Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI s...Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes.展开更多
Functional near-infrared imaging (fNIR) is a non-invasive, convenient, safe and stable imaging method to test biological state. It can obtain the biological tissue hemodynamic data, thus becoming a powerful tool to me...Functional near-infrared imaging (fNIR) is a non-invasive, convenient, safe and stable imaging method to test biological state. It can obtain the biological tissue hemodynamic data, thus becoming a powerful tool to measure brain activities, mental workload, metabolism and cognitive activities state. First of all, we introduced the characteristics and current situation of fNIR in this article. Then we focused on the applications of fNIR, discussed some existing problems and future directions, including the prospect in aerospace field. Our purpose is to give a comprehensive description of fNIR and show its potential in aerospace field.展开更多
Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography pla...Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering brains.It can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μm.Experiments performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCaMP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering brains.The newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease.展开更多
Objective: To explore the possibility of using cortical infrared thermography (CIT) and temperature in studying the principle of acupuncture and moxibustion. Methods: The changes of the cerebral cortical temperature d...Objective: To explore the possibility of using cortical infrared thermography (CIT) and temperature in studying the principle of acupuncture and moxibustion. Methods: The changes of the cerebral cortical temperature during electro-acupuncture (EA) measured by CIT in twenty cats were observed. By opening the skull before experiments, the cortex of animals was revealed. The distribution of the conical temperature of the awakened animals was studied by AGA infrared thermovision, and the thermograms were analysed by computer. Results: (1) The thermograms of the profile of the cortex could be displayed clearly, the temperature was higher in the ante and lower in post-cortex than that in other regions. (2) No tendency of conical temperature ascending within 30 minutes in cats without EA. (3 ) After EA, the temperature of cortex generally increased by 0.3 to 1.7 degrees centigrade, and 5 min after EA, the increment of temperature was the highest, 10 min after EA, the temperature increment was higher than before EA, but lower than 5 min after EA. The conical temperature recovered 10 min after stopping the stimulation. (4) The temperature increment was more obvious in the regions of ant. ectosylvian, ant. supra-Sylvian and ant. Sylvian than that in other regions. No matter where the site of EA was, every group had its own special region of higher temperature increment. Conclusion: The temperature increased in the cortex were mainly in the somatosensory regions. The extent and position of temperature response of cortex after EA could be displayed with CIT directly by picture. The display of the temperature response could be taken as the indication of the nervous activity. CIT could be used to conduct the studies of the acupuncture and the brain.展开更多
文摘Diffusion weighted imaging(DWI) is a method of signal contrast generation based on the differences in Brownian motion. DWI is a method to evaluate the molecular function and micro-architecture of the human body. DWI signal contrast can be quantified by apparent diffusion coefficient maps and it acts as a tool for treatment respon-se evaluation and assessment of disease progression. Ability to detect and quantify the anisotropy of diffusion leads to a new paradigm called diffusion tensor imaging(DTI). DTI is a tool for assessment of the organs with highly organised fibre structure. DWI forms an integral part of modern state-of-art magnetic resonance imaging and is indispensable in neuroimaging and oncology. DWI is a field that has been undergoing rapid technical evolution and its applications are increasing every day. This review article provides insights in to the evolution of DWI as a new imaging paradigm and provides a summary of current role of DWI in various disease processes.
文摘Functional near-infrared imaging (fNIR) is a non-invasive, convenient, safe and stable imaging method to test biological state. It can obtain the biological tissue hemodynamic data, thus becoming a powerful tool to measure brain activities, mental workload, metabolism and cognitive activities state. First of all, we introduced the characteristics and current situation of fNIR in this article. Then we focused on the applications of fNIR, discussed some existing problems and future directions, including the prospect in aerospace field. Our purpose is to give a comprehensive description of fNIR and show its potential in aerospace field.
基金support from the European Research Council ERC-2010-StG-260991(DR)and ERC-2012-StG_20111109(AL and GGW)the National Institute of Health R21-EY026382-01(DR and SS)+1 种基金the German-Israeli Foundation(GIF)for Scientific Research and Development 1142-46.10/2011(DR and SS)the Helmholtz Association of German Research Centers and the Technische Universität München(DR and GGW)。
文摘Non-invasive observation of spatiotemporal activity of large neural populations distributed over entire brains is a longstanding goal of neuroscience.We developed a volumetric multispectral optoacoustic tomography platform for imaging neural activation deep in scattering brains.It can record 100 volumetric frames per second across scalable fields of view ranging between 50 and 1000 mm^(3) with respective spatial resolution of 35–200μm.Experiments performed in immobilized and freely swimming larvae and in adult zebrafish brains expressing the genetically encoded calcium indicator GCaMP5G demonstrate,for the first time,the fundamental ability to directly track neural dynamics using optoacoustics while overcoming the longstanding penetration barrier of optical imaging in scattering brains.The newly developed platform thus offers unprecedented capabilities for functional whole-brain observations of fast calcium dynamics;in combination with optoacoustics'well-established capacity for resolving vascular hemodynamics,it could open new vistas in the study of neural activity and neurovascular coupling in health and disease.
文摘Objective: To explore the possibility of using cortical infrared thermography (CIT) and temperature in studying the principle of acupuncture and moxibustion. Methods: The changes of the cerebral cortical temperature during electro-acupuncture (EA) measured by CIT in twenty cats were observed. By opening the skull before experiments, the cortex of animals was revealed. The distribution of the conical temperature of the awakened animals was studied by AGA infrared thermovision, and the thermograms were analysed by computer. Results: (1) The thermograms of the profile of the cortex could be displayed clearly, the temperature was higher in the ante and lower in post-cortex than that in other regions. (2) No tendency of conical temperature ascending within 30 minutes in cats without EA. (3 ) After EA, the temperature of cortex generally increased by 0.3 to 1.7 degrees centigrade, and 5 min after EA, the increment of temperature was the highest, 10 min after EA, the temperature increment was higher than before EA, but lower than 5 min after EA. The conical temperature recovered 10 min after stopping the stimulation. (4) The temperature increment was more obvious in the regions of ant. ectosylvian, ant. supra-Sylvian and ant. Sylvian than that in other regions. No matter where the site of EA was, every group had its own special region of higher temperature increment. Conclusion: The temperature increased in the cortex were mainly in the somatosensory regions. The extent and position of temperature response of cortex after EA could be displayed with CIT directly by picture. The display of the temperature response could be taken as the indication of the nervous activity. CIT could be used to conduct the studies of the acupuncture and the brain.
