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Flavonoids from Millettia nitita var. hirsutissima 被引量:4
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作者 冯 洁 梁 鸿 +1 位作者 赵玉英 吴增宝 《Journal of Chinese Pharmaceutical Sciences》 CAS 2006年第3期178-181,共4页
Aim To Methods The constituents tures were identified investigate the chemical constituents of MiUettia nitita var. hirsutissima. were isolated and purified by chromatographic techniques, and the strucby spectral evid... Aim To Methods The constituents tures were identified investigate the chemical constituents of MiUettia nitita var. hirsutissima. were isolated and purified by chromatographic techniques, and the strucby spectral evidences. Results Four flavonoids were isolated from the plant, including liquiritigenin ( 1 ), naringenin (2), maackiain (3), and 3R-vestitol (4). Conclusion Compounds 1 and 2 were obtained from the genus Millettia for the first time ; 3 and 4 were obtained from the plant for the first time. 展开更多
关键词 millettia nitita var. hirsutissima FLAVONOIDS 3R-vestitol
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我国崖豆藤属(Millettia)分布种化学成分及生物活性研究进展 被引量:3
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作者 王建荣 宗鑫凯 王祝年 《安徽农业科学》 CAS 北大核心 2008年第36期15936-15942,15973,共8页
综述了现已掌握的中国崖豆藤属11种植物提取的天然化合物132种,包括黄酮类、萜类、甾体类等。在此基础上,对该属植物化合物的生物活性的报道亦加以归纳,为今后我国崖豆藤属植物化学成分和药性药理研究提供参考。
关键词 崖豆藤属 黄酮类 生物活性
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Characterization of flavonoids in Millettia nitida var. hirsutissima by HPLC/DAD/ESI-MS^n 被引量:7
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作者 Min Ye, Wen-Zhi Yang, Ke-Di Liu, Xue Qiao, Bei-Jia Li, Jun Cheng, Jie Feng, De-An Guo, Yu-Ying Zhao State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China 《Journal of Pharmaceutical Analysis》 SCIE CAS 2012年第1期35-42,共8页
Millettia nitida var. hirsutissima is a Chinese herbal medicine used for the treatment of gynecological diseases. An HPLC/DAD/ESI-MSn method was established for the rapid separation and characterization of bioactive f... Millettia nitida var. hirsutissima is a Chinese herbal medicine used for the treatment of gynecological diseases. An HPLC/DAD/ESI-MSn method was established for the rapid separation and characterization of bioactive flavonoids in M. nitida var. hirsutissima. A total of 32 flavonoids were detected, of which 14 compounds were unambiguously characterized by comparing their retention time, UV, and MS spectra with those of the reference standards, and the others were tentatively identified based on their tandem mass spectrometry fragmentation data obtained in the negative ionization mode on line. Nineteen of these compounds characterized were reported from this plant for the first time. 展开更多
关键词 HPLC/DAD/ESI-MSn millettia nitida var. hirsutissima Mass spectrometry FLAVONOIDS
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岩豆(Millettia dielsiana Harms ex Diels)凝集素的分离纯化和性质研究 被引量:6
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作者 曾仲奎 郑建 刘荣华 《生物化学杂志》 CSCD 1992年第1期93-98,共6页
用猪甲状腺球蛋白-Sepharose 4B作亲和吸附剂,再经Sephadex G-100凝胶过滤,可以从岩豆种子中纯化出岩豆凝集素(MDL)。该凝集素可以凝集人类A、B、O型血细胞和兔红细胞,纯化的MDL凝集兔红细胞的能力可被D-松三糖、邻硝基-苯酚-D-半乳糖... 用猪甲状腺球蛋白-Sepharose 4B作亲和吸附剂,再经Sephadex G-100凝胶过滤,可以从岩豆种子中纯化出岩豆凝集素(MDL)。该凝集素可以凝集人类A、B、O型血细胞和兔红细胞,纯化的MDL凝集兔红细胞的能力可被D-松三糖、邻硝基-苯酚-D-半乳糖和N-乙酰半乳糖胺抑制,甘露糖也有弱的抑制作用。纯化的MDL在PAGE和SDS-PAGE上均显现单一蛋白质染色带,经Schiff’s试剂染色证明为糖蛋白;以酚-硫酸法测得其中性糖含量为6.0%;SDS-PAGE测得亚基分子量为32 000;Sephadex G-100分子筛柱测得其分子量为63 800;等电聚焦电泳显示其等电点为5.1;氨基酸组成分析表明其中Asp、Glu、Phe含量较高,但不含有Pro、Tyr。MDL也是一个强促有丝分裂原,对人外周血淋巴细胞转化率可达81.2%,细胞分裂比率达14.8%。 展开更多
关键词 岩豆
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Content Determination of Flavonoids in Radix Millettiae Speciosae from Different Areas of Guangxi 被引量:1
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作者 Jingwen GU Liuping WANG +1 位作者 Dongping TU Xiajun ZHONG 《Medicinal Plant》 CAS 2019年第1期31-33,共3页
[Objectives] This study aimed to investigate the quality of Radix Millettiae Speciosae at different planting sites in Guangxi. [Methods] The content of flavonoids in Radix Millettiae Speciosae was determined by HPLC. ... [Objectives] This study aimed to investigate the quality of Radix Millettiae Speciosae at different planting sites in Guangxi. [Methods] The content of flavonoids in Radix Millettiae Speciosae was determined by HPLC. The chromatographic conditions were as follows: column, ZORBAX SB-C_(18); mobile phase, acetonitrile-0.1% glacial acetic acid(42∶58); detection wavelength, 250(formononetin) and 310(maackiain) nm; flow rate, 1.0 mL/min; and column temperature, 30℃. [Results] Under the chromatographic conditions above, formononetin and maackiain could be completely separated from impurities. The standard curve had a good linear relationship(R^2>0.999 9). The precision and stability met analysis requirements. The average recovery rates were 97.53% and 98.54%, respectively, and the RSD values were 2.03% and 1.88%, respectively, indicating that the established method has good reproducibility, durability and accuracy. The content of formononetin was highest in the Radix Millettiae Speciosae from Yongning District, Nanning City, and the content of maackiain was highest in the Radix Millettiae Speciosae from Xichang Town, Hepu County. [Conclusions] The HPLC method established in this study is simple, accurate and stable. It can be used as a quality control method for Radix Millettiae Speciosae. The contents of flavonoids in Radix Millettiae Speciosae from Yongning District, Nanning City and Xichang Town, Hepu County were higher than those from other planting bases. 展开更多
关键词 RADIX millettiae Speciosae FLAVONOIDS FORMONONETIN Maackiain HPLC
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A Preliminary Study on Anti-inflammatory and Analgesic Effects of Millettia speciosa and Tinpspora sinensis and Their Compatibility 被引量:1
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作者 Shibo ZHAO Suoyi HUANG +5 位作者 Xinpeng CHEN Huanhui DENG Zhi PAN Kairen XIE Haoming YU Fen MO 《Medicinal Plant》 CAS 2020年第1期32-36,共5页
[Objectives]To study the anti-inflammatory and analgesic effects of Millettia speciosa and Tinpspora sinensis and their compatibility.[Methods](i)In the glacial acetic acid writhing experiment,60 SPF-grade Kunming mic... [Objectives]To study the anti-inflammatory and analgesic effects of Millettia speciosa and Tinpspora sinensis and their compatibility.[Methods](i)In the glacial acetic acid writhing experiment,60 SPF-grade Kunming mice were adopted,and the mice were randomly divided into 6 groups at male-female ratio of 1∶1,namely,the blank control group,M.speciosa group,T.sinensis group,M.speciosa compatible with T.sinensis group at the ratio of 1∶2(expressed as 1∶2 compatibility group),M.speciosa compatible with T.sinensis group at the ratio of 1∶1(expressed as 1∶1 compatibility group),and M.speciosa compatible with T.sinensis group at the ratio of 2∶1(expressed as 2∶1 compatibility group),12 mice for each group.Mice of the experimental groups were administered at a dose of 20 mL/kg,and the corresponding concentration of the Chinese medicine extract was given at 1 g/mL.The control group was administered with an equal volume of 0.9%physiological saline,and was intragastrically administered once every 24 h for 14 d.After intragastric administration for one hour on day 14,intraperitoneal injection of 0.5%glacial acetic acid solution was performed to induce pain.(ii)In the hot plate experiment,60 Kunming female SPF mice were adopted,grouped,intragastrically administered with the same glacial acetic acid writhing experiment for 14 d.After intragastric administration for one hour on day 14,the mice were placed on a hot plate apparatus at(55±0.5)℃.to measure the time of licking their hind feet.(iii)In the anti-inflammatory experiment,60 Kunming SPF mice were adopted,grouped,intragastrically administered with the same glacial acetic acid writhing experiment for 14 d.After intragastric administration for one hour on day 14,xylylene was administered to the left ears of mice at a dose of 50μL/piece to induce inflammation.[Results](i)In the glacial acetic acid writhing experiment,compared with the blank control group,the experimental group showed analgesic effects.Specifically,M.speciosa group,T.sinensis group,1∶2 compatibility group,1∶1 compatibility group,2∶1 compatibility group showed significant effect(P<0.05),the writhing inhibition rate was 17.65%,20.59%,29.41%,26.47%,and 44.12%,respectively,and 2∶1 compatibility group showed the most significant analgesic effects.(ii)In the hot plate experiment,compared with the control group,all experimental groups showed analgesic effect.Specifically,M.speciosa group,T.sinensis group,1∶2 compatibility group,1∶1 compatibility group,2∶1 compatibility group showed significant effect(P<0.05),the pain threshold improvement rates were 16.13%,14.55%,14.96%,29.95%,and 58.68%,respectively,and 2∶1 compatibility group showed the most significant analgesic effect.(iii)In the anti-inflammatory experiment,the swelling degree of the 1∶2 compatibility group was significantly different from that of the blank control group,M.speciosa group,T.sinensis group(P<0.05).and 1∶2 compatibility group showed the most significant anti-inflammatory effect.[Conclusions]M.speciosa,T.sinensis,and their compatibility had anti-inflammatory and analgesic effects.The 2∶1 compatibility group had the best analgesic effects,and 1∶2 compatibility group had the best anti-inflammatory effects. 展开更多
关键词 millettia speciosa Tinpspora SINENSIS Compatibility ANTI-INFLAMMATORY EFFECTS ANALGESIC EFFECTS
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Development and Processing of Millettia speciosa Instant Tea 被引量:1
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作者 Maoyuan WANG Qing YANG +3 位作者 Qinglong WANG Xiaoxia YAN Jianrong WANG Zhunian WANG 《Asian Agricultural Research》 2017年第3期102-105,共4页
This paper analyzed the effect of raw material crushing fineness,cooking time,ethanol content during ethanol precipitation and other factors on the preparation of raw material extract from Millettia speciosa Champ. in... This paper analyzed the effect of raw material crushing fineness,cooking time,ethanol content during ethanol precipitation and other factors on the preparation of raw material extract from Millettia speciosa Champ. instant tea. The raw materials of Millettia speciosa Champ.,Philippine flemingia root and radix fici simplicissimae were crushed into 10 mesh or finer powder,and cooked for 60 min. During ethanol precipitation,the ethanol content was about 50% to 70%,standing 12 h. The ophiopogon root was cooked in 1∶ 15 boiling water for 45 min,and chrysanthemum was leached for 45 min with 1∶ 20 demineralized water at 80 ℃. After concentration,preparation and spray drying,the finished Millettia speciosa Champ. instant tea was created. The detection of each product index indicated that Millettia speciosa Champ. instant tea had good taste and flavor,and there were no heavy metals,harmful substances and excessive microbes,thereby showing that the raw material of Millettia speciosa Champ. instant tea was selected reasonably,the mixture ratio was rational,and the processing technology was of some security,stability and maturity,which provided a theoretical basis for its development and application. 展开更多
关键词 millettia speciosa Champ Instant tea Processing technology Index detection
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GC-MS Analysis of Liposoluble Constituents from Buds,Flowers and Fruits of Millettia speciosa Champ. 被引量:1
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作者 Maoyuan WANG Qing YANG +3 位作者 Qinglong WANG Xiaoxia YAN Jianrong WANG Zhunian WANG 《Medicinal Plant》 2017年第4期10-14,共5页
[Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia specios... [Objectives] To study the material foundation of liposoluble constituents from buds,flowers and fruits of Millettia speciosa Champ.and provide a reference for the development of flowers and fruits of Millettia speciosa Champ.[Methods]The liposoluble constituents were extracted from buds,flowers and fruits of Millettia speciosa by Soxhlet extraction and solvent extraction method,and analyzed by GC-MS.[Results]24 compounds were identified from the liposoluble constituents of buds,accounting for 88. 31 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 52. 00%) and alcohols compounds( 17. 46%); 29 compounds were identified from the liposoluble constituents of flowers,accounting for 91. 38 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 60. 64%) and alcohols compounds( 17. 17%); 32 compounds were identified from the liposoluble constituents of fruits,accounting for 80. 01 % of the total liposoluble constituents,mainly comprising alkanes and olefins compounds( 32. 56%),phenyl and its derivatives compounds( 22. 46%) and fatty acids compounds( 12. 54%). 6 compounds were common in buds,flowers and fruits. [Conclusions] Although there were some differences in liposoluble constituents from flowers,fruits,leaves and roots of Millettia speciosa Champ.,the different parts of Millettia speciosa Champ. had development value. 展开更多
关键词 millettia speciosa CHAMP BUDS FLOWERS FRUITS GC-MS Liposoluble constituents
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Analysis on Development Potential of Millettia Specisoa Champ Industry in Guangdong Province
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作者 Shuaipeng MA Jing LI +4 位作者 Weiping LONG Shouxing WEI Xindao TAN Qianquan MA Bilan HUANG 《Asian Agricultural Research》 2014年第10期44-47,共4页
In recent years,Millettia specisoa Champ has attracted extensive attention because of its high medicinal and edible value. This paper will summarize the composition and application of Millettia specisoa Champ,analyze ... In recent years,Millettia specisoa Champ has attracted extensive attention because of its high medicinal and edible value. This paper will summarize the composition and application of Millettia specisoa Champ,analyze the advantages and existing problems in developing Millettia specisoa Champ industry in Guangdong Province according to the demand for Millettia specisoa Champ and the present situation in Guangdong Province,and put forward reasonable countermeasures and suggestions. 展开更多
关键词 millettia specisoa CHAMP GUANGDONG PROVINCE Develo
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HPLC Fingerprint and Chemical Pattern Recognition of Wild and Cultivated Millettia speciosa Champ.
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作者 Jianguang ZHANG Xuemin SHI +2 位作者 Ming CHEN Xiaoping ZHOU Xiangle MENG 《Medicinal Plant》 CAS 2020年第6期82-86,共5页
[Objectives]To establish HPLC fingerprints of wild and cultivated Millettia speciosa Champ.,and identify medicinal materials combined with chemical pattern recognition methods,and provide a reference system for the id... [Objectives]To establish HPLC fingerprints of wild and cultivated Millettia speciosa Champ.,and identify medicinal materials combined with chemical pattern recognition methods,and provide a reference system for the identification and quality control of M.speciosa from different sources.[Methods]20 batches of M.speciosa from different sources were determined by HPLC method,and the similarity analysis and evaluation were performed using the Similarity Evaluation System of Traditional Chinese Medicine Chromatographic Fingerprints(2012 edition).Principal component analysis(PCA)and least partial squares method-discrimination analysis(PLS-DA)were used to conduct chemical pattern recognition research on wild and cultivated M.speciosa.[Results]The HPLC fingerprints of wild and cultivated M.speciosa were established,10 common peaks were calibrated,and the similarity of 20 batches of samples was greater than 0.9;PCA can better classify M.speciosa from different sources into 2 categories,and PLS-DA can completely distinguish between wild and cultivated M.speciosa.[Conclusions]The established M.speciosa fingerprint,combined with chemical pattern recognition methods,can effectively distinguish between wild and cultivated M.speciosa,so it can provide a reference for quality control and evaluation of M.speciosa. 展开更多
关键词 millettia speciosa Champ. WILD CULTIVATED FINGERPRINT Quality control
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Quality Standard of Yi Herb Medicine Millettia dielsiana
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作者 Maliniu SHA Wenbing LI +4 位作者 Dongmei SHA Meiyi TONG Jing WANG Xinjia YAN Yuan LIU 《Medicinal Plant》 CAS 2022年第5期26-30,共5页
[Objectives]The paper was to establish the quality standard of Yi herb medicine Millettia dielsiana.[Methods]Yi herb medicine M.dielsiana was qualitatively identified by microscopic identification and thin layer ident... [Objectives]The paper was to establish the quality standard of Yi herb medicine Millettia dielsiana.[Methods]Yi herb medicine M.dielsiana was qualitatively identified by microscopic identification and thin layer identification.The content of total isoflavones was determined by UV-Vis spectrophotometry,and the contents of moisture,total ash,acid-insoluble ash and extract were checked according to the method introduced in Chinese Pharmacopoeia(2020 edition).[Results]The microscopic identification features,including stone cells,fiber bundles,calcium oxalate square crystals,starch granules,pigment blocks,ducts,etc.,were distinct.A TLC method for identification of M.dielsiana was established.The contents of water,total ash,acid-insoluble ash and extract should be no more than 13%,no more than 7%,no more than 0.5%and no less than 6%in 10 batches of samples,respectively.The total isoflavones of M.dielsiana based on genistein(C_(15)H_(10)O_(5)) should be no less than 0.25%.The linear relationship of genistein was good in the range of 0.002-0.007 mg/mL(R^(2)=0.9996);the average recovery was 97.01%and the RSD was 2.62%.[Conclusions]The method is simple,accurate and well-reproducible,and can be used for the quality control of Yi herb medicine M.dielsiana. 展开更多
关键词 Yi herb medicine millettia dielsiana GENISTEIN TLC UV-Vis spectrophotometry
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牛大力热风干燥工艺参数优化
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作者 沈向阳 谭子键 +2 位作者 陈嘉澍 黄伟彬 丁力行 《农机化研究》 北大核心 2024年第5期228-234,共7页
热风干燥有利于提高鲜制牛大力干燥时的干燥速率和产品品质。为此,对新鲜的牛大力进行单因素热风干燥实验,结果表明:干燥过程中热风温度越高、切片厚度越薄时,牛大力的干燥速率越快;而热风温度过高时,牛大力切片表面会发生褐化和裂纹。... 热风干燥有利于提高鲜制牛大力干燥时的干燥速率和产品品质。为此,对新鲜的牛大力进行单因素热风干燥实验,结果表明:干燥过程中热风温度越高、切片厚度越薄时,牛大力的干燥速率越快;而热风温度过高时,牛大力切片表面会发生褐化和裂纹。结合响应面优化分析方法,建立各因素与指标值之间的回归分析模型。由响应面优化分析和实验结果可知:当热风温度为50~60℃、切片厚度为3~7 mm和热风风速为0.5~1.5 m/s时,牛大力热风干燥的最佳干燥参数为:热风温度60℃,切片厚度5 mm,热风风速1.116 m/s。 展开更多
关键词 牛大力 热风干燥 工艺参数 响应面优化
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吕培文应用鸡血藤治疗下肢动脉硬化闭塞症经验
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作者 李田田 王雨 +1 位作者 徐旭英 吕培文 《北京中医药》 2024年第8期886-889,共4页
下肢动脉硬化闭塞症可导致的肢体疼痛及致残等情况,给人们健康及经济带来极大负担,中医药在其治疗上有一定的优势。吕培文教授认为“络脉瘀滞”是下肢动脉硬化闭塞症主要病理改变,提出了“络以通为用”的观念,从而形成以“活血通络”为... 下肢动脉硬化闭塞症可导致的肢体疼痛及致残等情况,给人们健康及经济带来极大负担,中医药在其治疗上有一定的优势。吕培文教授认为“络脉瘀滞”是下肢动脉硬化闭塞症主要病理改变,提出了“络以通为用”的观念,从而形成以“活血通络”为主的治法。鸡血藤具有补血活血、舒筋通络之功效,为补血活血类常用传统中药。临床上吕培文教授将其广泛应用于下肢动脉硬化闭塞症的治疗,切实针对“络脉瘀滞”的病因病机,辨证配伍补气、补血养阴、温经散寒、清热、活血化瘀、化痰祛湿、理气类药物,可达到活血通络之功效。 展开更多
关键词 吕培文 鸡血藤 下肢动脉硬化闭塞症 活血通络
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Chemical Constituents of Millettia speciosa 被引量:9
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作者 Ping Ding Jin-ying Qiu +1 位作者 Ge Ying Lei Dai 《Chinese Herbal Medicines》 CAS 2014年第4期332-334,共3页
Objective To study the chemical constituents from Millettia speciosa. Methods The compounds were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatography, and recrystallization. The structures we... Objective To study the chemical constituents from Millettia speciosa. Methods The compounds were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatography, and recrystallization. The structures were identified using physicochemical and spectral data. Results Thirteen compounds were isolated from M. speciosa and identified as docosanoic acid (1), tetracosane (2), octadecane (3), hexacosanoic acid (4), β-sitosteroi acetate (5), β-sitosterol (6), syringin (7), maackiain (8), formononetin (9), ψ-baptigenin (10), rotundic acid (11), pedunculoside (12), and daucosterol (13). Conclusion Compounds 5, 7, and 10-12 are obtained from this plant for the first time. 展开更多
关键词 ψ-baptigenin Leguminosae: millettia speciosa pedunculoside rotundic acid SYRINGIN
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2种A型淀粉的消化特性研究
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作者 黎保莲 黄一帆 +3 位作者 曹榆沛 刘熹 杨涛 方桂红 《粮食与油脂》 北大核心 2024年第5期7-11,21,共6页
以牛大力淀粉(MSS)和海南红山兰米淀粉(RRS)为研究对象,采用体外模拟消化模型建立一阶消化动力学方程,并对消化后淀粉的微观结构进行表征。结果表明:MSS抗消化能力优于RRS。经体外消化后,牛大力消化淀粉(MSDS)中的直链淀粉含量减少4.95%... 以牛大力淀粉(MSS)和海南红山兰米淀粉(RRS)为研究对象,采用体外模拟消化模型建立一阶消化动力学方程,并对消化后淀粉的微观结构进行表征。结果表明:MSS抗消化能力优于RRS。经体外消化后,牛大力消化淀粉(MSDS)中的直链淀粉含量减少4.95%,而海南红山兰米消化淀粉(RRDS)中的直链淀粉含量增加5.11%。在体外消化过程中,与原淀粉相比,MSDS和RRDS的短程有序结构比例逐渐增大,相对结晶度提高。 展开更多
关键词 牛大力淀粉 海南红山兰米淀粉 消化特性
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Chemical Constituents from Roots of Millettia speciosa 被引量:10
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作者 Man-qin Fu Geng-sheng Xiao +3 位作者 Yu-juan Xu Ji-jun Wu Yu-long Chen Samuel-X Qiu 《Chinese Herbal Medicines》 CAS 2016年第4期385-389,共5页
Objective To study the chemical constituents from the roots of Millettia speciosa.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. The structur... Objective To study the chemical constituents from the roots of Millettia speciosa.Methods The chemical constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. The structures were identified by means of spectral data. Results Fifteen compounds were isolated and identified as naringenin(1), liquiritigenin(2), garbanzol(3), 7-hydroxy-6,4′- dimethoxyisoflavone(4), calycosin(5), 2′,5′,7-trihydroxy-4′-methoxyisoflavone(6), 2′-hydroxybiochanin A(7), 6-methoxycalopogonium isoflavone A(8), demethylmedicarpin(9), 4,4′-dihydroxy-2′-methoxychalcone(10), 2′,4′-dihydroxy-4-methoxychalcone(11), rhododendrol(12), secoisolariciresinol(13), bisdihydrosiringenin(14), and polystachyol(15). Conclusion All compounds are obtained from this plant for the first time. 展开更多
关键词 Leguminosae liquiritigenin millettia speciosa naringenin
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岭南道地药材牛大力质量标准研究进展
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作者 苏汝彬 褚朝 +1 位作者 冯英苗 赵斌 《安徽农业科学》 CAS 2024年第12期16-21,共6页
牛大力为豆科植物美丽崖豆藤的干燥根,具有补虚润肺、强筋活络之效,为岭南地区著名的药食两用植物。综述了牛大力质量标准收载情况、品种鉴别、检查、有效成分测定方法研究及指纹图谱质量评价等方面的研究进展,分析了已有牛大力质量研... 牛大力为豆科植物美丽崖豆藤的干燥根,具有补虚润肺、强筋活络之效,为岭南地区著名的药食两用植物。综述了牛大力质量标准收载情况、品种鉴别、检查、有效成分测定方法研究及指纹图谱质量评价等方面的研究进展,分析了已有牛大力质量研究方法的优势与不足,提出了建立牛大力质量综合评价体系的方法,为牛大力药材质量评价研究与质量控制提供参考。 展开更多
关键词 牛大力 质量标准 指纹图谱 含量测定
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基于抗炎活性的香花崖豆藤化学成分研究
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作者 姚采平 邱飞 +2 位作者 郭燕华 李燕华 刘建锋 《中国药业》 CAS 2024年第5期34-37,共4页
目的分离香花崖豆藤中发挥抗炎活性的化学成分。方法香花崖豆藤70%乙醇冷浸提取物经聚酰胺柱梯度洗脱,得水洗脱部位(A)、40%乙醇洗脱部位(B)、70%乙醇洗脱部位(C)、100%乙醇洗脱部位(D)。采用凝胶色谱、半制备高效液相色谱对抗炎有效部... 目的分离香花崖豆藤中发挥抗炎活性的化学成分。方法香花崖豆藤70%乙醇冷浸提取物经聚酰胺柱梯度洗脱,得水洗脱部位(A)、40%乙醇洗脱部位(B)、70%乙醇洗脱部位(C)、100%乙醇洗脱部位(D)。采用凝胶色谱、半制备高效液相色谱对抗炎有效部位进行化学成分分离。以脂多糖(LPS)诱导的RAW264.7细胞为炎性模型,试验分为A组、B组、C组、D组(50μg/mL极性洗脱部位A,B,C,D),阳性对照组(0.5μmol/L地塞米松),模型组(10μg/mL LPS),空白组(常规培养基)。采用Griess法测定一氧化氮(NO)释放量;采用免疫印迹(Western blot)法测定诱导型一氧化氮合酶(iNOS)、环氧合酶2(COX-2)的蛋白表达水平,筛选抗炎有效部位。结果香花崖豆藤40%乙醇洗脱部位经分离得到2个单体化合物,分别鉴定为5,7-dihydroxy-2',3',4'-trimethoxyisoflavanone(化合物1)和5,7,4'-trihydroxyiso flavanone(化合物2)。与模型组比较,B组、C组、D组的NO释放量均显著减少(P<0.001),B组的iNOS蛋白表达水平显著降低(P<0.01)。结论香花崖豆藤40%乙醇洗脱部位具有较好的抗炎活性,可通过抑制iNOS蛋白的表达而发挥抗炎作用。 展开更多
关键词 香花崖豆藤 化学成分 抗炎活性 诱导型一氧化氮合酶 环氧合酶2
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蒸制次数对牛大力黄酮和多糖含量的影响
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作者 陈杰超 郭添枫 《中国中医药现代远程教育》 2024年第2期128-131,共4页
目的研究不同蒸制次数对牛大力饮片的黄酮和多糖含量的影响,为牛大力的蒸制研究提供参考。方法将同一批次牛大力根饮片随机分为对照组和1~5次蒸制组,共6组;分别采用超声波提取法和水提醇沉法提取各组饮片的黄酮和多糖,分别以芦丁和无水... 目的研究不同蒸制次数对牛大力饮片的黄酮和多糖含量的影响,为牛大力的蒸制研究提供参考。方法将同一批次牛大力根饮片随机分为对照组和1~5次蒸制组,共6组;分别采用超声波提取法和水提醇沉法提取各组饮片的黄酮和多糖,分别以芦丁和无水葡萄糖作为对照品,通过分光光度计测量黄酮和多糖的含量。结果多次蒸制可提高牛大力总黄酮的析出含量,2~5次蒸制析出含量显著提高,差异具有统计学意义(P<0.05),其中蒸晒3次含量最高;蒸制可提高牛大力多糖的析出含量,但差异无统计学意义(P>0.05)。结论蒸制能显著提高牛大力的总黄酮析出含量,对多糖含量的提高并不显著。 展开更多
关键词 牛大力 蒸制 黄酮 多糖 实验研究
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UPLC测定不同牛大力样品中刺桐碱的含量
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作者 吴渝 谢寅正 +5 位作者 邹子铭 凌晓彤 林炜瑜 李艺红 林润萍 李冬利 《广东化工》 CAS 2024年第2期112-115,共4页
目的:优化牛大力中刺桐碱的提取方法,并建立测定牛大力中刺桐碱含量的超高效液相色谱(UPLC)方法,从而比较不同牛大力中刺桐碱的含量。方法:采用单因素和正交实验优化牛大力中刺桐碱的提取,含量测定采用Agilent XDB-C_(18)(1.8μm,2.1... 目的:优化牛大力中刺桐碱的提取方法,并建立测定牛大力中刺桐碱含量的超高效液相色谱(UPLC)方法,从而比较不同牛大力中刺桐碱的含量。方法:采用单因素和正交实验优化牛大力中刺桐碱的提取,含量测定采用Agilent XDB-C_(18)(1.8μm,2.1×100 mm)色谱柱,乙腈水溶液梯度洗脱,检测波长278 nm,流速0.3 mL/min,柱温30℃。结果:确定牛大力中刺桐碱80℃水浴回流提取的最佳条件为料液比为1∶15 g/mL,提取时间为1.5 h,乙醇浓度为70%;建立的刺桐碱含量测定方法快速、准确、稳定、可靠。结论:22个不同的牛大力样品中刺桐碱含量差别较大,与品种、生长环境和生长年限等因素有关。 展开更多
关键词 牛大力 刺桐碱 提取工艺 超高效液相色谱法 含量测定
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