 months. According to the evaluation criterion of "Dandong 1995" for therapeutic effect of adult ischemic necrosis of the femoral head, the therapeutic effects were excellent in 33 hips, good in 17, fair in 3 and poor in 1, with the excellent and good rate of 92.6 %.Conclusions: This method is relatively simple with little invasion. It not only improves the microcirculation of the femoral head by local application of traditional Chinese medicine, but also provides mechanic buttress in the weightloading area to prevent collapse during repairing, which is beneficial to repair and reconstruction of femoral head. It may be a choice of minimal invasion surgery for ischemic necrosis of the femoral head at Stages Ⅰ, Ⅱ and Ⅲ of ARCO.
文摘On May 15, 2020, the Lancet published an article titled Use of Herbal Drugs to Treat COVID-19 Should be with Caution. While this is true of all drugs, herbal and otherwise, the data may be biased and deserve a scientific response. We believe these types of reports will unfairly and negatively impact the field of integrative medicine as a whole, and must be answered with facts and statistics that more accurately represent the current situation.
