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Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals 被引量:1
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作者 Tao Zhang Jun Wan +3 位作者 Zhajun Zhan Jian Bai Bingyu Liu Youcai Hu 《Acta Pharmaceutica Sinica B》 SCIE CAS CSCD 2018年第3期478-487,共10页
Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis,yet most clusters remain cryptic or down-regulated. Genome mining revealed an unconventional paraherquonin-like meroterpenoid ... Fungal genomes carry many gene clusters seemingly capable of natural products biosynthesis,yet most clusters remain cryptic or down-regulated. Genome mining revealed an unconventional paraherquonin-like meroterpenoid biosynthetic gene cluster in the chromosome of Neosartorya glabra.The cryptic or down-regulated pathway was activated by constitutive expression of pathway-specific regulator gene ber A encoded within ber biosynthetic gene cluster. Chemical analysis of mutant Ng-OE:ber A extracts enabled the isolation of four berkeleyacetal congeners, in which two of them are new. On the basis of careful bioinformatic analysis of the coding enzymes in the ber gene cluster, the biosynthetic pathway of berkeleyacetals was proposed. These results indicate that this approach would be valuable for discovery of novel natural products and will accelerate the exploitation of prodigious natural products in filamentous fungi. 展开更多
关键词 neosartorya glabra Meroterpenoid Berkeleyacetals Genome mining Cryptic gene cluster BIOSYNTHESIS
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