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A mussel-inspired supramolecular hydrogel with robust tissue anchor for rapid hemostasis of arterial and visceral bleedings 被引量:20
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作者 Ziwen Qiao Xueli Lv +9 位作者 Shaohua He Shumeng Bai Xiaochen Liu Linxi Hou Jingjing He Dongmei Tong Renjie Ruan Jin Zhang Jianxun Ding Huanghao Yang 《Bioactive Materials》 SCIE 2021年第9期2829-2840,共12页
In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesio... In recent years,the developed hemostatic technologies are still difficult to be applied to the hemostasis of massive arterial and visceral hemorrhage,owing to their weak hemostatic function,inferior wet tissue adhesion,and low mechanical properties.Herein,a mussel-inspired supramolecular interaction-cross-linked hydrogel with robust mechanical property(308.47±29.20 kPa)and excellent hemostatic efficiency(96.5%±2.1%)was constructed as a hemostatic sealant.Typically,we combined chitosan(CS)with silk fibroin(SF)by cross-linking them through tannic acid(TA)to maintain the structural stability of the hydrogel,especially for wet tissue adhesion ability(shear adhesive strength=29.66±0.36 kPa).Compared with other materials reported previously,the obtained CS/TA/SF hydrogel yielded a lower amount of blood loss and shorter time to hemostasis in various arterial and visceral bleeding models,which could be ascribed to the synergistic effect of wound closure under wet state as well as intrinsic hemostatic activity of CS.As a superior hemostatic sealant,the unique hydrogel proposed in this work can be exploited to offer significant advantages in the acute wound and massive hemorrhage with the restrictive access of therapeutic moieties. 展开更多
关键词 mussel-inspired hydrogel Supramolecular cross-linking Robust tissue anchor Hemostatic sealant Arterial and visceral bleeding models
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Mussel-inspired nanozyme catalyzed conductive and self-setting hydrogel for adhesive and antibacterial bioelectronics 被引量:14
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作者 Zhanrong Jia Xuanhan Lv +7 位作者 Yue Hou Kefeng Wang Fuzeng Ren Dingguo Xu Qun Wang Kelong Fan Chaoming Xie Xiong Lu 《Bioactive Materials》 SCIE 2021年第9期2676-2687,共12页
Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics;however,fabricating adhesive hydrogels with multiple functions remains a challenge.In this study,a mussel-inspired tannic ac... Adhesive hydrogels have broad applications ranging from tissue engineering to bioelectronics;however,fabricating adhesive hydrogels with multiple functions remains a challenge.In this study,a mussel-inspired tannic acid chelated-Ag(TA-Ag)nanozyme with peroxidase(POD)-like activity was designed by the in situ reduction of ultrasmall Ag nanoparticles(NPs)with TA.The ultrasmall TA-Ag nanozyme exhibited high catalytic activity to induce hydrogel self-setting without external aid.The nanozyme retained abundant phenolic hydroxyl groups and maintained the dynamic redox balance of phenol-quinone,providing the hydrogels with long-term and repeatable adhesiveness,similar to the adhesion of mussels.The phenolic hydroxyl groups also afforded uniform distribution of the nanozyme in the hydrogel network,thereby improving its mechanical properties and conductivity.Furthermore,the nanozyme endowed the hydrogel with antibacterial activity through synergistic effects of the reactive oxygen species generated via POD-like catalytic reactions and the intrinsic bactericidal activity of Ag.Owing to these advantages,the ultrasmall TA-Ag nanozyme-catalyzed hydrogel could be effectively used as an adhesive,antibacterial,and implantable bioelectrode to detect bio-signals,and as a wound dressing to accelerate tissue regeneration while preventing infection.Therefore,this study provides a promising approach for the fabrication of adhesive hydrogel bioelectronics with multiple functions via mussel-inspired nanozyme catalysis. 展开更多
关键词 mussel-inspired nanozyme Adhesive hydrogel Conductive hydrogel Antibacterial hydrogel BIOELECTRONICS
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Polypropylene Separators with Robust Mussel-inspired Coatings for High Lithium-ion Battery Performances 被引量:5
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作者 Chao Zhang Hong-Qing Liang +2 位作者 Jun-Ke Pi Guang-Peng Wu Zhi-Kang Xu 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2019年第10期1015-1022,I0005,共9页
The performances of lithium-ion batteries(LIBs)are dependent on the wettability and stability of porous separators.Musselinspired coatings seem to be useful to improve the surface wettability of commercialized polyole... The performances of lithium-ion batteries(LIBs)are dependent on the wettability and stability of porous separators.Musselinspired coatings seem to be useful to improve the surface wettability of commercialized polyolefin separators.However,it is still a challenge to guarantee their stability under polar electrolytes.Herein,we report a facile and versatile way to enhance the wettability and stability of polypropylene separators by constructing robust polydopamine(PDA)coatings triggered with CuSO4/H2O2.These coatings were conveniently deposited on the polypropylene separator surfaces and the PDA-coated separators exhibited the improved surface wettability and thermal stability.The electrolyte uptake increased nearly two folds from the pristine separator to the modified ones.Correspondingly,the ionic conductivity also rose from 0.82 mS·cm^-1 to 1.30 mS·cm^-1.Most importantly,the CuSO4/H2O2-triggered PDA coatings were very stable under strong polar electrolytes,endowing the cells with excellent cycle performance and enhanced C-rate capacity.Overall,the results unequivocally demonstrate that application of PDA coatings on polyolefin separator triggered by CuSO4/H2O2 is a facile and efficient method for improving the wettability and stability of separators for high LIBs performance. 展开更多
关键词 POLYPROPYLENE separator LITHIUM-ION battery Surface wettability DOPAMINE mussel-inspired COATINGS
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Recent Progress of Mussel-Inspired Underwater Adhesives 被引量:4
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作者 Ke Zhang Feilong Zhang +2 位作者 Yongyang Song Jun-Bing Fan Shutao Wang 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2017年第6期811-820,共10页
Underwater adhesion is greatly desired in tissue transplantation, medical treatment, ocean transportation, and so on. However, common commercial polymeric adhesives are rather weakened and easily destroyed in water en... Underwater adhesion is greatly desired in tissue transplantation, medical treatment, ocean transportation, and so on. However, common commercial polymeric adhesives are rather weakened and easily destroyed in water envi- ronment. In nature, some marine organisms, such as mussels, barnacles, or tube worms, exhibiting excellent under- water adhesion up to robust bonding on the rock of sea floor, can give exciting solutions to address the problem. Among these marine organisms, mussels exhibit unique underwater adhesion via the foot proteins of byssus. It has been verified that the catechol groups from the side chain of the mussel foot proteins is the main contribution to the unique underwater adhesion. Hence, inspired by the mussels' underwater adhesion, many mussel-mimetic polymers with catechol as end chains or side chains have been developed in the past decades. Here, we review recent progress of mussel-inspired underwater adhesives polymers from their catechol-functional design to their potential applica- tions in intermediates, anti-biofouling, self-healing of hydrogels, biological adhesives, and drug delivery. The re- view may provide basis and help for the development of the commercial underwater adhesives. 展开更多
关键词 underwater adhesives mussel-inspired CATECHOL polymeric adhesives
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Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation 被引量:2
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作者 Jie Sun Yingkang Huang +8 位作者 Huan Zhao Junjie Niu Xuwei Ling Can Zhu Lin Wang Huilin Yang Zhilu Yang Guoqing Pan Qin Shi 《Bioactive Materials》 SCIE 2022年第3期1-14,共14页
Upon the osteoporotic condition,sluggish osteogenesis,excessive bone resorption,and chronic inflammation make the osseointegration of bioinert titanium(Ti)implants with surrounding bone tissues difficult,often lead to... Upon the osteoporotic condition,sluggish osteogenesis,excessive bone resorption,and chronic inflammation make the osseointegration of bioinert titanium(Ti)implants with surrounding bone tissues difficult,often lead to prosthesis loosening,bone collapse,and implant failure.In this study,we firstly designed clickable mussel-inspired peptides(DOPA-N3)and grafted them onto the surfaces of Ti materials through robust catechol-TiO2 coordinative interactions.Then,two dibenzylcyclooctyne(DBCO)-capped bioactive peptides RGD and BMP-2 bioactive domain(BMP-2)were clicked onto the DOPA-N3-coated Ti material surfaces via bio-orthogonal reaction.We characterized the surface morphology and biocompatibility of the Ti substrates and optimized the osteogenic capacity of Ti surfaces through adjusting the ideal ratios of BMP-2/RGD at 3:1.In vitro,the dual-functionalized Ti substrates exhibited excellent promotion on adhesion and osteogenesis of mesenchymal stem cells(MSCs),and conspicuous immunopolarization-regulation to shift macrophages to alternative(M2)phenotypes and inhibit inflammation,as well as enhancement of osseointegration and mechanical stability in osteoporotic rats.In summary,our biomimetic surface modification strategy by bio-orthogonal reaction provided a convenient and feasible method to resolve the bioinertia and clinical complications of Ti-based implants,which was conducive to the long-term success of Ti implants,especially in the osteoporotic or inflammatory conditions. 展开更多
关键词 Titanium implant Clickable mussel-inspired peptide Bio-orthogonal reaction OSSEOINTEGRATION Immunopolarization
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Mussel-inspired multifunctional coating for bacterial infection prevention and osteogenic induction 被引量:1
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作者 Mingjun Li Christoph Schlaich +7 位作者 Jianguang Zhang Ievgen S.Donskyi Karin Schwibbert Frank Schreiber Yi Xi Jorg Radnik Tanja Schwerdtle Rainer Haag 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2021年第9期160-171,共12页
Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in bi... Bacterial infection and osteogenic integration are the two main problems that cause severe complications after surgeries. In this study, the antibacterial and osteogenic properties were simultaneously introduced in biomaterials, where copper nanoparticles(Cu NPs) were generated by in situ reductions of Cu ions into a mussel-inspired hyperbranched polyglycerol(MI-h PG) coating via a simple dip-coating method.This hyperbranched polyglycerol with 10 % catechol groups’ modification presents excellent antifouling property, which could effectively reduce bacteria adhesion on the surface. In this work, polycaprolactone(PCL) electrospun fiber membrane was selected as the substrate, which is commonly used in biomedical implants in bone regeneration and cardiovascular stents because of its good biocompatibility and easy post-modification. The as-fabricated Cu NPs-incorporated PCL membrane [PCL-(MI-h PG)-Cu NPs]was confirmed with effective antibacterial performance via in vitro antibacterial tests against Staphylococcus aureus(S. aureus), Escherichia coli(E. coli), and multi-resistant E. coli. In addition, the in vitro results demonstrated that osteogenic property of PCL-(MI-h PG)-Cu NPs was realized by upregulating the osteoblast-related gene expressions and protein activity. This study shows that antibacterial and osteogenic properties can be balanced in a surface coating by introducing Cu NPs. 展开更多
关键词 mussel-inspired coating CuNPs Multi-resistant bacteria ANTIBACTERIAL ANTIFOULING OSTEOGENESIS
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A multi-functional binder for high loading sulfur cathode 被引量:5
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作者 Ying Chu Ning Chen +3 位作者 Ximing Cui Anmin Liu Liang Zhen Qinmin Pan 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2020年第7期99-104,I0004,共7页
Lithium sulfur(Li-S)batteries are the promising power sources,but their commercialization is significantly impeded by poor energy-storage functions at high sulfur loading.Here we report that such an issue can be effec... Lithium sulfur(Li-S)batteries are the promising power sources,but their commercialization is significantly impeded by poor energy-storage functions at high sulfur loading.Here we report that such an issue can be effectively addressed by using a mussel-inspired binder comprised of chitosan grafted with catecholic moiety for sulfur cathodes.The resulting sulfur cathodes possess a high loading up to 12.2 mg cm-2 but also exhibit one of the best electrochemical properties among their counterparts.The excellent performances are attributed to the strong adhesion of the binder to sulfur particles,conducting agent,current collector,and polysulfide.The versatile adhesion effectively increases the sulfur loading,depresses the shuttle effect,and alleviates mechanical pulverization during cycling processes.The present investigation offers a new insight into high performance sulfur cathodes through a bio-adhesion viewpoint. 展开更多
关键词 Li-S batteries Sulfur cathode mussel-inspired binder Bio-adhesion High loading High performance
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Mussel‑Inspired Redox‑Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics 被引量:6
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作者 Donglin Gan Tao Shuai +6 位作者 Xiao Wang Ziqiang Huang Fuzeng Ren Liming Fang Kefeng Wang Chaoming Xie Xiong Lu 《Nano-Micro Letters》 SCIE EI CAS CSCD 2020年第12期117-132,共16页
Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanopar... Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of CPs.In this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and biocompatibility.This is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox activity.These CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term adhesiveness.The CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric path.The hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS NPs.This conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics. 展开更多
关键词 mussel-inspired Redox-active nanoparticles Conductive polymer Conductive hydrogel Adhesive bioelectronics
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Self-healing Hydrogelsand Underlying Reversible Intermolecular Interactions 被引量:3
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作者 Meng Wu Qiong-Yao Peng +1 位作者 Lin-Bo Han Hong-Bo Zeng 《Chinese Journal of Polymer Science》 SCIE CAS CSCD 2021年第10期1246-1261,I0005,共17页
Self-healing hydrogels have attracted growing attention over the past decade due to their biomimetic structure,biocompatibility,as well as enhanced lifespan and reliability,thereby have been widely used in various bio... Self-healing hydrogels have attracted growing attention over the past decade due to their biomimetic structure,biocompatibility,as well as enhanced lifespan and reliability,thereby have been widely used in various biomedical,electrical and environmental engineering applications.This feature article has reviewed our recent progress in self-healing hydrogels derived from mussel-inspired interactions,multiple hydrogen-bonding functional groups such as 2-ureido-4[1H]-pyrimidinohe(UPy),dynamic covalent bonds(eg,Schiff base reactions and boronic ester bonds).The underlying molecular basics of these interactions,hydrogel preparation principles,and corresponding performances and applications are introduced.The underlying reversible intermolecular interaction mechanisms in these hydrogels were investigated using nanomechanical techniques such as surface forces apparatus(SFA)and atomic force microscopy(AFM),providing fundamental insights into the self-healing mechanisms of the hydrogels.The remaining challenging issues and perspectives in this rapidly developing research area are also discussed. 展开更多
关键词 Self-healing hydrogels mussel-inspired Interaction Multiple hydrogen-bonding Dynamic covalent bonds Intermolecular forces
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Surface and Interface Engineering for Advanced Nanofiltration Membranes 被引量:1
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作者 Bian-Bian Guo Cheng-Ye Zhu Zhi-Kang Xu 《Chinese Journal of Polymer Science》 SCIE EI CAS CSCD 2022年第2期124-137,共14页
Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong adaptability.Over decades,it remains a challenge to break the upper li... Nanofiltration has been attracting great attention in alleviating the global water crisis because of its high efficiency,mild operation,and strong adaptability.Over decades,it remains a challenge to break the upper limit of performance and establish the formation-structureproperty relationship for nanofiltration membranes.This feature article summarizes our recent progress in the preparation of high-performance thin-film composite(TFC)nanofiltration membranes,focusing on the mussel-inspired deposition method and the optimized interfacial polymerization(IP).By accelerating the oxidation of polydopamine and equilibrating the rate of aggregation and deposition processes,the mussel-inspired deposition method realizes the rapid and uniform formation of selective coatings or nanofilms.Diverse deposition systems endow the selective layer with rich chemical structures and easy post-functionalization,highlighting its potential in water treatment.As for optimizing the conventional IP,the rapid polycondensation of amine and acid chloride groups is slowed down to enable the controllability of IP at the water-organic interface.The homogeneity and integrity of the TFC membranes are improved by constructing a uniform reaction platform and introducing a viscous medium to control the amine diffusion,which facilitates the water permeability and promotes the separation efficiency.We have proposed a series of practical strategies for improving TFC membranes and might provide more inspiration for other nanofiltration techniques. 展开更多
关键词 NANOFILTRATION Thin-film composite membranes mussel-inspired deposition Interfacial polymerization
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