Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public alike.There has also been an increased research focus within t...Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public alike.There has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut microbiota.However,compared to other ergogenic aids and dietary supplements,probiotics present unique study challenges.The objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active individuals.Methods:Four databases(MEDLINE,CINAHL,Cochrane CENTRAL,and Cochrane Database of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active individuals.An intervention with probiotics and inclusion of a control and/or placebo group were essential.Only peer-reviewed articles in English were considered,and there were no date restrictions.Results were extracted and presented in tabular form to detail study protocols,characteristics,and outcomes.Bias in randomized controlled trials was determined with the RoB 2.0 tool.Results:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over design.Approximately half the studies used a single probiotic and the other half a multi-strain preparation.The probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 days.Fewer than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut microbiota.The sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated females.Low-level adverse events were reported in only 2 studies,although the methodology of reporting varied widely.The risk of bias was generally low,although details on randomization were lacking in some studies.Conclusion:There is a substantial body of research on the effects of prob iotic supplementation in healthy athletes and physically active individuals.Considerable heterogeneity in probiotic selection and dosage as well as outcome measures has made clinical and mechanistic interpretation challenging for both health care practitioners and researchers.Attention to issues of randomization of participants,treatments and interventions,selection of outcomes,demographics,and reporting of adverse events will facilitate more trustworthy interpretation of probiotic study results and inform evidence-based guidelines.展开更多
Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs.The protective layer formed by tartaric...Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs.The protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity problems.These attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery applications.The aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration,sonication time and temperature on the formation of silver nanoparticles.Using Response Surface Methodology(RSM)with Face-Centered Central Composite Design(FCCD),the optimization process identifies the most favorable synthesis conditions.UV-Vis spectrum regression analysis shows that AgNPs stabilized with tartaric acid are more stable than AgNPs without tartaric acid.This highlights the increased stability that tartaric acid provides in AgNP ssssynthesis.Particle size distribution analysis showed a multimodal distribution for AgNPs with tartaric acid and showed the smallest size peak with an average size of 20.53 nm.The second peak with increasing intensity shows a dominant average size of 108.8 nm accompanied by one standard deviation of 4.225 nm and a zeta potential of−11.08 mV.In contrast,AgNPs synthesized with polyvinylpyrrolidone(PVP)showed a unimodal particle distribution with an average particle size of 81.62 nm and a zeta potential of−2.96 mV.The more negative zeta potential of AgNP-tartaric acid indicates its increased stability.Evaluation of antibacterial activity showed that AgNPs stabilized with tartaric acid showed better performance against E.coli and B.subtilis bacteria compared with AgNPs-PVP.In summary,this study highlights the potential of tartaric acid in AgNP synthesis and suggests an avenue for the development of stable AgNPs with versatile applications.展开更多
This study focuses on the extraction of cellulose nanocrystals (CNC), from microcrystalline cellulose (MCC), derived from Ayous sawdust. The process involves multiple steps and a large amount of chemical products. The...This study focuses on the extraction of cellulose nanocrystals (CNC), from microcrystalline cellulose (MCC), derived from Ayous sawdust. The process involves multiple steps and a large amount of chemical products. The objective of this research was to determine the effects of factors that impact the isolation process and to identify the optimal conditions for CNC isolation by using the response surface methodology. The factors that varied during the process were the quantity of MCC, the concentration of sulfuric acid, the hydrolysis time and temperature, and the ultrasonic treatment time. The response measured was the yield. The study found that with 5.80 g of microcrystalline cellulose, a sulfuric acid concentration of 63.50% (w/w), a hydrolysis time of 53 minutes, a hydrolysis temperature of 69˚C, and a sonication time of 19 minutes are the ideal conditions for isolation. The experimental yield achieved was (37.84 ± 0.99) %. The main factors influencing the process were the sulfuric acid concentration, hydrolysis time and temperature, with a significant influence (p < 0.05). Infrared characterization results showed that nanocrystals were indeed isolated. With a crystallinity of 35.23 and 79.74, respectively, for Ayous wood fiber and nanocrystalline cellulose were observed by X-ray diffraction, with the formation of type II cellulose, thermodynamically more stable than native cellulose type I.展开更多
In this study, coconut husk cellulose was employed as a cost-effective and environmentally friendly adsorbent to eliminate methylene blue (MB) dye from aqueous solutions. The successful development of response surface...In this study, coconut husk cellulose was employed as a cost-effective and environmentally friendly adsorbent to eliminate methylene blue (MB) dye from aqueous solutions. The successful development of response surface methodology paired with a central composite design (RSM-CCD) enabled the optimization and modelling of the adsorption process. The study investigated the individual and combined effects of three variables (pH, contact time, and initial MB dye concentration) on the adsorption of MB dye onto coconut husk cellulose. The developed RSM-CCD model exhibited a remarkable degree of precision in predicting the removal efficiency of MB dye within the specified experimental parameters. This was demonstrated by the strong regression parameters, with an R<sup>2</sup> value of 99.79% and an adjusted R<sup>2</sup> value of 99.6%. The study depicted that the optimal parameters for attaining a 98.8827% removal of MB dye using coconut husk cellulose were as follows: an initial MB dye concentration of 30 mg∙L<sup>−1</sup>, contact time of 120 minutes, and pH 7 at a fixed adsorbent dose of 0.5 g. The Freundlich isotherm model provided the most satisfactory description of the equilibrium adsorption isotherms, suggesting that MB dye adsorption onto coconut husk cellulose occurs on a heterogeneous surface. The experimental results demonstrated a strong agreement with the pseudo-second-order kinetics model, indicating that the number of active sites present on the cellulose adsorbent predominantly influences the adsorption process of MB dye. Additionally, the adsorbent made from coconut husk cellulose exhibited the potential to be reused, as it retained its efficiency for a maximum of three cycles of adsorption of MB dye. The results of this study show that coconut husk cellulose has the potential to be an effective and sustainable adsorbent for removing MB dye from aqueous solutions.展开更多
In a global dynamic analysis,the coexisting attractors and their basins are the main tools to understand the system behavior and safety.However,both basins and attractors can be drastically influenced by uncertainties...In a global dynamic analysis,the coexisting attractors and their basins are the main tools to understand the system behavior and safety.However,both basins and attractors can be drastically influenced by uncertainties.The aim of this work is to illustrate a methodology for the global dynamic analysis of nondeterministic dynamical systems with competing attractors.Accordingly,analytical and numerical tools for calculation of nondeterministic global structures,namely attractors and basins,are proposed.First,based on the definition of the Perron-Frobenius,Koopman and Foias linear operators,a global dynamic description through phase-space operators is presented for both deterministic and nondeterministic cases.In this context,the stochastic basins of attraction and attractors’distributions replace the usual basin and attractor concepts.Then,numerical implementation of these concepts is accomplished via an adaptative phase-space discretization strategy based on the classical Ulam method.Sample results of the methodology are presented for a canonical dynamical system.展开更多
Caulerpa sertularioides is an invasive potential blooming green alga in China but it remains poorly studied.We studied the effects of ecological factors on its growth.Optimum conditions of ecological factors,i.e.,irra...Caulerpa sertularioides is an invasive potential blooming green alga in China but it remains poorly studied.We studied the effects of ecological factors on its growth.Optimum conditions of ecological factors,i.e.,irradiance,temperature,and salinity,for the growth of its fragments were determined in the response surface methodology(RSM).The specific growth rates(SGR)of the fragments were determined in single-factor experiment.The results show that the SGR of C.sertularioides peaked under the conditions of irradiance 37.5μmol/(m~2·s),temperature25℃,and salinity 30.Meanwhile,using the Box-Behnken design,the conditions were further optimized and verified to be:irradiance 39.03μmol/(m~2·s),temperature 25.29℃,and salinity 30.06,under which the SGR reached 4.66%.The results provide new theoretical data and solutions for the cultivation,invasion prediction,and monitoring of Caulerpa species in China and the world.The RSM method may have great potential applications in the environmental adaptation characteristics of new macroalgal cultivars,intensive orientation cultured germplasm,and environmental hazard analysis of cultivated species in the field.展开更多
Waste Glass(WGs)and Coir Fiber(CF)are not widely utilized,even though their silica and cellulose content can be used to create construction materials.This study aimed to optimize mortar compressive strength using Resp...Waste Glass(WGs)and Coir Fiber(CF)are not widely utilized,even though their silica and cellulose content can be used to create construction materials.This study aimed to optimize mortar compressive strength using Response Surface Methodology(RSM).The Central Composite Design(CCD)was applied to determine the optimization of WGs and CF addition to the mortar compressive strength.Compressive strength and microstructure testing with Scanning Electron Microscope(SEM),Fourier-transform Infrared Spectroscopy(FT-IR),and X-Ray Diffraction(XRD)were conducted to specify the mechanical ability and bonding between the matrix,CF,and WGs.The results showed that the chemical treatment of CF produced 49.15%cellulose,with an average particle size of 1521μm.The regression of a second-order polynomial model yielded an optimum composition consisting of 12.776%WGs and 2.344%CF with a predicted compressive strength of 19.1023 MPa.C-S-H gels were identified in the mortars due to the dissolving of SiO_(2) in WGs and cement.The silica from WGs increased the C-S-H phase.CF plays a role in preventing,bridging,and branching micro-cracks before reaching maximum stress.WGs aggregates and chemically treated CF are suitable to be composited in mortar to increase compressive strength.展开更多
As a kind of natural fiber,ramie fiber has distinctive advantages in textile application,but the application is limited due to the traditional degumming mode.Compared with the traditional degumming process,the microbi...As a kind of natural fiber,ramie fiber has distinctive advantages in textile application,but the application is limited due to the traditional degumming mode.Compared with the traditional degumming process,the microbial degumming process has many advantages.To obtain the optimal conditions for degumming ramie with Bacillus subtilis DZ_(5)(BS DZ_(5)),a combined statistical approach of orthogonal array design(OAD)and response surface methodology(RSM)was used.The influences of initial pH of the bacteria medium,culture temperature,shaking speed,degumming time and inoculum size on submerged fermentation degumming were evaluated by using fractional factorial design.The main factors in the analysis were culture temperature,shaking speed and initial pH.The residual gum mass fraction was used as the optimization index,and the optimal conditions for degumming were determined by central composite design and RSM.Thus with only a limited number of experiments,an optimal ramie microbial degumming condition was found as the culture temperature of 40℃,the initial pH in the culture medium of 8.5,the shaking speed of 205 r/min,the degumming time of 96 h and the inoculum size of 5%.After microbial degumming of ramie under the optimal conditions,there was only 10.6%residual gum by mass in the fiber.In addition,the effective degumming of BS DZ_(5)was also confirmed by a scanning electron microscope(SEM).展开更多
[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single fac...[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material.展开更多
Gymnodimine (GYM), a fast-acting marine toxin, is destructive to aquaculture and human health through contaminated shellfish. The current detection methods in GYM have definite drawbacks in operation, such as the dema...Gymnodimine (GYM), a fast-acting marine toxin, is destructive to aquaculture and human health through contaminated shellfish. The current detection methods in GYM have definite drawbacks in operation, such as the demand for delicate instruments and the consumption of time. Therefore, silver colloid was utilized as a surface-enhanced Raman scattering (SERS) desirable substrate for sensitive and rapid detection of GYM in lake and shellfish samples. The theoretical spectrum of GYM is calculated by density functional theory (DFT), and the substrate performance is evaluated by a rhodamine 6 G probe. Under the optimal SERS experimental condition calculated by the response surface methodology, the low limit of detection of 0.105 μM with R<sup>2</sup> of 0.9873 and a broad linearity range of 0.1 - 10 μM was achieved for GYM detection. In addition, the substrate was satisfyingly applied to detect gymnodimine in the lake and shellfish matrix samples with LOD as low as 0.148 μM and 0.170 μM, respectively. These results demonstrated a promising SERS platform for detecting marine toxins in seafood for food safety and pharmaceutical research.展开更多
This study aimed to investigate optimal fermentation conditions of biological acetic acid fermentation for vinegar production. Optimization was performed on 3 acetic acid bacteria strains namely VMA1, VMA7 and VMAO us...This study aimed to investigate optimal fermentation conditions of biological acetic acid fermentation for vinegar production. Optimization was performed on 3 acetic acid bacteria strains namely VMA1, VMA7 and VMAO using Response Surface Methodology (RSM). A Box-Behnken-Design (BBD) was achieved with three different independent process parameters involving: fermentation temperature, original alcohol concentration and original acetic acid concentration and one dependent variable (acetic acid yield). The results showed that the mathematical models describe correctly the relationship between responses and factors (F values of the models (p R<sup>2</sup> (coefficient of correlation) respectively 0.96, 0.94, 0.98, and adjusted R<sup>2</sup> 0.95, 0.92, 0.98). The maximum acidity was obtained respectively at fermentation temperatures, original alcohol concentrations and original acetic acid concentrations ranging from [37.5°C - 45°C], [16% - 20% (v/v)], [1.5% - 2% (w/v)] for VMA1, [40°C - 45°C], [14.5% - 20% (v/v)], [1.7% - 2% (w/v)] for VMA7 and [42°C - 45°C], [17% - 20% (v/v)], [1.5% - 2% (w/v)] for VMAO. The use of these acetic strains in the production of vinegar may seriously lead to a decrease or even an ablation of the costs related to the cooling of bioreactors especially in warm and hot countries, in the context of global warming.展开更多
A new composite photocatalyst of modified oyster shell powder/Ce-N-TiO<sub>2</sub> was prepared by sol-gel method. Based on single factor experiment, Ce doping rate, N doping rate and calcination temperatu...A new composite photocatalyst of modified oyster shell powder/Ce-N-TiO<sub>2</sub> was prepared by sol-gel method. Based on single factor experiment, Ce doping rate, N doping rate and calcination temperature were taken as input variables. Based on the central composite design (BBD) response surface model, two functional relationship models between three independent variables and glyphosate removal rate were established to evaluate the influence degree of independent variables and interaction on catalyst. The significance of the model and regression coefficient was tested by variance analysis. The analysis of the obtained data showed that the degradation performance of the composite photocatalyst was significantly affected by the calcination temperature and the rate of N doping, while the rate of Ce doping had little effect;at the calcination temperature of 505.440°C, the degradation rate of glyphosate reached the maximum of 82.15% under the preparation conditions of 17.057 mol% N doping and 0.165 mol% Ce doping, respectively.展开更多
The philosophical foundation of the mainstream neoclassical economics is empirical philosophy.The controversies of economic methodology over inductive and deductive methods,over verificationistic and falsificationisti...The philosophical foundation of the mainstream neoclassical economics is empirical philosophy.The controversies of economic methodology over inductive and deductive methods,over verificationistic and falsificationistic approaches,and over positive and normative analyses in the evolution of economics are associated with those in the philosophy of science.The evolution of philosophy of science suggests that the above-mentioned pairs of economic methodologies should be appropriately combined when used in economics.It is not sensible to overemphasize either one inside each pair of economic methodologies.展开更多
The results of years of dental study serve as the foundation for the practise of medicine and,for that matter,dentistry.Doctors may have their own preferences for techniques and materials,but whether directly or indir...The results of years of dental study serve as the foundation for the practise of medicine and,for that matter,dentistry.Doctors may have their own preferences for techniques and materials,but whether directly or indirectly,their decisions are influenced by systematic reviews and meta-analyses.However,due to poorly conducted or presented research,this very basic foundation may not be reliable.Bias in research is one of several factors that might make study results or research itself unreliable.Bias can be introduced into research at many stages,deliberately or unknowingly.Bias can appear at any point during the research process,even before the study itself begins.There are many biases in research,but some of them are more relevant to dentistry research than others.Because it is said that“eyes see what the mind knows”,it is essential to have a complete understanding of the different types of bias,how and when they get entrenched,and what steps may be taken to prevent or lessen them if they do occur.This comprehensive summary of bias in dentistry research is provided by this synoptic review.The goal is to identify gaps and measures that have been taken-or that should have been taken-by providing both descriptive and evaluative summaries,as well as examples from the literature,when needed.展开更多
Historical materialism provides a methodology for solving the problem of ecological justice,that is,consciously constructing the socialist power system is the prerequisite and foundation for realizing ecological justi...Historical materialism provides a methodology for solving the problem of ecological justice,that is,consciously constructing the socialist power system is the prerequisite and foundation for realizing ecological justice.In essence,the fundamental nature of the socialist power system,namely,“affinity to the people”,determines the realistic possibility of ecological justice.展开更多
This research aimed at optimizing the reaction conditions for the catalytic hydrothermal liquefaction (HTL) of water hyacinth using iron oxide/nickel oxide nanocomposite as catalysts. The iron oxide/nickel oxide nanoc...This research aimed at optimizing the reaction conditions for the catalytic hydrothermal liquefaction (HTL) of water hyacinth using iron oxide/nickel oxide nanocomposite as catalysts. The iron oxide/nickel oxide nanocomposite was synthesized by the co-precipitation method and used in the hydrothermal liquefaction of water hyacinth. The composition and structural morphology of the synthesized catalysts were determined using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic absorption spectroscopy (AAS). The particle size distribution of the catalyst nanoparticles was determined by the Image J software. Three reaction parameters were optimized using the response surface methodology (RSM). These were: temperature, residence time, and catalyst dosage. A maximum bio-oil yield of 59.4 wt% was obtained using iron oxide/nickel oxide nanocomposite compared to 50.7 wt% obtained in absence of the catalyst. The maximum bio-oil yield was obtained at a temperature of 320°C, 1.5 g of catalyst dosage, and 60 min of residence time. The composition of bio-oil was analyzed using gas chromatography-mass spectroscopy (GC-MS) and elemental analysis. The GC-MS results showed an increase of hydrocarbons from 58.3% for uncatalyzed hydrothermal liquefaction to 88.66% using iron oxide/nickel oxide nanocomposite. Elemental analysis results revealed an increase in the hydrogen and carbon content and a reduction in the Nitrogen, Oxygen, and Sulphur content of the bio-oil during catalytic HTL compared to HTL in absence of catalyst nanoparticles. The high heating value increased from 33.5 MJ/Kg for uncatalyzed hydrothermal liquefaction to 38.6 MJ/Kg during the catalytic HTL. The catalyst nanoparticles were recovered from the solid residue by sonication and magnetic separation and recycled. The recycled catalyst nanoparticles were still efficient as hydrothermal liquefaction (HTL) catalysts and were recycled four times. The application of iron oxide/ nickel oxide nanocomposites in the HTL of water hyacinth increases the yield of bio-oil and improves its quality by reducing hetero atoms thus increasing its energy performance as fuel. Iron oxide/nickel oxide nanocomposites used in this study are widely available and can be easily recovered magnetically and recycled. This will potentially lead to an economical, environmentally friendly, and sustainable way of converting biomass into biofuel.展开更多
This study,through a re-conceptualization of sociological complexity theory’s epistemological sources,specifically in Edgar Morin’s formulation,sheds light on the theoretical models as well as empirical methodologie...This study,through a re-conceptualization of sociological complexity theory’s epistemological sources,specifically in Edgar Morin’s formulation,sheds light on the theoretical models as well as empirical methodologies of sociological analysis of today’s complex,interconnected,diverse and globalized society and global disorder.Complexity theory leads to a shift in perspective and a transformation of the epistemological status of social sciences with an in-depth intervention of disorder,contingency,case,singular,and non-repeatable in the sociological analysis.The notion of dialogic interplay is placed at the paradigm level and stands out at the heart of the concepts,analyzing the social system as auto-eco-organizer.Similarly,the notion of‘emergence’at macro-micro levels imposes itself as complex,logically requiring overcoming simple,linear thinking and model of explanation to adopt the perspective of organizational rotativity in which the product retroacts by transforming the one producing it,by conceiving a circularity of co-production between individuals and society through interactions.Declining epistemology and sociological complexity theory in the empirical methodology setting,the complex sociological approach is phenomenon-,event/information-and crisis-centered,privileging observation,participation-intervention,and‘live inquiry’.The open,in-depth and possibly non-directive interview is part of clinical sociological methodology,raising the question of the observer-phenomenon-observed relation.展开更多
In this paper, by means of effective testing practices, main strategies of integration testing for GUI software, including differentiating strategy for distinguished system, strategy of personnel organization, increme...In this paper, by means of effective testing practices, main strategies of integration testing for GUI software, including differentiating strategy for distinguished system, strategy of personnel organization, incremental testing strategy based on baseline version, testing strategy of circulating loop through the whole life, and the strategy of test suite construction, were briefly investigated. Moreover, for the code analysis, the FTA (Fault Tree analysis) is proposed to deal with the software change in regression testing. For test suite constructing, the constructing methods for baseline version and the incremental change are deeply discussed, in which main points focus on the testing strategy based on “Sheet/Form”, the “Grey-box approach” for integration testing process, and the application of the improved STD (State Transform Diagram) in state testing. At the same time, the suite construction of integration testing for two types, including small scale program and large scale software, is analyzed and discussed in detail. For testing execution, the specific method based on “Cross-testing” is investigated. Concurrently, by a lot of examples, all results of testing activity indicate that these strategies and methods are useful and fitted to integration testing for GUI software.展开更多
English teaching methodology is the guidance in the process of English teaching. Based on the analysis of multi-source data, quantitative research and visualized analysis, we are aimed to analyze the frontier of Engli...English teaching methodology is the guidance in the process of English teaching. Based on the analysis of multi-source data, quantitative research and visualized analysis, we are aimed to analyze the frontier of English teaching methodology and try to explore the advanced English teaching methodology, improve the English teaching and provide the scientific data and appropriate methods for the local English teaching.展开更多
This paper introduces the conception of open complex giant system and the methodology for dealing with the system, with stress on its profound significance in development of science and technology. The authors conclud...This paper introduces the conception of open complex giant system and the methodology for dealing with the system, with stress on its profound significance in development of science and technology. The authors conclude that the reductionism underlying the exact science is not suitable to open complex giant system, and the only feasible alternative is the meta-synthetic engineering from the qualitative to the quantitative.展开更多
文摘Background:The purported ergogenic and health effects of probiotics have been a topic of great intrigue among researchers,practitioners,and the lay public alike.There has also been an increased research focus within the realm of sports science and exercise medicine on the athletic gut microbiota.However,compared to other ergogenic aids and dietary supplements,probiotics present unique study challenges.The objectives of this systematic scoping review were to identify and characterize study methodologies of randomized controlled trials investigating supplementation with probiotics in athletes and physically active individuals.Methods:Four databases(MEDLINE,CINAHL,Cochrane CENTRAL,and Cochrane Database of Systematic Reviews)were searched for randomized controlled studies involving healthy athletes or physically active individuals.An intervention with probiotics and inclusion of a control and/or placebo group were essential.Only peer-reviewed articles in English were considered,and there were no date restrictions.Results were extracted and presented in tabular form to detail study protocols,characteristics,and outcomes.Bias in randomized controlled trials was determined with the RoB 2.0 tool.Results:A total of 45 studies were included in the review,with 35 using a parallel group design and 10 using a cross-over design.Approximately half the studies used a single probiotic and the other half a multi-strain preparation.The probiotic dose ranged from 2×10^(8)to 1×10^(11)colony forming units daily,and the length of intervention was between 7 and 150 days.Fewer than half the studies directly assessed gastrointestinal symptoms,gut permeability,or the gut microbiota.The sex ratio of participants was heavily weighted toward males,and only 3 studies exclusively investigated females.Low-level adverse events were reported in only 2 studies,although the methodology of reporting varied widely.The risk of bias was generally low,although details on randomization were lacking in some studies.Conclusion:There is a substantial body of research on the effects of prob iotic supplementation in healthy athletes and physically active individuals.Considerable heterogeneity in probiotic selection and dosage as well as outcome measures has made clinical and mechanistic interpretation challenging for both health care practitioners and researchers.Attention to issues of randomization of participants,treatments and interventions,selection of outcomes,demographics,and reporting of adverse events will facilitate more trustworthy interpretation of probiotic study results and inform evidence-based guidelines.
基金funded by the Directorate of Research and Community Service (DRPM,Direktorat Riset dan Pengabdian Kepada Masyarakat)ITS through the ITS Research Local Grant (No:1665/PKS/ITS/2023).
文摘Silver nanoparticles(AgNPs)synthesized using tartaric acid as a capping agent have a great impact on the reaction kinetics and contribute significantly to the stability of AgNPs.The protective layer formed by tartaric acid is an important factor that protects the silver surface and reduces potential cytotoxicity problems.These attributes are critical for assessing the compatibility of AgNPs with biological systems and making them suitable for drug delivery applications.The aim of this research is to conduct a comprehensive study of the effect of tartaric acid concentration,sonication time and temperature on the formation of silver nanoparticles.Using Response Surface Methodology(RSM)with Face-Centered Central Composite Design(FCCD),the optimization process identifies the most favorable synthesis conditions.UV-Vis spectrum regression analysis shows that AgNPs stabilized with tartaric acid are more stable than AgNPs without tartaric acid.This highlights the increased stability that tartaric acid provides in AgNP ssssynthesis.Particle size distribution analysis showed a multimodal distribution for AgNPs with tartaric acid and showed the smallest size peak with an average size of 20.53 nm.The second peak with increasing intensity shows a dominant average size of 108.8 nm accompanied by one standard deviation of 4.225 nm and a zeta potential of−11.08 mV.In contrast,AgNPs synthesized with polyvinylpyrrolidone(PVP)showed a unimodal particle distribution with an average particle size of 81.62 nm and a zeta potential of−2.96 mV.The more negative zeta potential of AgNP-tartaric acid indicates its increased stability.Evaluation of antibacterial activity showed that AgNPs stabilized with tartaric acid showed better performance against E.coli and B.subtilis bacteria compared with AgNPs-PVP.In summary,this study highlights the potential of tartaric acid in AgNP synthesis and suggests an avenue for the development of stable AgNPs with versatile applications.
文摘This study focuses on the extraction of cellulose nanocrystals (CNC), from microcrystalline cellulose (MCC), derived from Ayous sawdust. The process involves multiple steps and a large amount of chemical products. The objective of this research was to determine the effects of factors that impact the isolation process and to identify the optimal conditions for CNC isolation by using the response surface methodology. The factors that varied during the process were the quantity of MCC, the concentration of sulfuric acid, the hydrolysis time and temperature, and the ultrasonic treatment time. The response measured was the yield. The study found that with 5.80 g of microcrystalline cellulose, a sulfuric acid concentration of 63.50% (w/w), a hydrolysis time of 53 minutes, a hydrolysis temperature of 69˚C, and a sonication time of 19 minutes are the ideal conditions for isolation. The experimental yield achieved was (37.84 ± 0.99) %. The main factors influencing the process were the sulfuric acid concentration, hydrolysis time and temperature, with a significant influence (p < 0.05). Infrared characterization results showed that nanocrystals were indeed isolated. With a crystallinity of 35.23 and 79.74, respectively, for Ayous wood fiber and nanocrystalline cellulose were observed by X-ray diffraction, with the formation of type II cellulose, thermodynamically more stable than native cellulose type I.
文摘In this study, coconut husk cellulose was employed as a cost-effective and environmentally friendly adsorbent to eliminate methylene blue (MB) dye from aqueous solutions. The successful development of response surface methodology paired with a central composite design (RSM-CCD) enabled the optimization and modelling of the adsorption process. The study investigated the individual and combined effects of three variables (pH, contact time, and initial MB dye concentration) on the adsorption of MB dye onto coconut husk cellulose. The developed RSM-CCD model exhibited a remarkable degree of precision in predicting the removal efficiency of MB dye within the specified experimental parameters. This was demonstrated by the strong regression parameters, with an R<sup>2</sup> value of 99.79% and an adjusted R<sup>2</sup> value of 99.6%. The study depicted that the optimal parameters for attaining a 98.8827% removal of MB dye using coconut husk cellulose were as follows: an initial MB dye concentration of 30 mg∙L<sup>−1</sup>, contact time of 120 minutes, and pH 7 at a fixed adsorbent dose of 0.5 g. The Freundlich isotherm model provided the most satisfactory description of the equilibrium adsorption isotherms, suggesting that MB dye adsorption onto coconut husk cellulose occurs on a heterogeneous surface. The experimental results demonstrated a strong agreement with the pseudo-second-order kinetics model, indicating that the number of active sites present on the cellulose adsorbent predominantly influences the adsorption process of MB dye. Additionally, the adsorbent made from coconut husk cellulose exhibited the potential to be reused, as it retained its efficiency for a maximum of three cycles of adsorption of MB dye. The results of this study show that coconut husk cellulose has the potential to be an effective and sustainable adsorbent for removing MB dye from aqueous solutions.
基金support of the Brazil-ian research agencies,the National Council for Scientific and Technological Development (CNPq)(Nos. 301355/2018-5 and 200198/2022-0)FAPERJ-CNE (No. E-26/202.711/2018)+1 种基金FAPERJ Nota 10 (No. E-26/200.357/2020)CAPES (Finance code 001 and 88881.310620/2018-01)。
文摘In a global dynamic analysis,the coexisting attractors and their basins are the main tools to understand the system behavior and safety.However,both basins and attractors can be drastically influenced by uncertainties.The aim of this work is to illustrate a methodology for the global dynamic analysis of nondeterministic dynamical systems with competing attractors.Accordingly,analytical and numerical tools for calculation of nondeterministic global structures,namely attractors and basins,are proposed.First,based on the definition of the Perron-Frobenius,Koopman and Foias linear operators,a global dynamic description through phase-space operators is presented for both deterministic and nondeterministic cases.In this context,the stochastic basins of attraction and attractors’distributions replace the usual basin and attractor concepts.Then,numerical implementation of these concepts is accomplished via an adaptative phase-space discretization strategy based on the classical Ulam method.Sample results of the methodology are presented for a canonical dynamical system.
基金The National Natural Science Foundation of China under contract Nos 31970216,32270219 and 31670199。
文摘Caulerpa sertularioides is an invasive potential blooming green alga in China but it remains poorly studied.We studied the effects of ecological factors on its growth.Optimum conditions of ecological factors,i.e.,irradiance,temperature,and salinity,for the growth of its fragments were determined in the response surface methodology(RSM).The specific growth rates(SGR)of the fragments were determined in single-factor experiment.The results show that the SGR of C.sertularioides peaked under the conditions of irradiance 37.5μmol/(m~2·s),temperature25℃,and salinity 30.Meanwhile,using the Box-Behnken design,the conditions were further optimized and verified to be:irradiance 39.03μmol/(m~2·s),temperature 25.29℃,and salinity 30.06,under which the SGR reached 4.66%.The results provide new theoretical data and solutions for the cultivation,invasion prediction,and monitoring of Caulerpa species in China and the world.The RSM method may have great potential applications in the environmental adaptation characteristics of new macroalgal cultivars,intensive orientation cultured germplasm,and environmental hazard analysis of cultivated species in the field.
基金funded by the Ministry of Education,Culture,Research,and the Technology,Indonesia for Matching Fund (Kedaireka)Scheme in 2022 with Contract No.155/E1/KS.06.02/2022.
文摘Waste Glass(WGs)and Coir Fiber(CF)are not widely utilized,even though their silica and cellulose content can be used to create construction materials.This study aimed to optimize mortar compressive strength using Response Surface Methodology(RSM).The Central Composite Design(CCD)was applied to determine the optimization of WGs and CF addition to the mortar compressive strength.Compressive strength and microstructure testing with Scanning Electron Microscope(SEM),Fourier-transform Infrared Spectroscopy(FT-IR),and X-Ray Diffraction(XRD)were conducted to specify the mechanical ability and bonding between the matrix,CF,and WGs.The results showed that the chemical treatment of CF produced 49.15%cellulose,with an average particle size of 1521μm.The regression of a second-order polynomial model yielded an optimum composition consisting of 12.776%WGs and 2.344%CF with a predicted compressive strength of 19.1023 MPa.C-S-H gels were identified in the mortars due to the dissolving of SiO_(2) in WGs and cement.The silica from WGs increased the C-S-H phase.CF plays a role in preventing,bridging,and branching micro-cracks before reaching maximum stress.WGs aggregates and chemically treated CF are suitable to be composited in mortar to increase compressive strength.
基金National Natural Science Foundation of China(No.51863020)。
文摘As a kind of natural fiber,ramie fiber has distinctive advantages in textile application,but the application is limited due to the traditional degumming mode.Compared with the traditional degumming process,the microbial degumming process has many advantages.To obtain the optimal conditions for degumming ramie with Bacillus subtilis DZ_(5)(BS DZ_(5)),a combined statistical approach of orthogonal array design(OAD)and response surface methodology(RSM)was used.The influences of initial pH of the bacteria medium,culture temperature,shaking speed,degumming time and inoculum size on submerged fermentation degumming were evaluated by using fractional factorial design.The main factors in the analysis were culture temperature,shaking speed and initial pH.The residual gum mass fraction was used as the optimization index,and the optimal conditions for degumming were determined by central composite design and RSM.Thus with only a limited number of experiments,an optimal ramie microbial degumming condition was found as the culture temperature of 40℃,the initial pH in the culture medium of 8.5,the shaking speed of 205 r/min,the degumming time of 96 h and the inoculum size of 5%.After microbial degumming of ramie under the optimal conditions,there was only 10.6%residual gum by mass in the fiber.In addition,the effective degumming of BS DZ_(5)was also confirmed by a scanning electron microscope(SEM).
基金Supported by Guilin Scientific Research and Technology Development Program(20210202-1,2020011203-1,2020011203-2)Open Project of Guangxi Key Laboratory of Cancer Immunology and Microenvironment Regulation(2022KF005)+1 种基金Guangxi Science and Technology Major Project(Guike AA22096020)Fund for Central Guiding Local Science and Technology Development(ZY20230102).
文摘[Objectives]To optimize the solid-state fermentation process of Flos Sophorae Immaturus by Penicillium with Sophora japonica cv.jinhuai as raw material.[Methods]The fermentation conditions were optimized by single factor experiment and response surface methodology with quercetin content as the dependent variable.[Results]According to the established model,the optimal fermentation process of Flos Sophorae Immaturus was obtained as follows:temperature 29.97℃,time 6.88 d,rotation speed 180.86 rpm,inoculation amount 3.93 mL,and the expected content of quercetin was 34.8053 mg/g.Based on this,the fermentation parameters were adjusted,and the actual content was 33.67 mg/g,which was close to the predicted value.[Conclusions]The optimization of fermentation process of Flos Sophorae Immaturus by response surface methodology provides a reference for the development and utilization of this medicinal material.
文摘Gymnodimine (GYM), a fast-acting marine toxin, is destructive to aquaculture and human health through contaminated shellfish. The current detection methods in GYM have definite drawbacks in operation, such as the demand for delicate instruments and the consumption of time. Therefore, silver colloid was utilized as a surface-enhanced Raman scattering (SERS) desirable substrate for sensitive and rapid detection of GYM in lake and shellfish samples. The theoretical spectrum of GYM is calculated by density functional theory (DFT), and the substrate performance is evaluated by a rhodamine 6 G probe. Under the optimal SERS experimental condition calculated by the response surface methodology, the low limit of detection of 0.105 μM with R<sup>2</sup> of 0.9873 and a broad linearity range of 0.1 - 10 μM was achieved for GYM detection. In addition, the substrate was satisfyingly applied to detect gymnodimine in the lake and shellfish matrix samples with LOD as low as 0.148 μM and 0.170 μM, respectively. These results demonstrated a promising SERS platform for detecting marine toxins in seafood for food safety and pharmaceutical research.
文摘This study aimed to investigate optimal fermentation conditions of biological acetic acid fermentation for vinegar production. Optimization was performed on 3 acetic acid bacteria strains namely VMA1, VMA7 and VMAO using Response Surface Methodology (RSM). A Box-Behnken-Design (BBD) was achieved with three different independent process parameters involving: fermentation temperature, original alcohol concentration and original acetic acid concentration and one dependent variable (acetic acid yield). The results showed that the mathematical models describe correctly the relationship between responses and factors (F values of the models (p R<sup>2</sup> (coefficient of correlation) respectively 0.96, 0.94, 0.98, and adjusted R<sup>2</sup> 0.95, 0.92, 0.98). The maximum acidity was obtained respectively at fermentation temperatures, original alcohol concentrations and original acetic acid concentrations ranging from [37.5°C - 45°C], [16% - 20% (v/v)], [1.5% - 2% (w/v)] for VMA1, [40°C - 45°C], [14.5% - 20% (v/v)], [1.7% - 2% (w/v)] for VMA7 and [42°C - 45°C], [17% - 20% (v/v)], [1.5% - 2% (w/v)] for VMAO. The use of these acetic strains in the production of vinegar may seriously lead to a decrease or even an ablation of the costs related to the cooling of bioreactors especially in warm and hot countries, in the context of global warming.
文摘A new composite photocatalyst of modified oyster shell powder/Ce-N-TiO<sub>2</sub> was prepared by sol-gel method. Based on single factor experiment, Ce doping rate, N doping rate and calcination temperature were taken as input variables. Based on the central composite design (BBD) response surface model, two functional relationship models between three independent variables and glyphosate removal rate were established to evaluate the influence degree of independent variables and interaction on catalyst. The significance of the model and regression coefficient was tested by variance analysis. The analysis of the obtained data showed that the degradation performance of the composite photocatalyst was significantly affected by the calcination temperature and the rate of N doping, while the rate of Ce doping had little effect;at the calcination temperature of 505.440°C, the degradation rate of glyphosate reached the maximum of 82.15% under the preparation conditions of 17.057 mol% N doping and 0.165 mol% Ce doping, respectively.
基金the Research Project titled“The Role of the Global Development Initiative in Promoting Balanced,Coordinated and Inclusive Global Development”(ID:3162022ZYE03)and funded by the Basic Research Funds for Centrally Administered Institutions of Tertiary Education.
文摘The philosophical foundation of the mainstream neoclassical economics is empirical philosophy.The controversies of economic methodology over inductive and deductive methods,over verificationistic and falsificationistic approaches,and over positive and normative analyses in the evolution of economics are associated with those in the philosophy of science.The evolution of philosophy of science suggests that the above-mentioned pairs of economic methodologies should be appropriately combined when used in economics.It is not sensible to overemphasize either one inside each pair of economic methodologies.
文摘The results of years of dental study serve as the foundation for the practise of medicine and,for that matter,dentistry.Doctors may have their own preferences for techniques and materials,but whether directly or indirectly,their decisions are influenced by systematic reviews and meta-analyses.However,due to poorly conducted or presented research,this very basic foundation may not be reliable.Bias in research is one of several factors that might make study results or research itself unreliable.Bias can be introduced into research at many stages,deliberately or unknowingly.Bias can appear at any point during the research process,even before the study itself begins.There are many biases in research,but some of them are more relevant to dentistry research than others.Because it is said that“eyes see what the mind knows”,it is essential to have a complete understanding of the different types of bias,how and when they get entrenched,and what steps may be taken to prevent or lessen them if they do occur.This comprehensive summary of bias in dentistry research is provided by this synoptic review.The goal is to identify gaps and measures that have been taken-or that should have been taken-by providing both descriptive and evaluative summaries,as well as examples from the literature,when needed.
文摘Historical materialism provides a methodology for solving the problem of ecological justice,that is,consciously constructing the socialist power system is the prerequisite and foundation for realizing ecological justice.In essence,the fundamental nature of the socialist power system,namely,“affinity to the people”,determines the realistic possibility of ecological justice.
文摘This research aimed at optimizing the reaction conditions for the catalytic hydrothermal liquefaction (HTL) of water hyacinth using iron oxide/nickel oxide nanocomposite as catalysts. The iron oxide/nickel oxide nanocomposite was synthesized by the co-precipitation method and used in the hydrothermal liquefaction of water hyacinth. The composition and structural morphology of the synthesized catalysts were determined using X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and atomic absorption spectroscopy (AAS). The particle size distribution of the catalyst nanoparticles was determined by the Image J software. Three reaction parameters were optimized using the response surface methodology (RSM). These were: temperature, residence time, and catalyst dosage. A maximum bio-oil yield of 59.4 wt% was obtained using iron oxide/nickel oxide nanocomposite compared to 50.7 wt% obtained in absence of the catalyst. The maximum bio-oil yield was obtained at a temperature of 320°C, 1.5 g of catalyst dosage, and 60 min of residence time. The composition of bio-oil was analyzed using gas chromatography-mass spectroscopy (GC-MS) and elemental analysis. The GC-MS results showed an increase of hydrocarbons from 58.3% for uncatalyzed hydrothermal liquefaction to 88.66% using iron oxide/nickel oxide nanocomposite. Elemental analysis results revealed an increase in the hydrogen and carbon content and a reduction in the Nitrogen, Oxygen, and Sulphur content of the bio-oil during catalytic HTL compared to HTL in absence of catalyst nanoparticles. The high heating value increased from 33.5 MJ/Kg for uncatalyzed hydrothermal liquefaction to 38.6 MJ/Kg during the catalytic HTL. The catalyst nanoparticles were recovered from the solid residue by sonication and magnetic separation and recycled. The recycled catalyst nanoparticles were still efficient as hydrothermal liquefaction (HTL) catalysts and were recycled four times. The application of iron oxide/ nickel oxide nanocomposites in the HTL of water hyacinth increases the yield of bio-oil and improves its quality by reducing hetero atoms thus increasing its energy performance as fuel. Iron oxide/nickel oxide nanocomposites used in this study are widely available and can be easily recovered magnetically and recycled. This will potentially lead to an economical, environmentally friendly, and sustainable way of converting biomass into biofuel.
文摘This study,through a re-conceptualization of sociological complexity theory’s epistemological sources,specifically in Edgar Morin’s formulation,sheds light on the theoretical models as well as empirical methodologies of sociological analysis of today’s complex,interconnected,diverse and globalized society and global disorder.Complexity theory leads to a shift in perspective and a transformation of the epistemological status of social sciences with an in-depth intervention of disorder,contingency,case,singular,and non-repeatable in the sociological analysis.The notion of dialogic interplay is placed at the paradigm level and stands out at the heart of the concepts,analyzing the social system as auto-eco-organizer.Similarly,the notion of‘emergence’at macro-micro levels imposes itself as complex,logically requiring overcoming simple,linear thinking and model of explanation to adopt the perspective of organizational rotativity in which the product retroacts by transforming the one producing it,by conceiving a circularity of co-production between individuals and society through interactions.Declining epistemology and sociological complexity theory in the empirical methodology setting,the complex sociological approach is phenomenon-,event/information-and crisis-centered,privileging observation,participation-intervention,and‘live inquiry’.The open,in-depth and possibly non-directive interview is part of clinical sociological methodology,raising the question of the observer-phenomenon-observed relation.
文摘In this paper, by means of effective testing practices, main strategies of integration testing for GUI software, including differentiating strategy for distinguished system, strategy of personnel organization, incremental testing strategy based on baseline version, testing strategy of circulating loop through the whole life, and the strategy of test suite construction, were briefly investigated. Moreover, for the code analysis, the FTA (Fault Tree analysis) is proposed to deal with the software change in regression testing. For test suite constructing, the constructing methods for baseline version and the incremental change are deeply discussed, in which main points focus on the testing strategy based on “Sheet/Form”, the “Grey-box approach” for integration testing process, and the application of the improved STD (State Transform Diagram) in state testing. At the same time, the suite construction of integration testing for two types, including small scale program and large scale software, is analyzed and discussed in detail. For testing execution, the specific method based on “Cross-testing” is investigated. Concurrently, by a lot of examples, all results of testing activity indicate that these strategies and methods are useful and fitted to integration testing for GUI software.
文摘English teaching methodology is the guidance in the process of English teaching. Based on the analysis of multi-source data, quantitative research and visualized analysis, we are aimed to analyze the frontier of English teaching methodology and try to explore the advanced English teaching methodology, improve the English teaching and provide the scientific data and appropriate methods for the local English teaching.
文摘This paper introduces the conception of open complex giant system and the methodology for dealing with the system, with stress on its profound significance in development of science and technology. The authors conclude that the reductionism underlying the exact science is not suitable to open complex giant system, and the only feasible alternative is the meta-synthetic engineering from the qualitative to the quantitative.
