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Identification of injury type using somatosensory and motor evoked potentials in a rat spinal cord injury model 被引量:1
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作者 Rong Li Han-Lei Li +2 位作者 Hong-Yan Cui Yong-Can Huang Yong Hu 《Neural Regeneration Research》 SCIE CAS CSCD 2023年第2期422-427,共6页
The spinal cord is at risk of injury during spinal surgery.If intraoperative spinal co rd injury is identified early,irreve rsible impairment or loss of neurological function can be prevented.Different types of spinal... The spinal cord is at risk of injury during spinal surgery.If intraoperative spinal co rd injury is identified early,irreve rsible impairment or loss of neurological function can be prevented.Different types of spinal cord injury result in damage to diffe rent spinal cord regions,which may cause diffe rent somatosensory and motor evoked potential signal res ponses.In this study,we examined electrophysiological and histopathological changes between contusion,distra ction,and dislocation spinal cord injuries in a rat model.We found that contusion led to the most severe dorsal white matter injury and caused considerable attenuation of both somatosensory and motor evoked potentials.Dislocation resulted in loss of myelinated axons in the lateral region of the injured spinal cord along the rostrocaudal axis.The amplitude of attenuation in motor evoked potential responses caused by dislocation was greater than that caused by contusion.After distraction injury,extracellular spaces were slightly but not significantly enlarged;somatosensory evoked potential res ponses slightly decreased and motor evoked potential responses were lost.Correlation analysis showed that histological and electrophysiological findings we re significantly correlated and related to injury type.Intraope rative monitoring of both somatosensory and motor evoked potentials has the potential to identify iatrogenic spinal cord injury type during surgery. 展开更多
关键词 contusion injury dislocation injury distraction injury electropnysiology heterogeneity HISTOPATHOLOGY injury mechanism motor evoked potential somatosensory evoked potential spinal cord injury
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Correlation study between the changes of motor evoked potential and the improvement of spinal canal volume in minimally invasive transforaminal lumbar interbody fusion
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作者 CHEN Huan-xiong HE Xian-bo +6 位作者 LI Guo-jun TANG Song-jie ZHONG Zhen-hao HUANG Tao LIN You-cai LIN Su-yu MENG Zhi-bin 《Journal of Hainan Medical University》 CAS 2023年第8期26-31,共6页
Objective:To analyze the correlation between the amplitude changes of motor evoked potential(MEP),the 3D volume changes of spinal canal measuring by postoperative CT and the improvement rate of clinical symptoms after... Objective:To analyze the correlation between the amplitude changes of motor evoked potential(MEP),the 3D volume changes of spinal canal measuring by postoperative CT and the improvement rate of clinical symptoms after the spinal canal decompression in minimally invasive transforaminal lumbar interbody fusion(MIS-TLIF),and to explore the predictive value of the changes of both MEP amplitude and spinal canal volume in the assessment of long-term clinical prognosis in MIS-TLIF.Methods:A retrospective study of 68 patients with L4/5 spinal stenosis treated with MIS-TLIF was performed.The changes of both intraoperative MEP amplitude and 3D spinal canal volume during the spinal canal decompression,as well as the visual analogue scale(VAS)and Oswestry dysfunction index(ODI)scores in the long-term follow-up were all recorded.Results:The values of intraoperative MEP amplitude was 159.04%higher in 68 patients with MIS-TLIF after spinal canal decompression(P<0.01).The 3 postoperative 3D spinal canal volume(4.89±1.27)cm increased by 31.22%in comparison 3 with preoperative date(3.78±1.08)cm(P<0.01).The VAS and ODI scores were improved to 78.55%and 80.60%,respectively at the last follow-up(P<0.01).The improvement rate of MEP amplitude on the decompression side was positively correlated with the improvement rate of postoperative spinal canal volume(r=0.272,P=0.025).The improvement rate of postoperative spinal canal volume was positively correlated with the improvement rate of VAS and ODI at the last follow-up(r=0.656,r=0.490,P<0.01).Moreover,the improvement rate of MEP amplitude on the decompression side was also positively correlated with the improvement rate of VAS and ODI at the last follow-up(r=0.322 and 0.235,respectively,P<0.05).Conclusion:The increase of MEP amplitude after spinal canal decompression in patients with lumbar spinal stenosis treated by MIS-TLIF was closely correlated with both of the increase of spinal canal volume and the improvement of clinical symptoms.Therefore,MEP amplitude monitoring was not only the one of the important monitoring methods for predicting the prognosis of MIS-TLIF but also the reliably predictive value in the long-term clinical prognosis in MIS-TLIF. 展开更多
关键词 Lumbar spinal stenosis Minimally invasive transforaminal lumbar interbody fusion motor evoked potentials Spinal canal volume
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Cortical evoked potential changes in a rat model of acute ischemic stroke Detection of somatosensory evoked potential and motor evoked potential 被引量:1
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作者 Yang Shao 《Neural Regeneration Research》 SCIE CAS CSCD 2010年第7期550-554,共5页
BACKGROUND: Studies have shown that latency changes of some elements in a somatosensory evoked potential (SEP) and motor evoked potential (MEP) can reflect electrical activity of cerebral cortical neurons and con... BACKGROUND: Studies have shown that latency changes of some elements in a somatosensory evoked potential (SEP) and motor evoked potential (MEP) can reflect electrical activity of cerebral cortical neurons and conduction of white matter nerve fibers. However, there is a paucity of information regarding the dynamic observation of SEP and MEP following cerebral ischemic injury. OBJECTIVE: To explore SEP and MEP changes following acute ischemic stroke, and investigate the role of evoked potentials in monitoring brain function in stroke. DESIGN, TIME AND SETTING: A randomized, controlled, animal experiment was performed at the Chongqing Key Laboratory of Neurology, Affiliated Hospital of Chongqing Medical University from September 2007 to August 2008. MATERIALS" Hydrogen blood flow detector was purchased from Soochow University Medical Instrument Co., China, and Power lab system was purchased from AD Instruments, Inc., USA. METHODS A total of 36 healthy, adult, male, Sprague Dawley rats were randomly assigned to four groups (n = 9), including three ischemia groups (12, 24 and 72 hours of ischemia) and a sham-surgery group. The rat model of acute ischemic stroke was established by middle cerebral artery occlusion (MCAO) in the left hemisphere. MAIN OUTCOME MEASURES" SEP and MEP of the left limbs were detected, and cerebral blood flow was measured by the hydrogen cleaning method. RESULTS: The latency of positive wave 1 (P1), negative wave 1 (N1) and positive wave 2 (P2) waves in SEP, and latency of negative wave 1,2 (N1, N2) waves in MEP were significantly prolonged with increasing ischemic duration following MCAO (P 〈 0.01), but cerebral blood flow was significantly decreased (P 〈 0.05, or P 〈 0.01). CONLUSION: Ischemic stroke prolongs the latency of SEP waves (P1, N1, P2) and MEP waves (N1, N2), and cerebral cortical evoked potential may correlate with cerebral blood flow changes. This indicates that SEP and MEP can be used to evaluate brain function following acute ischemic stroke. 展开更多
关键词 somatosensory evoked potential motor evoked potential LATENCY cerebral blood flow brain function acute ischemic stroke neural regeneration
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INTRAOPERATIVE LOCALIZATION OF CORTICAL MOTOR EVOKED POTENTIALS IN CENTRAL SULCUS LESIONS 被引量:1
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作者 费智敏 丁赵琦 +6 位作者 张珏 崔华 李学民 周彩芳 书国伟 周正文 王勇 《Journal of Shanghai Second Medical University(Foreign Language Edition)》 2007年第2期100-103,共4页
Objective To study direct cortical electrical stimulation technique for the recording of motor evoked potentials under general anesthesia in central sulcus lesions. Methods The largest N20-P25 response was recorded fr... Objective To study direct cortical electrical stimulation technique for the recording of motor evoked potentials under general anesthesia in central sulcus lesions. Methods The largest N20-P25 response was recorded from postcentral gyrus by intraoperative monitoring of cortical motor evoked potentials in 10 patients with intracranial lesions near or in the central area. The muscles of upper extremity in all patients were activated by delivering stimulus to cortical areas continuously. Moving the cortical electrodes forward, the largest P20-N25 response, SEP phase reversal,was obtained as a motor center stimulus. In this site of cortex, a short train stimulation elicited reproducible muscle action potentials that could be observed from the oscilloscope without averaging.Results MEPs can be recorded, pre-and post-operatively, without motor deficits of upper limbs in all patients.Conclusion This technique seems to be preferable for intraoperative localization of motor evoked potentials in central sulcus lesions under total intravenous anesthesia. 展开更多
关键词 intraoperative monitoring motor evoked potentials transcortical stimulation train stimulation central sulcus lesions
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Why do stroke patients with negative motor evoked potential show poor limb motor function recovery?
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作者 Zhibin Song Lijuan Dang +4 位作者 Yanling Zhou Yanjiang Dong Haimao Liang Zhengfeng Zhu Suyue Pan 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第29期2713-2724,共12页
Negative motor evoked potentials after cerebral infarction, indicative of poor recovery of limb motor function, tend to be accompanied by changes in fractional anisotropy values and the cerebral pe-duncle area on the ... Negative motor evoked potentials after cerebral infarction, indicative of poor recovery of limb motor function, tend to be accompanied by changes in fractional anisotropy values and the cerebral pe-duncle area on the affected side, but the characteristics of these changes have not been reported. This study included 57 cases of cerebral infarction whose motor evoked potentials were tested in the 24 hours after the first inspection for diffusion tensor imaging, in which 29 cases were in the negative group and 28 cases in the positive group. Twenty-nine patients with negative motor evoked potentials were divided into two groups according to fractional anisotropy on the affected side of the cerebral peduncle: a fractional anisotropy 〈 0.36 group and a fractional anisotropy 〉 0.36 group. All patients underwent a regular magnetic resonance imaging and a diffusion tensor imaging examina- tion at 1 week, 1, 3, 6 and 12 months after cerebral infarction. The FugI-Meyer scores of their hemiplegic limbs were tested before the magnetic resonance and diffusion tensor imaging exami-nations. In the negative motor evoked potential group, fractional anisotropy in the affected cerebral peduncle declined progressively, which was most obvious in the first 1-3 months after the onset of cerebral infarction. The areas and area asymmetries of the cerebral peduncle on the affected side were significantly decreased at 6 and 12 months after onset. At 12 months after onset, the area asymmetries of the cerebral peduncle on the affected side were lower than the normal lower limit value of 0.83. FugI-Meyer scores in the fractional anisotropy ≥0.36 group were significantly higher than in the fractional anisotropy 〈 0.36 group at 3-12 months after onset. The fractional anisotropy of the cerebral peduncle in the positive motor evoked potential group decreased in the first 1 month after onset, and stayed unchanged from 3-12 months; there was no change in the area of the cerebral peduncle in the first 1-12 months after cerebral infarction. These findings confirmed that if the fractional anisotropy of the cerebral peduncle on the affected side is 〈 0.36 and the area asym-metries 〈 0.83 in patients with negative motor evoked potential after cerebral infarction, then poor hemiplegic limb motor function recovery may occur. 展开更多
关键词 neural regeneration NEUROIMAGING cerebral infarction motor evoked potential fractional anisotropy cerebralpeduncle magnetic resonance diffusion tensor imaging grants-supported paper NEUROREGENERATION
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MOTOR EVOKED POTENTIAL OF MAGNETIC STIMULATION IN THE DETERMINATION OF S_1 RADICULOPATHY
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作者 杨哲 陈君长 +3 位作者 赵龙柱 王坤正 鱼全生 王勇 《Journal of Pharmaceutical Analysis》 CAS 1997年第1期39-42,共4页
Motor evoked potentlal (MEP) elicited by magnetic stimulation was utilised to diagnose S1 radiculopathy non-invasively. Magnetic stimulation estimated motor nerve conduction time (MNCT), which was used in combination ... Motor evoked potentlal (MEP) elicited by magnetic stimulation was utilised to diagnose S1 radiculopathy non-invasively. Magnetic stimulation estimated motor nerve conduction time (MNCT), which was used in combination with F response recorded from soleus, allowed calculation of motor root conduction time (MRCT). 50 healthy controls and 30 patients with S1 radiculopathy were studied- The results showed that no difference was seen in MNCT in all patients, but MRCT were markedly prolonged in 87% of the patients, which was higher than the prolongation of F wave latency in 71% or the patients. it is concluded that MEP of magnetic stimulation is a useful technique for non-invasive diagnosis of S, radiculopathy. 展开更多
关键词 magnetic stimulation motor evoked potential F wave latency RADICULOPATHY
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Involuntary muscle spasm expressed as motor evoked potential after olfactory mucosa autograft in patients with chronic spinal cord injury and complete paraplegia
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作者 Koichi Iwatsuki Toshiki Yoshimine +6 位作者 Yoshiyuki Sankai Fumihiro Tajima Masao Umegaki Yu-Ichiro Ohnishi Masahiro Ishihara Koshi Ninomiya Takashi Moriwaki 《Journal of Biomedical Science and Engineering》 2013年第9期908-916,共9页
Object: The efficacy of olfactory mucosa autograft (OMA) for chronic spinal cord injury has been reported. New activity in response to voluntary effort has been documented by electromyography (EMG), but the emergence ... Object: The efficacy of olfactory mucosa autograft (OMA) for chronic spinal cord injury has been reported. New activity in response to voluntary effort has been documented by electromyography (EMG), but the emergence of motor evoked potential (MEP) reflecting electrophysiological conductivity in the central nervous system, including the corticospinal pathway, after OMA, and the best indications for OMA, have not been clarified. Here, we report the emergence of MEPs after OMA and offer recom-mendations for appropriate indications based on the presence of involuntary muscle spasm (IMS). We used analysis of MEP to examine the efficacy of OMA for patients with complete paraplegia due to chronic spinal cord injury. To clarify the indications for OMA, we investigated the association of IMS and efficacy of OMA. Methods: Four patients, 3 men and 1 woman, were enrolled. The mean age of the cases was 30.3 ± 9.5 years (range, 19 to 40 years). All 4 cases were American Spinal Injury Association (ASISA) grade A. The mean duration from injury to OMA was 95.8 ± 68.2 months (range, 17 to 300 months). Samples of olfactory mucosa were removed, cut into smaller pieces, and grafted into the sites of spinal cord lesions after laminectomy. Postoperative subcutaneous fluid collection, postoperative meningitis, postoperative nosebleed, postoperative infection in the nasal cavity, impaired olfaction, neoplastic tissue overgrowth at the autograft site, new sensory disturbance, and involuntary muscle spasm were investigated as safety issues. Improvements in ASIA grade, variations in ASIA scores, EMG, SSEP, and improved urological function were evaluated as efficacy indicators. Results: There were no serious adverse events in this series. In 2 of the 4 cases, an improvement in motor function below the level of injury was recognized. In one, the motor score was 50 until 16 weeks after surgery, and it increased to 52 from 20 weeks after surgery. In the other, the motor score was 50 until 20 weeks after surgery, and it increased to 52 at 24 weeks after surgery with a further increase to 54 at 48 weeks after surgery. The emergence of MEP was recognized in the latter case at 96 weeks after surgery. The other 2 cases had no improvement in ASIA motor score. Both of these cases who showed improvements in the ASIA motor scores exhibited relative IMS compared with those who had no ASIA motor score recovery. Conclusions: We recognized the emergence of MEPs in a case with complete paraplegia due to chronic spinal cord injury after OMA. IMS might be a candidate of indication of OMA. 展开更多
关键词 Olfactory Mucosa Autograft Spinal Cord Injury TRANSPLANTATION Voluntary Movement motor evoked potential
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CLINICAL STUDY OF MOTOR EVOKED POTENTIALS BY MAGNETIC STIMULATION IN CERVICAL SPONDYLOTIC MYELOPATHY
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作者 杨哲 陈君长 +5 位作者 赵龙柱 李幼芬 王坤正 袁国莲 杨大志 和平 《Journal of Pharmaceutical Analysis》 CAS 1998年第2期176-180,共5页
The combined use of motor .yoked pot'ntlais (MEPs) with F way, recording was cornpared with somatesemory evoked potentials (SEPs) in order to evaluate the clinical value or MEPs incervical spondylotic myelopathy. ... The combined use of motor .yoked pot'ntlais (MEPs) with F way, recording was cornpared with somatesemory evoked potentials (SEPs) in order to evaluate the clinical value or MEPs incervical spondylotic myelopathy. Magnetic stimulation of motor cortex with F wave recording was used assess central motor conduction. time, (CMCT). and central somatoseusory conduction time(CSCT)was evaluated by SEPs in 20 pailents surffring from myeloP8thy of cervical spondylosis. Theresults were comapared with 20 control subjects. The results showed that CMCT of Patients was obviously prolonged then that of contral subjects, the sbnormal rate was 80% which was higher than70K of SEPs slid that the prolongation or CMCT had a good correlation with the severe degree ofmyelopathy. The Painless and noninvasive .magnetic stimulation of PEPs could figure out the compressed degree of motor descending pathway and was. useful technique for diagnosis of cervicalspondylotic myelopathy. 展开更多
关键词 motor evoked potentials cervical spondylotic myelopathy
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Recording of spared motor evoked potentials and its augmentation by 4-aminopyridine in chronic spinal cord-injured rats
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作者 余科炜 李家顺 +5 位作者 戎伟芳 贾连顺 袁文 叶晓健 石志才 戴伯军 《Chinese Medical Journal》 SCIE CAS CSCD 2001年第2期43-49,106-107,共9页
Objective To research the direct electrophysiological evidence of discomplete spinal cord injury (SCI) and the effect of 4-aminopyridine on it.Methods Motor evoked potentials (MEPs), both spinal cord recorded MEPs (... Objective To research the direct electrophysiological evidence of discomplete spinal cord injury (SCI) and the effect of 4-aminopyridine on it.Methods Motor evoked potentials (MEPs), both spinal cord recorded MEPs (scMEPs) and extracellularly recorded MEPs (exMEPs) were recorded and characterized on a T13 epidural electrode (scMEPs) and an extracellular microelectrode (exMEPs) for 10 normal rats and 40 rats with lesions of various severity (sham, 35?g*cm force (gcf), 70?gcf, 100?gcf impact injury) at the T8-T9 cord using the Allen's drop model. The incline plane and Tarlov techniques were used to assess clinical neurological function. Results MEPs in the normal rats were elicited by applying transcortical suprathreshold stimulation consisting of 3-4 early negative peaks (N1, N2, N3 and N4) followed by several late waves. The N1 and N2 peaks were largest in the anterior and ventrolateral funiculus, respectively, which was indicative of extrapyramidal pathways. The 100?gcf impact injuries and the cord transection abolished the MEP distal to the lesion, whereas the 35?gcf injuries resulted in a latency shift and amplitude decrement of the MEP peaks. Eighteen of the 20 rats with 70?gcf injuries showed clinical paraplegia. Among them, 7 rats had neurophysiological evidence of residual conduction pathways through the lesioned cord segment, such as the presence of N1 and N2 peaks in the scMEPs or exMEPs. After 4-aminopyridine (4-AP) administrations (1?mg/kg), the amplitude of the spared exMEP increased significantly and spread more widely. Conclusions MEPs evoked by transcortical stimulation travel mostly in the extrapyramidal tract. MEP monitoring could provide an excellent method of detecting the functional integrity of the motor tracts after SCI, and could even detect spared motor fibers after discomplete SCI. Furthermore, the use of 4-AP or other K+ channel blocking agents may be a potential treatment for patients with chronic moderate to severe SCI. 展开更多
关键词 motor evoked potential · microelectrode · discomplete spinal cord injury · 4 aminopyridine · rat
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Intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation for preservation of facial nerve function in patients with large acoustic neuroma 被引量:10
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作者 LIU Bai-yun TIAN Yong-ji +4 位作者 LIU Wen LIU Shu-ling QIAO Hui ZHANG Jun-ting Jim Gui-jun 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第4期323-325,共3页
Background Although various monitoring techniques have been used routinely in the treatment of the lesions in the skull base, iatrogenic facial paresis or paralysis remains a significant clinical problem. The aim of t... Background Although various monitoring techniques have been used routinely in the treatment of the lesions in the skull base, iatrogenic facial paresis or paralysis remains a significant clinical problem. The aim of this study was to investigate the effect of intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation on preservation of facial nerve function. Method From January to November 2005, 19 patients with large acoustic neuroma were treated using intraoperative facial motor evoked potentials monitoring with transcranial electrical stimulation (TCEMEP) for preservation of facial nerve function. The relationship between the decrease of MEP amplitude after tumor removal and the postoperative function of the facial nerve was analyzed. Results MEP amplitude decreased more than 75% in 11 patients, of which 6 presented significant facial paralysis (H-B grade 3), and 5 had mild facial paralysis (H-B grade 2). In the other 8 patients, whose MEP amplitude decreased less than 75%, 1 experienced significant facial paralysis, 5 had mild facial paralysis, and 2 were normal. Conclusions Intraoperative TCEMEP can be used to predict postoperative function of the facial nerve. The decreased MEP amplitude above 75 % is an alarm point for possible severe facial paralysis. 展开更多
关键词 acoustic neuroma motor evoked potentials cranial nerves
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VALUE OF MOTOR EVOKED POTENTIALS BY MAGNETIC STIMULATION IN DIAGNOSIS OF LUMBOSACRAL RADICULOPATHY
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作者 杨哲 陈群长 +6 位作者 赵龙柱 王坤正 鱼全生 李辉 金辽沙 杨大志 卢居安 《Journal of Pharmaceutical Analysis》 CAS 1996年第2期129-135,168,共8页
Motor root conduction time(MRCT) was calculated by combining the magnetic stimulatiou eliciting motor evoked poentials (MEP)in lumbosacral region with F wave in popliteal rossa.Motor nerve conduction time(MNCT)and MRC... Motor root conduction time(MRCT) was calculated by combining the magnetic stimulatiou eliciting motor evoked poentials (MEP)in lumbosacral region with F wave in popliteal rossa.Motor nerve conduction time(MNCT)and MRCT were calculated reliably from the tibialis and the soleal MEPS in 40 patients suffering from L5 or S1 radlculopathies owing to disc protrusion,and in 50 healthy controls.Meanwhile,corticals somatosensory evoked potentials(SEP)were recorded by segmental cutaneous nerve stimulation for comparison.The results showed that no differences were seen in MNCT in all patients,but MRCT was markedly prolonged in 85%or the patients,which was higher than the prolongation of SEP in 45% or the patients.It is concluded that magnetic stimulation of MEP is a useful technique ror non-invasive diagnosis of lumbosacral radlculopathies. 展开更多
关键词 magnetic stimuiation motor evoked potentials lumbosacral radiculopathy
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CORRELATION OF THE MAGNETIC MOTOR EVOKED POTENTIAL TECHNIQUE WITH PATHOLOGICAL CHANGES ASSOCIATED WITH SPINAL CORD INJURY IN ADULT CATS
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作者 李幼芬 杨哲 +5 位作者 苏敏 陈君长 赵龙柱 袁国莲 李宗英 杨大志 《Journal of Pharmaceutical Analysis》 CAS 1999年第1期66-70,共5页
To determine whether the pathological changes caused by injury to the spinal cord can be correlated with values obtained by the Magnetic Motor Evoked Potential (MEPs) technique, we studied spinal cords from 41 adult ... To determine whether the pathological changes caused by injury to the spinal cord can be correlated with values obtained by the Magnetic Motor Evoked Potential (MEPs) technique, we studied spinal cords from 41 adult cats who were divided into 4 groups. The groups ranged from normal cats whose spinal cords were not compressed, to slightly, moderately and severely injured. MEPs were recorded before compression and in 30 minutes, 6 hours, 1 week, 2 week and 4 week after the compression unit was installed. Pathological changes with increased pressure were seen in blood vessels, nerve cells and fibers, Nissl substance and the central canal. A reversal of pathological changes was observed in slight or moderate injury during the 4 weeks of the experiment. Extensive injury, however, caused irreversible changes in the nerve cells with loss of motor function. The latency of MEPs at 30 minutes and 6 hours in the slightly injured group was 037 and 038 times greater than the baseline and returned to normal levels in 4 weeks. In the moderately injured group, the latency was increased 077 and 081 times and in the severely injured 132 and 136 times over the baseline. Recovery in the second group was partial and not at all in the severely injured. Thus, there appears to be good correlation between observed pathological changes, motor functions and MEPs. 展开更多
关键词 spinal cord injury pathologic change motor evoked potentials
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Neurogenic motor evoked potential changes after acute experimental spinal cord injury 被引量:1
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作者 沈强 贾连顺 周许辉 《Chinese Journal of Traumatology》 CAS 2000年第3期153-158,共6页
Objective: To better understand the characteristics of the neurogenic motor evoked potential (NMEP) before and after acute spinal cord injury. Methods: We recorded and characterized the spinal cord NMEP from 48 normal... Objective: To better understand the characteristics of the neurogenic motor evoked potential (NMEP) before and after acute spinal cord injury. Methods: We recorded and characterized the spinal cord NMEP from 48 normal rats and from 38 rats with spinal cord hemisection lesion. Spinal cord NMEPs were elicited by applying a range of current intensities with bipolar microelectrode stimuli to the C4 cord segment and recording the responses from sciatic nerves with bipolar microelectrodes placed in the neurilemma. Results: The evoked potentials consisted of three stable and reproducible negative and three positive peaks. The mean ±SD latencies of N1 were 2.89 ± 0.22 ms on the right side and 2.89 ± 0.24 ms on the left side. The mean conduction velocity was 47.9 m/s. The mean ±SD amplitudes of N1 were 3.61 ± 2.10 μV on the right side and 3.83 ± 2.32 μV on the left side. The amplitudes of N1 were significantly different among the eight stimulus intensity groups (right side: F= 2.22 , df= 7?201 , P= 0.03 ; left side: F= 2.11 , df=7?206, P= 0.04 ). The amplitude was largest when the stimulus intensity was 1.1 2.5 mA. The latencies of N1 were not significantly different among the eight stimulus intensity groups (right side: F= 0.40 , df= 7?201 , P= 0.9 ; left side: F= 1.20 , df=7?206, P= 0.3 ). The amplitudes and latencies of N2, N3 were not significantly different among the eight stimulus intensity groups. There were no significant changes in latency and amplitude between the left and the right side nerve responses. Thirty eight rats underwent T9 cord right side hemisection. Among them, 20 (53%), 30 (79%), and 32 (84%) rats could not be recorded in corresponding to N1, N2, and N3, respectively, in the right side sciatic nerves; and 13 (79%), 18 (47%), and 21 (55%), in corresponding to N1, N2, and N3 in the left side sciatic nerves. The latency was significantly delayed on the both right and left sides. The amplitude N1 was significantly depressed on the both sides, with N3 significantly depressed on the right side and N2 not significantly depressed. Conclusions: The amplitude of N is significantly different among the eight stimulus intensity groups. The amplitude is largest when the stimulus intensity is 1.1 2.5 mA. The light injury results in a significant latency delay in N1, N2, and N3 waves and a significant amplitude attenuation in N1. The N1 amplitude is sensitive to the degree of the lesion and conducts bilaterally. N2 and N3 conduct mainly along the ipsilateral posterolaterial tracts in the rats. 展开更多
关键词 Spinal cord injuries evoked potential neurogenic motor
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Changes of evoked potential and expression of nestin in subventricular zones in rats after focal cerebral ischemia 被引量:1
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作者 高洁 王永堂 +3 位作者 王丽丽 曾琳 伍亚民 邵阳 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第3期131-136,共6页
Objective: To study the characteristics of latency of somatosensory evoked potential (SEP) and motor evoked potential (MEP) and the expression of nestin in subventricular zones (SVZ) after persistent focal cere... Objective: To study the characteristics of latency of somatosensory evoked potential (SEP) and motor evoked potential (MEP) and the expression of nestin in subventricular zones (SVZ) after persistent focal cerebral ischemia in rats. Methods: The model of cerebral ischemia in rats was made by middle cerebral artery occlusion (MCAO). All animals of ischemia were sacrificed after 12 h, 1 d, 3 d, 7 d, and 14 d to observe the changes of latency of SEP and MEP and to detect the expression of nestin, with an immunohistochemical approach. Results: The latencies of P1 (positive wave 1), N1 (negative wave 1) and P2 (positive wave 2) in SEP were significantly prolonged after MCAO. The latencies of N1 and N2 waves in MEP were postponed gradually and no statistical difference of latency of N1 wave was found in rats at 7 d and 14 d after MCAO. The expression of nestin increased at 12 h, and showed a significant augmentation at 3 d and peaked at 7 d, then declined slightly at 14 d after MCAO. Conclusion: The cerebral ischemia prolonged the latency of EP waves and the expression of nestin was up-regulated and reached the peak at 7 d, showing the ischemia induced the proliferation of nervous stem cells. The SEP and MEP may evaluate the proliferation in SVZ after brain ischemia. 展开更多
关键词 brain ischemia somatosensory evoked potential motor evoked potential NESTIN
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EFFECTS OF TRANSCRANIAL MAGNETIC STIMULATION ON MOTOR CORTICAL EXCITABILITY AND NEUROFUNCTION AFTER CEREBRAL ISCHEMIA-REPERFUSION INJURY IN RATS 被引量:21
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作者 Hong-lin Feng Li Yan Yu-zhou Guan Li-ying Cui 《Chinese Medical Sciences Journal》 CAS CSCD 2005年第4期226-230, ,共5页
Objective To clarify the effects of repetitive transcranial magnetic stimulation (rTMS) on rat motor cortical excitabi- lity and neurofunction after cerebral ischemia-reperfusion injury. Methods After determined awake... Objective To clarify the effects of repetitive transcranial magnetic stimulation (rTMS) on rat motor cortical excitabi- lity and neurofunction after cerebral ischemia-reperfusion injury. Methods After determined awake resting motor threshold (MT) and motor evoked potentials (MEPs) of right hindlimbs, 20 Sprague-Dawley rats were subjected to middle cerebral artery occlusion (MCAO) reperfusion injury, then rTMS were applied to rTMS group (n = 10) at different time, while control group (n = 10) received no stimulation. A week later, MT and MEPs were evaluated again, as well as neurological deficits and infarct volume. The effects of rTMS and MCAO reperfusion injury on these parameters were analyzed. Results After MCAO reperfusion, both MT level and neurological deficit scores increased, distinct focal infarction formed, and latency of MEP elongated. Compared with the control group, the increased extent of MT and neurological scores of rats receiving rTMS were significantly lower (P < 0.05), as well as the infarct volumes reduced significantly(P < 0.05). But MEP was not affected by rTMS obviously. There was a positive linear correlation between postinjury MT and infarct volume (r = 0.64, P < 0.05). Conclusion rTMS may facilitate neurofunction recovery after cerebral ischemia-reperfusion. Postinjury MT could provide prognostic information after MCAO reperfusion injury. 展开更多
关键词 repetitive transcranial magnetic stimulation cerebral ischemia-reperfusion.injury motor threshold motor evoked potential
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Local injection of bone morphogenetic protein 7 promotes neuronal regeneration and motor function recovery after acute spinal cord injury 被引量:6
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作者 Chen Chen Guang-Chao Bai +2 位作者 Hong-Liang Jin Kun Lei Kuan-Xin Li 《Neural Regeneration Research》 SCIE CAS CSCD 2018年第6期1054-1060,共7页
After spinal cord injury,the number of glial cells and motor neurons expressing bone morphogenetic protein 7(BMP7)increases,indicating that upregulation of BMP7 can promote nerve repair.We,therefore,tested whether d... After spinal cord injury,the number of glial cells and motor neurons expressing bone morphogenetic protein 7(BMP7)increases,indicating that upregulation of BMP7 can promote nerve repair.We,therefore,tested whether direct injection of BMP7 into acutely injured ratalalo createrywith 50 ng BMP7(BMP7 group)or physiological saline(control group)for 7 consecutive days.Electrophysiological examination showed that the amplitude of N1 in motor evoked potentials(MEP)decreased after spinal cord injury.At 8 weeks post-operation,the amplitude of N1 in the BMP7 group was remarkably higher than that at 1 week post-operation and was higher than that of the control group.Basso,Beattie,Bresnahan scale(BBB)scores,hematoxylin-eosin staining,and western blot assay showed that at 1,2,4 and 8 weeks post-operation,BBB scores were increased;Nissl body staining was stronger;the number of Nissl-stained bodies was increased;the number of vacuoles gradually decreased;the number of synapses was increased;and the expression of neuronal marker,neurofilament protein 200,was increased in the hind limbs of the BMP7 group compared with the control group.Western blot assay showed that the expression of GFAP protein in BMP7 group and control group did not change significantly and there was no significant difference between the BMP7 and control groups.These data confirmed that local injection of BMP7 can promote neuronal regeneration after spinal cord injury and promote recovery of motor function in rats. 展开更多
关键词 nerve regeneration BEHAVIOR Basso Beattie Bresnahan scale score motor evoked potential wave Nissl staining NEURONS glial cells neurofilament protein 200 glial fibrillary acidic protein neural regeneration
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Effects of cortical intermittent theta burst stimulation combined with precise root stimulation on motor function after spinal cord injury: a case series study 被引量:4
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作者 Ye-Ran Mao Zhong-Xia Jin +10 位作者 Ya Zheng Jian Fan Li-Juan Zhao Wei Xu Xiao Hu Chun-Ya Gu Wei-Wei Lu Guang-Yue Zhu Yu-Hui Chen Li-Ming Cheng Dong-Sheng Xu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第8期1821-1826,共6页
Activation and reconstruction of the spinal cord circuitry is important for improving motor function following spinal cord injury.We conducted a case series study to investigate motor function improvement in 14 patien... Activation and reconstruction of the spinal cord circuitry is important for improving motor function following spinal cord injury.We conducted a case series study to investigate motor function improvement in 14 patients with chronic spinal cord injury treated with 4 weeks of unilateral(right only)cortical intermittent theta burst stimulation combined with bilateral magnetic stimulation of L3-L4 nerve roots,five times a week.Bilateral resting motor evoked potential amplitude was increased,central motor conduction time on the side receiving cortical stimulation was significantly decreased,and lower extremity motor score,Berg balance score,spinal cord independence measure-III score,and 10 m-walking speed were all increased after treatment.Right resting motor evoked potential amplitude was positively correlated with lower extremity motor score after 4 weeks of treatment.These findings suggest that cortical intermittent theta burst stimulation combined with precise root stimulation can improve nerve conduction of the corticospinal tract and lower limb motor function recovery in patients with chronic spinal cord injury. 展开更多
关键词 central motor conduction time intermittent theta burst lower extremity motor score motor evoked potential stimulation NEUROMODULATION neuronal plasticity spinal cord injury transcranial magnetic stimulation
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Corticospinal excitability during motor imagery is diminished by continuous repetition-induced fatigue
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作者 Akira Nakashima Takefumi Moriuchi +7 位作者 Daiki Matsuda Takashi Hasegawa Jirou Nakamura Kimika Anan Katsuya Satoh Tomotaka Suzuki Toshio Higashi Kenichi Sugawara 《Neural Regeneration Research》 SCIE CAS CSCD 2021年第6期1031-1036,共6页
Application of continuous repetition of motor imagery can improve the performance of exercise tasks.However,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards fo... Application of continuous repetition of motor imagery can improve the performance of exercise tasks.However,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards for interventions using motor imagery.Moreover,identification of motor imagery intervention time is necessary because it exhibits possible central fatigue.Therefore,the purpose of this study was to elucidate the development of fatigue during continuous repetition of motor imagery through objective and subjective evaluation.The study involved two experiments.In experiment 1,14 healthy young volunteers were required to imagine grasping and lifting a 1.5-L plastic bottle using the whole hand.Each participant performed the motor imagery task 100 times under each condition with 48 hours interval between two conditions:500 mL or 1500 mL of water in the bottle during the demonstration phase.Mental fatigue and a decrease in pinch power appeared under the 1500-mL condition.There were changes in concentration ability or corticospinal excitability,as assessed by motor evoked potentials,between each set with continuous repetition of motor imagery also under the 1500-mL condition.Therefore,in experiment 2,12 healthy volunteers were required to perform the motor imagery task 200 times under the 1500-mL condition.Both concentration ability and corticospinal excitability decreased.This is the first study to show that continuous repetition of motor imagery can decrease corticospinal excitability in addition to producing mental fatigue.This study was approved by the Institutional Ethics Committee at the Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121302)on January 30,2019. 展开更多
关键词 central nervous system CONCENTRATION continuous repetition of motor imagery corticospinal excitability mental fatigue motor evoked potential motor imagery muscle fatigue NEUROPHYSIOLOGY transcranial magnetic stimulation
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Combining Motor Imagery and Action Observation with Vibratory Stimulation Increases Corticomotor Excitability in Healthy Young Adults
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作者 Nodoka Kimura Tomoya Furuta +1 位作者 Gen Miura Eiichi Naito 《Journal of Behavioral and Brain Science》 2022年第5期177-195,共19页
Vibratory stimulation but also motor imagery and action observation can induce corticomotor modulation, as a bottom-up stimulus and top-down stimuli, respectively. However, it remains unknown whether the combination o... Vibratory stimulation but also motor imagery and action observation can induce corticomotor modulation, as a bottom-up stimulus and top-down stimuli, respectively. However, it remains unknown whether the combination of motor imagery, action observation, and vibratory stimulation can effectively increase corticomotor excitability. This study aimed to investigate the effect of motor imagery and/or action observation, in the presence or absence of vibratory stimulation, on the corticomotor excitability of healthy young adults. Vibratory stimulation was provided to the palm of the right hand. Action observation consisted in viewing a movie of someone else’s finger flexion and extension movements. The imagery condition required the participants to imagine they were moving their fingers while viewing the movie and attempting to move their fingers in accordance with the movie. Eleven right-handed healthy young adults were asked to perform six conditions randomly: 1) vibratory stimulation, imagery, and action observation, 2) vibratory stimulation and action observation, 3) vibratory stimulation and viewing of a blank screen, 4) imagery and action observation, 5) action observation, and 6) viewing of a blank screen. Single-pulse transcranial magnetic stimulation was conducted to assess corticomotor excitability and the peak-to-peak amplitude of the motor evoked potentials. The results showed that vibratory stimulation increases corticospinal excitability. The findings further revealed that performing motor imagery while viewing finger movement is more effective at inducing an augmentation of corticomotor excitability compared to action observation alone. Thus, the combination of motor imagery, action observation, and vibratory stimulation can effectively augment corticomotor excitability. 展开更多
关键词 motor evoked potential Transcranial Magnetic Stimulation Vibratory Stimulation motor Imagery Action Observation
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Combined monitoring of evoked potentials during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms 被引量:20
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作者 KANG De-zhi WU Zan-yi +4 位作者 LAN Qing YU Liang-hong LIN Zhang-ya WANG Chen-yang LIN Yuan-xiang 《Chinese Medical Journal》 SCIE CAS CSCD 2007年第18期1567-1573,共7页
Background Neurophysiologic monitoring during surgery is to prevent permanent neurological injury resulting from surgical manipulation. To improve the accuracy and sensitivity of intraoperative neuromonitoring, combin... Background Neurophysiologic monitoring during surgery is to prevent permanent neurological injury resulting from surgical manipulation. To improve the accuracy and sensitivity of intraoperative neuromonitoring, combined monitoring of transcranial electrical stimulation motor evoked potentials (TES-MEPs), somatosensory evoked potentials (SSEPs) and brainstem auditory evoked potentials (BAEPs) was attempted in microsurgery for lesions adjacent to the brainstem and intracranial aneurysms. Methods Monitoring of combined TES-MEPs with SSEPs was attempted in 68 consecutive patients with lesions adjacent to the brainstem as well as intracranial aneurysms. Among them, 31 patients (31 operations, 28 of posterior cranial fossa tumors, 3 of posterior circulation aneurysms) were also subjected to monitoring of BAEPs. The correlation of monitoring results and clinical outcome was studied prospectively. Results Combined monitoring of evoked potentials (EPs) was done in 64 (94.1%) of the 68 patients. MEPs monitoring was impossible for 4 patients (5.9%). No complication was observed during the combined monitoring in all the patients. In 45 (66.2%) of the 68 patients, EPs were stable, and they were neurologically intact. Motor dysfunction was detected by MEPs in 8 patients, SSEPs in 5, and BAEPs in 4, respectively. Conclusions A close relationship exists between postoperative motor function and the results of TES-MEPs monitoring TES-MEPs are superior to SSEPs and BAEPs in detecting motor dysfunction, but combined EPs serve as a safe, effective and invasive method for intraoperative monitoring of the function of the motor nervous system. Monitoring of combined EPs during microsurgery for lesions adjacent to the brainstem and intracranial aneurysms may detect potentially hazardous maneuvers and improve the safety of subsequent procedures. 展开更多
关键词 motor evoked potential transcranial electrical stimulation somatosensory evoked potential brainstem auditory evoked potential BRAINSTEM intracranial aneurysm
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