Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α h...Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1α in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1α in patients with DVT compared to a healthy control group, utilizing ELISA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1α in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1α in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.展开更多
文摘Deep vein thrombosis (DVT) remains a significant clinical challenge, with complex underlying pathophysiological mechanisms. Among the myriad factors contributing to DVT, the transcription factors NF-κβ and HIF-1α have been increasingly recognized for their roles. This study aims to deepen the understanding of NF-κβ and HIF-1α in the pathogenesis of DVT and explore potential therapeutic implications. This research investigates the expression of NF-κβ and HIF-1α in patients with DVT compared to a healthy control group, utilizing ELISA techniques for quantification. The results of the study showed that the expression of NF-κβ and HIF-1α in the blood samples of patients with DVT was significantly higher than that of normal subjects, and the difference was statistically significant (P κβ and HIF-1α in the peripheral blood of DVT patients, suggesting their critical roles in inflammation and hypoxia regulation, with potential for future research into their mechanisms and therapeutic applications.
