In March,the annual national conferences-the 5th Session of the 10th National People's Congress(NPC)and the 5th Session of the 10th National People's Politic Consultative Congress (CPPCC),were held in Beijing....In March,the annual national conferences-the 5th Session of the 10th National People's Congress(NPC)and the 5th Session of the 10th National People's Politic Consultative Congress (CPPCC),were held in Beijing.35 representatives and members of NPC and CPPCC from Tibet Autonomous Region(TAR) took part into these two big conventions.展开更多
THE eyes and ears of the country are turned every March to the annual sessions of the National People’s Congress (NPC) and Chinese People’s Political Consultative Conference (CPPCC), and increasingly so is worldwide...THE eyes and ears of the country are turned every March to the annual sessions of the National People’s Congress (NPC) and Chinese People’s Political Consultative Conference (CPPCC), and increasingly so is worldwide attention.展开更多
为降低中点箝位型(neutral point clamped,NPC)三电平整流器的电流谐波,在dq同步旋转坐标系下推导出带中点电压耦合项的NPC三电平整流器数学模型,并分析中点电压对电流控制的影响。对模型中的中点电压耦合项和交流侧等效电阻会增大电流...为降低中点箝位型(neutral point clamped,NPC)三电平整流器的电流谐波,在dq同步旋转坐标系下推导出带中点电压耦合项的NPC三电平整流器数学模型,并分析中点电压对电流控制的影响。对模型中的中点电压耦合项和交流侧等效电阻会增大电流谐波及无法通过常规方法进行准确估计的问题,设计一种混合参数自适应的迭代学习控制方法,以进行解耦控制并消除不确定参数的影响。通过构造Lyapunov函数和理论推导验证控制方法的稳定性。在整流器硬件平台上进行试验验证,结果表明,所设计的控制方法可有效降低电流谐波。展开更多
The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human body.In neurons,lipids are involved in signaling pathways controlling autophagy,a lyso...The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human body.In neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely known.In this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in neurons.Then we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.展开更多
β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unkno...β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.展开更多
为进一步提高中点电压钳制(neutral point clamped,NPC)H桥级联五电平逆变器的动态响应、降低控制器计算负担的同时确保装置低损耗运行,文中在电压矢量矩形区域分类的基础上,提出一种以满足动态响应和降低开关损耗为目标的两级优化模型...为进一步提高中点电压钳制(neutral point clamped,NPC)H桥级联五电平逆变器的动态响应、降低控制器计算负担的同时确保装置低损耗运行,文中在电压矢量矩形区域分类的基础上,提出一种以满足动态响应和降低开关损耗为目标的两级优化模型预测电压控制策略。首先根据逆变器数学模型和期望电流进行目标电压矢量计算、修正,接着基于矩形区域分类对目标电压矢量进行定位;并以定位后的候选矢量为基础,设计了两级优化目标函数以输出满足要求的最优矢量。仿真和实验结果验证了该方法的有效性,与空间矢量脉宽调制以及传统模型预测电流、电压控制策略相比,该文所研究的两级优化模型预测电压控制策略,在确保逆变器动态响应的前提下既能降低控制器计算负担,还能有效减少器件开关损耗。展开更多
Optimization calculations of 209 polychlorinated biphenyls (PCBs) were carried out at the B3LYP/6-31G* level. It was found that there is significant correlation between the Cl substitution position and some structural...Optimization calculations of 209 polychlorinated biphenyls (PCBs) were carried out at the B3LYP/6-31G* level. It was found that there is significant correlation between the Cl substitution position and some structural parameters. Consequently, Cl substitution positions were taken as theoretical descriptors to establish a novel QSPR model for predicting –lgS_w of all PCB congeners. The model achieved in this work contains four variables, of which r2 = 0.9527, q2 = 0.9490 and SD = 0.25 with large t values. In addition, the variation inflation factors (VIFs) of variables in this model are all less than 5.0, suggesting high accuracy of the –lgS_w predicting model. And the results of cross-validation test and method validation also show that the model exhibits optimum stability and better predictive capability than that from the AM1 method.展开更多
"It’s time for deepening the reform,and we will keep forging ahead resolutely",spokesman Zhao Qizheng made this remark as the prelude to 2012 CPPCC & NPC on the first press conference of the Fifth
This paper presents the design and implementation of a 3 kVA three-phase active T-type neutral-point clamped (NPC) inverter with GaN power devices for low-voltage microgrids. The designed inverter is used in a battery...This paper presents the design and implementation of a 3 kVA three-phase active T-type neutral-point clamped (NPC) inverter with GaN power devices for low-voltage microgrids. The designed inverter is used in a battery-based energy system (BESS) for power conversion optimization in applications to low-voltage microgrids. A modular design method has been developed for the design and implementation of the AT-NPC inverter. Experimental verification has been carried out based on a 3-kW three-phase T-Type NPC grid-connected inverter. FPGA based digital control technique has been developed for the current control of the three-level three-phase grid inverter. A maximum efficiency of 98.49% has been achieved within a load range from 50% to 75%.展开更多
As the world's major economies still kept in the mires of recesssion,China realized a speedy recovery with a 8.7-percent economic growth in2009.so,although,NPC & CPPCC has closed its curtains in Beijing on Mar...As the world's major economies still kept in the mires of recesssion,China realized a speedy recovery with a 8.7-percent economic growth in2009.so,although,NPC & CPPCC has closed its curtains in Beijing on March 14,2010,we still can heard about the comments on them.During the two sessions,the world media focused their attentions on what China next steps will be implemented,and which展开更多
THE National People’s Congress(NPC)concluded its annual session on March 16,2016.The session,which convened on March 5,reviewed and approved the outline of the 13th Five-Year Plan(2016-2020)
The third session of the 12th National People’s Congress(NPC)began in Beijing on March 5,2015.At the opening meeting,Chinese Premier Li Keqiang delivered the government work report and gave an overview of the 2015 wo...The third session of the 12th National People’s Congress(NPC)began in Beijing on March 5,2015.At the opening meeting,Chinese Premier Li Keqiang delivered the government work report and gave an overview of the 2015 work plan.The ten-and-a-half-day session reviewed a draft amendment to the country’s Legislation Law.Lawmakers have now set the stage for an important year in China’s efforts to deepen re-展开更多
文摘In March,the annual national conferences-the 5th Session of the 10th National People's Congress(NPC)and the 5th Session of the 10th National People's Politic Consultative Congress (CPPCC),were held in Beijing.35 representatives and members of NPC and CPPCC from Tibet Autonomous Region(TAR) took part into these two big conventions.
文摘THE eyes and ears of the country are turned every March to the annual sessions of the National People’s Congress (NPC) and Chinese People’s Political Consultative Conference (CPPCC), and increasingly so is worldwide attention.
文摘为降低中点箝位型(neutral point clamped,NPC)三电平整流器的电流谐波,在dq同步旋转坐标系下推导出带中点电压耦合项的NPC三电平整流器数学模型,并分析中点电压对电流控制的影响。对模型中的中点电压耦合项和交流侧等效电阻会增大电流谐波及无法通过常规方法进行准确估计的问题,设计一种混合参数自适应的迭代学习控制方法,以进行解耦控制并消除不确定参数的影响。通过构造Lyapunov函数和理论推导验证控制方法的稳定性。在整流器硬件平台上进行试验验证,结果表明,所设计的控制方法可有效降低电流谐波。
基金funded by grants from Fondo Nacional de Desarrollo Científico y Tecnológico,FONDECYT 1200499 to EM,11200592 to MJY,1211329 to ACby the ANID PIA ACT172066 to EM and AC+3 种基金by the ANID postdoctoral fellowship 3210630 to MPHCby the ANID doctoral fellowship 21230122 to DPNby the ANID doctoral fellowship 21211189 to PRby the ANID doctoral fellowship by the ANID doctoral fellowship 21210611 to FDC。
文摘The brain is,after the adipose tissue,the organ with the greatest amount of lipids and diversity in their composition in the human body.In neurons,lipids are involved in signaling pathways controlling autophagy,a lysosome-dependent catabolic process essential for the maintenance of neuronal homeostasis and the function of the primary cilium,a cellular antenna that acts as a communication hub that transfers extracellular signals into intracellular responses required for neurogenesis and brain development.A crosstalk between primary cilia and autophagy has been established;however,its role in the control of neuronal activity and homeostasis is barely known.In this review,we briefly discuss the current knowledge regarding the role of autophagy and the primary cilium in neurons.Then we review the recent literature about specific lipid subclasses in the regulation of autophagy,in the control of primary cilium structure and its dependent cellular signaling in physiological and pathological conditions,specifically focusing on neurons,an area of research that could have major implications in neurodevelopment,energy homeostasis,and neurodegeneration.
基金supported by the National Natural Science Foundation of China,Nos.82104158(to XT),31800887(to LY),31972902(to LY),82001422(to YL)China Postdoctoral Science Foundation,No.2020M683750(to LY)partially by Young Talent Fund of University Association for Science and Technology in Shaanxi Province of China,No.20200307(to LY).
文摘β-Sitosterol is a type of phytosterol that occurs naturally in plants.Previous studies have shown that it has anti-oxidant,anti-hyperlipidemic,anti-inflammatory,immunomodulatory,and anti-tumor effects,but it is unknown whetherβ-sitosterol treatment reduces the effects of ischemic stroke.Here we found that,in a mouse model of ischemic stroke induced by middle cerebral artery occlusion,β-sitosterol reduced the volume of cerebral infarction and brain edema,reduced neuronal apoptosis in brain tissue,and alleviated neurological dysfunction;moreover,β-sitosterol increased the activity of oxygen-and glucose-deprived cerebral cortex neurons and reduced apoptosis.Further investigation showed that the neuroprotective effects ofβ-sitosterol may be related to inhibition of endoplasmic reticulum stress caused by intracellular cholesterol accumulation after ischemic stroke.In addition,β-sitosterol showed high affinity for NPC1L1,a key transporter of cholesterol,and antagonized its activity.In conclusion,β-sitosterol may help treat ischemic stroke by inhibiting neuronal intracellular cholesterol overload/endoplasmic reticulum stress/apoptosis signaling pathways.
文摘虚拟同步机VSG(virtual synchronous generator)通过模拟同步机特性为新能源并网提供惯性和阻尼。然而,电力电子开关器件高频开关过程中可能会发生断路故障,导致输出电流波形严重畸变,影响电网安全稳定运行。针对中点箝位型NPC(neutral point clamped)三电平VSG桥臂故障问题,提出一种中点电压均衡的VSG容错模型预测控制策略。分析NPC三电平VSG单相桥臂故障后运行机理,在开关器件故障后利用直流侧电容组成虚拟桥臂,重构为VSG桥臂故障容错结构。建立故障情况下预测电流模型,重构故障状态空间电压矢量,将直流侧中点电容电压引入容错模型代价函数,减小电容电压波动,实现VSG桥臂故障容错运行。实验结果表明,在开关器件发生故障后,NPC三电平VSG能容错连续运行,验证了所提模型预测容错控制策略的有效性,提高了VSG运行可靠性。
文摘为进一步提高中点电压钳制(neutral point clamped,NPC)H桥级联五电平逆变器的动态响应、降低控制器计算负担的同时确保装置低损耗运行,文中在电压矢量矩形区域分类的基础上,提出一种以满足动态响应和降低开关损耗为目标的两级优化模型预测电压控制策略。首先根据逆变器数学模型和期望电流进行目标电压矢量计算、修正,接着基于矩形区域分类对目标电压矢量进行定位;并以定位后的候选矢量为基础,设计了两级优化目标函数以输出满足要求的最优矢量。仿真和实验结果验证了该方法的有效性,与空间矢量脉宽调制以及传统模型预测电流、电压控制策略相比,该文所研究的两级优化模型预测电压控制策略,在确保逆变器动态响应的前提下既能降低控制器计算负担,还能有效减少器件开关损耗。
基金This work was supported by the 973 National Basic Research Program of China (2003CB415002)the China Postdoctoral Science Foundation (No. 2003033486)
文摘Optimization calculations of 209 polychlorinated biphenyls (PCBs) were carried out at the B3LYP/6-31G* level. It was found that there is significant correlation between the Cl substitution position and some structural parameters. Consequently, Cl substitution positions were taken as theoretical descriptors to establish a novel QSPR model for predicting –lgS_w of all PCB congeners. The model achieved in this work contains four variables, of which r2 = 0.9527, q2 = 0.9490 and SD = 0.25 with large t values. In addition, the variation inflation factors (VIFs) of variables in this model are all less than 5.0, suggesting high accuracy of the –lgS_w predicting model. And the results of cross-validation test and method validation also show that the model exhibits optimum stability and better predictive capability than that from the AM1 method.
文摘"It’s time for deepening the reform,and we will keep forging ahead resolutely",spokesman Zhao Qizheng made this remark as the prelude to 2012 CPPCC & NPC on the first press conference of the Fifth
文摘This paper presents the design and implementation of a 3 kVA three-phase active T-type neutral-point clamped (NPC) inverter with GaN power devices for low-voltage microgrids. The designed inverter is used in a battery-based energy system (BESS) for power conversion optimization in applications to low-voltage microgrids. A modular design method has been developed for the design and implementation of the AT-NPC inverter. Experimental verification has been carried out based on a 3-kW three-phase T-Type NPC grid-connected inverter. FPGA based digital control technique has been developed for the current control of the three-level three-phase grid inverter. A maximum efficiency of 98.49% has been achieved within a load range from 50% to 75%.
文摘As the world's major economies still kept in the mires of recesssion,China realized a speedy recovery with a 8.7-percent economic growth in2009.so,although,NPC & CPPCC has closed its curtains in Beijing on March 14,2010,we still can heard about the comments on them.During the two sessions,the world media focused their attentions on what China next steps will be implemented,and which
文摘THE National People’s Congress(NPC)concluded its annual session on March 16,2016.The session,which convened on March 5,reviewed and approved the outline of the 13th Five-Year Plan(2016-2020)
文摘The third session of the 12th National People’s Congress(NPC)began in Beijing on March 5,2015.At the opening meeting,Chinese Premier Li Keqiang delivered the government work report and gave an overview of the 2015 work plan.The ten-and-a-half-day session reviewed a draft amendment to the country’s Legislation Law.Lawmakers have now set the stage for an important year in China’s efforts to deepen re-
