Meige syndrome is a neurological disorder discovered by Henry Meige,a French neurologist.The initial clinical manifestations are blepharospasm in both eyes and the characteristic facial appearance of tiger face lines....Meige syndrome is a neurological disorder discovered by Henry Meige,a French neurologist.The initial clinical manifestations are blepharospasm in both eyes and the characteristic facial appearance of tiger face lines.The patient displays an abnormal facial expression.Trauma,psychological,endocrine,and pharmacological factors may play a role in secondary Meige syndrome.Here we describe these clinical signs with pictures.展开更多
BACKGROUND Meigs syndrome is a rare neoplastic disease characterized by the triad of benign solid ovarian tumor,ascites,and pleural effusion.In postmenopausal women with pleural effusions,ascites,elevated CA-125 level...BACKGROUND Meigs syndrome is a rare neoplastic disease characterized by the triad of benign solid ovarian tumor,ascites,and pleural effusion.In postmenopausal women with pleural effusions,ascites,elevated CA-125 level,and pelvic masses,the probability of disseminated disease is high.Nevertheless,the final diagnosis is based on its histopathologic features following surgical removal of a mass lesion.Here we describe a case of Meigs syndrome with pleural effusion as the initial manifestation.CASE SUMMARY A 52-year-old woman presented with a 2-mo history of dry cough and oppression in the chest and was admitted to our hospital due to recurrent pleural effusion and gradual worsening of dyspnea that had occurred over the previous month.Two months before admission,the patient underwent repeated chest drainage and empirical anti-tuberculosis treatment.However,the pleural fluid accumulation persisted,and the patient began to experience dyspnea on exertion leading to admission.A computed tomography scan of the chest,abdominal ultrasound,and magnetic resonance imaging confirmed the presence of right-sided pleural effusion and ascites with a right ovarian mass.Serum tumor markers showed raised CA-125.With a suspicion of a malignant tumor,the patient underwent laparoscopic excision of the ovarian mass and the final pathology was consistent with an ovarian fibrothecoma.On the seventh day postoperation,the patient had resolution of the right-sided pleural effusion.CONCLUSION Despite the relatively high risk of malignancy when an ovarian mass associated with hydrothorax is found in a patient with elevated serum levels of CA-125,clinicians should be aware about rare benign syndromes,like Meigs,for which surgery remains the preferred treatment.展开更多
BACKGROUND Meigs’syndrome is regarded as a benign ovarian tumor accompanied by pleural effusion and ascites,both of which resolve after removal of the tumor.Patients often seek treatment in the Department of Respirat...BACKGROUND Meigs’syndrome is regarded as a benign ovarian tumor accompanied by pleural effusion and ascites,both of which resolve after removal of the tumor.Patients often seek treatment in the Department of Respiratory and Critical Care Medicine or other internal medicine departments due to symptoms caused by ascites or hydrothorax.Here,we report a rare case of Meigs'syndrome caused by granulosa cell tumor accompanied with intrathoracic lesions.CASE SUMMARY A 52-year-old women was admitted to the Department of Respiratory and Critical Care Medicine due to coughing and expectoration accompanied with shortness of breath.Chest X-ray and chest computed tomography showed a modest volume of pleural fluid with pleural thickening in the right lung.The carbohydrate antigen 125(CA125)concentration was 150.8 U/mL(normal,0-35 U/mL)and no tumor cells were observed in pleural fluid.Nodules and a neoplasm with a fish meat-like appearance in the parietal pleura and nodules with a‘string of beads’-like appearance in the diaphragm were found by thoracoscopic examination.Furthermore,pelvic magnetic resonance revealed a pelvic mass measuring about 11.6 cm×10.0 cm×12.4 cm with heterogeneous signal intensity and multiple hypointense separations.Total abdominal hysterectomy,bilateral adnexectomy,and separation of pelvic adhesion were performed under general anesthesia.The pathology results showed granulosa cell tumor.At the 2-mo follow-up after the surgery,the hydrothorax subsided,and the CA125 level returned to normal.CONCLUSION For postmenopausal women with unexplained hydrothorax and elevated CA125,in addition to being suspected of having gynecological malignancy,Meigs’syndrome should be considered.展开更多
BACKGROUND Ascites,pleural effusion and raised CA-125 in the absence of malignancy in systemic lupus erythematosus is known as Tjalma syndrome.CASE SUMMARY We report a special case of a systemic lupus erythematosus pa...BACKGROUND Ascites,pleural effusion and raised CA-125 in the absence of malignancy in systemic lupus erythematosus is known as Tjalma syndrome.CASE SUMMARY We report a special case of a systemic lupus erythematosus patient presenting with Tjalma syndrome.She presented with ascites and elevated CA-125 in the absence of benign or malignant ovarian tumor and no pleural effusions,which is an unusual presentation for this rare condition.CONCLUSION Tjalma syndrome can present with massive ascites alone without pleural or pericardial effusions.展开更多
Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),S...Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),Sānyīnjiāo(三阴交SP6),Tāixī(太溪KI3),dance tremor control area of scalp acupuncture(舞蹈震颤控制区),Yángbái(阳白GB14),Sīzhúkōng(丝竹空TE23),Yíngxiāng(迎香LI20),Dìcāng(地仓ST4),Jiāchē(颊车ST6) and Xiàguān(下关ST7),and the needle retention continued for 40 min.The treatment was applied once a day,and there was a 5-day treatment and a 2-day rest every week.One course of treatment included a week,and there were 4 courses of treatment in total.After treatment,the clinical efficacy of the patients was evaluated.Results:4 cases were cured,9 cases were effective,1 case was ineffective,and the effective rate was 92.9%.Conclusions:Acupuncture had a satisfactory clinical therapeutic effect on patients of Meige’s syndrome Ⅱ.展开更多
Meigs’syndrome(MS),a rare complication of benign ovarian tumors,is easily misdiagnosed as ovarian cancer(OC).We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018.Se...Meigs’syndrome(MS),a rare complication of benign ovarian tumors,is easily misdiagnosed as ovarian cancer(OC).We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018.Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma(OTF)and healthy control groups(all P<0.05).However,the serum HE4 levels were lower in the MS group than in the OC group(P<0.001).A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups(all P<0.05).However,these variables were higher in the MS group than in the OC group(both P<0.05).The neutrophil-to-lymphocyte ratio(NLR)was also significantly lower,whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group(both P<0.05).The NLR,platelet-to-lymphocyte ratio,and systemic immune index were significantly higher in the MS group than in the OTF and control groups(all P<0.05).The hypoxia-inducible factor-1 mRNA levels were also significantly higher,whereas the glucose transporter 1,lactate dehydrogenase,and enolase 1 mRNA levels were lower in peripheral CD4+T cells obtained preoperatively in a patient with MS than those in patients with OTF,patients with OC,and controls(all P<0.05).The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS(P<0.001).These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.展开更多
文摘Meige syndrome is a neurological disorder discovered by Henry Meige,a French neurologist.The initial clinical manifestations are blepharospasm in both eyes and the characteristic facial appearance of tiger face lines.The patient displays an abnormal facial expression.Trauma,psychological,endocrine,and pharmacological factors may play a role in secondary Meige syndrome.Here we describe these clinical signs with pictures.
文摘BACKGROUND Meigs syndrome is a rare neoplastic disease characterized by the triad of benign solid ovarian tumor,ascites,and pleural effusion.In postmenopausal women with pleural effusions,ascites,elevated CA-125 level,and pelvic masses,the probability of disseminated disease is high.Nevertheless,the final diagnosis is based on its histopathologic features following surgical removal of a mass lesion.Here we describe a case of Meigs syndrome with pleural effusion as the initial manifestation.CASE SUMMARY A 52-year-old woman presented with a 2-mo history of dry cough and oppression in the chest and was admitted to our hospital due to recurrent pleural effusion and gradual worsening of dyspnea that had occurred over the previous month.Two months before admission,the patient underwent repeated chest drainage and empirical anti-tuberculosis treatment.However,the pleural fluid accumulation persisted,and the patient began to experience dyspnea on exertion leading to admission.A computed tomography scan of the chest,abdominal ultrasound,and magnetic resonance imaging confirmed the presence of right-sided pleural effusion and ascites with a right ovarian mass.Serum tumor markers showed raised CA-125.With a suspicion of a malignant tumor,the patient underwent laparoscopic excision of the ovarian mass and the final pathology was consistent with an ovarian fibrothecoma.On the seventh day postoperation,the patient had resolution of the right-sided pleural effusion.CONCLUSION Despite the relatively high risk of malignancy when an ovarian mass associated with hydrothorax is found in a patient with elevated serum levels of CA-125,clinicians should be aware about rare benign syndromes,like Meigs,for which surgery remains the preferred treatment.
基金Supported by the Scientific Research Project of Sichuan Provincial Health and Family Planning Commission,No.18PJ409.
文摘BACKGROUND Meigs’syndrome is regarded as a benign ovarian tumor accompanied by pleural effusion and ascites,both of which resolve after removal of the tumor.Patients often seek treatment in the Department of Respiratory and Critical Care Medicine or other internal medicine departments due to symptoms caused by ascites or hydrothorax.Here,we report a rare case of Meigs'syndrome caused by granulosa cell tumor accompanied with intrathoracic lesions.CASE SUMMARY A 52-year-old women was admitted to the Department of Respiratory and Critical Care Medicine due to coughing and expectoration accompanied with shortness of breath.Chest X-ray and chest computed tomography showed a modest volume of pleural fluid with pleural thickening in the right lung.The carbohydrate antigen 125(CA125)concentration was 150.8 U/mL(normal,0-35 U/mL)and no tumor cells were observed in pleural fluid.Nodules and a neoplasm with a fish meat-like appearance in the parietal pleura and nodules with a‘string of beads’-like appearance in the diaphragm were found by thoracoscopic examination.Furthermore,pelvic magnetic resonance revealed a pelvic mass measuring about 11.6 cm×10.0 cm×12.4 cm with heterogeneous signal intensity and multiple hypointense separations.Total abdominal hysterectomy,bilateral adnexectomy,and separation of pelvic adhesion were performed under general anesthesia.The pathology results showed granulosa cell tumor.At the 2-mo follow-up after the surgery,the hydrothorax subsided,and the CA125 level returned to normal.CONCLUSION For postmenopausal women with unexplained hydrothorax and elevated CA125,in addition to being suspected of having gynecological malignancy,Meigs’syndrome should be considered.
基金Supported by Zhejiang Provincial Health Commission Medical and Health Science and Technology Project,No.2020KY686。
文摘BACKGROUND Ascites,pleural effusion and raised CA-125 in the absence of malignancy in systemic lupus erythematosus is known as Tjalma syndrome.CASE SUMMARY We report a special case of a systemic lupus erythematosus patient presenting with Tjalma syndrome.She presented with ascites and elevated CA-125 in the absence of benign or malignant ovarian tumor and no pleural effusions,which is an unusual presentation for this rare condition.CONCLUSION Tjalma syndrome can present with massive ascites alone without pleural or pericardial effusions.
基金Supported by the Construction Project of The Third Traditional Chinese Medicine Master Inheritance Studiothe National Famous Traditional Chinese Medicine Inheritance Studio:20180713
文摘Objective:To observe the clinical efficacy of acupuncture for Meige’s syndrome Ⅱ.Methods:Fourteen patients of Meige’s syndrome Ⅱ were treated with acupuncture.The acupoints included bilateral Tāichōng(太冲LR3),Sānyīnjiāo(三阴交SP6),Tāixī(太溪KI3),dance tremor control area of scalp acupuncture(舞蹈震颤控制区),Yángbái(阳白GB14),Sīzhúkōng(丝竹空TE23),Yíngxiāng(迎香LI20),Dìcāng(地仓ST4),Jiāchē(颊车ST6) and Xiàguān(下关ST7),and the needle retention continued for 40 min.The treatment was applied once a day,and there was a 5-day treatment and a 2-day rest every week.One course of treatment included a week,and there were 4 courses of treatment in total.After treatment,the clinical efficacy of the patients was evaluated.Results:4 cases were cured,9 cases were effective,1 case was ineffective,and the effective rate was 92.9%.Conclusions:Acupuncture had a satisfactory clinical therapeutic effect on patients of Meige’s syndrome Ⅱ.
基金supported by the National Natural Science Foundation of China(No.81772779)“Professionals from SixPronged Top-Talent Program”of Jiangsu Province(No.LGY2017068)+2 种基金“The Six Top Talent Project”of Jiangsu Province(No.2015-WSN-034)Medical Talent of Empowering Medicine through Science and Education Program of Jiangsu Province(No.ZDRCA2016003)Key Laboratory for Medicine of Jiangsu Province of China(No.ZDXKB2016005).
文摘Meigs’syndrome(MS),a rare complication of benign ovarian tumors,is easily misdiagnosed as ovarian cancer(OC).We retrospectively reviewed the clinical laboratory data of patients diagnosed with MS from 2009 to 2018.Serum carbohydrate antigen 125 and HE4 levels were higher in the MS group than in the ovarian thecoma-fibroma(OTF)and healthy control groups(all P<0.05).However,the serum HE4 levels were lower in the MS group than in the OC group(P<0.001).A routine blood test showed that the absolute counts and percentages of lymphocytes were significantly lower in the MS group than in the OTF and control groups(all P<0.05).However,these variables were higher in the MS group than in the OC group(both P<0.05).The neutrophil-to-lymphocyte ratio(NLR)was also significantly lower,whereas the lymphocyte-to-monocyte ratio was higher in the MS group than in the OC group(both P<0.05).The NLR,platelet-to-lymphocyte ratio,and systemic immune index were significantly higher in the MS group than in the OTF and control groups(all P<0.05).The hypoxia-inducible factor-1 mRNA levels were also significantly higher,whereas the glucose transporter 1,lactate dehydrogenase,and enolase 1 mRNA levels were lower in peripheral CD4+T cells obtained preoperatively in a patient with MS than those in patients with OTF,patients with OC,and controls(all P<0.05).The expression of these four glucose metabolism genes was preferentially restored to normal levels after the tumor resection of MS(P<0.001).These clinical laboratory features can be useful in improving the preoperative diagnostic accuracy of MS.
