Background:Infants born outside perinatal centers may have compromised outcomes due to the transfer speed and effi ciency to an appropriate tertiary center.This study aimed to evaluate the impact of regional coordinat...Background:Infants born outside perinatal centers may have compromised outcomes due to the transfer speed and effi ciency to an appropriate tertiary center.This study aimed to evaluate the impact of regional coordinated changes in perinatal supports and retrieval services on the outcome of transported neonates in Beijing,China.Methods:Information about transported newborns between phase 1(July 1,2004 to June 30,2006)and phase 2(July 1,2007 to June 30,2009)was collected.The strategic changes during phase 2 included standardized neonatal transport procedures,skilled attendants,a perinatal consulting service,and preferential admission of transported neonates to the intensive care unit of the tertiary care center.Data from phase 2(after-strategic changes)were compared with those of phase 1(the period of pre-strategic changes)after a 12-month washout period,especially regarding the reduction in mortality and selected morbidity.Results:There was a large increase in the number of transported infants in phase 2 compared with phase 1(2797 vs.567 patients).The average monthly rate of increase of transported infants was 383.3%(from 24 infants per month to 116 infants per month).The mortality rate of transported neonates reduced significantly from phase 1 to phase 2(5.11%vs.2.82%;P=0.005),particularly for preterm infants(8.47%vs.4.34%;P=0.006).In addition,transported neonates during phase 2 had signifi cantly decreased morbidities.Conclusions:Regional coordinated strategies optimizing the perinatal services and transport of outborn sick and preterm infants to tertiary care centers improved survival outcomes considerably.These findings have vital implications for health outcomes and resource planning.展开更多
Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root.Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke.Here,we investigate the neuroprotective effect of ba...Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root.Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke.Here,we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy.Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia（8% oxygen at 37°C） for 2 hours,before being injected with baicalin（120 mg/kg intraperitoneally） and examined 24 hours later.Baicalin effectively reduced cerebral infarct volume and neuronal loss,inhibited apoptosis,and upregulated the expression of p-Akt and glutamate transporter 1.Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B（PI3 K/Akt） inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1,and weakened the associated neuroprotective effect.Our findings provide the first evidence,to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3 K/Akt signaling pathway.展开更多
基金supported by a grant from Capital Medical Development Funding committee(2005-3044).
文摘Background:Infants born outside perinatal centers may have compromised outcomes due to the transfer speed and effi ciency to an appropriate tertiary center.This study aimed to evaluate the impact of regional coordinated changes in perinatal supports and retrieval services on the outcome of transported neonates in Beijing,China.Methods:Information about transported newborns between phase 1(July 1,2004 to June 30,2006)and phase 2(July 1,2007 to June 30,2009)was collected.The strategic changes during phase 2 included standardized neonatal transport procedures,skilled attendants,a perinatal consulting service,and preferential admission of transported neonates to the intensive care unit of the tertiary care center.Data from phase 2(after-strategic changes)were compared with those of phase 1(the period of pre-strategic changes)after a 12-month washout period,especially regarding the reduction in mortality and selected morbidity.Results:There was a large increase in the number of transported infants in phase 2 compared with phase 1(2797 vs.567 patients).The average monthly rate of increase of transported infants was 383.3%(from 24 infants per month to 116 infants per month).The mortality rate of transported neonates reduced significantly from phase 1 to phase 2(5.11%vs.2.82%;P=0.005),particularly for preterm infants(8.47%vs.4.34%;P=0.006).In addition,transported neonates during phase 2 had signifi cantly decreased morbidities.Conclusions:Regional coordinated strategies optimizing the perinatal services and transport of outborn sick and preterm infants to tertiary care centers improved survival outcomes considerably.These findings have vital implications for health outcomes and resource planning.
基金supported by the Chinese Medicine Research Foundation of Jiangxi Provincial Health Department of China,No.2013A040the Science and Technology Program of Jiangxi Provincial Health Department of China,No.20123023the Science and Technology Support Program of Jiangxi Province of China,No.2009BSB11209
文摘Baicalin is a flavonoid compound extracted from Scutellaria baicalensis root.Recent evidence indicates that baicalin is neuroprotective in models of ischemic stroke.Here,we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic encephalopathy.Seven-day-old pups underwent left common carotid artery ligation followed by hypoxia（8% oxygen at 37°C） for 2 hours,before being injected with baicalin（120 mg/kg intraperitoneally） and examined 24 hours later.Baicalin effectively reduced cerebral infarct volume and neuronal loss,inhibited apoptosis,and upregulated the expression of p-Akt and glutamate transporter 1.Intracerebroventricular injection of the phosphoinositide 3-kinase/protein kinase B（PI3 K/Akt） inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1,and weakened the associated neuroprotective effect.Our findings provide the first evidence,to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3 K/Akt signaling pathway.
