Evidence from recent earthquakes has shown destructive consequences of fault-induced permanent ground movement on structures.Such observations have increased the demand for improvements in the design of structures tha...Evidence from recent earthquakes has shown destructive consequences of fault-induced permanent ground movement on structures.Such observations have increased the demand for improvements in the design of structures that are dramatically vulnerable to surface fault ruptures.In this study a novel connection between the raft and the piles is proposed to mitigate the hazards associated with a normal fault on pile-raft systems by means of 3D finite element(FE)modeling.Before embarking on the parametric study,the strain-softening constitutive law used for numerical modeling of the sand has been validated against centrifuge test results.The exact location of the fix-head and unconnected pile-raft systems relative to the outcropping fault rupture in the free-field is parametrically investigated,revealing different failure mechanisms.The performance of the proposed connection for protecting the pile-raft system against normal fault-induced deformations is assessed by comparing the geotechnical and structural responses of both types of foundation.The results indicate that the pocket connection can relatively reduce the cap rotation and horizontal and vertical displacements of the raft in most scenarios.The proposed connection decreases the bending moment response of the piles to their bending moment capacity,verging on a fault offset of 0.6 m at bedrock.展开更多
Monocular 3D object detection is challenging due to the lack of accurate depth information.Some methods estimate the pixel-wise depth maps from off-the-shelf depth estimators and then use them as an additional input t...Monocular 3D object detection is challenging due to the lack of accurate depth information.Some methods estimate the pixel-wise depth maps from off-the-shelf depth estimators and then use them as an additional input to augment the RGB images.Depth-based methods attempt to convert estimated depth maps to pseudo-LiDAR and then use LiDAR-based object detectors or focus on the perspective of image and depth fusion learning.However,they demonstrate limited performance and efficiency as a result of depth inaccuracy and complex fusion mode with convolutions.Different from these approaches,our proposed depth-guided vision transformer with a normalizing flows(NF-DVT)network uses normalizing flows to build priors in depth maps to achieve more accurate depth information.Then we develop a novel Swin-Transformer-based backbone with a fusion module to process RGB image patches and depth map patches with two separate branches and fuse them using cross-attention to exchange information with each other.Furthermore,with the help of pixel-wise relative depth values in depth maps,we develop new relative position embeddings in the cross-attention mechanism to capture more accurate sequence ordering of input tokens.Our method is the first Swin-Transformer-based backbone architecture for monocular 3D object detection.The experimental results on the KITTI and the challenging Waymo Open datasets show the effectiveness of our proposed method and superior performance over previous counterparts.展开更多
●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTG)who do not exhibit typical glaucoma manifestations.●METHODS:A retrospective analysis was...●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTG)who do not exhibit typical glaucoma manifestations.●METHODS:A retrospective analysis was conducted on 90 atypical NTG patients who underwent cranial magnetic resonance imaging(MRI)due to atypical symptoms.The demographic characteristics,clinical parameters,and radiological findings were recorded.●RESULTS:Among the patients,66.7%had abnormal radiology results,with the most common findings being gliosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benign intracranial mass lesions(11%).Non-glaucomatous visual field defects were more frequently observed in patients with abnormal neuroimaging results.However,there were no significant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiological results.The mean age of the patients was 58.74y.Interestingly,there was a significant age difference,with the abnormal radiology group having a higher median age(P=0.021).●CONCLUSION:The study highlights the importance of cranial imaging in older NTG patients to detect underlying pathologies and prevent misdiagnosis.It suggests that neuroimaging may be warranted in NTG patients with atypical visual field defects incompatible with glaucoma.However,routine neuroimaging in all NTG patients without classic neurological signs may not be necessary.展开更多
Unsupervised methods based on density representation have shown their abilities in anomaly detection,but detection performance still needs to be improved.Specifically,approaches using normalizing flows can accurately ...Unsupervised methods based on density representation have shown their abilities in anomaly detection,but detection performance still needs to be improved.Specifically,approaches using normalizing flows can accurately evaluate sample distributions,mapping normal features to the normal distribution and anomalous features outside it.Consequently,this paper proposes a Normalizing Flow-based Bidirectional Mapping Residual Network(NF-BMR).It utilizes pre-trained Convolutional Neural Networks(CNN)and normalizing flows to construct discriminative source and target domain feature spaces.Additionally,to better learn feature information in both domain spaces,we propose the Bidirectional Mapping Residual Network(BMR),which maps sample features to these two spaces for anomaly detection.The two detection spaces effectively complement each other’s deficiencies and provide a comprehensive feature evaluation from two perspectives,which leads to the improvement of detection performance.Comparative experimental results on the MVTec AD and DAGM datasets against the Bidirectional Pre-trained Feature Mapping Network(B-PFM)and other state-of-the-art methods demonstrate that the proposed approach achieves superior performance.On the MVTec AD dataset,NF-BMR achieves an average AUROC of 98.7%for all 15 categories.Especially,it achieves 100%optimal detection performance in five categories.On the DAGM dataset,the average AUROC across ten categories is 98.7%,which is very close to supervised methods.展开更多
This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma(NTG),a condition that continues to baffle clinicians and researchers alike.NTG,ch...This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma(NTG),a condition that continues to baffle clinicians and researchers alike.NTG,characterized by optic nerve damage and visual field loss despite normal intraocular pressure,has long puzzled clinicians.One emerging perspective suggests that alterations in ocular blood flow,particularly within the optic nerve head,may play a pivotal role in its pathogenesis.While NTG shares commonalities with its high-tension counterpart,its unique pathogenesis and potential ties to cardiovascular health make it a fascinating subject of exploration.It navigates through the complex web of vascular dysregulation,blood pressure and perfusion pressure,neurovascular coupling,and oxidative stress,seeking to uncover the hidden threads that tie the heart and eyes together in NTG.This review explores into the intricate mechanisms connecting cardiovascular factors to NTG,shedding light on how cardiac dynamics can influence ocular health,particularly in cases where intraocular pressure remains within the normal range.NTG's enigmatic nature,often characterized by seemingly contradictory risk factors and clinical profiles,underscores the need for a holistic approach to patient care.Drawing parallels to cardiac health,we examine into the shared vascular terrain connecting the heart and the eyes.Cardiovascular factors,including systemic blood flow,endothelial dysfunction,and microcirculatory anomalies,may exert a profound influence on ocular perfusion,impacting the delicate balance within the optic nerve head.By elucidating the subtle clues and potential associations between cardiology and NTG,this review invites clinicians to consider a broader perspective in their evaluation and management of this elusive condition.As the understanding of these connections evolves,so too may the prospects for early diagnosis and tailored interventions,ultimately enhancing the quality of life for those living with NTG.展开更多
The abandonment of date palm grove of the former Al-Ahsa Oasis in the eastern region of Saudi Arabia has resulted in the conversion of delicate agricultural area into urban area.The current state of the oasis is influ...The abandonment of date palm grove of the former Al-Ahsa Oasis in the eastern region of Saudi Arabia has resulted in the conversion of delicate agricultural area into urban area.The current state of the oasis is influenced by both expansion and degradation factors.Therefore,it is important to study the spatiotemporal variation of vegetation cover for the sustainable management of oasis resources.This study used Landsat satellite images in 1987,2002,and 2021 to monitor the spatiotemporal variation of vegetation cover in the Al-Ahsa Oasis,applied multi-temporal Normalized Difference Vegetation Index(NDVI)data spanning from 1987 to 2021 to assess environmental and spatiotemporal variations that have occurred in the Al-Ahsa Oasis,and investigated the factors influencing these variation.This study reveals that there is a significant improvement in the ecological environment of the oasis during 1987–2021,with increase of NDVI values being higher than 0.10.In 2021,the highest NDVI value is generally above 0.70,while the lowest value remains largely unchanged.However,there is a remarkable increase in NDVI values between 0.20 and 0.30.The area of low NDVI values(0.00–0.20)has remained almost stable,but the region with high NDVI values(above 0.70)expands during 1987–2021.Furthermore,this study finds that in 1987–2002,the increase of vegetation cover is most notable in the northern region of the study area,whereas from 2002 to 2021,the increase of vegetation cover is mainly concentrated in the northern and southern regions of the study area.From 1987 to 2021,NDVI values exhibit the most pronounced variation,with a significant increase in the“green”zone(characterized by NDVI values exceeding 0.40),indicating a substantial enhancement in the ecological environment of the oasis.The NDVI classification is validated through 50 ground validation points in the study area,demonstrating a mean accuracy of 92.00%in the detection of vegetation cover.In general,both the user’s and producer’s accuracies of NDVI classification are extremely high in 1987,2002,and 2021.Finally,this study suggests that environmental authorities should strengthen their overall forestry project arrangements to combat sand encroachment and enhance the ecological environment of the Al-Ahsa Oasis.展开更多
Through high-precision engraving,self-affine sandstone joint surfaces with various joint roughness coefficients(JRC=3.21e12.16)were replicated and the shear sliding tests under unloading normal stress were conducted r...Through high-precision engraving,self-affine sandstone joint surfaces with various joint roughness coefficients(JRC=3.21e12.16)were replicated and the shear sliding tests under unloading normal stress were conducted regarding various initial normal stresses(1e7 MPa)and numbers of shearing cycles(1 e5).The peak shear stress of fractures decreased with shear cycles due to progressively smooth surface morphologies,while increased with both JRC and initial normal stress and could be verified using the nonlinear Barton-Bandis failure criterion.The joint friction angle of fractures exponentially increased by 62.22%e64.87%with JRC while decreased by 22.1%e24.85%with shearing cycles.After unloading normal stress,the sliding initiation time of fractures increased with both JRC and initial normal stress due to more tortuous fracture morphologies and enhanced shearing resistance capacity.The surface resistance index(SRI)of fractures decreased by 4.35%e32.02%with increasing shearing cycles due to a more significant reduction of sliding initiation shear stress than that for sliding initiation normal stress,but increased by a factor of 0.41e1.64 with JRC.After sliding initiation,the shear displacement of fractures showed an increase in power function.By defining a sliding rate threshold of 5105 m/s,transition from“quasi-static”to“dynamic”sliding of fractures was identified,and the increase of sliding acceleration steepened with JRC while slowed down with shearing cycles.The normal displacement experienced a slight increase before shear sliding due to deformation recovery as the unloading stress was unloaded,and then enhanced shear dilation after sliding initiation due to climbing effects of surface asperities.Dilation was positively related to the shear sliding velocity of fractures.Wear characteristics of the fracture surfaces after shearing failure were evaluated using binary calculation,indicating an increasing shear area ratio by 45.24%e91.02%with normal stress.展开更多
In order to improve the fitting accuracy of college students’ test scores, this paper proposes two-component mixed generalized normal distribution, uses maximum likelihood estimation method and Expectation Conditiona...In order to improve the fitting accuracy of college students’ test scores, this paper proposes two-component mixed generalized normal distribution, uses maximum likelihood estimation method and Expectation Conditional Maxinnization (ECM) algorithm to estimate parameters and conduct numerical simulation, and performs fitting analysis on the test scores of Linear Algebra and Advanced Mathematics of F University. The empirical results show that the two-component mixed generalized normal distribution is better than the commonly used two-component mixed normal distribution in fitting college students’ test data, and has good application value.展开更多
Normal tension glaucoma(NTG)is a multifactorial optic neuropathy characterized by normal intraocular pressure,progressive retinal ganglion cell(RGC)death,and glaucomatous visual field loss.Recent studies have describe...Normal tension glaucoma(NTG)is a multifactorial optic neuropathy characterized by normal intraocular pressure,progressive retinal ganglion cell(RGC)death,and glaucomatous visual field loss.Recent studies have described the mechanisms underlying the pathogenesis of NTG.In addition to controlling intraocular pressure,neuroprotection and reduction of RGC degeneration may be beneficial therapies for NTG.In this review,we summarized the main regulatory mechanisms of RGC death in NTG,including autophagy,glutamate neurotoxicity,oxidative stress,neuroinflammation,immunity,and vasoconstriction.Autophagy can be induced by retinal hypoxia and axonal damage.In this process,ischemia can cause mutations of optineurin and activate the nuclear factor-kappa B pathway.Glutamate neurotoxicity is induced by the over-stimulation of N-methyl-D-aspartate membrane receptors by glutamate,which occurs in RGCs and induces progressive glaucomatous optic neuropathy.Oxidative stress also participates in NTG-related glaucomatous optic neuropathy.It impairs the mitochondrial and DNA function of RGCs through the apoptosis signal-regulating kinase-JUN N-terminal kinase pathway.Moreover,it increases inflammation and the immune response of RGCs.Endothelin 1 causes endothelial dysfunction and impairment of ocular blood flow,promoting vasospasm and glaucomatous optic neuropathy,as a result of NTG.In conclusion,we discussed research progress on potential options for the protection of RGCs,including TANK binding kinase 1 inhibitors regulating autophagy,N-methyl-D-aspartate receptor antagonists inhibiting glutamate toxicity,ASK1 inhibitors regulating mitochondrial function,and antioxidants inhibiting oxidative stress.In NTG,RGC death is regulated by a network of mechanisms,while various potential targets protect RGCs.Collectively,these findings provide insight into the pathogenesis of NTG and potential therapeutic strategies.展开更多
Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric dat...Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric data which also poses great challenges to data analysis,from the extraction of raw data to the identification of differential metabolites.To date,a large number of analytical tools and processes have been developed and constructed to serve untargeted metabolomics research.The different selection of analytical tools and parameter settings lead to varied results of untargeted metabolomics data.Our goal is to establish an easily operated platform and obtain a repeatable analysis result.Methods:We used the R language basic environment to construct the preprocessing system of the original data and the LAMP(Linux+Apache+MySQL+PHP)architecture to build a cloud mass spectrum data analysis system.Results:An open-source analysis software for untargeted metabolomics data(openNAU)was constructed.It includes the extraction of raw mass data and quality control for the identification of differential metabolic ion peaks.A reference metabolomics database based on public databases was also constructed.Conclusions:A complete analysis system platform for untargeted metabolomics was established.This platform provides a complete template interface for the addition and updating of the analysis process,so we can finish complex analyses of untargeted metabolomics with simple human-computer interactions.The source code can be downloaded from https://github.com/zjuRong/openNAU.展开更多
Alps are an important geographical area of the European continent and,in this area,temperature increase is most evident.However,the 1991-2020 climate normal in the Alps has still not been thoroughly investigated.Aimin...Alps are an important geographical area of the European continent and,in this area,temperature increase is most evident.However,the 1991-2020 climate normal in the Alps has still not been thoroughly investigated.Aiming to fill this gap with a focus on high-elevation environments,minimum and maximum daily air temperature acquired by 23 automatic weather station were used.The results show that the mean annual values of minimum and maximum temperature for the 1991-2020 climate normal in the Alps are-2.4℃ and 4.4℃,respectively,with a warming rate of 0.5℃/10 years.The mean annual temperature comparison between 1961-1990 and 1971-2000,1961-1990 and 1981-2010,1961-1990 and 1991-2020 climate normal show an increase of 0.3℃,0.5℃ and 0.9℃,respectively.The results also confirm that seasonal and annual temperatures are rising through the whole Alpine arc,mainly in summer and autumn.This work highlights that annual minimum and maximum temperature do not seem to be affected by a positive elevation-dependent warming.Instead,a positive elevation-dependent warming in the maximum values of the annual minimum temperature was found.If anthropogenic emissions maintain the trend of the last decades,the expected mean annual temperature of the 2001-2030 climate normal is-0.2℃,with an increase of 0.5℃ if compared to the 1991-2020 climate normal and with an increase of 1.5℃ if compared to the 1961-1990 climate normal.This study highlights the warming rate that is now present in the European Alps,provides indications on the warming rate that will occur in the coming years and highlights the importance of carrying out investigations that consider not only the last 30-year climate normal,but also the most recent 30-year climate normal by comparing them with each other.展开更多
Slide-hold-slide(SHS)test is an essential experimental approach for studying the frictional stability of faults.The origin SHS framework was established based on a consistent constant normal stress,which cannot truly ...Slide-hold-slide(SHS)test is an essential experimental approach for studying the frictional stability of faults.The origin SHS framework was established based on a consistent constant normal stress,which cannot truly reflect the stress disturbance around fault zones.In this paper,we conducted a series of'dynamic SHS tests',which includes normal stress oscillations in the relaxation stage with different oscillation amplitudes and frequencies on synthetic quartz gouge using a double direct shear assembly.The experimental results reveal that the amplitude of the normal load oscillation has a remarkable effect on the frictional relaxation and healing patterns.However,the frequency of the normal load oscillation has a minor effect.Additionally,the shear loading rate is proportional to the normal loading rate during the relaxation stage,and the normal stiffness of the quartz layer remains nearly constant under various loading conditions.The creep rate during the hold phase is not obviously affected by the normal load oscillation,while the precursory slip is also sensitive to the oscillation amplitude.This study provides insights into the evolution of frictional stability in discontinuities and is beneficial for controlling relative disasters in fault zones.展开更多
Fault activation has been the focus of research community for years.However,the studies of fault activation remain immature,such as the fault activation mode and its major factors under constant normal stiffness(CNS)c...Fault activation has been the focus of research community for years.However,the studies of fault activation remain immature,such as the fault activation mode and its major factors under constant normal stiffness(CNS)conditions associated with large thickness of fault surrounding rock mass.In this study,the rock friction experiments were conducted to understand the fault activation modes under the CNS conditions.Two major parameters,i.e.the initial normal stress and loading rate,were considered and calibrated in the tests.To reveal the response mechanism of fault activation,the local strains near the fault plane were recorded,and the macroscopic stresses and displacements were analyzed.The testing results show that the effect of displacement-controlled loading rate is more pronounced under the CNS conditions than that under constant normal load(CNL)conditions.Both the normal and shear stresses drop suddenly when the stick-slip occurs.The decrease and increase of the normal stress are synchronous with the shear stress in the regular stick-slip scenario,but mismatch with the shear stress during the chaotic stick-slip process.The results are helpful for understanding the fault sliding mode and the prediction and prevention of fault slip.展开更多
In this paper,we study the ground state standing wave solutions for the focusing bi-harmonic nonlinear Schrodinger equation with aμ-Laplacian term(BNLS).Such BNLS models the propagation of intense laser beams in a bu...In this paper,we study the ground state standing wave solutions for the focusing bi-harmonic nonlinear Schrodinger equation with aμ-Laplacian term(BNLS).Such BNLS models the propagation of intense laser beams in a bulk medium with a second-order dispersion term.Denoting by Qpthe ground state for the BNLS withμ=0,we prove that in the mass-subcritical regime p∈(1,1+8/d),there exist orbit ally stable ground state solutions for the BNLS when p∈(-λ0,∞)for someλ0=λ0(p,d,‖Qp‖L2)>0.Moreover,in the mass-critical case p=1+8/d,we prove the orbital stability on a certain mass level below‖Q*‖L2,provided thatμ∈(-λ1,0),where■and Q*=Q1+8/d.The proofs are mainly based on the profile decomposition and a sharp Gagliardo-Nirenberg type inequality.Our treatment allows us to fill the gap concerning the existence of the ground states for the BNLS when p is negative and p∈(1,1+8/d].展开更多
In recent years,more and more attention has been paid to normal childbirth.The World Health Organization(WHO),International Confederation of Midwives(ICM),Chinese Maternal and Child Health Association(CMCHA)have activ...In recent years,more and more attention has been paid to normal childbirth.The World Health Organization(WHO),International Confederation of Midwives(ICM),Chinese Maternal and Child Health Association(CMCHA)have actively advocated normal childbirth[[1],[2],[3]].It is proved that normal childbirth can improve birth outcomes.展开更多
Rock joints are one of the vital discontinuities in a natural rock mass.How to accurately and conveniently determine joint normal stiffness is therefore significant in rock mechanics.Here,first,seven existing methods ...Rock joints are one of the vital discontinuities in a natural rock mass.How to accurately and conveniently determine joint normal stiffness is therefore significant in rock mechanics.Here,first,seven existing methods for determining joint normal stiffness were introduced and reviewed,among which MethodⅠ(the indirect measurement method),MethodⅡ(the direct determination method),MethodⅢ(the across-joint strain gauge measurement method)and MethodⅣ(the deformation measuring ring method)are via destructive uniaxial compression testing,while MethodⅤ(the best fitting method),MethodⅥ(the rapid evaluation method)and MethodⅦ(the effective modulus method)are through wave propagation principles and nondestructive ultrasonic testing.Subsequently,laboratory tests of intact and jointed sandstone specimens were conducted following the testing requirements and pro-cedures of those seven methods.A comparison among those methods was then performed.The results show that Method I,i.e.the benchmark method,is reliable and stable.MethodⅡhas a conceptual drawback,and its accuracy is acceptable at only very low stress levels.Relative errors in the results from MethodⅢare very large.With MethodⅣ,the testing results are sufficiently accurate despite the strict testing environment and complicated testing procedures.The results from MethodⅤare greatly unstable and significantly dependent on the natural frequency of the transducers.The joint normal stiffness determined with MethodⅥis stable and accurate,although data processing is complex.MethodⅦcould be adopted to determine the joint normal stiffness corresponding to the rock elastic deformation phase only.Consequently,it is suggested that MethodsⅠ,ⅣandⅥshould be adopted for the mea-surement of joint normal stiffness.The findings could be helpful in selecting an appropriate method to determine joint normal stiffness and,hence,to better solve discontinuous rock mass problems.展开更多
The degradation of the shear stress between pile-clay interface caused by undrained cyclic jacking affects the jacking force.A series of large displacement monotonic shear,cyclic shear and post-cyclic monotonic steel ...The degradation of the shear stress between pile-clay interface caused by undrained cyclic jacking affects the jacking force.A series of large displacement monotonic shear,cyclic shear and post-cyclic monotonic steel plate-clay interface shear te sts were performed under the constant normal load(CNL)condition to inve stigate the effects of normal stre ss,cyclic amplitude,and number of cycles on a steel plate-clay interface using the GDS multi-function interface shear tester.Based on the experimental results,in monotonic shear tests,change of shear stress took place in the specimen,the shear stress rapidly reached the peak value at shear displacement of 1 mm,and then abruptly decreased to the residual value.In cyclic shear te sts,accumulated displacement was a better parameter to describe the soil degradation characteristics,and the degradation degree of shear stress became greater with the increasing of normal stress and accumulated displacement.Shear stress in post-cyclic monotonic shear tests did not generate a peak value and was lower than that in monotonic shear tests under the same normal stress.The soil was completely disturbed and reached the residual strength when the cumulative displacement approached 6 m.An empirical equation to evaluate shear stress degradation mechanism was formulated and the procedure of parameter identification was presented.展开更多
In this paper,we study normalized solutions of the Chern-Simons-Schrödinger system with general nonlinearity and a potential in H^(1)(ℝ^(2)).When the nonlinearity satisfies some general 3-superlinear conditions,w...In this paper,we study normalized solutions of the Chern-Simons-Schrödinger system with general nonlinearity and a potential in H^(1)(ℝ^(2)).When the nonlinearity satisfies some general 3-superlinear conditions,we obtain the existence of ground state normalized solutions by using the minimax procedure proposed by Jeanjean in[L.Jeanjean,Existence of solutions with prescribed norm for semilinear elliptic equations,Nonlinear Anal.(1997)].展开更多
基金Babol Noshirvani University of Technology under Grant No.P/M/1102。
文摘Evidence from recent earthquakes has shown destructive consequences of fault-induced permanent ground movement on structures.Such observations have increased the demand for improvements in the design of structures that are dramatically vulnerable to surface fault ruptures.In this study a novel connection between the raft and the piles is proposed to mitigate the hazards associated with a normal fault on pile-raft systems by means of 3D finite element(FE)modeling.Before embarking on the parametric study,the strain-softening constitutive law used for numerical modeling of the sand has been validated against centrifuge test results.The exact location of the fix-head and unconnected pile-raft systems relative to the outcropping fault rupture in the free-field is parametrically investigated,revealing different failure mechanisms.The performance of the proposed connection for protecting the pile-raft system against normal fault-induced deformations is assessed by comparing the geotechnical and structural responses of both types of foundation.The results indicate that the pocket connection can relatively reduce the cap rotation and horizontal and vertical displacements of the raft in most scenarios.The proposed connection decreases the bending moment response of the piles to their bending moment capacity,verging on a fault offset of 0.6 m at bedrock.
基金supported in part by the Major Project for New Generation of AI (2018AAA0100400)the National Natural Science Foundation of China (61836014,U21B2042,62072457,62006231)the InnoHK Program。
文摘Monocular 3D object detection is challenging due to the lack of accurate depth information.Some methods estimate the pixel-wise depth maps from off-the-shelf depth estimators and then use them as an additional input to augment the RGB images.Depth-based methods attempt to convert estimated depth maps to pseudo-LiDAR and then use LiDAR-based object detectors or focus on the perspective of image and depth fusion learning.However,they demonstrate limited performance and efficiency as a result of depth inaccuracy and complex fusion mode with convolutions.Different from these approaches,our proposed depth-guided vision transformer with a normalizing flows(NF-DVT)network uses normalizing flows to build priors in depth maps to achieve more accurate depth information.Then we develop a novel Swin-Transformer-based backbone with a fusion module to process RGB image patches and depth map patches with two separate branches and fuse them using cross-attention to exchange information with each other.Furthermore,with the help of pixel-wise relative depth values in depth maps,we develop new relative position embeddings in the cross-attention mechanism to capture more accurate sequence ordering of input tokens.Our method is the first Swin-Transformer-based backbone architecture for monocular 3D object detection.The experimental results on the KITTI and the challenging Waymo Open datasets show the effectiveness of our proposed method and superior performance over previous counterparts.
文摘●AIM:To assess the necessity of neuroimaging in patients with neurological or atypical findings of normal tension glaucoma(NTG)who do not exhibit typical glaucoma manifestations.●METHODS:A retrospective analysis was conducted on 90 atypical NTG patients who underwent cranial magnetic resonance imaging(MRI)due to atypical symptoms.The demographic characteristics,clinical parameters,and radiological findings were recorded.●RESULTS:Among the patients,66.7%had abnormal radiology results,with the most common findings being gliosis(34.4%),sequelae of cerebrovascular events and vascular malformations(14.4%),and benign intracranial mass lesions(11%).Non-glaucomatous visual field defects were more frequently observed in patients with abnormal neuroimaging results.However,there were no significant differences in intraocular pressure,optic disc parameters,retinal nerve fiber layer thickness,and visual field indices between patients with normal and abnormal radiological results.The mean age of the patients was 58.74y.Interestingly,there was a significant age difference,with the abnormal radiology group having a higher median age(P=0.021).●CONCLUSION:The study highlights the importance of cranial imaging in older NTG patients to detect underlying pathologies and prevent misdiagnosis.It suggests that neuroimaging may be warranted in NTG patients with atypical visual field defects incompatible with glaucoma.However,routine neuroimaging in all NTG patients without classic neurological signs may not be necessary.
基金This work was supported in part by the National Key R&D Program of China 2021YFE0110500in part by the National Natural Science Foundation of China under Grant 62062021in part by the Guiyang Scientific Plan Project[2023]48-11.
文摘Unsupervised methods based on density representation have shown their abilities in anomaly detection,but detection performance still needs to be improved.Specifically,approaches using normalizing flows can accurately evaluate sample distributions,mapping normal features to the normal distribution and anomalous features outside it.Consequently,this paper proposes a Normalizing Flow-based Bidirectional Mapping Residual Network(NF-BMR).It utilizes pre-trained Convolutional Neural Networks(CNN)and normalizing flows to construct discriminative source and target domain feature spaces.Additionally,to better learn feature information in both domain spaces,we propose the Bidirectional Mapping Residual Network(BMR),which maps sample features to these two spaces for anomaly detection.The two detection spaces effectively complement each other’s deficiencies and provide a comprehensive feature evaluation from two perspectives,which leads to the improvement of detection performance.Comparative experimental results on the MVTec AD and DAGM datasets against the Bidirectional Pre-trained Feature Mapping Network(B-PFM)and other state-of-the-art methods demonstrate that the proposed approach achieves superior performance.On the MVTec AD dataset,NF-BMR achieves an average AUROC of 98.7%for all 15 categories.Especially,it achieves 100%optimal detection performance in five categories.On the DAGM dataset,the average AUROC across ten categories is 98.7%,which is very close to supervised methods.
文摘This comprehensive review embarks on a captivating journey into the complex relationship between cardiology and normal-tension glaucoma(NTG),a condition that continues to baffle clinicians and researchers alike.NTG,characterized by optic nerve damage and visual field loss despite normal intraocular pressure,has long puzzled clinicians.One emerging perspective suggests that alterations in ocular blood flow,particularly within the optic nerve head,may play a pivotal role in its pathogenesis.While NTG shares commonalities with its high-tension counterpart,its unique pathogenesis and potential ties to cardiovascular health make it a fascinating subject of exploration.It navigates through the complex web of vascular dysregulation,blood pressure and perfusion pressure,neurovascular coupling,and oxidative stress,seeking to uncover the hidden threads that tie the heart and eyes together in NTG.This review explores into the intricate mechanisms connecting cardiovascular factors to NTG,shedding light on how cardiac dynamics can influence ocular health,particularly in cases where intraocular pressure remains within the normal range.NTG's enigmatic nature,often characterized by seemingly contradictory risk factors and clinical profiles,underscores the need for a holistic approach to patient care.Drawing parallels to cardiac health,we examine into the shared vascular terrain connecting the heart and the eyes.Cardiovascular factors,including systemic blood flow,endothelial dysfunction,and microcirculatory anomalies,may exert a profound influence on ocular perfusion,impacting the delicate balance within the optic nerve head.By elucidating the subtle clues and potential associations between cardiology and NTG,this review invites clinicians to consider a broader perspective in their evaluation and management of this elusive condition.As the understanding of these connections evolves,so too may the prospects for early diagnosis and tailored interventions,ultimately enhancing the quality of life for those living with NTG.
文摘The abandonment of date palm grove of the former Al-Ahsa Oasis in the eastern region of Saudi Arabia has resulted in the conversion of delicate agricultural area into urban area.The current state of the oasis is influenced by both expansion and degradation factors.Therefore,it is important to study the spatiotemporal variation of vegetation cover for the sustainable management of oasis resources.This study used Landsat satellite images in 1987,2002,and 2021 to monitor the spatiotemporal variation of vegetation cover in the Al-Ahsa Oasis,applied multi-temporal Normalized Difference Vegetation Index(NDVI)data spanning from 1987 to 2021 to assess environmental and spatiotemporal variations that have occurred in the Al-Ahsa Oasis,and investigated the factors influencing these variation.This study reveals that there is a significant improvement in the ecological environment of the oasis during 1987–2021,with increase of NDVI values being higher than 0.10.In 2021,the highest NDVI value is generally above 0.70,while the lowest value remains largely unchanged.However,there is a remarkable increase in NDVI values between 0.20 and 0.30.The area of low NDVI values(0.00–0.20)has remained almost stable,but the region with high NDVI values(above 0.70)expands during 1987–2021.Furthermore,this study finds that in 1987–2002,the increase of vegetation cover is most notable in the northern region of the study area,whereas from 2002 to 2021,the increase of vegetation cover is mainly concentrated in the northern and southern regions of the study area.From 1987 to 2021,NDVI values exhibit the most pronounced variation,with a significant increase in the“green”zone(characterized by NDVI values exceeding 0.40),indicating a substantial enhancement in the ecological environment of the oasis.The NDVI classification is validated through 50 ground validation points in the study area,demonstrating a mean accuracy of 92.00%in the detection of vegetation cover.In general,both the user’s and producer’s accuracies of NDVI classification are extremely high in 1987,2002,and 2021.Finally,this study suggests that environmental authorities should strengthen their overall forestry project arrangements to combat sand encroachment and enhance the ecological environment of the Al-Ahsa Oasis.
基金support from the National Natural Science Foundation of China(Grant Nos.52174092 and 52104125)the Fundamental Research Funds for the Central Universities,China(Grant No.2022YCPY0202)is gratefully acknowledged.
文摘Through high-precision engraving,self-affine sandstone joint surfaces with various joint roughness coefficients(JRC=3.21e12.16)were replicated and the shear sliding tests under unloading normal stress were conducted regarding various initial normal stresses(1e7 MPa)and numbers of shearing cycles(1 e5).The peak shear stress of fractures decreased with shear cycles due to progressively smooth surface morphologies,while increased with both JRC and initial normal stress and could be verified using the nonlinear Barton-Bandis failure criterion.The joint friction angle of fractures exponentially increased by 62.22%e64.87%with JRC while decreased by 22.1%e24.85%with shearing cycles.After unloading normal stress,the sliding initiation time of fractures increased with both JRC and initial normal stress due to more tortuous fracture morphologies and enhanced shearing resistance capacity.The surface resistance index(SRI)of fractures decreased by 4.35%e32.02%with increasing shearing cycles due to a more significant reduction of sliding initiation shear stress than that for sliding initiation normal stress,but increased by a factor of 0.41e1.64 with JRC.After sliding initiation,the shear displacement of fractures showed an increase in power function.By defining a sliding rate threshold of 5105 m/s,transition from“quasi-static”to“dynamic”sliding of fractures was identified,and the increase of sliding acceleration steepened with JRC while slowed down with shearing cycles.The normal displacement experienced a slight increase before shear sliding due to deformation recovery as the unloading stress was unloaded,and then enhanced shear dilation after sliding initiation due to climbing effects of surface asperities.Dilation was positively related to the shear sliding velocity of fractures.Wear characteristics of the fracture surfaces after shearing failure were evaluated using binary calculation,indicating an increasing shear area ratio by 45.24%e91.02%with normal stress.
文摘In order to improve the fitting accuracy of college students’ test scores, this paper proposes two-component mixed generalized normal distribution, uses maximum likelihood estimation method and Expectation Conditional Maxinnization (ECM) algorithm to estimate parameters and conduct numerical simulation, and performs fitting analysis on the test scores of Linear Algebra and Advanced Mathematics of F University. The empirical results show that the two-component mixed generalized normal distribution is better than the commonly used two-component mixed normal distribution in fitting college students’ test data, and has good application value.
基金supported in part by the Technology Foundation of Tianjin Eye Hospital of China, No. YKQN1911 (to WCS)Tianjin Health Science and Technology Project, No. TJWJ2021QN071 (to WCS)Translational Medicine Research Project of State Key Laboratory of Experimental Hematology of China, No. Z21-11 (to BQH)
文摘Normal tension glaucoma(NTG)is a multifactorial optic neuropathy characterized by normal intraocular pressure,progressive retinal ganglion cell(RGC)death,and glaucomatous visual field loss.Recent studies have described the mechanisms underlying the pathogenesis of NTG.In addition to controlling intraocular pressure,neuroprotection and reduction of RGC degeneration may be beneficial therapies for NTG.In this review,we summarized the main regulatory mechanisms of RGC death in NTG,including autophagy,glutamate neurotoxicity,oxidative stress,neuroinflammation,immunity,and vasoconstriction.Autophagy can be induced by retinal hypoxia and axonal damage.In this process,ischemia can cause mutations of optineurin and activate the nuclear factor-kappa B pathway.Glutamate neurotoxicity is induced by the over-stimulation of N-methyl-D-aspartate membrane receptors by glutamate,which occurs in RGCs and induces progressive glaucomatous optic neuropathy.Oxidative stress also participates in NTG-related glaucomatous optic neuropathy.It impairs the mitochondrial and DNA function of RGCs through the apoptosis signal-regulating kinase-JUN N-terminal kinase pathway.Moreover,it increases inflammation and the immune response of RGCs.Endothelin 1 causes endothelial dysfunction and impairment of ocular blood flow,promoting vasospasm and glaucomatous optic neuropathy,as a result of NTG.In conclusion,we discussed research progress on potential options for the protection of RGCs,including TANK binding kinase 1 inhibitors regulating autophagy,N-methyl-D-aspartate receptor antagonists inhibiting glutamate toxicity,ASK1 inhibitors regulating mitochondrial function,and antioxidants inhibiting oxidative stress.In NTG,RGC death is regulated by a network of mechanisms,while various potential targets protect RGCs.Collectively,these findings provide insight into the pathogenesis of NTG and potential therapeutic strategies.
文摘Objective:As an important part of metabolomics analysis,untargeted metabolomics has become a powerful tool in the study of tumor mechanisms and the discovery of metabolic markers with high-throughput spectrometric data which also poses great challenges to data analysis,from the extraction of raw data to the identification of differential metabolites.To date,a large number of analytical tools and processes have been developed and constructed to serve untargeted metabolomics research.The different selection of analytical tools and parameter settings lead to varied results of untargeted metabolomics data.Our goal is to establish an easily operated platform and obtain a repeatable analysis result.Methods:We used the R language basic environment to construct the preprocessing system of the original data and the LAMP(Linux+Apache+MySQL+PHP)architecture to build a cloud mass spectrum data analysis system.Results:An open-source analysis software for untargeted metabolomics data(openNAU)was constructed.It includes the extraction of raw mass data and quality control for the identification of differential metabolic ion peaks.A reference metabolomics database based on public databases was also constructed.Conclusions:A complete analysis system platform for untargeted metabolomics was established.This platform provides a complete template interface for the addition and updating of the analysis process,so we can finish complex analyses of untargeted metabolomics with simple human-computer interactions.The source code can be downloaded from https://github.com/zjuRong/openNAU.
基金the framework of the Gio Mon Project,co-financed by“Fondazione Cassa di Risparmio di Torino”。
文摘Alps are an important geographical area of the European continent and,in this area,temperature increase is most evident.However,the 1991-2020 climate normal in the Alps has still not been thoroughly investigated.Aiming to fill this gap with a focus on high-elevation environments,minimum and maximum daily air temperature acquired by 23 automatic weather station were used.The results show that the mean annual values of minimum and maximum temperature for the 1991-2020 climate normal in the Alps are-2.4℃ and 4.4℃,respectively,with a warming rate of 0.5℃/10 years.The mean annual temperature comparison between 1961-1990 and 1971-2000,1961-1990 and 1981-2010,1961-1990 and 1991-2020 climate normal show an increase of 0.3℃,0.5℃ and 0.9℃,respectively.The results also confirm that seasonal and annual temperatures are rising through the whole Alpine arc,mainly in summer and autumn.This work highlights that annual minimum and maximum temperature do not seem to be affected by a positive elevation-dependent warming.Instead,a positive elevation-dependent warming in the maximum values of the annual minimum temperature was found.If anthropogenic emissions maintain the trend of the last decades,the expected mean annual temperature of the 2001-2030 climate normal is-0.2℃,with an increase of 0.5℃ if compared to the 1991-2020 climate normal and with an increase of 1.5℃ if compared to the 1961-1990 climate normal.This study highlights the warming rate that is now present in the European Alps,provides indications on the warming rate that will occur in the coming years and highlights the importance of carrying out investigations that consider not only the last 30-year climate normal,but also the most recent 30-year climate normal by comparing them with each other.
基金supported by Fundamental Research Funds for the Central Universities (22dfx06)Natural Science Foundation of Guangdong Province-Joint Program for Offshore Wind Power (2022A1515240009).
文摘Slide-hold-slide(SHS)test is an essential experimental approach for studying the frictional stability of faults.The origin SHS framework was established based on a consistent constant normal stress,which cannot truly reflect the stress disturbance around fault zones.In this paper,we conducted a series of'dynamic SHS tests',which includes normal stress oscillations in the relaxation stage with different oscillation amplitudes and frequencies on synthetic quartz gouge using a double direct shear assembly.The experimental results reveal that the amplitude of the normal load oscillation has a remarkable effect on the frictional relaxation and healing patterns.However,the frequency of the normal load oscillation has a minor effect.Additionally,the shear loading rate is proportional to the normal loading rate during the relaxation stage,and the normal stiffness of the quartz layer remains nearly constant under various loading conditions.The creep rate during the hold phase is not obviously affected by the normal load oscillation,while the precursory slip is also sensitive to the oscillation amplitude.This study provides insights into the evolution of frictional stability in discontinuities and is beneficial for controlling relative disasters in fault zones.
基金supported by the Key Projects of the Yalong River Joint Fund of the National Natural Science Foundation of China(Grant No.U1865203)the National Natural Science Foundation of China(Grant Nos.52109142 and 41941018).
文摘Fault activation has been the focus of research community for years.However,the studies of fault activation remain immature,such as the fault activation mode and its major factors under constant normal stiffness(CNS)conditions associated with large thickness of fault surrounding rock mass.In this study,the rock friction experiments were conducted to understand the fault activation modes under the CNS conditions.Two major parameters,i.e.the initial normal stress and loading rate,were considered and calibrated in the tests.To reveal the response mechanism of fault activation,the local strains near the fault plane were recorded,and the macroscopic stresses and displacements were analyzed.The testing results show that the effect of displacement-controlled loading rate is more pronounced under the CNS conditions than that under constant normal load(CNL)conditions.Both the normal and shear stresses drop suddenly when the stick-slip occurs.The decrease and increase of the normal stress are synchronous with the shear stress in the regular stick-slip scenario,but mismatch with the shear stress during the chaotic stick-slip process.The results are helpful for understanding the fault sliding mode and the prediction and prevention of fault slip.
基金partially supported by the National Natural Science Foundation of China(11501137)partially supported by the National Natural Science Foundation of China(11501395,12071323)the Guangdong Basic and Applied Basic Research Foundation(2016A030310258,2020A1515011019)。
文摘In this paper,we study the ground state standing wave solutions for the focusing bi-harmonic nonlinear Schrodinger equation with aμ-Laplacian term(BNLS).Such BNLS models the propagation of intense laser beams in a bulk medium with a second-order dispersion term.Denoting by Qpthe ground state for the BNLS withμ=0,we prove that in the mass-subcritical regime p∈(1,1+8/d),there exist orbit ally stable ground state solutions for the BNLS when p∈(-λ0,∞)for someλ0=λ0(p,d,‖Qp‖L2)>0.Moreover,in the mass-critical case p=1+8/d,we prove the orbital stability on a certain mass level below‖Q*‖L2,provided thatμ∈(-λ1,0),where■and Q*=Q1+8/d.The proofs are mainly based on the profile decomposition and a sharp Gagliardo-Nirenberg type inequality.Our treatment allows us to fill the gap concerning the existence of the ground states for the BNLS when p is negative and p∈(1,1+8/d].
基金This manuscript was supported by Beijing Natural Science Foundation(Grant No.7222106).
文摘In recent years,more and more attention has been paid to normal childbirth.The World Health Organization(WHO),International Confederation of Midwives(ICM),Chinese Maternal and Child Health Association(CMCHA)have actively advocated normal childbirth[[1],[2],[3]].It is proved that normal childbirth can improve birth outcomes.
基金supported by the Shenzhen Fundamental Research Program(Grant No.JCYJ20220818095605012)the National Natural Science Foundation of China(Grant No.51909026)the Fund of Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization(Grant No.2020-08).
文摘Rock joints are one of the vital discontinuities in a natural rock mass.How to accurately and conveniently determine joint normal stiffness is therefore significant in rock mechanics.Here,first,seven existing methods for determining joint normal stiffness were introduced and reviewed,among which MethodⅠ(the indirect measurement method),MethodⅡ(the direct determination method),MethodⅢ(the across-joint strain gauge measurement method)and MethodⅣ(the deformation measuring ring method)are via destructive uniaxial compression testing,while MethodⅤ(the best fitting method),MethodⅥ(the rapid evaluation method)and MethodⅦ(the effective modulus method)are through wave propagation principles and nondestructive ultrasonic testing.Subsequently,laboratory tests of intact and jointed sandstone specimens were conducted following the testing requirements and pro-cedures of those seven methods.A comparison among those methods was then performed.The results show that Method I,i.e.the benchmark method,is reliable and stable.MethodⅡhas a conceptual drawback,and its accuracy is acceptable at only very low stress levels.Relative errors in the results from MethodⅢare very large.With MethodⅣ,the testing results are sufficiently accurate despite the strict testing environment and complicated testing procedures.The results from MethodⅤare greatly unstable and significantly dependent on the natural frequency of the transducers.The joint normal stiffness determined with MethodⅥis stable and accurate,although data processing is complex.MethodⅦcould be adopted to determine the joint normal stiffness corresponding to the rock elastic deformation phase only.Consequently,it is suggested that MethodsⅠ,ⅣandⅥshould be adopted for the mea-surement of joint normal stiffness.The findings could be helpful in selecting an appropriate method to determine joint normal stiffness and,hence,to better solve discontinuous rock mass problems.
基金financially supported by the Fundamental Research Funds for the Study on Formation and Evolution Mechanism of Soil Plug of Jacked Pipe Pile Cyclic Penetration in Clay (Grant No.52078483)。
文摘The degradation of the shear stress between pile-clay interface caused by undrained cyclic jacking affects the jacking force.A series of large displacement monotonic shear,cyclic shear and post-cyclic monotonic steel plate-clay interface shear te sts were performed under the constant normal load(CNL)condition to inve stigate the effects of normal stre ss,cyclic amplitude,and number of cycles on a steel plate-clay interface using the GDS multi-function interface shear tester.Based on the experimental results,in monotonic shear tests,change of shear stress took place in the specimen,the shear stress rapidly reached the peak value at shear displacement of 1 mm,and then abruptly decreased to the residual value.In cyclic shear te sts,accumulated displacement was a better parameter to describe the soil degradation characteristics,and the degradation degree of shear stress became greater with the increasing of normal stress and accumulated displacement.Shear stress in post-cyclic monotonic shear tests did not generate a peak value and was lower than that in monotonic shear tests under the same normal stress.The soil was completely disturbed and reached the residual strength when the cumulative displacement approached 6 m.An empirical equation to evaluate shear stress degradation mechanism was formulated and the procedure of parameter identification was presented.
基金Supported by the National Natural Science Foundation of China (11971393).
文摘In this paper,we study normalized solutions of the Chern-Simons-Schrödinger system with general nonlinearity and a potential in H^(1)(ℝ^(2)).When the nonlinearity satisfies some general 3-superlinear conditions,we obtain the existence of ground state normalized solutions by using the minimax procedure proposed by Jeanjean in[L.Jeanjean,Existence of solutions with prescribed norm for semilinear elliptic equations,Nonlinear Anal.(1997)].
