Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental ...Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.展开更多
A two and a half dimensional(2.5D)multi-domain indirect boundary element method(IBEM)is developed to study the wave scattering of obliquely incident P-,SV-and SH-waves by a hill-valley staggered topography in a multi-...A two and a half dimensional(2.5D)multi-domain indirect boundary element method(IBEM)is developed to study the wave scattering of obliquely incident P-,SV-and SH-waves by a hill-valley staggered topography in a multi-layered half-space.The IBEM algorithm includes using 2.5D full-space and half-space Green’s functions to construct scattered fields in decomposed closed and opened half-space regions,respectively,and using the dynamic stiffness method to solve the free fields.All regions are finally integrated by introducing the compatibility conditions to obtain the total wave fields.The proposed 2.5D IBEM has the flexibility in dealing with complex boundaries by directly applying the fictitious loads on the regions’boundaries,with a less storage requirement compared to the full 3D models.Besides,by combining the specific advantages of the two kinds of Green’s functions,the method is well suitable for handling coupled topographies with high accuracy.The method is validated by comparison with published results for a single valley as well as a single hill topography.The effects of height-to-width ratio of hill and layering on dynamic responses are further parametrically investigated by numerical implementations in frequency domain.Results show that the interaction between valley and hills can lead to a more significant amplification within the valley region,and dynamic responses are deeply influenced by the height-to-width of hill,simultaneously depending on incident angle and frequency.Besides,the site effects become more complex when the stratification feature is taken into account.展开更多
The impacts of low and high-frequency variability from teleconnections between large scale atmospheric processes and local weather as well as emissions changes on concentrations of particulate matter of 2.5 μm or les...The impacts of low and high-frequency variability from teleconnections between large scale atmospheric processes and local weather as well as emissions changes on concentrations of particulate matter of 2.5 μm or less in diameter ([PM2.5]) were examined for the Fairbanks Metropolitan Area (FMA). October to March and May to August mean [PM2.5] were 1.8 and 3.1 μg·m-3 higher for positive than negative annual mean Pacific Decadal Oscillation. Annual mean [PM2.5] were 3.8 μg·m-3 lower for positive than negative Southern Oscillation Index. On 1999-2018 average, [PM2.5] decreased 2.9 μg·m-3·decade-1. On average over October to March, decadal and inter-annual variability caused higher or similar differences in mean observed [PM2.5] and its species than emission-control measures. The 2006 implementation of Tier 2 for new vehicles decreased observed sulfate concentrations the strongest (~4.95 μg·m-3·decade-1) of all occurred emissions changes. On average, observed [PM2.5] showed elevated values at all sites when wind blew from directions of hot springs. The same was found for the sulfate, ammonium and non-metal components of PM2.5. Observations showed that these geothermal waters contain sulfate, ammonia, boric acid and non-metals. Hot springs of such composition are known to emit hydrogen sulfide and ammonia that can serve as precursors for ammonium and sulfate aerosols.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82071190 and 82371438(to LC)Innovative Strong School Project of Guangdong Medical University,No.4SG21230G(to LC)Scientific Research Foundation of Guangdong Medical University,No.GDMUM2020017(to CL)。
文摘Alzheimer s disease,among the most common neurodegenerative disorders,is chara cterized by progressive cognitive impairment.At present,the Alzheimer’s disease main risk remains genetic ris ks,but major environmental fa ctors are increasingly shown to impact Alzheimer’s disease development and progression.Microglia,the most important brain immune cells,play a central role in Alzheimer’s disease pathogenesis and are considered environmental and lifestyle"sensors."Factors like environmental pollution and modern lifestyles(e.g.,chronic stress,poor dietary habits,sleep,and circadian rhythm disorde rs)can cause neuroinflammato ry responses that lead to cognitive impairment via microglial functioning and phenotypic regulation.However,the specific mechanisms underlying interactions among these facto rs and microglia in Alzheimer’s disease are unclear.Herein,we:discuss the biological effects of air pollution,chronic stress,gut micro biota,sleep patterns,physical exercise,cigarette smoking,and caffeine consumption on microglia;consider how unhealthy lifestyle factors influence individual susceptibility to Alzheimer’s disease;and present the neuroprotective effects of a healthy lifestyle.Toward intervening and controlling these environmental risk fa ctors at an early Alzheimer’s disease stage,understanding the role of microglia in Alzheimer’s disease development,and to rgeting strategies to to rget microglia,co uld be essential to future Alzheimer’s disease treatments.
文摘A two and a half dimensional(2.5D)multi-domain indirect boundary element method(IBEM)is developed to study the wave scattering of obliquely incident P-,SV-and SH-waves by a hill-valley staggered topography in a multi-layered half-space.The IBEM algorithm includes using 2.5D full-space and half-space Green’s functions to construct scattered fields in decomposed closed and opened half-space regions,respectively,and using the dynamic stiffness method to solve the free fields.All regions are finally integrated by introducing the compatibility conditions to obtain the total wave fields.The proposed 2.5D IBEM has the flexibility in dealing with complex boundaries by directly applying the fictitious loads on the regions’boundaries,with a less storage requirement compared to the full 3D models.Besides,by combining the specific advantages of the two kinds of Green’s functions,the method is well suitable for handling coupled topographies with high accuracy.The method is validated by comparison with published results for a single valley as well as a single hill topography.The effects of height-to-width ratio of hill and layering on dynamic responses are further parametrically investigated by numerical implementations in frequency domain.Results show that the interaction between valley and hills can lead to a more significant amplification within the valley region,and dynamic responses are deeply influenced by the height-to-width of hill,simultaneously depending on incident angle and frequency.Besides,the site effects become more complex when the stratification feature is taken into account.
文摘The impacts of low and high-frequency variability from teleconnections between large scale atmospheric processes and local weather as well as emissions changes on concentrations of particulate matter of 2.5 μm or less in diameter ([PM2.5]) were examined for the Fairbanks Metropolitan Area (FMA). October to March and May to August mean [PM2.5] were 1.8 and 3.1 μg·m-3 higher for positive than negative annual mean Pacific Decadal Oscillation. Annual mean [PM2.5] were 3.8 μg·m-3 lower for positive than negative Southern Oscillation Index. On 1999-2018 average, [PM2.5] decreased 2.9 μg·m-3·decade-1. On average over October to March, decadal and inter-annual variability caused higher or similar differences in mean observed [PM2.5] and its species than emission-control measures. The 2006 implementation of Tier 2 for new vehicles decreased observed sulfate concentrations the strongest (~4.95 μg·m-3·decade-1) of all occurred emissions changes. On average, observed [PM2.5] showed elevated values at all sites when wind blew from directions of hot springs. The same was found for the sulfate, ammonium and non-metal components of PM2.5. Observations showed that these geothermal waters contain sulfate, ammonia, boric acid and non-metals. Hot springs of such composition are known to emit hydrogen sulfide and ammonia that can serve as precursors for ammonium and sulfate aerosols.
