[Objectives]This study was conducted to screen lavandulyl flavonoids with anti-inflammatory activity from Sophora flavescens.[Methods]35 compounds were screened from traditional Chinese medicine S.flavescens using the...[Objectives]This study was conducted to screen lavandulyl flavonoids with anti-inflammatory activity from Sophora flavescens.[Methods]35 compounds were screened from traditional Chinese medicine S.flavescens using the nitric oxide(NO)anti-inflammatory activity model.[Results]Five components,8(xanthohumol),13(kurarinol),27(4-methoxysalicylic acid),28(b-resorcic acid)and 30(b-resorcic acid),exhibited significant anti-inflammatory activity,with IC 50 values of 5.99,4.76,6.96,3.41 and 5.22μM,respectively.Especially,8(xanthohumol)and 13(kurarinol)were typical lavandulyl flavonoids in S.flavescens,which were worth further exploration.Furthermore,UPLC-Q-Exactive and GNPS molecular networking technique were used for rapid analysis of lavandulyl flavonoids from S.flavescens.A total of 15 components were identified.[Conclusions]This work lays a theoretical foundation for further separation and analysis of lavandulyl flavonoids with anti-inflammatory activity from S.flavescens.展开更多
The fast development of IP services forces the traffic flow in the networks to move gradually from Time Division Multiplexing(TDM) services to packet data services.To adapt to the change,low-cost Ethernet technologies...The fast development of IP services forces the traffic flow in the networks to move gradually from Time Division Multiplexing(TDM) services to packet data services.To adapt to the change,low-cost Ethernet technologies are introduced into the Metropolitan Area Network(MAN).Ring network control protocols and ring network protection technologies are applied to guarantee manageability and reliability required in the telecom networks.The Ethernet Ring Protection(ERP) and Resilient Packet Ring(RPR) are two different ring protection technologies.The Transport Multi-Protocol Label Switching(T-MPLS) network uses the T-MPLS Shared Protection Ring(TM-SPRing) technology to provide ring protection.Carriers can expand the protection as needed and use appropriate ring technologies to meet the requirements of Carrier Ethernet(CE).展开更多
The End-to-End Reconfigurability (E2R) project aims at realizing the convergence of the heterogeneous radio networks and the optimal utilization of the radio resources. With the continuous development of E2R technolog...The End-to-End Reconfigurability (E2R) project aims at realizing the convergence of the heterogeneous radio networks and the optimal utilization of the radio resources. With the continuous development of E2R technology and cognitive theory, the evolution from existing radio networks to future reconfigurable radio networks with the cognitive ability becomes possible. Nowadays the research aspects of E2R include the system architecture of reconfigurable radio networks and some key technologies for their evolution.展开更多
In the computer field,network security is a crucial integrant.It is necessary to pay attention on the application of virtual network technology,so as to raise the standard of computer network security to a new level[2...In the computer field,network security is a crucial integrant.It is necessary to pay attention on the application of virtual network technology,so as to raise the standard of computer network security to a new level[2].In view of this,this paper will analyze the application of virtual network technology in computer network security and propose some strategies for future reference.展开更多
Computer network technology has a very important role in electronic information engineering.The application of this technology not only enriches the traditional information engineering functions,but also effectively g...Computer network technology has a very important role in electronic information engineering.The application of this technology not only enriches the traditional information engineering functions,but also effectively guarantees the efficiency and quality.At present,due to the wide variety of external information that Chinese citizens are exposed to,in addition to the variegated and mixed content,it is easy for information to be leaked or stolen.In order to avoid similar situations,it is necessary for people to pay more attention to network system security,so as to ensure that the quality of life of citizens can be guaranteed.In view of that,this paper discusses and analyzes the application of computer network technology in electronic information engineering.展开更多
Wireless Sensor Network (WSN) has been emerging in the last decade as a powerful tool for connecting physical and digital world. WSN has been used in many applications such habitat monitoring, building monitoring, sma...Wireless Sensor Network (WSN) has been emerging in the last decade as a powerful tool for connecting physical and digital world. WSN has been used in many applications such habitat monitoring, building monitoring, smart grid and pipeline monitoring. In addition, few researchers have been experimenting with WSN in many mission-critical applications such as military applications. This paper surveys the literature for experimenting work done in border surveillance and intrusion detection using the technology of WSN. The potential benefits of using WSN in border surveillance are huge;however, up to our knowledge very few attempts of solving many critical issues about this application could be found in the literature.展开更多
The advantages of the multimedia network technology, such as the rich network information resources, the strong interactivity and the multi-user ability, have brought great convenience to the modem education and teach...The advantages of the multimedia network technology, such as the rich network information resources, the strong interactivity and the multi-user ability, have brought great convenience to the modem education and teaching, promoted the transformation of the traditional teaching mode, and facilitated the introduction of the high-quality art teaching resources and improved the art education. The quality is promoting the innovation of the art education, driving the development of the art education in colleges and universities. Art education is of great significance to the human and the social development We should pay attention to the development of the art education, combine the multimedia network technology, apply the modem educational technology and methods to reform and transform the teaching modes, teaching contents and teaching methods of the art education to make more artistic amateurs to learn and enjoy the art knowledge.展开更多
The issues of wireless communication network autonomy,the definition of capability level and the concept of AI-native solution based on the integration of the information communication data technology(ICDT)are first i...The issues of wireless communication network autonomy,the definition of capability level and the concept of AI-native solution based on the integration of the information communication data technology(ICDT)are first introduced in this paper.A series of innovative technologies proposed by ZTE Corporation,such as an autonomous evolution network and intelligent orchestration network,are then analyzed.These technologies are developed to realize the evolution of wireless networks to Level-4 and Level-5 intelligent networks.It is expected that the future AI-native intelligent network system will be built based on innovative technologies such as digital twins,intent-based networking,and the data plane and intelligent plane.These new technical paradigms will promote the development of intelligent B5G and 6G networks.展开更多
Marine data buoy can provide a long-term, continuous, real-time, reliable data of ocean observation in a variety of complex marine environment. It is one of the most reliable, most effective and important means of oce...Marine data buoy can provide a long-term, continuous, real-time, reliable data of ocean observation in a variety of complex marine environment. It is one of the most reliable, most effective and important means of ocean monitoring technology. In this paper, the classification, main theory and technology system of marine data buoy are summarized. The typical technological breakthrough of the development of marine data buoy in recent years is summarized. The composition and application of marine monitoring network in China was introduced, and the gap between the technology of China's marine data buoy and the international advanced countries is compared.Combined on the situation and demand of China's current situation and needs, the development trend of marine data buoy and buoy monitoring network are expected.展开更多
This paper discussed the necessity of establishing a computer network in a mining railway transport management system. The network structure and the system security design, associated with the real development conditi...This paper discussed the necessity of establishing a computer network in a mining railway transport management system. The network structure and the system security design, associated with the real development condition of a mining area, were brought forward, and the system evaluation was given.展开更多
With the development of database and computer network technology, traditional TV news production mode (TVNPM) faces great challenge. Up to now, evolution of TVNPM has experienced two stages: In the beginning, TV news ...With the development of database and computer network technology, traditional TV news production mode (TVNPM) faces great challenge. Up to now, evolution of TVNPM has experienced two stages: In the beginning, TV news is produced completely by hand, named as pipelining TVNPM in this paper. This production mode is limited to space and time, so its production cycle is very time-consuming, and it requires a lot of harmony in different departments; Subsequently, thanks to applications of database technology, a new TVNPM appears, which is named as pooled information resource TVNPM. Compared with pipelining TVNPM, this mode promotes information sharing. However, with the development of network technology, especially the Intranet and the Internet, the pooled information resource TVNPM receives strong impact, and it is referred to contrive a new TVNPM. This new TVNPM must support information sharing, remote collaboration, and interaction in communications so as to improve group work efficiency. In this paper, we present such a new TVNPM, namely, Network TVNPM, give a suit of system solution to support the new TVNPM, introduce the new workflow, and in the end analyze the advantages of Network TVNPM.展开更多
This paper introduces a novel robot for outer surface inspection of boiler tubes. The paper describes the hardware system, wireless communication strategy, communication procedure and system software of the robot. The...This paper introduces a novel robot for outer surface inspection of boiler tubes. The paper describes the hardware system, wireless communication strategy, communication procedure and system software of the robot. The WLAN technology is used in the robot. It solves the problem of shielding generated by iron boiler and 11Mbps bandwidth made it possible for video and control stream real-time transmit within the same channel. Though TCP/IP protocol is robust, serial server is a transparent channel but cannot detect error and retransmit the data. In order to improve the reliability of serial communication, a new communication protocol is proposed.展开更多
Microwave transmission in a space network is greatly restricted due to precious radio spectrum resources. To meet the demand for large-bandwidth, global seamless coverage and on-demanding access, the Space All-Optical...Microwave transmission in a space network is greatly restricted due to precious radio spectrum resources. To meet the demand for large-bandwidth, global seamless coverage and on-demanding access, the Space All-Optical Network(SAON) becomes a promising paradigm. In this paper, the related space optical communications and network programs around the world are first briefly introduced. Then the intelligent Space All-Optical Network(i-SAON), which can be deemed as an advanced SAON, is illustrated, with the emphasis on its features of high survivability, sensing and reconfiguration intelligence, and large capacity for all optical load and switching. Moreover, some key technologies for i-SAON are described, including the rapid adjustment and control of the laser beam direction, the deep learning-based multi-path anti-fault routing, the intelligent multi-fault diagnosis and switching selection mechanism, and the artificial intelligence-based spectrum sensing and situational forecasting.展开更多
With the current development trend of Ethernet gradually towards the control network of plant-floor layer and devices layer, much management information on Intelligent Circuit Breaker Controller (ICBC) is becoming dis...With the current development trend of Ethernet gradually towards the control network of plant-floor layer and devices layer, much management information on Intelligent Circuit Breaker Controller (ICBC) is becoming distributed and networked. This paper describes a mixing structure of complex industrial field control network based on Ethernet frame, then mainly discusses three network management methods of ICBC, such as the interconnection method based on PCI, embedded gateway and em- bedded Web server. At the same time, it also gives the basic hardware framework of implementing interconnection, the type of main components, and the real-time operation system supporting the embedded TCP/IP protocols and Web server.展开更多
The detection system integrates control technology, network technology, video encoding and decoding, video transmiss-ion, multi-single chip microcomputer communication, dat-abase technology, computer software and robo...The detection system integrates control technology, network technology, video encoding and decoding, video transmiss-ion, multi-single chip microcomputer communication, dat-abase technology, computer software and robot technology. The robot can adaptively adjust its status according to diameter (from 400 mm to 650 mm) of pipeline. The maximum detection distance is up to 1 000 m. The method of video coding in the system is based on fractal transformation. The experiments show that the coding scheme is fast and good PSNR. The precision of on-line detection is up to 3% thickness of pipeline wall. The robot can also have a high precision of location up to 0.03 m. The control method is based on network and characterized by on-line and real-time. The experiment in real gas pipeline shows that the performance of the detection system is good.展开更多
In LEO satellite communication networks,the number of satellites has increased sharply, the relative velocity of satellites is very fast, then electronic signal aliasing occurs from time to time. Those aliasing signal...In LEO satellite communication networks,the number of satellites has increased sharply, the relative velocity of satellites is very fast, then electronic signal aliasing occurs from time to time. Those aliasing signals make the receiving ability of the signal receiver worse, the signal processing ability weaker,and the anti-interference ability of the communication system lower. Aiming at the above problems, to save communication resources and improve communication efficiency, and considering the irregularity of interference signals, the underdetermined blind separation technology can effectively deal with the problem of interference sensing and signal reconstruction in this scenario. In order to improve the stability of source signal separation and the security of information transmission, a greedy optimization algorithm can be executed. At the same time, to improve network information transmission efficiency and prevent algorithms from getting trapped in local optima, delete low-energy points during each iteration process. Ultimately, simulation experiments validate that the algorithm presented in this paper enhances both the transmission efficiency of the network transmission system and the security of the communication system, achieving the process of interference sensing and signal reconstruction in the LEO satellite communication system.展开更多
Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content...Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content weight.Methods:The experimental groups were divided into:0:10,1:4,1:2,1:1,2:1,4:1,10:0.The relative content(Ri)of the chemical constituents of ginger's volatile oil was determined using gas chromatography-mass spectrometry(GC-MS).Additionally,the physicochemical and biological property parameters(LogP,MDCK,PPB,MW)of the components were considered.To assess the quantitative effect of the components,a grading score was performed,and the quantitative effect index(Ki)was calculated.Subsequently,the target effect index(Ti)was calculated by combining the component-target matching score(Fit score).Using these calculations,the target effect score A was determined under the influence of multiple components targeting different targets.Key targets with A≥1000 were identified.To predict the targets related to head wind disease,the Comparative Toxicogenomics Database(https://ctdbase.org/),Gene Cards(https://www.genecards.org/),and Disgenet database(https://www.disgenet.org/)were utilized.The key targets,obtained from different proportions of ginger's volatile oil and gingerol,were intersected with the predicted targets.This facilitated network pharmacological analysis and verification of the efficacy.Results:The content of volatile oil in ginger demonstrated an impact on key targets associated with the volatile oil group.Each specific combination of volatile oil consistently activated distinct pathways,with variations stemming from changes in content.Experimental testing revealed that different combinations of ginger's volatile oil and gingerol effectively alleviated migraine symptoms in rats.Conclusion:Through the application of content-weighted network pharmacology technology and pharmacodynamic verification,it was determined that altering the ratio between ginger's volatile oil and gingerol leads to variations in potential targets and pathways,consequently impacting its efficacy.展开更多
基金Supported by Guizhou Provincial Science and Technology(ZK(2022)-362,ZK(2024)-047,[2023]ZK01)The Innovation and Entrepreneurship Training Program for Undergraduates from China[202210660131,202310660082]+2 种基金Science Foundation of Guizhou Education Technology(2022-064)University Engineering Research Center for the Prevention and Treatment of Chronic Diseases by Authentic Medicinal Materials in Guizhou Province([2023]035)Science and Technology Research Project of Guizhou Administration of Traditional Chinese Medicine(QZYY-2024-134).
文摘[Objectives]This study was conducted to screen lavandulyl flavonoids with anti-inflammatory activity from Sophora flavescens.[Methods]35 compounds were screened from traditional Chinese medicine S.flavescens using the nitric oxide(NO)anti-inflammatory activity model.[Results]Five components,8(xanthohumol),13(kurarinol),27(4-methoxysalicylic acid),28(b-resorcic acid)and 30(b-resorcic acid),exhibited significant anti-inflammatory activity,with IC 50 values of 5.99,4.76,6.96,3.41 and 5.22μM,respectively.Especially,8(xanthohumol)and 13(kurarinol)were typical lavandulyl flavonoids in S.flavescens,which were worth further exploration.Furthermore,UPLC-Q-Exactive and GNPS molecular networking technique were used for rapid analysis of lavandulyl flavonoids from S.flavescens.A total of 15 components were identified.[Conclusions]This work lays a theoretical foundation for further separation and analysis of lavandulyl flavonoids with anti-inflammatory activity from S.flavescens.
基金supported by the National High-Tech Research and Development Plan of China ("863" Program) under Grant No.2006AA01Z246.
文摘The fast development of IP services forces the traffic flow in the networks to move gradually from Time Division Multiplexing(TDM) services to packet data services.To adapt to the change,low-cost Ethernet technologies are introduced into the Metropolitan Area Network(MAN).Ring network control protocols and ring network protection technologies are applied to guarantee manageability and reliability required in the telecom networks.The Ethernet Ring Protection(ERP) and Resilient Packet Ring(RPR) are two different ring protection technologies.The Transport Multi-Protocol Label Switching(T-MPLS) network uses the T-MPLS Shared Protection Ring(TM-SPRing) technology to provide ring protection.Carriers can expand the protection as needed and use appropriate ring technologies to meet the requirements of Carrier Ethernet(CE).
基金supported by the National Natural Science Foundation of China under Grant No. 60632030the E3 Project(FP7-ICT-2007-216248) with in Community’s Seventh Framework Program.
文摘The End-to-End Reconfigurability (E2R) project aims at realizing the convergence of the heterogeneous radio networks and the optimal utilization of the radio resources. With the continuous development of E2R technology and cognitive theory, the evolution from existing radio networks to future reconfigurable radio networks with the cognitive ability becomes possible. Nowadays the research aspects of E2R include the system architecture of reconfigurable radio networks and some key technologies for their evolution.
文摘In the computer field,network security is a crucial integrant.It is necessary to pay attention on the application of virtual network technology,so as to raise the standard of computer network security to a new level[2].In view of this,this paper will analyze the application of virtual network technology in computer network security and propose some strategies for future reference.
文摘Computer network technology has a very important role in electronic information engineering.The application of this technology not only enriches the traditional information engineering functions,but also effectively guarantees the efficiency and quality.At present,due to the wide variety of external information that Chinese citizens are exposed to,in addition to the variegated and mixed content,it is easy for information to be leaked or stolen.In order to avoid similar situations,it is necessary for people to pay more attention to network system security,so as to ensure that the quality of life of citizens can be guaranteed.In view of that,this paper discusses and analyzes the application of computer network technology in electronic information engineering.
文摘Wireless Sensor Network (WSN) has been emerging in the last decade as a powerful tool for connecting physical and digital world. WSN has been used in many applications such habitat monitoring, building monitoring, smart grid and pipeline monitoring. In addition, few researchers have been experimenting with WSN in many mission-critical applications such as military applications. This paper surveys the literature for experimenting work done in border surveillance and intrusion detection using the technology of WSN. The potential benefits of using WSN in border surveillance are huge;however, up to our knowledge very few attempts of solving many critical issues about this application could be found in the literature.
文摘The advantages of the multimedia network technology, such as the rich network information resources, the strong interactivity and the multi-user ability, have brought great convenience to the modem education and teaching, promoted the transformation of the traditional teaching mode, and facilitated the introduction of the high-quality art teaching resources and improved the art education. The quality is promoting the innovation of the art education, driving the development of the art education in colleges and universities. Art education is of great significance to the human and the social development We should pay attention to the development of the art education, combine the multimedia network technology, apply the modem educational technology and methods to reform and transform the teaching modes, teaching contents and teaching methods of the art education to make more artistic amateurs to learn and enjoy the art knowledge.
文摘The issues of wireless communication network autonomy,the definition of capability level and the concept of AI-native solution based on the integration of the information communication data technology(ICDT)are first introduced in this paper.A series of innovative technologies proposed by ZTE Corporation,such as an autonomous evolution network and intelligent orchestration network,are then analyzed.These technologies are developed to realize the evolution of wireless networks to Level-4 and Level-5 intelligent networks.It is expected that the future AI-native intelligent network system will be built based on innovative technologies such as digital twins,intent-based networking,and the data plane and intelligent plane.These new technical paradigms will promote the development of intelligent B5G and 6G networks.
基金Taishan Scholars Construction Project Special Funds of Shandong Province
文摘Marine data buoy can provide a long-term, continuous, real-time, reliable data of ocean observation in a variety of complex marine environment. It is one of the most reliable, most effective and important means of ocean monitoring technology. In this paper, the classification, main theory and technology system of marine data buoy are summarized. The typical technological breakthrough of the development of marine data buoy in recent years is summarized. The composition and application of marine monitoring network in China was introduced, and the gap between the technology of China's marine data buoy and the international advanced countries is compared.Combined on the situation and demand of China's current situation and needs, the development trend of marine data buoy and buoy monitoring network are expected.
文摘This paper discussed the necessity of establishing a computer network in a mining railway transport management system. The network structure and the system security design, associated with the real development condition of a mining area, were brought forward, and the system evaluation was given.
文摘With the development of database and computer network technology, traditional TV news production mode (TVNPM) faces great challenge. Up to now, evolution of TVNPM has experienced two stages: In the beginning, TV news is produced completely by hand, named as pipelining TVNPM in this paper. This production mode is limited to space and time, so its production cycle is very time-consuming, and it requires a lot of harmony in different departments; Subsequently, thanks to applications of database technology, a new TVNPM appears, which is named as pooled information resource TVNPM. Compared with pipelining TVNPM, this mode promotes information sharing. However, with the development of network technology, especially the Intranet and the Internet, the pooled information resource TVNPM receives strong impact, and it is referred to contrive a new TVNPM. This new TVNPM must support information sharing, remote collaboration, and interaction in communications so as to improve group work efficiency. In this paper, we present such a new TVNPM, namely, Network TVNPM, give a suit of system solution to support the new TVNPM, introduce the new workflow, and in the end analyze the advantages of Network TVNPM.
文摘This paper introduces a novel robot for outer surface inspection of boiler tubes. The paper describes the hardware system, wireless communication strategy, communication procedure and system software of the robot. The WLAN technology is used in the robot. It solves the problem of shielding generated by iron boiler and 11Mbps bandwidth made it possible for video and control stream real-time transmit within the same channel. Though TCP/IP protocol is robust, serial server is a transparent channel but cannot detect error and retransmit the data. In order to improve the reliability of serial communication, a new communication protocol is proposed.
基金supported by CAST Fund for Distinguished Young TalentsCASC Scientific and Technological Innovative Research and Design Projects
文摘Microwave transmission in a space network is greatly restricted due to precious radio spectrum resources. To meet the demand for large-bandwidth, global seamless coverage and on-demanding access, the Space All-Optical Network(SAON) becomes a promising paradigm. In this paper, the related space optical communications and network programs around the world are first briefly introduced. Then the intelligent Space All-Optical Network(i-SAON), which can be deemed as an advanced SAON, is illustrated, with the emphasis on its features of high survivability, sensing and reconfiguration intelligence, and large capacity for all optical load and switching. Moreover, some key technologies for i-SAON are described, including the rapid adjustment and control of the laser beam direction, the deep learning-based multi-path anti-fault routing, the intelligent multi-fault diagnosis and switching selection mechanism, and the artificial intelligence-based spectrum sensing and situational forecasting.
基金Project (No. F2005000077) supported by the Natural ScienceFoundation of Hebei Province, China
文摘With the current development trend of Ethernet gradually towards the control network of plant-floor layer and devices layer, much management information on Intelligent Circuit Breaker Controller (ICBC) is becoming distributed and networked. This paper describes a mixing structure of complex industrial field control network based on Ethernet frame, then mainly discusses three network management methods of ICBC, such as the interconnection method based on PCI, embedded gateway and em- bedded Web server. At the same time, it also gives the basic hardware framework of implementing interconnection, the type of main components, and the real-time operation system supporting the embedded TCP/IP protocols and Web server.
基金Supported by the National High technology Research and Development Program of China (No.2002 AA442110)
文摘The detection system integrates control technology, network technology, video encoding and decoding, video transmiss-ion, multi-single chip microcomputer communication, dat-abase technology, computer software and robot technology. The robot can adaptively adjust its status according to diameter (from 400 mm to 650 mm) of pipeline. The maximum detection distance is up to 1 000 m. The method of video coding in the system is based on fractal transformation. The experiments show that the coding scheme is fast and good PSNR. The precision of on-line detection is up to 3% thickness of pipeline wall. The robot can also have a high precision of location up to 0.03 m. The control method is based on network and characterized by on-line and real-time. The experiment in real gas pipeline shows that the performance of the detection system is good.
基金supported by National Natural Science Foundation of China (62171390)Central Universities of Southwest Minzu University (ZYN2022032,2023NYXXS034)the State Scholarship Fund of the China Scholarship Council (NO.202008510081)。
文摘In LEO satellite communication networks,the number of satellites has increased sharply, the relative velocity of satellites is very fast, then electronic signal aliasing occurs from time to time. Those aliasing signals make the receiving ability of the signal receiver worse, the signal processing ability weaker,and the anti-interference ability of the communication system lower. Aiming at the above problems, to save communication resources and improve communication efficiency, and considering the irregularity of interference signals, the underdetermined blind separation technology can effectively deal with the problem of interference sensing and signal reconstruction in this scenario. In order to improve the stability of source signal separation and the security of information transmission, a greedy optimization algorithm can be executed. At the same time, to improve network information transmission efficiency and prevent algorithms from getting trapped in local optima, delete low-energy points during each iteration process. Ultimately, simulation experiments validate that the algorithm presented in this paper enhances both the transmission efficiency of the network transmission system and the security of the communication system, achieving the process of interference sensing and signal reconstruction in the LEO satellite communication system.
基金Chinese Medicine Pharmaceutical Key Discipline of Shaanxi province(303061107)National key Research and Development plan(2018-YFC1706904)+2 种基金Discipline Innovation team Project of Shaanxi University of Chinese Medicine(2019-YL11)Shaanxi Province Key subject of pharmacy engineering of Shaanxi Provincial Traditional Chinese Medicine administration(2017001)Key R&D Plan of Shaanxi Province,Development of Nasal Formulations of Ginger Medicinal Components Based on"Component Traditional Chinese Medicine"(2020SF-316).
文摘Background:Exploring the efficacy,potential components,and mechanism of the combination of ginger essential oil and gingerols in the treatment of head wind disease based on network pharmacology technology with content weight.Methods:The experimental groups were divided into:0:10,1:4,1:2,1:1,2:1,4:1,10:0.The relative content(Ri)of the chemical constituents of ginger's volatile oil was determined using gas chromatography-mass spectrometry(GC-MS).Additionally,the physicochemical and biological property parameters(LogP,MDCK,PPB,MW)of the components were considered.To assess the quantitative effect of the components,a grading score was performed,and the quantitative effect index(Ki)was calculated.Subsequently,the target effect index(Ti)was calculated by combining the component-target matching score(Fit score).Using these calculations,the target effect score A was determined under the influence of multiple components targeting different targets.Key targets with A≥1000 were identified.To predict the targets related to head wind disease,the Comparative Toxicogenomics Database(https://ctdbase.org/),Gene Cards(https://www.genecards.org/),and Disgenet database(https://www.disgenet.org/)were utilized.The key targets,obtained from different proportions of ginger's volatile oil and gingerol,were intersected with the predicted targets.This facilitated network pharmacological analysis and verification of the efficacy.Results:The content of volatile oil in ginger demonstrated an impact on key targets associated with the volatile oil group.Each specific combination of volatile oil consistently activated distinct pathways,with variations stemming from changes in content.Experimental testing revealed that different combinations of ginger's volatile oil and gingerol effectively alleviated migraine symptoms in rats.Conclusion:Through the application of content-weighted network pharmacology technology and pharmacodynamic verification,it was determined that altering the ratio between ginger's volatile oil and gingerol leads to variations in potential targets and pathways,consequently impacting its efficacy.
