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t-BuOLi Catalyzed Esterification of N-Benzyl-N-Boc-amides with Carbohydrates
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作者 Ye Danfeng Xu Bing Wan Yunhui 《有机化学》 SCIE CAS CSCD 北大核心 2024年第9期2924-2932,共9页
Based on a strategy of ground-state destabilisation of the N—C bond,a general protocol for the esterification of amides with carbohydrates was reported.This protocol offers mild reaction conditions,excellent yields,a... Based on a strategy of ground-state destabilisation of the N—C bond,a general protocol for the esterification of amides with carbohydrates was reported.This protocol offers mild reaction conditions,excellent yields,and broad substrate compatibility,thereby demonstrating great potential for the synthesis of glycoconjugates.Additionally,this method provides an alternative approach for addressing the challenging task of esterifying sterically hindered secondary hydroxyl group of carbohydrates and paving the way for advancements in carbohydrate-based pharmaceuticals. 展开更多
关键词 t-BuOLi n-benzyl-n-boc-amides ESTERIFICATION glycoconjugates
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