Southern Africa has experienced electric power deficits over the last decade. This has been due in part to the member countries＇ inadequate electrical power supply system, as well as load growth in areas which were n...Southern Africa has experienced electric power deficits over the last decade. This has been due in part to the member countries＇ inadequate electrical power supply system, as well as load growth in areas which were not adequately planned for. This has induced the formation of organizations such as SADC （Southern African Development Community） and SAPP （Southern African Power Pool） that have the common goal of achieving development and economic growth in the region which comprises of 15 member countries. This paper presents results from a security analysis of the region＇s electric power supply system using a baseline level of performance. This was carried out by performing a steady-state contingency analysis on a SADC power network model subject to the N-1 criteria which expresses the ability of the power network to experience a contingency without causing an overload or failure in any other part of the network. Simulations were carried out using DigSilent.展开更多
论文旨在研究锦鲤(Cyprinus carpio var. koi)GNPTAB(alpha/beta subunits of N-acetylglucosamine-1-phosphotransferase)基因的分子生物学特征及对维氏气单胞菌感染的应答规律。对锦鲤GNPTAB基因CDS区进行生物信息学分析,利用实时荧...论文旨在研究锦鲤(Cyprinus carpio var. koi)GNPTAB(alpha/beta subunits of N-acetylglucosamine-1-phosphotransferase)基因的分子生物学特征及对维氏气单胞菌感染的应答规律。对锦鲤GNPTAB基因CDS区进行生物信息学分析,利用实时荧光定量PCR技术研究GNPTAB基因的组织分布和维氏气单胞菌(Aeromonas veronii)感染机体后的时序表达规律。结果显示,GNPTAB基因CDS区片段长度为3 747 bp,推测编码1 248个氨基酸,含有4个结构域。实时荧光定量PCR分析显示,GNPTAB基因在健康锦鲤各组织中均有表达,在肝脏表达量最高,其次是肌肉、肠道、脾脏、皮肤、中肾、头肾。维氏气单胞菌人工感染锦鲤6~72 h,GNPTAB基因在肠道组织主要呈现上调表达,在肝脏、头肾、脾脏、皮肤、肌肉组织中主要呈现下调表达。维氏气单胞菌感染锦鲤后,GNPTAB基因在这些组织中出现表达差异,推测GNPTAB参与了机体的病理生理过程或免疫应答反应。展开更多
目的探究N-乙酰半胱氨酸对支气管哮喘大鼠CXC趋化因子配体(CXCL)8-CXC趋化因子受体(CXCR)1/2及瞬时受体电位通道蛋白(TRP)V1神经元敏感性的影响。方法选取80只SPF级SD雄性大鼠,随机分为正常(NO)组、模型(MO)组、N-乙酰半胱氨酸(NAC)组...目的探究N-乙酰半胱氨酸对支气管哮喘大鼠CXC趋化因子配体(CXCL)8-CXC趋化因子受体(CXCR)1/2及瞬时受体电位通道蛋白(TRP)V1神经元敏感性的影响。方法选取80只SPF级SD雄性大鼠,随机分为正常(NO)组、模型(MO)组、N-乙酰半胱氨酸(NAC)组、急支糖浆(ES)组,每组20只,对MO组、NAC组、ES组进行支气管哮喘建模,建模成功后,NAC组、ES组每天分别于腹腔内注射2 ml N-乙酰半胱氨酸注射液、急支糖浆灌胃10 g/kg剂量,NO组、MO组同期灌胃同体积生理盐水,通过苏木素-伊红(HE)染色法检测肺组织病理形态、酶联免疫吸附试验(ELISA)、实时荧光定量聚合酶链反应(RT-PCR)、Western印迹检测血清及肺组织中CXCL8、CXCR1、CXCR2、TRPV1含量、mRNA及蛋白表达,并分析N-乙酰半胱氨酸对支气管哮喘大鼠CXCL8-CXCR1/2及TRPV1神经元敏感性。结果与NO组相比,MO组咳嗽次数明显增加(P<0.05),而NAC组、ES组与MO组相比,其咳嗽次数明显降低(P<0.05),且NAC组比ES组降低明显(P<0.05);与NO组相比,MO组细支气管管腔、肺泡腔内可见渗出液、脱落的上皮细胞等,远端肺泡可见局部肺不张及周围肺大泡,且肺间质明显增厚,炎性细胞浸润明显,而与MO组比较,ES组、NAC组症状明显减少,部分肺间质的组织结构趋向正常,部分肺泡轻度扩张,且NAC组比ES组明显降低(P<0.05);与NO组对比,MO组CXCL8、CXCR1、CXCR2、TRPV1含量、mRNA及蛋白表达均明显升高(P<0.05),NAC组、ES组与MO组相比均显著降低(P<0.05),且NAC组比ES组明显降低(P<0.05)。结论N-乙酰半胱氨酸可以显著降低咳嗽次数,减少支气管哮喘症状,可使CXCL8-CXCR1/2及TRPV1神经元敏感性显著降低。展开更多
城市电网涵盖多个电压等级,调度操作复杂,为降低城市电网N-1后的运行风险,同时解决N-1-1发生时导致大面积停电的问题,提出一种转供区域识别方法,并结合研究场景对其进行分区处理,在保证求解准确度的前提下提高问题求解效率。提出降低城...城市电网涵盖多个电压等级,调度操作复杂,为降低城市电网N-1后的运行风险,同时解决N-1-1发生时导致大面积停电的问题,提出一种转供区域识别方法,并结合研究场景对其进行分区处理,在保证求解准确度的前提下提高问题求解效率。提出降低城市电网N-1-1运行风险拓扑重构双层优化模型,综合考虑了N-1-1时的负荷损失量和N-1后节点电压偏移量与设备负载率均衡度,使用二进制蝙蝠算法(Binary Bat Algorithm,BBA)对模型进行求解。最后通过某地区实际城市电网算例分析,验证了所提模型的有效性。展开更多
文摘Southern Africa has experienced electric power deficits over the last decade. This has been due in part to the member countries＇ inadequate electrical power supply system, as well as load growth in areas which were not adequately planned for. This has induced the formation of organizations such as SADC （Southern African Development Community） and SAPP （Southern African Power Pool） that have the common goal of achieving development and economic growth in the region which comprises of 15 member countries. This paper presents results from a security analysis of the region＇s electric power supply system using a baseline level of performance. This was carried out by performing a steady-state contingency analysis on a SADC power network model subject to the N-1 criteria which expresses the ability of the power network to experience a contingency without causing an overload or failure in any other part of the network. Simulations were carried out using DigSilent.
文摘目的探究N-乙酰半胱氨酸对支气管哮喘大鼠CXC趋化因子配体(CXCL)8-CXC趋化因子受体(CXCR)1/2及瞬时受体电位通道蛋白(TRP)V1神经元敏感性的影响。方法选取80只SPF级SD雄性大鼠,随机分为正常(NO)组、模型(MO)组、N-乙酰半胱氨酸(NAC)组、急支糖浆(ES)组,每组20只,对MO组、NAC组、ES组进行支气管哮喘建模,建模成功后,NAC组、ES组每天分别于腹腔内注射2 ml N-乙酰半胱氨酸注射液、急支糖浆灌胃10 g/kg剂量,NO组、MO组同期灌胃同体积生理盐水,通过苏木素-伊红(HE)染色法检测肺组织病理形态、酶联免疫吸附试验(ELISA)、实时荧光定量聚合酶链反应(RT-PCR)、Western印迹检测血清及肺组织中CXCL8、CXCR1、CXCR2、TRPV1含量、mRNA及蛋白表达,并分析N-乙酰半胱氨酸对支气管哮喘大鼠CXCL8-CXCR1/2及TRPV1神经元敏感性。结果与NO组相比,MO组咳嗽次数明显增加(P<0.05),而NAC组、ES组与MO组相比,其咳嗽次数明显降低(P<0.05),且NAC组比ES组降低明显(P<0.05);与NO组相比,MO组细支气管管腔、肺泡腔内可见渗出液、脱落的上皮细胞等,远端肺泡可见局部肺不张及周围肺大泡,且肺间质明显增厚,炎性细胞浸润明显,而与MO组比较,ES组、NAC组症状明显减少,部分肺间质的组织结构趋向正常,部分肺泡轻度扩张,且NAC组比ES组明显降低(P<0.05);与NO组对比,MO组CXCL8、CXCR1、CXCR2、TRPV1含量、mRNA及蛋白表达均明显升高(P<0.05),NAC组、ES组与MO组相比均显著降低(P<0.05),且NAC组比ES组明显降低(P<0.05)。结论N-乙酰半胱氨酸可以显著降低咳嗽次数,减少支气管哮喘症状,可使CXCL8-CXCR1/2及TRPV1神经元敏感性显著降低。
文摘城市电网涵盖多个电压等级,调度操作复杂,为降低城市电网N-1后的运行风险,同时解决N-1-1发生时导致大面积停电的问题,提出一种转供区域识别方法,并结合研究场景对其进行分区处理,在保证求解准确度的前提下提高问题求解效率。提出降低城市电网N-1-1运行风险拓扑重构双层优化模型,综合考虑了N-1-1时的负荷损失量和N-1后节点电压偏移量与设备负载率均衡度,使用二进制蝙蝠算法(Binary Bat Algorithm,BBA)对模型进行求解。最后通过某地区实际城市电网算例分析,验证了所提模型的有效性。
