目的比较龈下刮治和根面平整术(scaling and root planning,SRP)联合Nd:YAP激光与单纯SRP治疗对牙周炎患者疗效的差异和龈下微生物的影响。方法选择符合纳入标准的牙周炎患者。每位患者龈上洁治1周后为本研究基线,随机半口分组。试验侧...目的比较龈下刮治和根面平整术(scaling and root planning,SRP)联合Nd:YAP激光与单纯SRP治疗对牙周炎患者疗效的差异和龈下微生物的影响。方法选择符合纳入标准的牙周炎患者。每位患者龈上洁治1周后为本研究基线,随机半口分组。试验侧采用SRP联合Nd:YAP激光治疗;对照侧仅采用SRP治疗。每位患者选择一组同颌同名单根牙,进行龈沟液(gingival crevicular fluid,GCF)和龈下菌斑取样。分别在基线、治疗完成后6周和12周进行探诊深度(probing depth,PD)和探诊出血(bleeding on probing,BOP)的数据采集、龈沟液及龈下菌斑样本的采集。ELISA法检测龈沟液中炎症因子白细胞介素6(interleukin-6,IL-6)的浓度。16S rDNA高通量测序对各龈下菌斑样本的菌群构成进行分析和比较。结果试验侧与对照侧的各项临床指标较基线时均有显著改善(P<0.05),但两组间无明显差异。两组的IL-6浓度较基线均显著下降,治疗后6周,试验侧的IL-6浓度明显低于对照组(P<0.05)。龈下菌斑α多样性分析,治疗后6周及12周,对照侧的Shannon指数高于基线,Simpson指数低于基线(P<0.05)。测序结果显示,治疗后6周,试验侧的普氏菌属(Prevotella)和Saccharibacteria_incertae_incerta_sedis的相对丰度较基线显著下降;密螺旋体属(Treponema)的相对丰度低于对照侧,嗜二氧化碳噬细胞菌属(Capnocytophaga)的相对丰度高于对照侧(P<0.05),12周时无明显差异。结论在本研究中,Nd:YAP激光联合SRP和单纯SRP治疗牙周炎均有明显效果,而两种治疗方法在临床指标上无明显差异,辅助使用Nd:YAP激光在短时间内更有利于GCF IL-6浓度的降低和部分牙周致病菌的控制。展开更多
We present a continuously tunable high-power continuous wave(CW)single-frequency(SF)Nd:YAlO_(3)/lithium triborate(Nd:YAP/LBO)laser with dual-wavelength output,which is implemented by combining an optimized and locked ...We present a continuously tunable high-power continuous wave(CW)single-frequency(SF)Nd:YAlO_(3)/lithium triborate(Nd:YAP/LBO)laser with dual-wavelength output,which is implemented by combining an optimized and locked etalon with an intracavity nonlinear loss.The obtained output powers of the stable SF 1080 and 540 nm lasers are 2.39 and 4.18 W,respectively.After the etalon is locked to an oscilating mode of the laser,the wideband continuous frequency tuning and long-term stable single-longitudinal-mode operation of the laser are successfully realized,which can be well used for the applications of quantum information and quantum computation.To the best of our knowledge,this is the first realization of the continuously tunable high-power CW SF 1080/540 nm dual-wavelength laser.展开更多
基金supported by the National Natural Science Foundation of China(Nos.62105192,61975100,and 62027821)Applied Basic Research Program of Shanxi Province(No.201901D211186)+1 种基金Program for the Innovative Talents of High Education Institutions of ShanxiFund for Shanxi"1331 Project"Key Subjects Construction。
文摘We present a continuously tunable high-power continuous wave(CW)single-frequency(SF)Nd:YAlO_(3)/lithium triborate(Nd:YAP/LBO)laser with dual-wavelength output,which is implemented by combining an optimized and locked etalon with an intracavity nonlinear loss.The obtained output powers of the stable SF 1080 and 540 nm lasers are 2.39 and 4.18 W,respectively.After the etalon is locked to an oscilating mode of the laser,the wideband continuous frequency tuning and long-term stable single-longitudinal-mode operation of the laser are successfully realized,which can be well used for the applications of quantum information and quantum computation.To the best of our knowledge,this is the first realization of the continuously tunable high-power CW SF 1080/540 nm dual-wavelength laser.
